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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046275
UUCD1 version UUC-HoS-00029
Ensembl Protein ID ENSP00000274140.4
UniProt Accession O60337; A5PKZ4; B4DKJ2; B4DT33; D3DTC8; O14670; Q86X77; MARH6_HUMAN
Genbank Protein ID BAA25523.1; BAG59204.1; BAG61845.1; EAX08065.1; EAX08066.1; AAH46148.1; AAI36462.1; AAI36463.1; AAI42680.1; AAI42695.1; AAB66840.1
Protein Name E3 ubiquitin-protein ligase MARCH6; Doa10 homolog; Membrane-associated RING finger protein 6; Membrane-associated RING-CH protein VI; Protein TEB-4; RING finger protein 176; RING-type E3 ubiquitin transferase MARCH6
Genbank Nucleotide ID AB011169; AK296585; AK300034; AC012640; CH471102; BC046148; BC136461; BC136462; BC142679; BC142694; AF009301
Gene Name MARCH6; KIAA0597; RNF176; TEB4
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000145495.14 ENST00000449913.6 ENSP00000414643.2
ENSG00000145495.14 ENST00000502795.5 ENSP00000426000.1
ENSG00000145495.14 ENST00000503788.5 ENSP00000425930.1
ENSG00000145495.14 ENST00000274140.9 ENSP00000274140.4
ENSG00000145495.14 ENST00000510792.1 ENSP00000424512.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
miRTarBasemicroRNATRANSFACTargetScan
RepTarmiRNAMapSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtBioGRID
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 19103148; 19651899; 20357004
Reviewed
Classification
Family Identity E-value Score Source Orthology
E3 activity/RING/RING 28.79 1.00e-15 80.90 IUUC-Sce-106352
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that promotes ubiquitination of DIO2, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1.
 E3 ubiquitin-protein ligase that promotes ubiquitination of DIO2, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1.
Protein Sequence
(Fasta)
MDTAEEDICR VCRSEGTPEK PLYHPCVCTG SIKFIHQECL VQWLKHSRKE YCELCKHRFA 60
FTPIYSPDMP SRLPIQDIFA GLVTSIGTAI RYWFHYTLVA FAWLGVVPLT ACRIYKCLFT 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046275|E3,RING|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CCCTCCCCCT CCCGTGTCGC TCGCTTTCTG TCAGCCTCTC TCCCTCTCCC TCTCCCCTCT 60
CCTTCCTCTC GCTTCCTCTC TCGCACCTGA GCGTACGCAC CTGCCCGGGC CCGGCTCCCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046275|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR011016--Znf_RING-CH
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS51292--ZF_RING_CH
Pfam

PF12906--RINGv
SMART

SM00744--RINGv
Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0044322--C:endoplasmic reticulum quality control compartment
GO:0000835--C:ER ubiquitin ligase complex
GO:0030176--C:integral component of endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:0016020--C:membrane
GO:0019899--F:enzyme binding
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:1904264--F:ubiquitin protein ligase activity involved in ERAD pathway
GO:0004842--F:ubiquitin-protein transferase activity
GO:1990381--F:ubiquitin-specific protease binding
GO:0008270--F:zinc ion binding
GO:1904380--P:endoplasmic reticulum mannose trimming
GO:0036503--P:ERAD pathway
GO:0010498--P:proteasomal protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0030433--P:ubiquitin-dependent ERAD pathway
KEGG hsa:10299
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000529 Aegilops tauschii 25.66 1.00e-54 208.00
IUUC-Aml-002317 Ailuropoda melanoleuca 98.87 0.00e+00 1512.00
IUUC-Atr-002732 Amborella trichopoda 29.83 1.00e-61 232.00
IUUC-Apl-003346 Anas platyrhynchos 91.45 0.00e+00 1425.00
IUUC-Aca-004674 Anolis carolinensis 92.22 0.00e+00 1410.00
IUUC-Aly-005919 Arabidopsis lyrata 30.00 5.00e-66 246.00
IUUC-Ath-007662 Arabidopsis thaliana 29.84 2.00e-66 247.00
IUUC-Ago-007857 Ashbya gossypii 37.68 2.00e-11 65.50
IUUC-Acl-008114 Aspergillus clavatus 40.00 8.00e-22 100.00
IUUC-Afl-008703 Aspergillus flavus 40.00 9.00e-22 99.80
IUUC-Afu-008872 Aspergillus fumigatus 49.15 1.00e-31 132.00
IUUC-Ani-009237 Aspergillus nidulans 49.57 2.00e-30 128.00
IUUC-Ang-009656 Aspergillus niger 40.00 2.00e-21 99.00
IUUC-Aor-010019 Aspergillus oryzae 48.31 3.00e-31 131.00
IUUC-Ate-010367 Aspergillus terreus 49.15 8.00e-32 133.00
IUUC-Ame-011557 Astyanax mexicanus 90.05 0.00e+00 961.00
IUUC-Bgr-011974 Blumeria graminis 44.35 1.00e-28 123.00
IUUC-Bta-013572 Bos taurus 98.42 0.00e+00 1473.00
IUUC-Bci-013727 Botrytis cinerea 41.53 1.00e-27 119.00
IUUC-Bdi-014478 Brachypodium distachyon 30.59 2.00e-65 244.00
IUUC-Bol-015765 Brassica oleracea 31.37 3.00e-65 243.00
IUUC-Bra-017013 Brassica rapa 30.60 4.00e-63 237.00
IUUC-Cel-018256 Caenorhabditis elegans 43.37 2.00e-115 410.00
IUUC-Cja-019361 Callithrix jacchus 97.54 0.00e+00 1528.00
IUUC-Cfa-021059 Canis familiaris 98.99 0.00e+00 1515.00
IUUC-Cpo-022259 Cavia porcellus 95.09 0.00e+00 1414.00
IUUC-Csa-024132 Chlorocebus sabaeus 99.78 0.00e+00 1515.00
IUUC-Cho-024752 Choloepus hoffmanni 90.28 0.00e+00 942.00
IUUC-Cin-025673 Ciona intestinalis 47.61 0.00e+00 743.00
IUUC-Cgl-026714 Colletotrichum gloeosporioides 38.93 8.00e-23 103.00
IUUC-Cne-026977 Cryptococcus neoformans 45.71 6.00e-20 94.00
IUUC-Cme-027283 Cyanidioschyzon merolae 40.26 5.00e-17 83.60
IUUC-Dre-027968 Danio rerio 89.23 0.00e+00 996.00
IUUC-Dno-029848 Dasypus novemcinctus 98.44 0.00e+00 1549.00
IUUC-Dor-031149 Dipodomys ordii 81.04 0.00e+00 1047.00
IUUC-Dse-031295 Dothistroma septosporum 47.06 2.00e-25 112.00
IUUC-Dme-031749 Drosophila melanogaster 47.35 1.00e-156 547.00
IUUC-Ete-032230 Echinops telfairi 81.83 0.00e+00 964.00
IUUC-Eca-034268 Equus caballus 98.87 0.00e+00 1504.00
IUUC-Eeu-034731 Erinaceus europaeus 79.29 0.00e+00 1107.00
IUUC-Fca-036434 Felis catus 98.99 0.00e+00 1521.00
IUUC-Fal-036963 Ficedula albicollis 94.19 0.00e+00 1439.00
IUUC-Fox-038040 Fusarium oxysporum 57.61 2.00e-29 125.00
IUUC-Fso-038260 Fusarium solani 40.71 2.00e-28 122.00
IUUC-Gmo-038917 Gadus morhua 77.99 0.00e+00 1179.00
IUUC-Ggr-039905 Gaeumannomyces graminis 43.59 2.00e-26 115.00
IUUC-Gga-041150 Gallus gallus 93.78 0.00e+00 1445.00
IUUC-Gac-042399 Gasterosteus aculeatus 82.81 0.00e+00 913.00
IUUC-Gma-042674 Glycine max 30.37 1.00e-70 261.00
IUUC-Ggo-045093 Gorilla gorilla 99.89 0.00e+00 1519.00
IUUC-Hvu-047562 Hordeum vulgare 32.14 5.00e-22 100.00
IUUC-Itr-048106 Ictidomys tridecemlineatus 99.34 3.00e-141 494.00
IUUC-Kpa-049197 Komagataella pastoris 40.54 3.00e-22 101.00
IUUC-Lch-050358 Latimeria chalumnae 90.54 0.00e+00 983.00
IUUC-Lpe-051172 Leersia perrieri 27.08 1.00e-84 308.00
IUUC-Loc-051866 Lepisosteus oculatus 92.39 0.00e+00 1033.00
IUUC-Lma-053314 Leptosphaeria maculans 43.22 4.00e-28 120.00
IUUC-Laf-054000 Loxodonta africana 82.70 0.00e+00 1308.00
IUUC-Mcc-055595 Macaca mulatta 99.66 0.00e+00 1501.00
IUUC-Meu-056541 Macropus eugenii 90.58 0.00e+00 758.00
IUUC-Mor-057197 Magnaporthe oryzae 41.03 1.00e-25 113.00
IUUC-Mpo-057582 Magnaporthe poae 41.03 3.00e-24 108.00
IUUC-Mtr-057848 Medicago truncatula 31.50 2.00e-68 254.00
IUUC-Mla-058855 Melampsora laricipopulina 32.26 9.00e-08 52.40
IUUC-Mga-059985 Meleagris gallopavo 92.83 0.00e+00 1409.00
IUUC-Mvi-060425 Microbotryum violaceum 30.67 5.00e-18 87.40
IUUC-Mmr-061236 Microcebus murinus 99.21 0.00e+00 1484.00
IUUC-Mdo-062693 Monodelphis domestica 94.11 0.00e+00 1453.00
IUUC-Mmu-064221 Mus musculus 98.11 0.00e+00 1508.00
IUUC-Mac-064930 Musa acuminata 54.72 9.00e-18 81.60
IUUC-Mpu-066231 Mustela putorius furo 96.74 0.00e+00 1512.00
IUUC-Mlu-067461 Myotis lucifugus 98.53 0.00e+00 1506.00
IUUC-Nfi-068608 Neosartorya fischeri 49.15 2.00e-31 132.00
IUUC-Ncr-068743 Neurospora crassa 42.61 6.00e-27 117.00
IUUC-Nle-069646 Nomascus leucogenys 100.00 0.00e+00 1519.00
IUUC-Opr-070365 Ochotona princeps 81.76 0.00e+00 1179.00
IUUC-Ont-071418 Oreochromis niloticus 84.85 0.00e+00 939.00
IUUC-Oan-073127 Ornithorhynchus anatinus 94.34 0.00e+00 1322.00
IUUC-Ocu-074853 Oryctolagus cuniculus 97.09 0.00e+00 1434.00
IUUC-Oba-075890 Oryza barthii 30.21 5.00e-62 233.00
IUUC-Obr-076659 Oryza brachyantha 30.28 1.00e-64 241.00
IUUC-Ogl-077236 Oryza glaberrima 30.13 1.00e-64 242.00
IUUC-Ogu-078167 Oryza glumaepatula 30.21 2.00e-62 234.00
IUUC-Oin-079695 Oryza indica 29.20 8.00e-46 179.00
IUUC-Olo-080267 Oryza longistaminata 26.06 7.00e-37 150.00
IUUC-Ome-081382 Oryza meridionalis 36.67 4.00e-09 55.10
IUUC-Oni-083058 Oryza nivara 30.21 6.00e-62 233.00
IUUC-Opu-083911 Oryza punctata 30.00 8.00e-65 242.00
IUUC-Oru-084882 Oryza rufipogon 30.21 6.00e-62 233.00
IUUC-Osa-085984 Oryza sativa 30.28 2.00e-65 244.00
IUUC-Ola-087523 Oryzias latipes 85.03 0.00e+00 955.00
IUUC-Olu-087805 Ostreococcus lucimarinus 29.17 8.00e-08 52.00
IUUC-Oga-088607 Otolemur garnettii 96.73 0.00e+00 1381.00
IUUC-Oar-089601 Ovis aries 98.53 0.00e+00 1464.00
IUUC-Ptr-091477 Pan troglodytes 100.00 0.00e+00 1519.00
IUUC-Pan-092525 Papio anubis 99.74 0.00e+00 1274.00
IUUC-Psi-094098 Pelodiscus sinensis 92.39 0.00e+00 1424.00
IUUC-Pma-094706 Petromyzon marinus 84.76 1.00e-53 201.00
IUUC-Pno-094876 Phaeosphaeria nodorum 54.79 3.00e-25 112.00
IUUC-Ppa-095692 Physcomitrella patens 31.26 5.00e-65 243.00
IUUC-Pfo-096116 Poecilia formosa 81.52 0.00e+00 910.00
IUUC-Pab-098038 Pongo abelii 100.00 0.00e+00 1519.00
IUUC-Pop-099523 Populus trichocarpa 30.34 5.00e-67 249.00
IUUC-Pca-101000 Procavia capensis 85.85 0.00e+00 895.00
IUUC-Ppe-101729 Prunus persica 31.53 2.00e-67 251.00
IUUC-Pva-102450 Pteropus vampyrus 97.20 0.00e+00 1457.00
IUUC-Pgr-103425 Puccinia graminis 43.64 2.00e-23 106.00
IUUC-Ptt-103985 Puccinia triticina 51.28 1.00e-20 96.70
IUUC-Pte-104148 Pyrenophora teres 24.82 1.00e-25 112.00
IUUC-Pyt-104663 Pyrenophora triticirepentis 31.87 1.00e-27 120.00
IUUC-Rno-105989 Rattus norvegicus 97.89 0.00e+00 1507.00
IUUC-Sce-106352 Saccharomyces cerevisiae 28.79 5.00e-16 80.90
IUUC-Sja-107820 Schizosaccharomyces japonicus 34.39 8.00e-31 129.00
IUUC-Spo-108307 Schizosaccharomyces pombe 46.73 1.00e-29 125.00
IUUC-Smo-109022 Selaginella moellendorffii 31.68 8.00e-91 328.00
IUUC-Sit-110338 Setaria italica 29.81 4.00e-61 230.00
IUUC-Sly-111874 Solanum lycopersicum 30.06 2.00e-65 244.00
IUUC-Stu-112495 Solanum tuberosum 30.21 5.00e-66 246.00
IUUC-Sar-113497 Sorex araneus 91.62 7.00e-140 491.00
IUUC-Sbi-114728 Sorghum bicolor 29.78 1.00e-63 238.00
IUUC-Sre-115100 Sporisorium reilianum 45.30 2.00e-25 112.00
IUUC-Ssc-115407 Sus scrofa 98.87 0.00e+00 1510.00
IUUC-Tgu-117016 Taeniopygia guttata 94.19 0.00e+00 1440.00
IUUC-Tru-118345 Takifugu rubripes 87.35 0.00e+00 928.00
IUUC-Tsy-119470 Tarsius syrichta 89.73 0.00e+00 1394.00
IUUC-Tni-119846 Tetraodon nigroviridis 74.83 0.00e+00 1127.00
IUUC-Tca-121135 Theobroma cacao 30.48 6.00e-71 263.00
IUUC-Tre-121940 Trichoderma reesei 60.87 1.00e-25 113.00
IUUC-Tvi-122339 Trichoderma virens 61.33 5.00e-27 117.00
IUUC-Tae-122752 Triticum aestivum 30.39 4.00e-61 230.00
IUUC-Tur-126371 Triticum urartu 25.76 1.00e-55 212.00
IUUC-Tme-127133 Tuber melanosporum 48.60 1.00e-26 116.00
IUUC-Ttr-128802 Tursiops truncatus 91.82 0.00e+00 1358.00
IUUC-Uma-129384 Ustilago maydis 22.63 1.00e-24 109.00
IUUC-Vda-130026 Verticillium dahliae 45.22 1.00e-28 123.00
IUUC-Vpa-130798 Vicugna pacos 96.30 0.00e+00 1280.00
IUUC-Vvi-130911 Vitis vinifera 30.51 1.00e-68 255.00
IUUC-Xtr-132891 Xenopus tropicalis 87.21 0.00e+00 1360.00
IUUC-Xma-133659 Xiphophorus maculatus 87.08 0.00e+00 938.00
IUUC-Yli-134628 Yarrowia lipolytica 44.74 1.00e-26 115.00
IUUC-Zma-135318 Zea mays 30.25 3.00e-62 234.00
Created Date 25-Jun-2017

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