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Tag Content
UUCD2 ID IUUC-Pab-098141
UUCD1 version UUC-PoA-00635
Ensembl Protein ID ENSPPYP00000016901.2
UniProt Accession H2PEI5; H2PEI5_PONAB
Genbank Protein ID ENSPPYP00000016901
Protein Name Uncharacterized protein
Genbank Nucleotide ID ABGA01222544
Gene Name FBXW7
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSPPYG00000015122.2 ENSPPYT00000017582.2 ENSPPYP00000016901.2
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 6.90e-61 199.5 543 576
UBD/Beta-Prp 2.40e-102 342.2 294 576
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    HtdsvtclafsdtllvsGsdDgtikvWDlrtgvl 35
           H++ vtcl+f+ ++++++sdDgt+k+WDl+tg  
   Q: 543  HQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEF 576
           9*********449******************976 PP
   

   UBD/Beta-Prp
   S: 3    ktlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlk 91
           k+lkgh+++vitc++f   ++ +++gs+d+t+kvw++ tgk+lr+l gh+++v++ ++ ++  i+++gs+Drt+kvw+ +tg+c+htl 
   Q: 294  KVLKGHDDHVITCLQF--CGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLY 378
           6799************..*******************************************..************************** PP
   S: 92   ghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgght 180
           gh+++v+++++++  +++vsGs+d t+rvwd+etgqcl+ +l gh ++v+cv++++  + +vsG++D +v++Wd +t+++l+tl+g ht
   Q: 379  GHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLH-VLMGHVAAVRCVQYDG--RRVVSGAYDFMVKVWDPETETCLHTLQG-HT 461
           *************..************************.****************..***************************9.** PP
   S: 181  dsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvis 269
           ++vysl+fd    ++vsgsld+++++wd++tg+c++tl+gh++ ++ +++   d++lvsg++D +++iWd+++g++l+tlq++n++ ++
   Q: 462  NRVYSLQFDG--IHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELK--DNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSA 546
           *********9..9**************************************..************************************ PP
   S: 270  vavlsfgdnvlvlgsedskvniwklkknep 299
           v++l+f++n +++ s+d++v++w+lk+ e+
   Q: 547  VTCLQFNKNFVITSSDDGTVKLWDLKTGEF 576
           *************************98776 PP
   
Organism Pongo abelii
Protein Sequence
(Fasta)
MCVPRSGLIL SCICLYCGVL LPVLLPNLPF LTCLSMSTLE SVTYLPEKGL YCQRLPSSRT 60
HGGTESLKGK NTENMGFYGT LKMIFYKMKR KLDHGSEVRS FSLGKKPCKV SEYTSTTGLV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Pab-098141|E3,WD_repeat;UBD,Beta-Prp|Pongo abelii
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TATAATTGAT GTGCAGTCTG CATTGCTGAA TCCTGGACTG CACCATTCTG TGTTCAAGGG 60
AAGATGTAAT CTGATCCCTC TGCTGCTGAG GGAGGAATCT GTTCAGTCAA GGCTTTGACA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Pab-098141|E3,WD_repeat;UBD,Beta-Prp|Pongo abelii
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0853--WD repeat
Interpro

IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF12937--F-box-like
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00256--FBOX
SM00320--WD40
Gene Ontology

GO:0005737--C:cytoplasm
GO:0016021--C:integral component of membrane
GO:1990452--C:Parkin-FBXW7-Cul1 ubiquitin ligase complex
GO:0019005--C:SCF ubiquitin ligase complex
GO:0097027--F:ubiquitin-protein transferase activator activity
GO:0032876--P:negative regulation of DNA endoreduplication
GO:0045741--P:positive regulation of epidermal growth factor-activated receptor activity
GO:0070374--P:positive regulation of ERK1 and ERK2 cascade
GO:1903378--P:positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1901800--P:positive regulation of proteasomal protein catabolic process
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:2000060--P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0051443--P:positive regulation of ubiquitin-protein transferase activity
GO:0050821--P:protein stabilization
GO:0016567--P:protein ubiquitination
GO:1903146--P:regulation of mitophagy
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0007062--P:sister chromatid cohesion
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002406 Ailuropoda melanoleuca 99.63 0.00e+00 1098.00
IUUC-Apl-003489 Anas platyrhynchos 98.55 0.00e+00 1101.00
IUUC-Aca-005318 Anolis carolinensis 99.16 0.00e+00 1198.00
IUUC-Ago-007794 Ashbya gossypii 31.07 2.00e-61 229.00
IUUC-Acl-008123 Aspergillus clavatus 32.40 1.00e-74 274.00
IUUC-Afl-008730 Aspergillus flavus 31.33 1.00e-73 271.00
IUUC-Afu-009014 Aspergillus fumigatus 32.53 7.00e-75 275.00
IUUC-Ani-009332 Aspergillus nidulans 33.47 6.00e-80 291.00
IUUC-Ang-009790 Aspergillus niger 31.52 2.00e-75 276.00
IUUC-Aor-010215 Aspergillus oryzae 30.71 3.00e-74 272.00
IUUC-Ate-010535 Aspergillus terreus 32.54 5.00e-76 278.00
IUUC-Ame-010898 Astyanax mexicanus 95.01 0.00e+00 1042.00
IUUC-Bgr-012075 Blumeria graminis 33.47 6.00e-79 288.00
IUUC-Bta-012391 Bos taurus 99.84 0.00e+00 1242.00
IUUC-Bci-013725 Botrytis cinerea 33.20 6.00e-78 285.00
IUUC-Cel-018495 Caenorhabditis elegans 48.73 7.00e-131 461.00
IUUC-Cja-018902 Callithrix jacchus 100.00 0.00e+00 1101.00
IUUC-Cfa-020237 Canis familiaris 100.00 0.00e+00 1100.00
IUUC-Cpo-022234 Cavia porcellus 100.00 0.00e+00 1206.00
IUUC-Cre-022837 Chlamydomonas reinhardtii 37.42 6.00e-49 188.00
IUUC-Csa-023532 Chlorocebus sabaeus 100.00 0.00e+00 1102.00
IUUC-Cho-025026 Choloepus hoffmanni 82.25 0.00e+00 731.00
IUUC-Cin-025516 Ciona intestinalis 70.34 2.00e-140 491.00
IUUC-Csv-026312 Ciona savignyi 75.47 0.00e+00 749.00
IUUC-Cgl-026492 Colletotrichum gloeosporioides 34.82 2.00e-84 306.00
IUUC-Cne-027018 Cryptococcus neoformans 33.08 2.00e-72 267.00
IUUC-Cme-027168 Cyanidioschyzon merolae 31.11 3.00e-30 127.00
IUUC-Dre-028303 Danio rerio 94.09 0.00e+00 1045.00
IUUC-Dno-029576 Dasypus novemcinctus 97.26 0.00e+00 1082.00
IUUC-Dor-030196 Dipodomys ordii 97.28 0.00e+00 1077.00
IUUC-Dse-031558 Dothistroma septosporum 38.98 7.00e-70 258.00
IUUC-Dme-031702 Drosophila melanogaster 76.61 0.00e+00 800.00
IUUC-Ete-032791 Echinops telfairi 90.93 0.00e+00 999.00
IUUC-Eca-033424 Equus caballus 99.84 0.00e+00 1243.00
IUUC-Eeu-034996 Erinaceus europaeus 95.28 0.00e+00 1061.00
IUUC-Fca-036422 Felis catus 99.27 0.00e+00 1102.00
IUUC-Fal-037267 Ficedula albicollis 98.35 0.00e+00 1092.00
IUUC-Fox-037800 Fusarium oxysporum 34.07 1.00e-83 304.00
IUUC-Fso-038258 Fusarium solani 34.21 8.00e-83 301.00
IUUC-Gmo-039119 Gadus morhua 80.90 0.00e+00 936.00
IUUC-Ggr-039781 Gaeumannomyces graminis 34.66 1.00e-84 307.00
IUUC-Gga-040667 Gallus gallus 99.27 0.00e+00 1103.00
IUUC-Gac-042423 Gasterosteus aculeatus 75.45 0.00e+00 825.00
IUUC-Ggo-044422 Gorilla gorilla 100.00 0.00e+00 1101.00
IUUC-Hsa-045898 Homo sapiens 100.00 0.00e+00 1101.00
IUUC-Itr-048241 Ictidomys tridecemlineatus 99.79 0.00e+00 967.00
IUUC-Kpa-049097 Komagataella pastoris 32.06 8.00e-76 278.00
IUUC-Lch-050414 Latimeria chalumnae 97.97 0.00e+00 1081.00
IUUC-Loc-052348 Lepisosteus oculatus 97.29 0.00e+00 1095.00
IUUC-Lma-053185 Leptosphaeria maculans 32.60 1.00e-72 268.00
IUUC-Laf-054054 Loxodonta africana 99.09 0.00e+00 1100.00
IUUC-Mcc-055056 Macaca mulatta 100.00 0.00e+00 1102.00
IUUC-Meu-056778 Macropus eugenii 96.85 3.00e-180 625.00
IUUC-Mor-057133 Magnaporthe oryzae 39.13 6.00e-73 269.00
IUUC-Mpo-057542 Magnaporthe poae 39.13 2.00e-73 270.00
IUUC-Mla-059081 Melampsora laricipopulina 32.57 3.00e-76 279.00
IUUC-Mga-059255 Meleagris gallopavo 99.09 0.00e+00 1101.00
IUUC-Mvi-060490 Microbotryum violaceum 38.75 1.00e-66 248.00
IUUC-Mmr-061292 Microcebus murinus 100.00 0.00e+00 1100.00
IUUC-Mdo-062304 Monodelphis domestica 98.90 0.00e+00 1105.00
IUUC-Mmu-063610 Mus musculus 98.19 0.00e+00 1101.00
IUUC-Mpu-065931 Mustela putorius furo 100.00 0.00e+00 1100.00
IUUC-Mlu-066976 Myotis lucifugus 98.55 0.00e+00 1103.00
IUUC-Nfi-068428 Neosartorya fischeri 31.93 1.00e-74 274.00
IUUC-Ncr-068688 Neurospora crassa 35.97 1.00e-86 314.00
IUUC-Nle-070174 Nomascus leucogenys 100.00 0.00e+00 1101.00
IUUC-Opr-070851 Ochotona princeps 86.58 0.00e+00 650.00
IUUC-Ont-071997 Oreochromis niloticus 94.58 0.00e+00 1093.00
IUUC-Oan-072936 Ornithorhynchus anatinus 99.09 0.00e+00 1101.00
IUUC-Ocu-074742 Oryctolagus cuniculus 100.00 0.00e+00 1103.00
IUUC-Obr-076806 Oryza brachyantha 31.52 1.00e-29 125.00
IUUC-Oin-079809 Oryza indica 31.52 1.00e-29 125.00
IUUC-Ola-087098 Oryzias latipes 93.39 0.00e+00 1059.00
IUUC-Olu-087837 Ostreococcus lucimarinus 34.47 3.00e-38 151.00
IUUC-Oga-088884 Otolemur garnettii 100.00 0.00e+00 780.00
IUUC-Oar-090220 Ovis aries 99.27 0.00e+00 1098.00
IUUC-Ptr-090492 Pan troglodytes 100.00 0.00e+00 1101.00
IUUC-Pan-091770 Papio anubis 100.00 0.00e+00 1102.00
IUUC-Psi-093207 Pelodiscus sinensis 99.83 0.00e+00 1208.00
IUUC-Pma-094749 Petromyzon marinus 83.57 0.00e+00 967.00
IUUC-Pno-095026 Phaeosphaeria nodorum 38.83 2.00e-70 260.00
IUUC-Pfo-096493 Poecilia formosa 95.56 0.00e+00 1052.00
IUUC-Pca-100571 Procavia capensis 99.74 0.00e+00 780.00
IUUC-Pva-102988 Pteropus vampyrus 98.91 0.00e+00 1102.00
IUUC-Pgr-103612 Puccinia graminis 35.41 2.00e-61 230.00
IUUC-Pte-104275 Pyrenophora teres 32.36 5.00e-73 269.00
IUUC-Pyt-104438 Pyrenophora triticirepentis 31.93 5.00e-72 265.00
IUUC-Rno-105706 Rattus norvegicus 98.00 0.00e+00 1099.00
IUUC-Sce-106314 Saccharomyces cerevisiae 29.39 6.00e-60 225.00
IUUC-Sha-107653 Sarcophilus harrisii 98.90 0.00e+00 1101.00
IUUC-Sja-107840 Schizosaccharomyces japonicus 33.83 2.00e-78 287.00
IUUC-Spo-108115 Schizosaccharomyces pombe 32.14 6.00e-62 231.00
IUUC-Sar-113600 Sorex araneus 92.20 0.00e+00 1008.00
IUUC-Sre-114901 Sporisorium reilianum 48.13 9.00e-67 249.00
IUUC-Ssc-115787 Sus scrofa 96.91 0.00e+00 1074.00
IUUC-Tgu-117510 Taeniopygia guttata 99.08 0.00e+00 1099.00
IUUC-Tru-117819 Takifugu rubripes 95.01 0.00e+00 1077.00
IUUC-Tsy-118828 Tarsius syrichta 98.73 0.00e+00 1101.00
IUUC-Tni-120468 Tetraodon nigroviridis 93.79 0.00e+00 1094.00
IUUC-Tre-122193 Trichoderma reesei 36.25 8.00e-85 308.00
IUUC-Tvi-122615 Trichoderma virens 35.03 3.00e-83 302.00
IUUC-Tme-127021 Tuber melanosporum 34.26 2.00e-83 303.00
IUUC-Tbe-127925 Tupaia belangeri 100.00 0.00e+00 1099.00
IUUC-Ttr-128899 Tursiops truncatus 98.37 0.00e+00 1098.00
IUUC-Uma-129449 Ustilago maydis 46.89 6.00e-66 246.00
IUUC-Vda-129802 Verticillium dahliae 36.05 5.00e-87 315.00
IUUC-Vpa-130082 Vicugna pacos 98.48 0.00e+00 922.00
IUUC-Xtr-132213 Xenopus tropicalis 98.34 0.00e+00 1088.00
IUUC-Xma-133646 Xiphophorus maculatus 95.49 0.00e+00 1075.00
IUUC-Yli-134429 Yarrowia lipolytica 34.27 2.00e-86 313.00
Created Date 25-Jun-2017

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