iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fca-035537

Ensembl Protein ID

ENSFCAP00000022197.1

UniProt Accession

M3X6E5; M3X6E5_FELCA

Genbank Protein ID

ENSFCAP00000022197

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AANG02099387

Gene Name

RNF139

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFCAG00000023310.1	ENSFCAT00000022981.1	ENSFCAP00000022197.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.40e-08	35.1	572	610

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlC 45
           CaiC+ +f +  +++pC+H fha Cl kw       + +++CP C
   Q: 572  CAICYHEFTTSARITPCNHYFHALCLRKW------LYIQDTCPMC 610
           ********999******************......********** PP

Organism

Felis catus

Protein Sequence
(Fasta)

ASQRFSLENA ILRPASGRGG VGPAGGALCS PPPKQLRTTF MGRLMALEVA LRVPCLYIID 60
AIFNSYYDSS QSRFCIGLQI FLRLLGIFVS SIVLILSQRS LFKFYMYSSA FLLAATSVLV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCTCGCAGA GATTTTCCCT GGAAAATGCC ATCCTCAGAC CGGCCTCCGG GCGGGGTGGG 60
GTAGGTCCGG CGGGCGGCGC CCTCTGCTCT CCTCCTCCCA AACAGCTCCG AACCACGTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR025754--TRC8_N_dom
IPR001841--Znf_RING
IPR011016--Znf_RING-CH
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF13705--TRC8_N
PF13639--zf-RING_2

SMART

SM00184--RING
SM00744--RINGv

Gene Ontology

GO:0036513--C:Derlin-1 retrotranslocation complex
GO:0005783--C:endoplasmic reticulum
GO:0016021--C:integral component of membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0036503--P:ERAD pathway
GO:0008285--P:negative regulation of cell proliferation
GO:0017148--P:negative regulation of translation
GO:2000060--P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0031648--P:protein destabilization
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0060628--P:regulation of ER to Golgi vesicle-mediated transport
GO:0070613--P:regulation of protein processing

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002401	Ailuropoda melanoleuca	96.94	0.00e+00	1214.00
IUUC-Apl-004214	Anas platyrhynchos	86.42	0.00e+00	971.00
IUUC-Aca-005326	Anolis carolinensis	77.72	0.00e+00	962.00
IUUC-Ame-011687	Astyanax mexicanus	74.45	0.00e+00	868.00
IUUC-Bta-013394	Bos taurus	95.58	0.00e+00	1236.00
IUUC-Bci-013813	Botrytis cinerea	42.86	9.00e-08	51.20
IUUC-Cja-019499	Callithrix jacchus	94.36	0.00e+00	1243.00
IUUC-Cfa-020357	Canis familiaris	96.65	0.00e+00	1214.00
IUUC-Cpo-021924	Cavia porcellus	95.53	0.00e+00	1171.00
IUUC-Csa-023513	Chlorocebus sabaeus	95.43	0.00e+00	1227.00
IUUC-Cho-024285	Choloepus hoffmanni	89.33	0.00e+00	1068.00
IUUC-Cin-025223	Ciona intestinalis	53.93	2.00e-74	271.00
IUUC-Csv-026018	Ciona savignyi	47.32	3.00e-64	238.00
IUUC-Dre-028660	Danio rerio	73.11	0.00e+00	792.00
IUUC-Dno-029463	Dasypus novemcinctus	92.81	1.00e-156	546.00
IUUC-Dor-030728	Dipodomys ordii	95.69	0.00e+00	1101.00
IUUC-Dse-031284	Dothistroma septosporum	43.40	7.00e-09	54.30
IUUC-Dme-032186	Drosophila melanogaster	43.83	8.00e-99	354.00
IUUC-Ete-032368	Echinops telfairi	88.15	0.00e+00	1148.00
IUUC-Eca-034325	Equus caballus	95.43	0.00e+00	1172.00
IUUC-Fal-037459	Ficedula albicollis	86.22	0.00e+00	949.00
IUUC-Gmo-039442	Gadus morhua	78.65	2.00e-98	353.00
IUUC-Ggr-039921	Gaeumannomyces graminis	31.91	6.00e-08	53.10
IUUC-Gga-041071	Gallus gallus	82.20	0.00e+00	989.00
IUUC-Gac-042483	Gasterosteus aculeatus	68.45	0.00e+00	896.00
IUUC-Ggo-044672	Gorilla gorilla	95.12	0.00e+00	1225.00
IUUC-Hsa-045836	Homo sapiens	94.36	0.00e+00	1188.00
IUUC-Itr-048588	Ictidomys tridecemlineatus	96.24	0.00e+00	1238.00
IUUC-Lch-050073	Latimeria chalumnae	76.19	0.00e+00	971.00
IUUC-Loc-052908	Lepisosteus oculatus	71.76	0.00e+00	940.00
IUUC-Lma-053202	Leptosphaeria maculans	42.59	3.00e-08	52.40
IUUC-Laf-053519	Loxodonta africana	92.68	0.00e+00	1238.00
IUUC-Mcc-054674	Macaca mulatta	89.39	4.00e-95	340.00
IUUC-Mor-057262	Magnaporthe oryzae	32.93	3.00e-08	53.90
IUUC-Mga-059922	Meleagris gallopavo	85.92	0.00e+00	958.00
IUUC-Mmr-061452	Microcebus murinus	94.98	0.00e+00	1163.00
IUUC-Mdo-062412	Monodelphis domestica	89.19	0.00e+00	1164.00
IUUC-Mmu-063147	Mus musculus	93.13	0.00e+00	1224.00
IUUC-Mpu-065929	Mustela putorius furo	96.49	0.00e+00	1213.00
IUUC-Mlu-067899	Myotis lucifugus	92.85	0.00e+00	1183.00
IUUC-Nle-070083	Nomascus leucogenys	95.12	0.00e+00	1222.00
IUUC-Opr-070461	Ochotona princeps	90.44	0.00e+00	1198.00
IUUC-Ont-072256	Oreochromis niloticus	70.38	0.00e+00	909.00
IUUC-Oan-073150	Ornithorhynchus anatinus	84.31	0.00e+00	941.00
IUUC-Ocu-073748	Oryctolagus cuniculus	92.87	0.00e+00	1180.00
IUUC-Oga-088565	Otolemur garnettii	95.99	0.00e+00	1223.00
IUUC-Oar-089432	Ovis aries	97.48	0.00e+00	1178.00
IUUC-Ptr-091422	Pan troglodytes	94.97	0.00e+00	1223.00
IUUC-Pan-092331	Papio anubis	95.27	0.00e+00	1226.00
IUUC-Psi-092933	Pelodiscus sinensis	83.90	0.00e+00	938.00
IUUC-Pfo-097466	Poecilia formosa	69.80	0.00e+00	911.00
IUUC-Pab-098702	Pongo abelii	94.97	0.00e+00	1222.00
IUUC-Pca-100125	Procavia capensis	89.85	0.00e+00	1185.00
IUUC-Pva-102628	Pteropus vampyrus	95.58	0.00e+00	1201.00
IUUC-Rno-104886	Rattus norvegicus	95.44	0.00e+00	1228.00
IUUC-Sha-106702	Sarcophilus harrisii	87.29	0.00e+00	1151.00
IUUC-Ssc-116164	Sus scrofa	94.66	0.00e+00	1243.00
IUUC-Tgu-116829	Taeniopygia guttata	83.87	0.00e+00	979.00
IUUC-Tru-118557	Takifugu rubripes	70.79	0.00e+00	868.00
IUUC-Tsy-119399	Tarsius syrichta	91.00	0.00e+00	670.00
IUUC-Tni-120006	Tetraodon nigroviridis	62.52	0.00e+00	758.00
IUUC-Tbe-127664	Tupaia belangeri	93.60	0.00e+00	1178.00
IUUC-Ttr-129144	Tursiops truncatus	94.66	0.00e+00	1234.00
IUUC-Vpa-130226	Vicugna pacos	95.27	0.00e+00	1230.00
IUUC-Vvi-131278	Vitis vinifera	41.07	1.00e-10	58.90
IUUC-Xtr-132461	Xenopus tropicalis	74.51	0.00e+00	907.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence