iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ptr-090529

UUCD1 version

UUC-PaT-00629

Ensembl Protein ID

ENSPTRP00000031516.3

UniProt Accession

H2QTG6; H2QTG6_PANTR

Genbank Protein ID

JAA01930.1; JAA18924.1; JAA29698.1; JAA41226.1

Protein Name

HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1

Genbank Nucleotide ID

AACZ03048303; GABF01003221; GABD01003402; GABE01003513

Gene Name

HACE1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000018451.3	ENSPTRT00000034101.3	ENSPTRP00000031516.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.30e-118	394.9	576	905

Active Site

Position(s)	Description	Evidence
876	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlp 91
           ++lk+ + v+f gEeg+++ Gv re+++ ls+e+ npd+ lf++s+ d +t+qpn++s++ np+hl++F+f+G++lg+al +++l+++ 
   Q: 576  AKLKQGIAVRFHGEEGMGQ-GVVREWFDILSNEIVNPDYALFTQSA-DGTTFQPNSNSYV-NPDHLNYFRFAGQILGLALNHRQLVNIY 661
           679999*************.**********************6666.67788*******9.89************************** PP
   S: 92   lsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvvey 180
           +++sfyk++lg +++++d++++dpe+ k+l++i++n   di++lgl+ltfsv+++++g ++e+ LkpgG +i Vt++Nk eYv+lv+e+
   Q: 662  FTRSFYKHILGIPVNYQDVASIDPEYGKNLQWILDN---DISDLGLELTFSVETDVFGAMEEVPLKPGGGSILVTQNNKAEYVQLVTEL 747
           **********************************99...************************************************** PP
   S: 181  rlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvT 269
           r+++ i+ q++af +Gf+  ip++l++lF+e elell++G++eidv+d+ k+t+y++gy++++p+iqwFwev+e++++eer  +LqFvT
   Q: 748  RMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEIDVSDWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVT 836
           ***************************************************************************************** PP
   S: 270  gssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kg 332
           gssr+P+gGfa+++     + f+i     +++ lP+s+TC+n+LkLPeY+skeilk++Ll+A + +  g
   Q: 837  GSSRVPHGGFANIMggsgLQNFTIAAvPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVALHCGsYG 905
           ******************8888888868888********************************986555 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MERAMEQLNR LTRSLRRART VELPEDNETA VYTLMPMVMA DQHRSVSELL SNSKFDVNYA 60
FGRVKRSLLH IAANCGSVEC LVLLLKKGAN PNYQDISGCT PLHLAARNGQ KKCMSKLLEY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGAAGGCCAC GCGAGCCCGG GAGGGACGCG GCGGCGGGGG CTGCAGGAAA GGCGCGAGCA 60
GAGGCGGCGG CGGGTGTACC GTAGGTGGTC GGTCCGGCAG CAGCCCGGCC CCCGGACGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0040--ANK repeat
KW-0181--Complete proteome
KW-0436--Ligase
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR000569--HECT_dom

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50237--HECT

Pfam

PF12796--Ank_2
PF00632--HECT

PRINTS

PR01415--ANKYRIN

SMART

SM00248--ANK
SM00119--HECTc

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0000139--C:Golgi membrane
GO:0016874--F:ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0007030--P:Golgi organization
GO:0061025--P:membrane fusion
GO:0070936--P:protein K48-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030334--P:regulation of cell migration

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000627	Aegilops tauschii	40.59	3.00e-83	305.00
IUUC-Aml-001490	Ailuropoda melanoleuca	98.14	0.00e+00	1866.00
IUUC-Atr-002582	Amborella trichopoda	43.41	4.00e-99	358.00
IUUC-Apl-003400	Anas platyrhynchos	88.03	0.00e+00	1153.00
IUUC-Aca-005375	Anolis carolinensis	91.43	0.00e+00	1738.00
IUUC-Aly-006157	Arabidopsis lyrata	44.32	4.00e-100	361.00
IUUC-Ath-007160	Arabidopsis thaliana	42.76	2.00e-94	342.00
IUUC-Afu-009022	Aspergillus fumigatus	42.66	2.00e-95	345.00
IUUC-Ani-009412	Aspergillus nidulans	42.79	2.00e-97	352.00
IUUC-Ate-010253	Aspergillus terreus	42.79	7.00e-96	347.00
IUUC-Ame-011847	Astyanax mexicanus	84.76	0.00e+00	1645.00
IUUC-Bta-012831	Bos taurus	97.86	0.00e+00	1824.00
IUUC-Bdi-014884	Brachypodium distachyon	42.99	2.00e-97	352.00
IUUC-Bol-016533	Brassica oleracea	52.55	5.00e-78	283.00
IUUC-Bra-016726	Brassica rapa	44.32	1.00e-100	362.00
IUUC-Cja-019160	Callithrix jacchus	99.56	0.00e+00	1894.00
IUUC-Cfa-020346	Canis familiaris	98.24	0.00e+00	1873.00
IUUC-Cpo-021766	Cavia porcellus	97.36	0.00e+00	1857.00
IUUC-Cre-022900	Chlamydomonas reinhardtii	43.12	5.00e-98	351.00
IUUC-Csa-023768	Chlorocebus sabaeus	99.67	0.00e+00	1898.00
IUUC-Cho-024688	Choloepus hoffmanni	94.02	0.00e+00	1179.00
IUUC-Cin-025417	Ciona intestinalis	50.86	5.00e-138	485.00
IUUC-Csv-025993	Ciona savignyi	44.04	0.00e+00	758.00
IUUC-Cme-027267	Cyanidioschyzon merolae	42.00	6.00e-87	316.00
IUUC-Dre-027819	Danio rerio	85.53	0.00e+00	1632.00
IUUC-Dno-029027	Dasypus novemcinctus	97.60	0.00e+00	1850.00
IUUC-Dor-030327	Dipodomys ordii	90.26	0.00e+00	1634.00
IUUC-Ete-032966	Echinops telfairi	90.66	0.00e+00	1710.00
IUUC-Eca-034339	Equus caballus	98.35	0.00e+00	1871.00
IUUC-Eeu-034544	Erinaceus europaeus	70.50	0.00e+00	698.00
IUUC-Fca-035617	Felis catus	98.15	0.00e+00	1338.00
IUUC-Fal-036687	Ficedula albicollis	91.30	0.00e+00	1765.00
IUUC-Gmo-039508	Gadus morhua	87.93	0.00e+00	831.00
IUUC-Gga-040845	Gallus gallus	91.51	0.00e+00	1783.00
IUUC-Gac-041894	Gasterosteus aculeatus	85.03	0.00e+00	1584.00
IUUC-Gma-044216	Glycine max	44.09	6.00e-101	364.00
IUUC-Ggo-044465	Gorilla gorilla	95.94	0.00e+00	1816.00
IUUC-Hsa-045731	Homo sapiens	99.89	0.00e+00	1901.00
IUUC-Hvu-047697	Hordeum vulgare	42.76	2.00e-96	349.00
IUUC-Itr-048716	Ictidomys tridecemlineatus	98.68	0.00e+00	1873.00
IUUC-Lch-050436	Latimeria chalumnae	89.17	0.00e+00	1698.00
IUUC-Lpe-051550	Leersia perrieri	43.21	2.00e-98	355.00
IUUC-Loc-052287	Lepisosteus oculatus	85.38	0.00e+00	1669.00
IUUC-Lma-053159	Leptosphaeria maculans	40.73	6.00e-93	337.00
IUUC-Laf-053846	Loxodonta africana	98.79	0.00e+00	1879.00
IUUC-Mcc-055845	Macaca mulatta	99.78	0.00e+00	1900.00
IUUC-Meu-056060	Macropus eugenii	98.27	0.00e+00	708.00
IUUC-Mtr-057633	Medicago truncatula	44.32	1.00e-101	366.00
IUUC-Mga-059935	Meleagris gallopavo	94.00	0.00e+00	1762.00
IUUC-Mmr-060960	Microcebus murinus	99.01	0.00e+00	1887.00
IUUC-Mdo-061851	Monodelphis domestica	93.42	0.00e+00	1823.00
IUUC-Mmu-063657	Mus musculus	97.03	0.00e+00	1852.00
IUUC-Mac-065229	Musa acuminata	43.41	6.00e-99	357.00
IUUC-Mpu-066161	Mustela putorius furo	99.25	0.00e+00	832.00
IUUC-Mlu-067354	Myotis lucifugus	96.36	0.00e+00	1798.00
IUUC-Nfi-068278	Neosartorya fischeri	42.66	1.00e-95	346.00
IUUC-Nle-069112	Nomascus leucogenys	99.78	0.00e+00	1898.00
IUUC-Opr-070686	Ochotona princeps	89.29	0.00e+00	815.00
IUUC-Ont-072398	Oreochromis niloticus	84.53	0.00e+00	1585.00
IUUC-Oan-073194	Ornithorhynchus anatinus	95.55	0.00e+00	1749.00
IUUC-Ocu-074397	Oryctolagus cuniculus	86.54	0.00e+00	1585.00
IUUC-Oba-075757	Oryza barthii	42.99	8.00e-98	353.00
IUUC-Obr-076553	Oryza brachyantha	43.44	2.00e-98	355.00
IUUC-Ogl-077520	Oryza glaberrima	42.99	1.00e-97	353.00
IUUC-Ogu-078278	Oryza glumaepatula	42.99	1.00e-97	353.00
IUUC-Oin-079767	Oryza indica	42.99	1.00e-97	353.00
IUUC-Olo-080380	Oryza longistaminata	42.83	4.00e-96	348.00
IUUC-Ome-081925	Oryza meridionalis	42.83	3.00e-96	348.00
IUUC-Oni-082619	Oryza nivara	42.99	1.00e-97	353.00
IUUC-Opu-083684	Oryza punctata	42.83	2.00e-96	348.00
IUUC-Oru-084501	Oryza rufipogon	42.99	1.00e-97	353.00
IUUC-Osa-086251	Oryza sativa	42.82	1.00e-97	350.00
IUUC-Ola-086777	Oryzias latipes	80.82	0.00e+00	1566.00
IUUC-Oga-088684	Otolemur garnettii	98.79	0.00e+00	1880.00
IUUC-Oar-089428	Ovis aries	97.77	0.00e+00	1833.00
IUUC-Pan-091702	Papio anubis	99.67	0.00e+00	1898.00
IUUC-Psi-093969	Pelodiscus sinensis	90.97	0.00e+00	1709.00
IUUC-Pno-094871	Phaeosphaeria nodorum	40.73	7.00e-93	337.00
IUUC-Ppa-095834	Physcomitrella patens	43.74	3.00e-97	352.00
IUUC-Pfo-097364	Poecilia formosa	86.07	0.00e+00	1611.00
IUUC-Pab-098574	Pongo abelii	99.89	0.00e+00	1901.00
IUUC-Pop-099468	Populus trichocarpa	44.32	6.00e-101	364.00
IUUC-Pca-100525	Procavia capensis	87.15	1.00e-179	623.00
IUUC-Ppe-101641	Prunus persica	43.86	6.00e-100	360.00
IUUC-Pva-102365	Pteropus vampyrus	86.91	0.00e+00	1608.00
IUUC-Pgr-103465	Puccinia graminis	40.46	5.00e-99	358.00
IUUC-Ptt-103813	Puccinia triticina	37.92	2.00e-88	322.00
IUUC-Pyt-104713	Pyrenophora triticirepentis	40.96	6.00e-94	341.00
IUUC-Rno-105153	Rattus norvegicus	96.81	0.00e+00	1854.00
IUUC-Sha-107319	Sarcophilus harrisii	93.31	0.00e+00	1817.00
IUUC-Smo-109640	Selaginella moellendorffii	43.28	1.00e-98	356.00
IUUC-Sit-110598	Setaria italica	43.67	6.00e-98	354.00
IUUC-Sly-111706	Solanum lycopersicum	44.55	9.00e-101	363.00
IUUC-Stu-112894	Solanum tuberosum	34.76	7.00e-54	205.00
IUUC-Sar-113449	Sorex araneus	81.82	4.00e-179	622.00
IUUC-Sbi-114042	Sorghum bicolor	43.96	2.00e-98	355.00
IUUC-Sre-114958	Sporisorium reilianum	45.21	5.00e-108	384.00
IUUC-Ssc-115865	Sus scrofa	98.24	0.00e+00	1873.00
IUUC-Tgu-117225	Taeniopygia guttata	91.30	0.00e+00	1779.00
IUUC-Tru-118026	Takifugu rubripes	82.40	0.00e+00	1566.00
IUUC-Tsy-119407	Tarsius syrichta	85.81	0.00e+00	1581.00
IUUC-Tni-120234	Tetraodon nigroviridis	83.97	0.00e+00	1270.00
IUUC-Tca-121479	Theobroma cacao	44.09	5.00e-102	367.00
IUUC-Tae-125214	Triticum aestivum	42.26	4.00e-96	347.00
IUUC-Tur-126774	Triticum urartu	29.17	6.00e-46	179.00
IUUC-Tbe-127708	Tupaia belangeri	88.25	0.00e+00	880.00
IUUC-Ttr-128667	Tursiops truncatus	98.02	0.00e+00	1870.00
IUUC-Uma-129355	Ustilago maydis	45.88	1.00e-108	386.00
IUUC-Vpa-130200	Vicugna pacos	98.19	0.00e+00	1816.00
IUUC-Vvi-131078	Vitis vinifera	43.86	4.00e-101	364.00
IUUC-Xtr-132176	Xenopus tropicalis	87.61	0.00e+00	1708.00
IUUC-Xma-133936	Xiphophorus maculatus	82.46	0.00e+00	940.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence