iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-066166

Ensembl Protein ID

ENSMPUP00000014009.1

UniProt Accession

M3YRP9; M3YRP9_MUSPF

Genbank Protein ID

ENSMPUP00000014009

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEYP01051106

Gene Name

USP19

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000014117.1	ENSMPUT00000014232.1	ENSMPUP00000014009.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.60e-115	384.4	663	1380

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsg 86
           tGl NlgNtC+mNSv+Q+Lsn++elr+++++ +++ ++n +np ++ g+l+  ++ l+++lwk++++a++p++l+++++++a++f+g
   Q: 663  TGLVNLGNTCFMNSVIQSLSNTRELRDFFHDrSFEAEINYNNPLGTGGRLAIGFAVLLRALWKGTHHAFQPSKLKAIVASKASQFTG 749
           7*****************************999****************************************************** PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssreep 168
           y+q+DaqEf+aflld+l+e+l++ +nkp++e+ ++d   ++de     a++++k++n+s+i+dlFqgq+ks+++c+ c++vs +++p
   Q: 750  YAQHDAQEFMAFLLDGLHEDLNRIQNKPYTETVDSD--GRPDEvvaeeAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCAKVSITFDP 834
           ********************************9999..6666666777*************************************** PP
   S: 169  fldlslpvpgkeetkke...................................................................... 185
           fl+l++p+p+k++  +                                                                       
   Q: 835  FLYLPVPLPQKQKVLPVfyfarephskpikflvsiskenssasevldslsqsvhvkpenlrlaeviknrfhrvflpshsldtvspsd 921
           ************87666********************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 922  tllcfellspelakervvvlevqqrpqvpsvpiskcaacqrkqqsedeklkrctrcyrvgycnqlcqkthwpdhkglcrpenigypf 1008
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 1009 lvsvpasrltyarlaqllegyarysvsvfqppfqpgrmalesqgpscttllstssleagdserdpiqppelqlvtpvaegdtgvpra 1095
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 1096 waapdrgpvpstsgissevlpsgpvevgslpagervsrpeaavpgyqhpseatnahtpqffiykidasnreqrledkgdsplelged 1182
           *************************************************************************************** PP
   S: 186  ..........................................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevL 230
                                                     +l++cL+ ft++e l  e+++yc++ck+++ea+k+l l++lP+vL
   Q: 1183 cslalvwrnnerlqefvlvaskelecaedpgsageaaraghfTLDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVL 1269
           *************************************************************************************** PP
   S: 231  ilhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk........Wll 308
           i++LkRfsf++  +++ kin+ vefp + Ldls+fc+ ++e+q    +Y+L+av++H+G++ +GHY+a+++  +++        W l
   Q: 1270 IVQLKRFSFRSFIWRD-KINDLVEFPVRnLDLSKFCIGQKEEQ--LPSYDLYAVINHYGGMIGGHYTACARLPNDRssqrsdvgWRL 1353
           ************8886.**********9**********99888..9**************************544445566777*** PP
   S: 309  fdDskVtevkeeevleetgstaYvlfYkrr 338
           fdDs+Vt+v+e++v++   + aYvlfY+rr
   Q: 1354 FDDSTVTTVDESQVVT---RYAYVLFYRRR 1380
           ****************...********996 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

PEPRAGCQGP KRAGGGGLAR LSVPCWRIWP QRVAKIAGPG RKRRSPDPDA VADPGALWLS 60
TKRLKMSGGA SATGPRRGPP GLEEATSKKK QKDRANQESK DGDPRRDTER RTHSRLGRAS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCGGAACCGA GAGCGGGTTG CCAGGGCCCT AAGAGGGCTG GCGGCGGCGG CCTCGCTCGG 60
TGAGTGGGAC GGGCCGCAAC TGGCCTGTCT GGCTGGAGCC GGGGAGGCCG CGACGCGGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR007052--CS_dom
IPR008978--HSP20-like_chaperone
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR002893--Znf_MYND

PROSITE

PS51203--CS
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS01360--ZF_MYND_1
PS50865--ZF_MYND_2

Pfam

PF04969--CS
PF00443--UCH
PF01753--zf-MYND

Gene Ontology

GO:0005829--C:cytosol
GO:0005789--C:endoplasmic reticulum membrane
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0046872--F:metal ion binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1901799--P:negative regulation of proteasomal protein catabolic process
GO:0048642--P:negative regulation of skeletal muscle tissue development
GO:0050821--P:protein stabilization
GO:1900037--P:regulation of cellular response to hypoxia
GO:1904292--P:regulation of ERAD pathway
GO:0030433--P:ubiquitin-dependent ERAD pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001999	Ailuropoda melanoleuca	96.06	0.00e+00	2635.00
IUUC-Apl-003368	Anas platyrhynchos	67.81	0.00e+00	1780.00
IUUC-Aca-004267	Anolis carolinensis	68.51	0.00e+00	1669.00
IUUC-Ame-010970	Astyanax mexicanus	70.37	0.00e+00	1348.00
IUUC-Bta-012905	Bos taurus	92.08	0.00e+00	2521.00
IUUC-Cja-018789	Callithrix jacchus	89.79	0.00e+00	2339.00
IUUC-Cfa-021004	Canis familiaris	96.01	0.00e+00	2633.00
IUUC-Cpo-021529	Cavia porcellus	87.15	0.00e+00	2250.00
IUUC-Csa-024035	Chlorocebus sabaeus	93.49	0.00e+00	2350.00
IUUC-Cho-025036	Choloepus hoffmanni	81.70	0.00e+00	1216.00
IUUC-Cin-025451	Ciona intestinalis	43.41	2.00e-86	314.00
IUUC-Csv-025931	Ciona savignyi	36.44	4.00e-111	395.00
IUUC-Dre-028556	Danio rerio	69.76	0.00e+00	1323.00
IUUC-Dno-029240	Dasypus novemcinctus	91.83	0.00e+00	2105.00
IUUC-Dor-030495	Dipodomys ordii	94.94	0.00e+00	1192.00
IUUC-Ete-032741	Echinops telfairi	92.41	0.00e+00	1868.00
IUUC-Eca-033661	Equus caballus	91.92	0.00e+00	2375.00
IUUC-Eeu-034648	Erinaceus europaeus	92.55	0.00e+00	833.00
IUUC-Fca-035646	Felis catus	96.75	0.00e+00	2627.00
IUUC-Fal-037094	Ficedula albicollis	70.16	0.00e+00	1713.00
IUUC-Gmo-038869	Gadus morhua	71.78	0.00e+00	845.00
IUUC-Gga-041170	Gallus gallus	68.17	0.00e+00	1667.00
IUUC-Gac-041901	Gasterosteus aculeatus	68.96	0.00e+00	1319.00
IUUC-Ggo-044708	Gorilla gorilla	90.54	0.00e+00	2357.00
IUUC-Hsa-046791	Homo sapiens	94.73	0.00e+00	2001.00
IUUC-Itr-048892	Ictidomys tridecemlineatus	89.15	0.00e+00	2262.00
IUUC-Lch-050456	Latimeria chalumnae	52.38	0.00e+00	1189.00
IUUC-Loc-052861	Lepisosteus oculatus	59.20	0.00e+00	1150.00
IUUC-Laf-053788	Loxodonta africana	90.12	0.00e+00	2252.00
IUUC-Mcc-055693	Macaca mulatta	89.83	0.00e+00	2431.00
IUUC-Meu-055921	Macropus eugenii	79.26	0.00e+00	1472.00
IUUC-Mga-059879	Meleagris gallopavo	66.91	0.00e+00	1714.00
IUUC-Mmr-060802	Microcebus murinus	91.31	0.00e+00	2396.00
IUUC-Mdo-061856	Monodelphis domestica	77.69	0.00e+00	1561.00
IUUC-Mmu-063874	Mus musculus	92.09	0.00e+00	2213.00
IUUC-Nle-070161	Nomascus leucogenys	90.16	0.00e+00	2408.00
IUUC-Opr-071015	Ochotona princeps	93.58	0.00e+00	1942.00
IUUC-Ont-072308	Oreochromis niloticus	67.10	0.00e+00	1374.00
IUUC-Oan-072723	Ornithorhynchus anatinus	68.57	0.00e+00	1581.00
IUUC-Ocu-073938	Oryctolagus cuniculus	90.02	0.00e+00	2475.00
IUUC-Ola-086375	Oryzias latipes	69.23	0.00e+00	1359.00
IUUC-Oga-088297	Otolemur garnettii	91.86	0.00e+00	2351.00
IUUC-Oar-089675	Ovis aries	89.69	0.00e+00	1738.00
IUUC-Ptr-091621	Pan troglodytes	94.35	0.00e+00	1995.00
IUUC-Pan-092118	Papio anubis	90.46	0.00e+00	2589.00
IUUC-Pma-094154	Petromyzon marinus	51.78	3.00e-114	405.00
IUUC-Pfo-097246	Poecilia formosa	59.09	0.00e+00	1427.00
IUUC-Pab-098551	Pongo abelii	93.77	0.00e+00	1975.00
IUUC-Pca-100158	Procavia capensis	85.87	0.00e+00	2225.00
IUUC-Pva-103160	Pteropus vampyrus	91.17	0.00e+00	2314.00
IUUC-Rno-105355	Rattus norvegicus	90.53	0.00e+00	2239.00
IUUC-Sha-107057	Sarcophilus harrisii	73.09	0.00e+00	1949.00
IUUC-Sar-113011	Sorex araneus	90.61	0.00e+00	1514.00
IUUC-Ssc-115761	Sus scrofa	93.44	0.00e+00	2583.00
IUUC-Tgu-116956	Taeniopygia guttata	64.12	0.00e+00	794.00
IUUC-Tru-118739	Takifugu rubripes	66.67	0.00e+00	1369.00
IUUC-Tsy-118827	Tarsius syrichta	82.47	0.00e+00	1246.00
IUUC-Tni-119921	Tetraodon nigroviridis	61.36	0.00e+00	1400.00
IUUC-Tbe-128017	Tupaia belangeri	91.48	0.00e+00	1915.00
IUUC-Ttr-128869	Tursiops truncatus	91.15	0.00e+00	2309.00
IUUC-Vpa-130427	Vicugna pacos	97.01	0.00e+00	937.00
IUUC-Xtr-132734	Xenopus tropicalis	61.58	0.00e+00	1625.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence