iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cin-025390

Ensembl Protein ID

ENSCINP00000008019.3

UniProt Accession

F6TXB9; F6TXB9_CIOIN

Protein Name

Tyrosine-protein kinase

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCING00000016554.2	ENSCINT00000008019.3	ENSCINP00000008019.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.10e-15	57.1	13	70

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 6    vqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
             +lydy+a + d+L++kkG+++++++ ++ +++W+++ +  ++  G +P+n+v+ ++
   Q: 13   YVALYDYDARTADDLSFKKGEQLFILNSTQSEGDWWEARSLVTQHTGYIPSNYVAPAN 70
           568***************************************************9876 PP

Organism

Ciona intestinalis

Protein Sequence
(Fasta)

MPSRPSLQGQ VRYVALYDYD ARTADDLSFK KGEQLFILNS TQSEGDWWEA RSLVTQHTGY 60
IPSNYVAPAN SVQCEEWFFG KIGRKDSERL LLNQENLRGT FLIRESETAP GTFSLSILDE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGATGATAGG ATAATCAGTA ATCAGTATAT ACATGTAAAT GAGCTAATAA GAAGAGCCGT 60
ACAAAACCAA ATCTGAAACT GAAAAACTCT TTTGTTTTGT CAAGTATGTT GTATGAAATG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0042127--P:regulation of cell proliferation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001713	Ailuropoda melanoleuca	69.94	0.00e+00	677.00
IUUC-Apl-004032	Anas platyrhynchos	71.64	0.00e+00	682.00
IUUC-Aca-004255	Anolis carolinensis	72.23	0.00e+00	682.00
IUUC-Ame-010954	Astyanax mexicanus	72.23	0.00e+00	677.00
IUUC-Bta-012982	Bos taurus	70.11	0.00e+00	677.00
IUUC-Cja-019694	Callithrix jacchus	72.23	0.00e+00	682.00
IUUC-Cfa-020060	Canis familiaris	70.54	0.00e+00	680.00
IUUC-Cpo-021557	Cavia porcellus	70.66	0.00e+00	679.00
IUUC-Csa-023711	Chlorocebus sabaeus	69.94	0.00e+00	678.00
IUUC-Cho-025014	Choloepus hoffmanni	70.93	0.00e+00	664.00
IUUC-Csv-026029	Ciona savignyi	95.65	0.00e+00	835.00
IUUC-Dre-028491	Danio rerio	70.84	0.00e+00	664.00
IUUC-Dno-029651	Dasypus novemcinctus	68.12	0.00e+00	669.00
IUUC-Dor-030202	Dipodomys ordii	72.67	0.00e+00	686.00
IUUC-Ete-033170	Echinops telfairi	68.82	0.00e+00	656.00
IUUC-Eca-033970	Equus caballus	71.33	0.00e+00	678.00
IUUC-Eeu-035004	Erinaceus europaeus	54.50	1.00e-111	394.00
IUUC-Fca-036113	Felis catus	70.54	0.00e+00	680.00
IUUC-Fal-037461	Ficedula albicollis	72.23	0.00e+00	683.00
IUUC-Gmo-038929	Gadus morhua	72.09	0.00e+00	665.00
IUUC-Gga-041107	Gallus gallus	71.64	0.00e+00	681.00
IUUC-Gac-042332	Gasterosteus aculeatus	69.51	0.00e+00	684.00
IUUC-Ggo-044469	Gorilla gorilla	70.72	0.00e+00	662.00
IUUC-Hsa-046192	Homo sapiens	69.94	0.00e+00	679.00
IUUC-Itr-049014	Ictidomys tridecemlineatus	69.94	0.00e+00	680.00
IUUC-Lch-050239	Latimeria chalumnae	72.89	0.00e+00	686.00
IUUC-Lpe-051534	Leersia perrieri	33.03	5.00e-20	91.70
IUUC-Loc-052812	Lepisosteus oculatus	70.72	0.00e+00	659.00
IUUC-Laf-053977	Loxodonta africana	69.94	0.00e+00	680.00
IUUC-Mcc-055626	Macaca mulatta	71.58	0.00e+00	675.00
IUUC-Meu-056155	Macropus eugenii	65.35	2.00e-175	607.00
IUUC-Mga-059310	Meleagris gallopavo	71.64	0.00e+00	681.00
IUUC-Mmr-061652	Microcebus murinus	72.02	0.00e+00	681.00
IUUC-Mdo-062963	Monodelphis domestica	71.58	0.00e+00	673.00
IUUC-Mmu-063893	Mus musculus	69.72	0.00e+00	677.00
IUUC-Mpu-066411	Mustela putorius furo	70.54	0.00e+00	680.00
IUUC-Mlu-067035	Myotis lucifugus	71.77	0.00e+00	677.00
IUUC-Nle-068978	Nomascus leucogenys	70.00	0.00e+00	654.00
IUUC-Opr-070299	Ochotona princeps	64.64	4.00e-172	596.00
IUUC-Ont-072127	Oreochromis niloticus	72.21	0.00e+00	682.00
IUUC-Oan-072997	Ornithorhynchus anatinus	71.40	0.00e+00	676.00
IUUC-Ocu-074403	Oryctolagus cuniculus	69.79	0.00e+00	676.00
IUUC-Obr-076855	Oryza brachyantha	32.11	4.00e-18	85.50
IUUC-Opu-083905	Oryza punctata	33.03	2.00e-19	90.10
IUUC-Ola-086527	Oryzias latipes	69.13	0.00e+00	681.00
IUUC-Oga-087957	Otolemur garnettii	72.23	0.00e+00	682.00
IUUC-Oar-090279	Ovis aries	70.11	0.00e+00	676.00
IUUC-Ptr-091050	Pan troglodytes	69.94	0.00e+00	679.00
IUUC-Pan-091862	Papio anubis	70.54	0.00e+00	679.00
IUUC-Psi-093310	Pelodiscus sinensis	72.07	0.00e+00	686.00
IUUC-Pma-094232	Petromyzon marinus	71.79	0.00e+00	689.00
IUUC-Pfo-096137	Poecilia formosa	71.21	0.00e+00	684.00
IUUC-Pab-097902	Pongo abelii	68.54	0.00e+00	676.00
IUUC-Pca-100245	Procavia capensis	70.93	0.00e+00	664.00
IUUC-Pva-102645	Pteropus vampyrus	70.72	0.00e+00	663.00
IUUC-Rno-105847	Rattus norvegicus	69.72	0.00e+00	677.00
IUUC-Sha-107539	Sarcophilus harrisii	70.02	0.00e+00	677.00
IUUC-Sit-110451	Setaria italica	31.46	5.00e-20	91.70
IUUC-Sar-113364	Sorex araneus	68.76	0.00e+00	638.00
IUUC-Ssc-115762	Sus scrofa	69.51	0.00e+00	677.00
IUUC-Tgu-117380	Taeniopygia guttata	72.23	0.00e+00	683.00
IUUC-Tru-117784	Takifugu rubripes	72.45	0.00e+00	681.00
IUUC-Tsy-119440	Tarsius syrichta	57.79	8.00e-152	529.00
IUUC-Tni-120843	Tetraodon nigroviridis	68.66	0.00e+00	668.00
IUUC-Tur-126643	Triticum urartu	31.13	3.00e-19	89.00
IUUC-Tbe-127707	Tupaia belangeri	70.72	0.00e+00	655.00
IUUC-Ttr-128893	Tursiops truncatus	72.15	0.00e+00	676.00
IUUC-Vpa-130060	Vicugna pacos	71.58	0.00e+00	676.00
IUUC-Xtr-132322	Xenopus tropicalis	71.58	0.00e+00	677.00
IUUC-Xma-134012	Xiphophorus maculatus	71.37	0.00e+00	684.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence