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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063135
Ensembl Protein ID ENSMUSP00000062782.7
UniProt Accession Q60992; A2AH49; VAV2_MOUSE
Genbank Protein ID AAC52761.1; CAM13732.1; CAM13732.1; CAM21000.1; CAM21000.1
Protein Name Guanine nucleotide exchange factor VAV2
Genbank Nucleotide ID U37017; AL731552; AL772282; AL772282; AL731552
Gene Name Vav2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000009621.18 ENSMUST00000185188.7 ENSMUSP00000138964.1
ENSMUSG00000009621.18 ENSMUST00000056176.7 ENSMUSP00000062782.7
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarmiRNAMap
RAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 1.20e-17 64.7 813 864
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 8    vlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           + y++ a +  eL+l++Gdvv++ +    d+gW+kg  e++g+ G fP+ +ve+
   Q: 813  ARYNFAARDMRELSLREGDVVKIYSRIGGDQGWWKG--ETNGRIGWFPSTYVEE 864
           67**********************************..9*************86 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly.
 Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly.
Protein Sequence
(Fasta)
MEQWRQCGRW LIDCKVLPPN HRVVWPSAVV FDLAQALRDG VLLCQLLHNL SPGSIDLKDI 60
NFRPQMSQFL CLKNIRTFLK VCHDKFGLRN SELFDPFDLF DVRDFGKVIS AVSRLSLHSI 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063135|UBD,SH3|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGCGCCTAGG AGCCGCGGAG CCTCGGAGTC CCAGTGCCCC GCGAGTGGCG TAGAGCCCGC 60
GGGCCCGGCG AACAAAGCGA CGGTGGAGCG AGCAGCTCAG GCGCCGGACG CAGGGAGCGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063135|UBD,SH3|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0037--Angiogenesis
KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR022613--CAMSAP_CH
IPR001715--CH-domain
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR002219--PE/DAG-bd
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR000980--SH2
IPR011511--SH3_2
IPR001452--SH3_domain
PROSITE

PS50021--CH
PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50001--SH2
PS50002--SH3
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2
Pfam

PF00130--C1_1
PF11971--CAMSAP_CH
PF00169--PH
PF00621--RhoGEF
PF00017--SH2
PF07653--SH3_2
PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
SMART

SM00109--C1
SM00033--CH
SM00233--PH
SM00325--RhoGEF
SM00252--SH2
SM00326--SH3
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005886--C:plasma membrane
GO:0005154--F:epidermal growth factor receptor binding
GO:0005085--F:guanyl-nucleotide exchange factor activity
GO:0046872--F:metal ion binding
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0001525--P:angiogenesis
GO:0016477--P:cell migration
GO:0030031--P:cell projection assembly
GO:0030032--P:lamellipodium assembly
GO:0030168--P:platelet activation
GO:0043552--P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0030193--P:regulation of blood coagulation
GO:0008361--P:regulation of cell size
GO:0010468--P:regulation of gene expression
GO:0043087--P:regulation of GTPase activity
GO:0035023--P:regulation of Rho protein signal transduction
GO:0007264--P:small GTPase mediated signal transduction
KEGG mmu:22325
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001437 Ailuropoda melanoleuca 92.93 0.00e+00 1469.00
IUUC-Apl-003262 Anas platyrhynchos 91.01 0.00e+00 1551.00
IUUC-Aca-004628 Anolis carolinensis 66.58 0.00e+00 927.00
IUUC-Ath-007352 Arabidopsis thaliana 38.60 9.00e-04 38.90
IUUC-Ame-011608 Astyanax mexicanus 79.28 0.00e+00 1408.00
IUUC-Bta-013147 Bos taurus 93.18 0.00e+00 1318.00
IUUC-Cel-018578 Caenorhabditis elegans 29.68 1.00e-75 278.00
IUUC-Cja-018877 Callithrix jacchus 91.00 0.00e+00 1400.00
IUUC-Cfa-020315 Canis familiaris 91.24 0.00e+00 1248.00
IUUC-Cpo-021543 Cavia porcellus 94.36 0.00e+00 1355.00
IUUC-Csa-024204 Chlorocebus sabaeus 92.75 0.00e+00 1612.00
IUUC-Cin-025115 Ciona intestinalis 36.63 5.00e-146 511.00
IUUC-Dre-028308 Danio rerio 80.97 0.00e+00 1444.00
IUUC-Dno-029584 Dasypus novemcinctus 87.63 0.00e+00 1151.00
IUUC-Dor-031014 Dipodomys ordii 83.33 0.00e+00 1230.00
IUUC-Eca-033448 Equus caballus 91.91 0.00e+00 1579.00
IUUC-Eeu-035182 Erinaceus europaeus 83.29 0.00e+00 670.00
IUUC-Fca-035460 Felis catus 92.72 0.00e+00 1331.00
IUUC-Fal-036684 Ficedula albicollis 89.80 0.00e+00 1557.00
IUUC-Gmo-038816 Gadus morhua 74.60 0.00e+00 1090.00
IUUC-Gga-040999 Gallus gallus 88.82 0.00e+00 1534.00
IUUC-Gac-041353 Gasterosteus aculeatus 76.56 0.00e+00 1153.00
IUUC-Ggo-044558 Gorilla gorilla 94.65 0.00e+00 1620.00
IUUC-Hsa-046208 Homo sapiens 94.76 0.00e+00 1623.00
IUUC-Itr-047931 Ictidomys tridecemlineatus 91.37 0.00e+00 1219.00
IUUC-Loc-052827 Lepisosteus oculatus 80.73 0.00e+00 1453.00
IUUC-Laf-054009 Loxodonta africana 91.60 0.00e+00 1561.00
IUUC-Mcc-055054 Macaca mulatta 94.65 0.00e+00 1621.00
IUUC-Mga-060106 Meleagris gallopavo 91.71 0.00e+00 1563.00
IUUC-Mmr-061118 Microcebus murinus 93.43 0.00e+00 1592.00
IUUC-Mdo-062380 Monodelphis domestica 87.76 0.00e+00 1284.00
IUUC-Mpu-066135 Mustela putorius furo 89.86 0.00e+00 1435.00
IUUC-Nle-069465 Nomascus leucogenys 88.09 0.00e+00 1483.00
IUUC-Ont-071945 Oreochromis niloticus 81.19 0.00e+00 1422.00
IUUC-Oan-073384 Ornithorhynchus anatinus 87.98 0.00e+00 1221.00
IUUC-Ola-087499 Oryzias latipes 76.36 0.00e+00 1080.00
IUUC-Oga-088444 Otolemur garnettii 90.97 0.00e+00 1297.00
IUUC-Oar-089576 Ovis aries 88.03 0.00e+00 1215.00
IUUC-Ptr-090507 Pan troglodytes 95.85 0.00e+00 1628.00
IUUC-Pan-092325 Papio anubis 92.40 0.00e+00 1568.00
IUUC-Psi-094021 Pelodiscus sinensis 88.70 0.00e+00 1518.00
IUUC-Pma-094372 Petromyzon marinus 53.38 0.00e+00 709.00
IUUC-Pfo-096732 Poecilia formosa 81.09 0.00e+00 1432.00
IUUC-Pab-098426 Pongo abelii 78.41 0.00e+00 1155.00
IUUC-Pca-100295 Procavia capensis 92.38 0.00e+00 1481.00
IUUC-Rno-105332 Rattus norvegicus 97.93 0.00e+00 1607.00
IUUC-Sha-106529 Sarcophilus harrisii 92.47 0.00e+00 1266.00
IUUC-Sit-110173 Setaria italica 34.09 1.80e-01 31.20
IUUC-Ssc-116176 Sus scrofa 93.56 0.00e+00 1456.00
IUUC-Tgu-116917 Taeniopygia guttata 91.14 0.00e+00 1420.00
IUUC-Tru-118398 Takifugu rubripes 78.47 0.00e+00 998.00
IUUC-Tni-120819 Tetraodon nigroviridis 78.98 0.00e+00 1209.00
IUUC-Xtr-132747 Xenopus tropicalis 78.83 0.00e+00 1362.00
Created Date 25-Jun-2017

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