iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPANG00000026098.2	ENSPANT00000028502.2	ENSPANP00000002892.1
ENSPANG00000026098.2	ENSPANT00000028538.1	ENSPANP00000002891.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.20e-17	63.7	784	835

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 8    vlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           + y++ a +  eL+l++Gdvv++ +    d+gW+kg  e++g+ G fP+ +ve+
   Q: 784  ARYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKG--ETNGRIGWFPSTYVEE 835
           67**********************************..9*************86 PP

Organism

Papio anubis

Protein Sequence
(Fasta)

MEQWRQCGRW LIDCKVLPPN HRVVWPSAVV FDLAQALRDG VLLCQLLHNL SPGSIDLKDI 60
NFRPQMSQFL CLKNIRTFLK VCHDKFGLRN SELFDPFDLF DVRDFGKVIS AVSRLSLHSI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGAGCCGCGG AGTCGTCGAG TCGCAGCGCC GGGCGTGAGG ACTGCGGGCG GGGCGAACAA 60
AGCGGCGGCG ACGCGGACGG CCCAGGCCCG GGACGCGCGG AGCGAGCGAC CCCACCGGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0862--Zinc

Interpro

IPR022613--CAMSAP_CH
IPR001715--CH-domain
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR002219--PE/DAG-bd
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR000980--SH2
IPR011511--SH3_2
IPR001452--SH3_domain

PROSITE

PS50021--CH
PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50001--SH2
PS50002--SH3
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2

Pfam

PF00130--C1_1
PF11971--CAMSAP_CH
PF00169--PH
PF00621--RhoGEF
PF00017--SH2
PF07653--SH3_2

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00109--C1
SM00033--CH
SM00233--PH
SM00325--RhoGEF
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005886--C:plasma membrane
GO:0046872--F:metal ion binding
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0016477--P:cell migration
GO:0030032--P:lamellipodium assembly
GO:0043552--P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0030193--P:regulation of blood coagulation
GO:0008361--P:regulation of cell size
GO:0010468--P:regulation of gene expression
GO:0035023--P:regulation of Rho protein signal transduction
GO:0007264--P:small GTPase mediated signal transduction

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001437	Ailuropoda melanoleuca	89.69	0.00e+00	1431.00
IUUC-Apl-003262	Anas platyrhynchos	88.02	0.00e+00	1510.00
IUUC-Aca-004628	Anolis carolinensis	66.36	0.00e+00	915.00
IUUC-Ath-007352	Arabidopsis thaliana	38.60	6.00e-04	39.30
IUUC-Ame-011608	Astyanax mexicanus	82.06	0.00e+00	1416.00
IUUC-Bta-013147	Bos taurus	88.73	0.00e+00	1266.00
IUUC-Cel-018578	Caenorhabditis elegans	28.24	1.00e-97	351.00
IUUC-Cja-018877	Callithrix jacchus	89.77	0.00e+00	1354.00
IUUC-Cfa-020315	Canis familiaris	95.73	0.00e+00	1267.00
IUUC-Cpo-021543	Cavia porcellus	88.32	0.00e+00	1270.00
IUUC-Csa-024204	Chlorocebus sabaeus	93.30	0.00e+00	1591.00
IUUC-Cin-025115	Ciona intestinalis	37.50	1.00e-147	517.00
IUUC-Csv-025995	Ciona savignyi	36.62	2.00e-148	520.00
IUUC-Dre-028308	Danio rerio	78.46	0.00e+00	1386.00
IUUC-Dno-029584	Dasypus novemcinctus	91.59	0.00e+00	1164.00
IUUC-Dor-031014	Dipodomys ordii	81.80	0.00e+00	1218.00
IUUC-Eca-033448	Equus caballus	87.59	0.00e+00	1524.00
IUUC-Eeu-035182	Erinaceus europaeus	83.79	0.00e+00	672.00
IUUC-Fca-035460	Felis catus	91.77	0.00e+00	1332.00
IUUC-Fal-036684	Ficedula albicollis	86.88	0.00e+00	1519.00
IUUC-Gmo-038816	Gadus morhua	78.28	0.00e+00	1098.00
IUUC-Gga-040999	Gallus gallus	91.78	0.00e+00	1551.00
IUUC-Gac-041353	Gasterosteus aculeatus	79.70	0.00e+00	1149.00
IUUC-Ggo-044558	Gorilla gorilla	94.65	0.00e+00	1590.00
IUUC-Hsa-046208	Homo sapiens	94.99	0.00e+00	1596.00
IUUC-Itr-047931	Ictidomys tridecemlineatus	87.44	0.00e+00	1174.00
IUUC-Loc-052827	Lepisosteus oculatus	77.41	0.00e+00	1375.00
IUUC-Laf-054009	Loxodonta africana	86.73	0.00e+00	1492.00
IUUC-Mcc-055054	Macaca mulatta	95.22	0.00e+00	1600.00
IUUC-Mla-059044	Melampsora laricipopulina	23.83	5.00e-19	90.50
IUUC-Mga-060106	Meleagris gallopavo	88.71	0.00e+00	1523.00
IUUC-Mmr-061118	Microcebus murinus	90.90	0.00e+00	1545.00
IUUC-Mdo-062380	Monodelphis domestica	91.52	0.00e+00	1304.00
IUUC-Mmu-063135	Mus musculus	92.40	0.00e+00	1589.00
IUUC-Mpu-066135	Mustela putorius furo	93.08	0.00e+00	1450.00
IUUC-Nle-069465	Nomascus leucogenys	88.26	0.00e+00	1456.00
IUUC-Ont-071945	Oreochromis niloticus	78.68	0.00e+00	1346.00
IUUC-Oan-073384	Ornithorhynchus anatinus	84.37	0.00e+00	1160.00
IUUC-Ola-087499	Oryzias latipes	79.86	0.00e+00	1083.00
IUUC-Oga-088444	Otolemur garnettii	96.21	0.00e+00	1327.00
IUUC-Oar-089576	Ovis aries	86.52	0.00e+00	1206.00
IUUC-Ptr-090507	Pan troglodytes	95.85	0.00e+00	1598.00
IUUC-Psi-094021	Pelodiscus sinensis	91.77	0.00e+00	1537.00
IUUC-Pfo-096732	Poecilia formosa	78.68	0.00e+00	1358.00
IUUC-Pab-098426	Pongo abelii	84.43	0.00e+00	1204.00
IUUC-Pca-100295	Procavia capensis	88.70	0.00e+00	1426.00
IUUC-Rno-105332	Rattus norvegicus	91.59	0.00e+00	1516.00
IUUC-Sha-106529	Sarcophilus harrisii	87.84	0.00e+00	1210.00
IUUC-Ssc-116176	Sus scrofa	89.34	0.00e+00	1407.00
IUUC-Tgu-116917	Taeniopygia guttata	88.01	0.00e+00	1384.00
IUUC-Tru-118398	Takifugu rubripes	75.76	0.00e+00	934.00
IUUC-Tni-120819	Tetraodon nigroviridis	76.89	0.00e+00	1147.00
IUUC-Xtr-132747	Xenopus tropicalis	81.40	0.00e+00	1363.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence