iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-013427

UUCD1 version

UUC-BoT-00858

Ensembl Protein ID

ENSBTAP00000002787.4

UniProt Accession

Q8HXA6; Q08DG3; ASB15_BOVIN

Genbank Protein ID

AAN23151.1; AAN23151.1; AAN23151.1; AAN23151.1; AAN23151.1; AAN23151.1; AAN23151.1; AAN23151.1; AAN23151.1; AAN38732.1; AAI23764.1

Protein Name

Ankyrin repeat and SOCS box protein 15

Genbank Nucleotide ID

AF541277; AF541269; AF541270; AF541271; AF541272; AF541273; AF541274; AF541275; AF541276; AF527382; BC123763

Gene Name

ASB15

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000002151.4	ENSBTAT00000002787.4	ENSBTAP00000002787.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	3.60e-14	52.5	524	578

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 1    lsklwllrseprSLqhLCRlaIrrclgsqrl...kaidkLPLPksLkdYLlyedy 52
           + +++++ ++p+SL+hLCRl+Irr++g qrl    + +kL LP+ +++Y+l ++y
   Q: 524  WPEIRQILENPCSLKHLCRLKIRRLMGLQRLcqpTLMEKLSLPPTIQRYILFKEY 578
           568999**********************************************988 PP

Organism

Bos taurus

Functional Description
(View)

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Protein Sequence
(Fasta)

MDANDDPDED HLTSYDVQLS IQESIEAGKT VFYPERFVPL SDQNRKLVEA IQQGHILELQ 60
EYVKYKYALD EADEKGWFPL HEAVVQPIQQ ILEVVLDASY KTLWEFKTSD GETPLTLAVK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GATTTAGGAA GGCAAGGCCC TGGATAAGAA TGACAAGACG ATCATTCCAA AAGGTGAGAT 60
TATGAAATAT TCGGTCTGTA CCTGATCAAC TAGCTTCAGT AGTTTAGTAT TAGGAATATG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0040--ANK repeat
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR001496--SOCS_box

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50225--SOCS

Pfam

PF12796--Ank_2
PF13606--Ank_3
PF07525--SOCS_box

PRINTS

PR01415--ANKYRIN

SMART

SM00248--ANK
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0035556--P:intracellular signal transduction

KEGG

bta:282591

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002210	Ailuropoda melanoleuca	93.54	0.00e+00	1151.00
IUUC-Apl-003801	Anas platyrhynchos	77.72	0.00e+00	944.00
IUUC-Aca-005290	Anolis carolinensis	69.45	0.00e+00	924.00
IUUC-Ame-011590	Astyanax mexicanus	54.89	6.00e-168	583.00
IUUC-Cja-019662	Callithrix jacchus	93.19	0.00e+00	1150.00
IUUC-Cfa-021155	Canis familiaris	93.94	0.00e+00	1134.00
IUUC-Csa-023294	Chlorocebus sabaeus	92.09	0.00e+00	1034.00
IUUC-Cho-024744	Choloepus hoffmanni	80.72	0.00e+00	902.00
IUUC-Dre-027559	Danio rerio	53.99	7.00e-180	623.00
IUUC-Dno-030076	Dasypus novemcinctus	91.20	0.00e+00	1131.00
IUUC-Dor-030347	Dipodomys ordii	75.52	0.00e+00	805.00
IUUC-Ete-032284	Echinops telfairi	80.23	0.00e+00	880.00
IUUC-Eca-034197	Equus caballus	86.90	0.00e+00	1061.00
IUUC-Eeu-034617	Erinaceus europaeus	84.29	0.00e+00	847.00
IUUC-Fca-035649	Felis catus	93.20	0.00e+00	1149.00
IUUC-Gga-040848	Gallus gallus	75.30	0.00e+00	920.00
IUUC-Gac-041696	Gasterosteus aculeatus	50.85	4.00e-128	452.00
IUUC-Ggo-044907	Gorilla gorilla	92.33	0.00e+00	1144.00
IUUC-Hsa-046111	Homo sapiens	91.99	0.00e+00	1135.00
IUUC-Itr-048869	Ictidomys tridecemlineatus	90.94	0.00e+00	1108.00
IUUC-Lch-050248	Latimeria chalumnae	69.44	0.00e+00	861.00
IUUC-Loc-052752	Lepisosteus oculatus	58.61	0.00e+00	686.00
IUUC-Laf-054585	Loxodonta africana	90.63	0.00e+00	1122.00
IUUC-Mcc-054651	Macaca mulatta	92.01	0.00e+00	1144.00
IUUC-Meu-056277	Macropus eugenii	90.58	2.00e-171	595.00
IUUC-Mga-060130	Meleagris gallopavo	75.68	0.00e+00	928.00
IUUC-Mmr-060879	Microcebus murinus	93.71	0.00e+00	1159.00
IUUC-Mdo-061877	Monodelphis domestica	86.88	0.00e+00	1074.00
IUUC-Mmu-063484	Mus musculus	87.82	0.00e+00	1091.00
IUUC-Mpu-066536	Mustela putorius furo	93.20	0.00e+00	1145.00
IUUC-Mlu-067317	Myotis lucifugus	92.01	0.00e+00	1134.00
IUUC-Nle-069895	Nomascus leucogenys	92.01	0.00e+00	1134.00
IUUC-Opr-070602	Ochotona princeps	76.61	0.00e+00	692.00
IUUC-Ont-071779	Oreochromis niloticus	48.79	2.00e-146	512.00
IUUC-Oan-073430	Ornithorhynchus anatinus	81.49	0.00e+00	1019.00
IUUC-Ocu-073921	Oryctolagus cuniculus	91.33	0.00e+00	1130.00
IUUC-Ola-087235	Oryzias latipes	46.05	2.00e-150	526.00
IUUC-Oga-089182	Otolemur garnettii	90.48	0.00e+00	1130.00
IUUC-Oar-089655	Ovis aries	98.30	0.00e+00	1199.00
IUUC-Ptr-090671	Pan troglodytes	91.99	0.00e+00	1136.00
IUUC-Pan-091931	Papio anubis	91.84	0.00e+00	1144.00
IUUC-Psi-093364	Pelodiscus sinensis	79.46	0.00e+00	984.00
IUUC-Pfo-097338	Poecilia formosa	46.73	2.00e-150	525.00
IUUC-Pab-098552	Pongo abelii	92.18	0.00e+00	1140.00
IUUC-Pca-100415	Procavia capensis	74.39	0.00e+00	815.00
IUUC-Pva-103077	Pteropus vampyrus	92.96	0.00e+00	698.00
IUUC-Rno-104893	Rattus norvegicus	88.68	0.00e+00	1095.00
IUUC-Sha-106824	Sarcophilus harrisii	85.37	0.00e+00	1051.00
IUUC-Sit-110762	Setaria italica	31.47	5.00e-18	85.50
IUUC-Sar-113300	Sorex araneus	77.12	0.00e+00	692.00
IUUC-Ssc-115956	Sus scrofa	95.24	0.00e+00	1164.00
IUUC-Tru-117639	Takifugu rubripes	46.72	1.00e-152	533.00
IUUC-Tsy-119263	Tarsius syrichta	93.59	0.00e+00	712.00
IUUC-Tni-120083	Tetraodon nigroviridis	49.06	2.00e-149	522.00
IUUC-Tbe-127228	Tupaia belangeri	86.90	0.00e+00	1036.00
IUUC-Ttr-128657	Tursiops truncatus	87.24	0.00e+00	1047.00
IUUC-Vpa-130435	Vicugna pacos	94.05	0.00e+00	1160.00
IUUC-Xtr-132951	Xenopus tropicalis	68.78	0.00e+00	826.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence