iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Apl-003983

Ensembl Protein ID

ENSAPLP00000003067.1

UniProt Accession

U3I746; U3I746_ANAPL

Genbank Protein ID

ENSAPLP00000003067

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ADON01107485

Gene Name

HERC2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAPLG00000003410.1	ENSAPLT00000003662.1	ENSAPLP00000003067.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.20e-86	290.0	4474	4803

Active Site

Position(s)	Description	Evidence
4772	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 7    krlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp.....ehlklFeflGrllgkalqdgrll 88
           ++++v+fvgE++ d+gG  +e +a++++elqn  ++l+  ++n++ +   n+d +l np      h+++F+flG+llg+a+++g +l
   Q: 4474 RVWKVKFVGESVDDCGGGYSESIAEMCEELQNGLTPLLIVTPNGRDESGANRDCFLLNPaakslLHMNMFRFLGVLLGIAIRTGSPL 4560
           4566*********************************************************************************** PP
   S: 89   dlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvk 175
            l+l+++++k+l g +l++ dl+evd++++  l++i++n+ ++ e +++ l f+     +++++ +++  +++ +++t +N+ eYv+
   Q: 4561 SLNLAEPVWKQLAGMNLTIADLSEVDKDFIPGLMYIRDNEATSEEFEAMSLPFT-----VPNASGQDIQLSSKYTHITLDNRAEYVR 4642
           ***************************************99999999999*999.....788999999******************* PP
   S: 176  lvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerk 262
           l ++yrl+e ++eqv+a+reG+ +v+p  llslFt  ele+++cG+++i ++ lk+ ++ykg ++++ + iqwFwev+e+fs++er+
   Q: 4643 LAINYRLHE-FDEQVAAVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVATYKG-IEPTASLIQWFWEVMESFSNTERS 4727
           *********.**************************************************77.************************ PP
   S: 263  afLqFvTgssrlPlgGfaelkprlfvirk....dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
            fL+Fv+g+ rlP + +a+++ r fvi+     +  d+ lP+s TCf++LkLP+Ys k++l+ekL yAi+ +k++++
   Q: 4728 LFLRFVWGRTRLP-RTIADFRGRDFVIQVldkyNPPDHFLPESYTCFFLLKLPRYSCKQVLEEKLKYAIHFCKSIDT 4803
           *************.8*************999988888***********************************99875 PP

Organism

Anas platyrhynchos

Protein Sequence
(Fasta)

MSSEAFCLAA QARFDSKWLK TDLQQLAFTR DGLCGLWNEM VKDGEIVYPG TELTQSSELP 60
PRKDDSTECQ TASKKEEQND KEKKDEEEAP PPTYRAKSIV ESWVWGKQPD VNELKECLHV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCTTCTG AGGCGTTTTG TCTGGCTGCG CAGGCGAGGT TCGACTCCAA ATGGTTGAAG 60
ACAGACCTAC AGGTGAGGAG TGGGCGACCT TTCAGGTGCT TTGCAGGCTG GGCTGCTGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR004939--APC_su10/DOC_dom
IPR016186--C-type_lectin-like/link
IPR021097--CPH_domain
IPR001199--Cyt_B5-like_heme/steroid-bd
IPR008979--Galactose-bd-like
IPR000569--HECT_dom
IPR010606--Mib_Herc2
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR014722--Rib_L2_dom2
IPR000433--Znf_ZZ

PROSITE

PS50255--CYTOCHROME_B5_2
PS51284--DOC
PS50237--HECT
PS51416--MIB_HERC2
PS00626--RCC1_2
PS50012--RCC1_3
PS01357--ZF_ZZ_1
PS50135--ZF_ZZ_2

Pfam

PF03256--ANAPC10
PF11515--Cul7
PF00173--Cyt-b5
PF00632--HECT
PF06701--MIB_HERC2
PF00415--RCC1
PF00569--ZZ

PRINTS

PR00633--RCCNDNSATION

SMART

SM01337--APC10
SM01117--Cyt-b5
SM00119--HECTc
SM00291--ZnF_ZZ

Gene Ontology

GO:0005743--C:mitochondrial inner membrane
GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0007283--P:spermatogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002112	Ailuropoda melanoleuca	91.52	0.00e+00	6864.00
IUUC-Atr-003065	Amborella trichopoda	35.29	1.00e-51	198.00
IUUC-Aca-004300	Anolis carolinensis	95.07	0.00e+00	8655.00
IUUC-Aly-006441	Arabidopsis lyrata	34.15	3.00e-45	176.00
IUUC-Ame-010621	Astyanax mexicanus	87.77	0.00e+00	7132.00
IUUC-Bta-013067	Bos taurus	90.50	0.00e+00	8242.00
IUUC-Bdi-014093	Brachypodium distachyon	33.76	6.00e-50	192.00
IUUC-Bol-015203	Brassica oleracea	34.27	1.00e-52	201.00
IUUC-Bra-016737	Brassica rapa	34.27	5.00e-48	186.00
IUUC-Cja-019687	Callithrix jacchus	89.74	0.00e+00	8075.00
IUUC-Cfa-020672	Canis familiaris	91.21	0.00e+00	8316.00
IUUC-Cpo-021819	Cavia porcellus	88.40	0.00e+00	8034.00
IUUC-Csa-023817	Chlorocebus sabaeus	91.23	0.00e+00	8282.00
IUUC-Cho-024387	Choloepus hoffmanni	91.45	0.00e+00	1832.00
IUUC-Cin-025709	Ciona intestinalis	54.40	0.00e+00	2219.00
IUUC-Csv-026336	Ciona savignyi	42.39	0.00e+00	3003.00
IUUC-Dre-027717	Danio rerio	84.30	0.00e+00	7476.00
IUUC-Dno-029296	Dasypus novemcinctus	91.29	0.00e+00	8288.00
IUUC-Dor-030979	Dipodomys ordii	85.67	0.00e+00	2755.00
IUUC-Dme-032171	Drosophila melanogaster	60.42	0.00e+00	1545.00
IUUC-Ete-032687	Echinops telfairi	85.71	0.00e+00	2690.00
IUUC-Eca-034046	Equus caballus	90.59	0.00e+00	8259.00
IUUC-Eeu-034859	Erinaceus europaeus	92.20	0.00e+00	1908.00
IUUC-Fca-036262	Felis catus	91.31	0.00e+00	8344.00
IUUC-Fal-037562	Ficedula albicollis	98.39	0.00e+00	8909.00
IUUC-Gmo-039054	Gadus morhua	88.68	0.00e+00	1120.00
IUUC-Gga-040359	Gallus gallus	98.95	0.00e+00	8981.00
IUUC-Gac-041879	Gasterosteus aculeatus	92.70	0.00e+00	1061.00
IUUC-Ggo-044692	Gorilla gorilla	94.62	0.00e+00	4236.00
IUUC-Hsa-045995	Homo sapiens	91.41	0.00e+00	8347.00
IUUC-Itr-048553	Ictidomys tridecemlineatus	87.56	0.00e+00	2254.00
IUUC-Lch-049808	Latimeria chalumnae	89.11	0.00e+00	3432.00
IUUC-Lpe-051482	Leersia perrieri	34.46	4.00e-47	183.00
IUUC-Loc-052685	Lepisosteus oculatus	87.62	0.00e+00	7824.00
IUUC-Laf-053372	Loxodonta africana	90.45	0.00e+00	8222.00
IUUC-Mcc-054693	Macaca mulatta	91.31	0.00e+00	8319.00
IUUC-Meu-056660	Macropus eugenii	98.05	0.00e+00	1956.00
IUUC-Mga-059371	Meleagris gallopavo	98.67	0.00e+00	7715.00
IUUC-Mmr-060787	Microcebus murinus	91.68	0.00e+00	8393.00
IUUC-Mdo-062518	Monodelphis domestica	92.29	0.00e+00	8332.00
IUUC-Mmu-063690	Mus musculus	90.20	0.00e+00	8218.00
IUUC-Mpu-066478	Mustela putorius furo	90.76	0.00e+00	8271.00
IUUC-Mlu-067596	Myotis lucifugus	86.70	0.00e+00	4224.00
IUUC-Nle-069445	Nomascus leucogenys	88.59	0.00e+00	2024.00
IUUC-Opr-070990	Ochotona princeps	86.08	0.00e+00	2938.00
IUUC-Ont-072285	Oreochromis niloticus	85.86	0.00e+00	7601.00
IUUC-Oan-072721	Ornithorhynchus anatinus	87.47	0.00e+00	3502.00
IUUC-Ocu-074273	Oryctolagus cuniculus	90.61	0.00e+00	8247.00
IUUC-Oba-075573	Oryza barthii	33.68	8.00e-46	179.00
IUUC-Obr-076107	Oryza brachyantha	33.77	4.00e-50	193.00
IUUC-Ogl-077193	Oryza glaberrima	33.68	7.00e-46	179.00
IUUC-Ogu-078817	Oryza glumaepatula	33.68	8.00e-46	179.00
IUUC-Oin-079609	Oryza indica	32.75	2.00e-49	190.00
IUUC-Olo-080629	Oryza longistaminata	33.68	9.00e-46	178.00
IUUC-Ome-081686	Oryza meridionalis	33.68	3.00e-46	180.00
IUUC-Opu-084137	Oryza punctata	33.94	2.00e-46	181.00
IUUC-Oru-085013	Oryza rufipogon	33.68	8.00e-46	179.00
IUUC-Osa-085597	Oryza sativa	33.68	9.00e-46	178.00
IUUC-Ola-087346	Oryzias latipes	94.28	0.00e+00	1212.00
IUUC-Oga-088742	Otolemur garnettii	90.71	0.00e+00	8199.00
IUUC-Oar-090093	Ovis aries	90.78	0.00e+00	8239.00
IUUC-Ptr-091034	Pan troglodytes	86.90	0.00e+00	5501.00
IUUC-Pan-092783	Papio anubis	89.20	0.00e+00	8103.00
IUUC-Psi-094027	Pelodiscus sinensis	96.29	0.00e+00	8416.00
IUUC-Pfo-096208	Poecilia formosa	82.90	0.00e+00	6202.00
IUUC-Pab-097681	Pongo abelii	86.57	0.00e+00	2409.00
IUUC-Pca-100705	Procavia capensis	92.88	0.00e+00	1144.00
IUUC-Pva-103147	Pteropus vampyrus	81.59	0.00e+00	2369.00
IUUC-Rno-105458	Rattus norvegicus	90.18	0.00e+00	8203.00
IUUC-Sha-106959	Sarcophilus harrisii	82.88	0.00e+00	7108.00
IUUC-Sit-109917	Setaria italica	36.47	1.00e-48	188.00
IUUC-Sly-110961	Solanum lycopersicum	35.33	1.00e-53	204.00
IUUC-Sar-113532	Sorex araneus	83.09	0.00e+00	1798.00
IUUC-Sbi-114352	Sorghum bicolor	32.39	7.00e-50	192.00
IUUC-Ssc-115337	Sus scrofa	85.87	0.00e+00	2800.00
IUUC-Tgu-116789	Taeniopygia guttata	98.37	0.00e+00	8952.00
IUUC-Tru-118129	Takifugu rubripes	84.86	0.00e+00	7632.00
IUUC-Tsy-119302	Tarsius syrichta	80.79	0.00e+00	1226.00
IUUC-Tni-120374	Tetraodon nigroviridis	83.54	0.00e+00	7467.00
IUUC-Tca-121094	Theobroma cacao	35.59	1.00e-54	207.00
IUUC-Tae-124157	Triticum aestivum	33.51	9.00e-50	192.00
IUUC-Tbe-128137	Tupaia belangeri	82.45	0.00e+00	2194.00
IUUC-Ttr-128273	Tursiops truncatus	86.95	0.00e+00	4845.00
IUUC-Vpa-130471	Vicugna pacos	80.96	0.00e+00	1453.00
IUUC-Xtr-132185	Xenopus tropicalis	88.47	0.00e+00	7981.00
IUUC-Xma-133233	Xiphophorus maculatus	85.10	0.00e+00	7556.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence