iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Sha-107539

Ensembl Protein ID

ENSSHAP00000020669.1

UniProt Accession

G3WZ14; G3WZ14_SARHA

Genbank Protein ID

ENSSHAP00000020669

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

AEFK01019372

Gene Name

SRC

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000017529.1	ENSSHAT00000020834.1	ENSSHAP00000020669.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	7.20e-14	51.7	85	139

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           ++ +lydye+ ++ +L++kkG+ ++++  ++++++W+ + + ++g+ G +P+n+v+ 
   Q: 85   TFVALYDYESRTETDLSFKKGERLQIV--NNTEGDWWLAHSLTTGQTGYIPSNYVAP 139
           5789***********************..8999*********************975 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

MGSSKSKPKD PSQRRRSLEP TENVLHSGFP ASQTPSKASV PDAHRTPNPP FGTTAPETKL 60
FGGFNTSDTV TSPQRSGPLA GGVTTFVALY DYESRTETDL SFKKGERLQI VNNTEGDWWL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGAAGTA GCAAAAGCAA ACCCAAAGAC CCCAGTCAGC GACGCCGAAG CCTGGAACCC 60
ACCGAGAATG TCCTCCACAG TGGCTTCCCT GCTTCTCAGA CCCCTAGCAA GGCATCTGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005884--C:actin filament
GO:0005901--C:caveola
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005770--C:late endosome
GO:0005764--C:lysosome
GO:0005743--C:mitochondrial inner membrane
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0002102--C:podosome
GO:0032587--C:ruffle membrane
GO:0005524--F:ATP binding
GO:0020037--F:heme binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0086098--P:angiotensin-activated signaling pathway involved in heart process
GO:0045453--P:bone resorption
GO:0060444--P:branching involved in mammary gland duct morphogenesis
GO:0016477--P:cell migration
GO:0071498--P:cellular response to fluid shear stress
GO:0036120--P:cellular response to platelet-derived growth factor stimulus
GO:0034614--P:cellular response to reactive oxygen species
GO:0030900--P:forebrain development
GO:0007229--P:integrin-mediated signaling pathway
GO:0035556--P:intracellular signal transduction
GO:2000811--P:negative regulation of anoikis
GO:0043154--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:2001237--P:negative regulation of extrinsic apoptotic signaling pathway
GO:2001243--P:negative regulation of intrinsic apoptotic signaling pathway
GO:0051902--P:negative regulation of mitochondrial depolarization
GO:0032463--P:negative regulation of protein homooligomerization
GO:0051974--P:negative regulation of telomerase activity
GO:0032211--P:negative regulation of telomere maintenance via telomerase
GO:0048477--P:oogenesis
GO:0036035--P:osteoclast development
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0010634--P:positive regulation of epithelial cell migration
GO:0070374--P:positive regulation of ERK1 and ERK2 cascade
GO:2000394--P:positive regulation of lamellipodium morphogenesis
GO:0050731--P:positive regulation of peptidyl-tyrosine phosphorylation
GO:0071803--P:positive regulation of podosome assembly
GO:0051897--P:positive regulation of protein kinase B signaling
GO:1900182--P:positive regulation of protein localization to nucleus
GO:0010954--P:positive regulation of protein processing
GO:0071902--P:positive regulation of protein serine/threonine kinase activity
GO:0051057--P:positive regulation of small GTPase mediated signal transduction
GO:0046777--P:protein autophosphorylation
GO:0031648--P:protein destabilization
GO:2001286--P:regulation of caveolin-mediated endocytosis
GO:0060491--P:regulation of cell projection assembly
GO:0022407--P:regulation of cell-cell adhesion
GO:2000641--P:regulation of early endosome to late endosome transport
GO:0033146--P:regulation of intracellular estrogen receptor signaling pathway
GO:0043393--P:regulation of protein binding
GO:0070555--P:response to interleukin-1
GO:0043149--P:stress fiber assembly
GO:0034446--P:substrate adhesion-dependent cell spreading
GO:0007179--P:transforming growth factor beta receptor signaling pathway
GO:0060065--P:uterus development

KEGG

shr:100926529

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001713	Ailuropoda melanoleuca	92.25	0.00e+00	1032.00
IUUC-Apl-004032	Anas platyrhynchos	78.57	0.00e+00	832.00
IUUC-Aca-004237	Anolis carolinensis	94.37	0.00e+00	1047.00
IUUC-Ath-007146	Arabidopsis thaliana	32.30	2.00e-22	101.00
IUUC-Ame-011887	Astyanax mexicanus	79.34	0.00e+00	883.00
IUUC-Bta-012982	Bos taurus	92.07	0.00e+00	1039.00
IUUC-Cja-019995	Callithrix jacchus	92.62	0.00e+00	1035.00
IUUC-Cfa-020060	Canis familiaris	93.47	0.00e+00	1044.00
IUUC-Cpo-021557	Cavia porcellus	91.79	0.00e+00	1011.00
IUUC-Csa-023711	Chlorocebus sabaeus	92.62	0.00e+00	1033.00
IUUC-Cin-025390	Ciona intestinalis	70.02	0.00e+00	662.00
IUUC-Csv-026029	Ciona savignyi	67.38	0.00e+00	635.00
IUUC-Dre-028491	Danio rerio	83.40	0.00e+00	891.00
IUUC-Dno-029651	Dasypus novemcinctus	89.45	0.00e+00	1002.00
IUUC-Dor-030202	Dipodomys ordii	83.41	0.00e+00	814.00
IUUC-Ete-033170	Echinops telfairi	94.76	0.00e+00	900.00
IUUC-Eca-033970	Equus caballus	89.35	0.00e+00	967.00
IUUC-Eeu-034950	Erinaceus europaeus	80.08	9.00e-132	462.00
IUUC-Fca-036113	Felis catus	93.47	0.00e+00	1044.00
IUUC-Fal-036785	Ficedula albicollis	95.18	0.00e+00	1070.00
IUUC-Gmo-038929	Gadus morhua	82.51	0.00e+00	790.00
IUUC-Gga-040899	Gallus gallus	94.93	0.00e+00	1061.00
IUUC-Gac-042332	Gasterosteus aculeatus	81.11	0.00e+00	897.00
IUUC-Ggo-044829	Gorilla gorilla	79.34	0.00e+00	847.00
IUUC-Hsa-046192	Homo sapiens	92.80	0.00e+00	1035.00
IUUC-Itr-049014	Ictidomys tridecemlineatus	92.42	0.00e+00	1025.00
IUUC-Lch-049892	Latimeria chalumnae	87.96	0.00e+00	970.00
IUUC-Loc-052812	Lepisosteus oculatus	82.50	0.00e+00	905.00
IUUC-Laf-053977	Loxodonta africana	92.62	0.00e+00	1039.00
IUUC-Mcc-055159	Macaca mulatta	90.78	0.00e+00	1027.00
IUUC-Mtr-058580	Medicago truncatula	30.09	1.00e-21	98.20
IUUC-Mga-060135	Meleagris gallopavo	94.43	0.00e+00	1058.00
IUUC-Mmr-061168	Microcebus murinus	90.24	0.00e+00	1024.00
IUUC-Mdo-063030	Monodelphis domestica	95.45	0.00e+00	1088.00
IUUC-Mmu-063893	Mus musculus	92.98	0.00e+00	1041.00
IUUC-Mpu-066411	Mustela putorius furo	93.47	0.00e+00	1044.00
IUUC-Mlu-068139	Myotis lucifugus	91.34	0.00e+00	1028.00
IUUC-Nle-070178	Nomascus leucogenys	90.77	0.00e+00	986.00
IUUC-Opr-070299	Ochotona princeps	74.95	0.00e+00	724.00
IUUC-Ont-072130	Oreochromis niloticus	80.76	0.00e+00	907.00
IUUC-Oan-072997	Ornithorhynchus anatinus	83.55	0.00e+00	821.00
IUUC-Ocu-074403	Oryctolagus cuniculus	91.18	0.00e+00	1018.00
IUUC-Ogl-077331	Oryza glaberrima	34.25	2.00e-23	104.00
IUUC-Ogu-078962	Oryza glumaepatula	34.70	7.00e-24	105.00
IUUC-Oin-079172	Oryza indica	34.70	6.00e-24	105.00
IUUC-Olo-080286	Oryza longistaminata	34.70	6.00e-24	106.00
IUUC-Ome-081400	Oryza meridionalis	34.70	5.00e-24	106.00
IUUC-Oni-082734	Oryza nivara	34.70	9.00e-24	105.00
IUUC-Oru-084741	Oryza rufipogon	34.70	5.00e-24	106.00
IUUC-Osa-085779	Oryza sativa	35.62	9.00e-24	105.00
IUUC-Ola-086527	Oryzias latipes	80.65	0.00e+00	904.00
IUUC-Oga-088493	Otolemur garnettii	92.44	0.00e+00	1030.00
IUUC-Oar-090279	Ovis aries	92.42	0.00e+00	1041.00
IUUC-Ptr-091050	Pan troglodytes	92.80	0.00e+00	1035.00
IUUC-Pan-091862	Papio anubis	93.66	0.00e+00	1039.00
IUUC-Psi-093071	Pelodiscus sinensis	96.06	0.00e+00	1072.00
IUUC-Pma-094232	Petromyzon marinus	79.92	0.00e+00	818.00
IUUC-Pfo-096578	Poecilia formosa	81.70	0.00e+00	917.00
IUUC-Pab-097902	Pongo abelii	91.14	0.00e+00	1031.00
IUUC-Ppe-102072	Prunus persica	34.53	6.00e-26	112.00
IUUC-Pva-103176	Pteropus vampyrus	78.78	0.00e+00	847.00
IUUC-Rno-105847	Rattus norvegicus	92.99	0.00e+00	1039.00
IUUC-Stu-112331	Solanum tuberosum	32.40	1.00e-22	101.00
IUUC-Sar-113364	Sorex araneus	80.00	0.00e+00	778.00
IUUC-Ssc-115762	Sus scrofa	91.24	0.00e+00	1034.00
IUUC-Tgu-117380	Taeniopygia guttata	75.28	0.00e+00	837.00
IUUC-Tru-117849	Takifugu rubripes	80.77	0.00e+00	873.00
IUUC-Tni-120843	Tetraodon nigroviridis	81.47	0.00e+00	910.00
IUUC-Ttr-128702	Tursiops truncatus	86.72	0.00e+00	956.00
IUUC-Vpa-130060	Vicugna pacos	83.74	0.00e+00	821.00
IUUC-Xtr-132291	Xenopus tropicalis	87.71	0.00e+00	950.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence