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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045926
UUCD1 version UUC-HoS-00011
Ensembl Protein ID ENSP00000480736.1
UniProt Accession O14512; A2VCU2; Q0IJ63; SOCS7_HUMAN
Genbank Protein ID BAA22432.1; AAI28608.1
Protein Name Suppressor of cytokine signaling 7; Nck, Ash and phospholipase C gamma-binding protein; Nck-associated protein 4
Genbank Nucleotide ID AB005216; AC115992
Gene Name SOCS7; NAP4; SOCS6
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000274229.2 ENST00000631692.1 ENSP00000488601.1
ENSG00000274229.2 ENST00000615473.2 ENSP00000480736.1
ENSG00000274229.2 ENST00000632687.1 ENSP00000487855.1
Annotation
Cancer Mutation
TCGACGAPIntOGen
mRNA Expression
TCGAICGCTHPAHPM
DNA & RNA Element
UTRdbcircRNADbCircNetmiRWalk
RepTarmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
InWeb_IM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box SOCS 12052866
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box 1.50e-13 52.0 506 553
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box
   S: 2    sklwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedy 52
           +++ +++s++ SLqhLCR++Ir++++++++   + LPLPk L++Y++++ y
   Q: 506  LYPVSRFSNVKSLQHLCRFRIRQLVRIDHI---PDLPLPKPLISYIRKFYY 553
           567899*********************998...*************99976 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
 Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
Protein Sequence
(Fasta)
MVFRNVGRPP EEEDVEAAPE PGPSELLCPR HRCALDPKAL PPGLALERTW GPAAGLEAQL 60
AALGLGQPAG PGVKTVGGGC CPCPCPPQPP PPQPQPPAAA PQAGEDPTET SDALLVLEGL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045926|E3,SOCS|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CCCGGCCGCC GCAGCTGATG GTGTTCCGCA ACGTGGGTCG GCCGCCGGAG GAGGAGGACG 60
TGGAGGCGGC CCCGGAGCCG GGACCCTCGG AACTGCTGTG TCCCCGGCAC CGCTGTGCCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045926|E3,SOCS|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0341--Growth regulation
KW-0472--Membrane
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0734--Signal transduction inhibitor
KW-0833--Ubl conjugation pathway
Interpro

IPR000980--SH2
IPR028423--SOCS7
IPR001496--SOCS_box
PROSITE

PS50001--SH2
PS50225--SOCS
Pfam

PF00017--SH2
PF07525--SOCS_box
SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0004860--F:protein kinase inhibitor activity
GO:0017124--F:SH3 domain binding
GO:0019221--P:cytokine-mediated signaling pathway
GO:0045444--P:fat cell differentiation
GO:0008286--P:insulin receptor signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0021819--P:layer formation in cerebral cortex
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0016567--P:protein ubiquitination
GO:0021942--P:radial glia guided migration of Purkinje cell
GO:0040008--P:regulation of growth
KEGG hsa:30837
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001668 Ailuropoda melanoleuca 91.19 0.00e+00 662.00
IUUC-Apl-003277 Anas platyrhynchos 91.78 5.00e-73 266.00
IUUC-Aca-004639 Anolis carolinensis 97.28 3.00e-108 383.00
IUUC-Ame-011301 Astyanax mexicanus 70.00 2.00e-130 459.00
IUUC-Bta-013483 Bos taurus 96.39 0.00e+00 740.00
IUUC-Cja-019765 Callithrix jacchus 99.69 8.00e-164 569.00
IUUC-Cfa-020109 Canis familiaris 98.41 0.00e+00 652.00
IUUC-Cpo-021555 Cavia porcellus 96.29 7.00e-179 620.00
IUUC-Csa-023580 Chlorocebus sabaeus 99.48 0.00e+00 733.00
IUUC-Cho-024431 Choloepus hoffmanni 99.21 3.00e-72 265.00
IUUC-Dre-028183 Danio rerio 70.45 1.00e-139 490.00
IUUC-Dno-028858 Dasypus novemcinctus 94.49 0.00e+00 722.00
IUUC-Dor-031071 Dipodomys ordii 79.25 4.00e-114 404.00
IUUC-Dme-031876 Drosophila melanogaster 43.65 3.00e-43 171.00
IUUC-Ete-032928 Echinops telfairi 70.86 2.00e-101 362.00
IUUC-Eca-033250 Equus caballus 93.67 1.00e-177 615.00
IUUC-Eeu-034946 Erinaceus europaeus 84.41 6.00e-52 198.00
IUUC-Fca-036589 Felis catus 94.98 0.00e+00 645.00
IUUC-Fal-037316 Ficedula albicollis 93.07 3.00e-112 397.00
IUUC-Gmo-038552 Gadus morhua 91.26 1.00e-53 201.00
IUUC-Gga-041248 Gallus gallus 96.76 3.00e-108 383.00
IUUC-Gac-041469 Gasterosteus aculeatus 83.47 9.00e-57 211.00
IUUC-Ggo-045282 Gorilla gorilla 100.00 1.00e-163 568.00
IUUC-Itr-048411 Ictidomys tridecemlineatus 95.97 6.00e-166 577.00
IUUC-Lch-049768 Latimeria chalumnae 71.08 4.00e-153 534.00
IUUC-Loc-051949 Lepisosteus oculatus 74.30 3.00e-129 456.00
IUUC-Laf-053410 Loxodonta africana 93.94 0.00e+00 714.00
IUUC-Mcc-054605 Macaca mulatta 92.03 0.00e+00 698.00
IUUC-Meu-056773 Macropus eugenii 79.87 1.00e-106 379.00
IUUC-Mmr-060927 Microcebus murinus 96.90 0.00e+00 717.00
IUUC-Mdo-061892 Monodelphis domestica 88.36 2.00e-175 609.00
IUUC-Mmu-064246 Mus musculus 93.99 0.00e+00 719.00
IUUC-Mpu-065995 Mustela putorius furo 95.18 0.00e+00 639.00
IUUC-Mlu-067526 Myotis lucifugus 91.22 0.00e+00 719.00
IUUC-Nle-069317 Nomascus leucogenys 91.67 1.00e-169 589.00
IUUC-Ont-072258 Oreochromis niloticus 66.75 2.00e-117 416.00
IUUC-Oan-073703 Ornithorhynchus anatinus 80.49 1.00e-36 144.00
IUUC-Ocu-074577 Oryctolagus cuniculus 89.44 0.00e+00 745.00
IUUC-Oga-088426 Otolemur garnettii 95.18 0.00e+00 708.00
IUUC-Oar-089407 Ovis aries 96.23 0.00e+00 664.00
IUUC-Ptr-091327 Pan troglodytes 100.00 0.00e+00 640.00
IUUC-Pan-092064 Papio anubis 99.47 0.00e+00 651.00
IUUC-Psi-093834 Pelodiscus sinensis 94.04 1.00e-153 535.00
IUUC-Pfo-097100 Poecilia formosa 62.50 1.00e-115 410.00
IUUC-Pab-097695 Pongo abelii 90.71 0.00e+00 698.00
IUUC-Pca-100569 Procavia capensis 90.13 2.00e-170 592.00
IUUC-Pva-102784 Pteropus vampyrus 95.70 0.00e+00 702.00
IUUC-Ptt-103775 Puccinia triticina 38.46 1.90e+00 28.10
IUUC-Rno-105485 Rattus norvegicus 95.35 0.00e+00 721.00
IUUC-Sha-106720 Sarcophilus harrisii 93.40 9.00e-173 600.00
IUUC-Sar-112975 Sorex araneus 84.28 3.00e-128 451.00
IUUC-Ssc-116369 Sus scrofa 97.08 0.00e+00 722.00
IUUC-Tgu-116867 Taeniopygia guttata 86.83 8.00e-125 439.00
IUUC-Tru-117562 Takifugu rubripes 80.56 8.00e-101 360.00
IUUC-Tsy-118999 Tarsius syrichta 93.40 4.00e-146 510.00
IUUC-Tni-120793 Tetraodon nigroviridis 68.62 3.00e-129 455.00
IUUC-Tbe-127671 Tupaia belangeri 99.07 8.00e-129 453.00
IUUC-Ttr-128491 Tursiops truncatus 81.95 2.00e-131 462.00
IUUC-Vpa-130104 Vicugna pacos 88.97 2.00e-175 608.00
IUUC-Xtr-132507 Xenopus tropicalis 80.05 2.00e-144 505.00
Created Date 25-Jun-2017

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