iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tru-117854

Ensembl Protein ID

ENSTRUP00000047002.1

UniProt Accession

H2VCQ9; H2VCQ9_TAKRU

Protein Name

Tyrosine-protein kinase

Gene Name

SRC (1 of many)

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000018366.1	ENSTRUT00000047159.1	ENSTRUP00000047000.1
ENSTRUG00000018366.1	ENSTRUT00000047160.1	ENSTRUP00000047001.1
ENSTRUG00000018366.1	ENSTRUT00000047161.1	ENSTRUP00000047002.1
ENSTRUG00000018366.1	ENSTRUT00000047162.1	ENSTRUP00000047003.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	3.30e-10	41.0	96	155

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeq....degWlkgvkelegkrGlfPenFvek 61
           ++ +lydye+ +  +Lt++kG  +++++++++    +++W+ + + ++g +G +P+n+v+ 
   Q: 96   TFVALYDYESRTASDLTFRKGHLLQIVNNTKKysfrEGDWWLA-HLTTGESGYIPSNYVAP 155
           5789***********************55553333399****9.59************975 PP

Organism

Takifugu rubripes

Protein Sequence
(Fasta)

MGAGKSKPKE PGQRSMSLDG TIGTGSDSGH FHHPRPAQQT QTPNRSPAVG TGRRGHQGQH 60
HQPPTNTPEI VPFGGVDHTG TITSPQRGPL SGGVTTFVAL YDYESRTASD LTFRKGHLLQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCGCACTCGG CGGCTCTGAT TTCTGGGCTC AATCTCAAGA CGCGTTAAAG GTGAGTTAAT 60
TAGGGCTTGT GTTGTTTATG AGGGGGAGAG AGAGAAAAAC GGCCTTCGCT GCCTCATTAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005524--F:ATP binding
GO:0070851--F:growth factor receptor binding
GO:0051427--F:hormone receptor binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0045453--P:bone resorption
GO:0007155--P:cell adhesion
GO:0016477--P:cell migration
GO:0007417--P:central nervous system development
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0045087--P:innate immune response
GO:0030520--P:intracellular estrogen receptor signaling pathway
GO:2001237--P:negative regulation of extrinsic apoptotic signaling pathway
GO:2001243--P:negative regulation of intrinsic apoptotic signaling pathway
GO:0036035--P:osteoclast development
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0048008--P:platelet-derived growth factor receptor signaling pathway
GO:0050847--P:progesterone receptor signaling pathway
GO:0051726--P:regulation of cell cycle
GO:0042127--P:regulation of cell proliferation
GO:0071801--P:regulation of podosome assembly

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ame-011887	Astyanax mexicanus	85.17	0.00e+00	946.00
IUUC-Gmo-038707	Gadus morhua	73.64	0.00e+00	792.00
IUUC-Gac-041976	Gasterosteus aculeatus	92.03	0.00e+00	1035.00
IUUC-Ont-072130	Oreochromis niloticus	95.09	0.00e+00	1068.00
IUUC-Ola-086527	Oryzias latipes	92.36	0.00e+00	1036.00
IUUC-Oar-090279	Ovis aries	80.58	0.00e+00	905.00
IUUC-Pfo-096578	Poecilia formosa	94.36	0.00e+00	1084.00
IUUC-Sly-111920	Solanum lycopersicum	32.00	1.00e-21	98.60
IUUC-Stu-112331	Solanum tuberosum	32.80	6.00e-23	102.00
IUUC-Tni-120843	Tetraodon nigroviridis	95.82	0.00e+00	1080.00
IUUC-Vvi-131181	Vitis vinifera	33.46	6.00e-22	99.80

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence