iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tni-119877

UUCD1 version

UUC-TeN-00746

Ensembl Protein ID

ENSTNIP00000005157.1

UniProt Accession

H3CA85; H3CA85_TETNG

Protein Name

Uncharacterized protein

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTNIG00000002605.1	ENSTNIT00000005303.1	ENSTNIP00000005157.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.30e-113	380.0	2112	2585

Active Site

Position(s)	Description	Evidence
2554	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysen..dketlqpnpdsglknp..................... 65
           ++d+k++levef+gEeg++l G+t+ef+al+++e+q+++lg++l++++  d+e++q++   glk+p                     
   Q: 2112 HADRKSVLEVEFQGEEGTGL-GPTLEFYALVAAEFQRTSLGIWLCDDDfpDDESRQVDLGGGLKPPgfyvqrscglfpaafpqdsee 2197
           6899****************.******************************************988********************* PP
   S: 66   ..ehlklFeflGrllgkalqdgrlldlplsksfykll.................................................. 100
             +  klF+flG++l+k++qd+rl+dlpls++f+kll                                                  
   Q: 2198 leRIAKLFHFLGIFLAKCIQDNRLVDLPLSQPFFKLLcmgdikstwsrqlyqscsfppgqeperlhlqpflllseseasteesqety 2284
           *************************************99**********99999999999999999999999999999999988888 PP
   S: 101  .........................lgkklsledleevdpelyks.lkeikena......es......................... 130
                                     +  l+++d++ v+p+   s lke+ke+a       s                         
   Q: 2285 svgsfdedsksefimdppkpkppawYHGILTWDDFQLVNPHSRASfLKELKELAmkrrqiLSskslsedekntrlqdlmlrnplgsg 2371
           88888877777777666666666655557***********987777*******9665555005666677788899999999999999 PP
   S: 131  ...dieelg....ldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfneviplellslFt 210
              +ie+lg    l+++f++s+++ g  + + Lkp+G+n++Vt+eN+eeYv+l++++++++gi++q+eafreGfn+v+++e++s+F+
   Q: 2372 pplSIEDLGypplLNFQFCPSSKVHGFSALD-LKPNGDNEMVTMENAEEYVELMFDLCMHTGIQKQMEAFREGFNRVFQMEKMSSFS 2457
           99978777655559******99988887777.******************************************************* PP
   S: 211  eeelellicGe..eeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvirk.das 294
           ++e+++++cG+  ++++++d+ + t+ k gyt+dsp++ +F++vl+++ss+erkafLqF+Tg+s+lP+gG+a+l+prl+++rk da+
   Q: 2458 HKEVQMILCGNqsPSWTADDIINYTEPKLGYTRDSPGFLRFVRVLCGMSSDERKAFLQFTTGCSTLPPGGLANLHPRLTIVRKvDAT 2544
           ***********6666777777777777************************************************************ PP
   S: 295  ddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           d+++Ps+nTC++yLkLPeY+s++i++e+Ll+A++e kgF+l+
   Q: 2545 DSSYPSVNTCVHYLKLPEYTSEDIMRERLLAATME-KGFHLN 2585
           ***********************************.****86 PP

Organism

Tetraodon nigroviridis

Protein Sequence
(Fasta)

MADVDPDTLL EWLQMGQGDE RDMQLIALEQ LCMLLLMSDN VDRCFETCPP RTFLPALCKI 60
FLDESAPDNV LEVTARAITY YLDVSAECTR RIVGVDGAIK ALCNRLVVVE LNNRTSRDLA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCTGACG TGGACCCAGA CACCCTGCTG GAGTGGCTGC AGATGGGCCA AGGTGACGAG 60
CGGGACATGC AGCTCATCGC TCTGGAGCAG CTCTGCATGC TCTTGCTCAT GTCGGACAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0040--ANK repeat
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR008979--Galactose-bd-like
IPR000569--HECT_dom
IPR010606--Mib_Herc2
IPR012919--SUN_dom

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50237--HECT
PS51416--MIB_HERC2

Pfam

PF12796--Ank_2
PF00632--HECT
PF06701--MIB_HERC2
PF07738--Sad1_UNC

SMART

SM00248--ANK
SM00119--HECTc

Gene Ontology

GO:0046872--F:metal ion binding
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001987	Ailuropoda melanoleuca	80.53	0.00e+00	3734.00
IUUC-Apl-003493	Anas platyrhynchos	80.55	0.00e+00	3742.00
IUUC-Aca-004521	Anolis carolinensis	85.55	0.00e+00	2501.00
IUUC-Ame-011258	Astyanax mexicanus	95.50	0.00e+00	2371.00
IUUC-Bta-012835	Bos taurus	80.35	0.00e+00	3738.00
IUUC-Cel-018153	Caenorhabditis elegans	52.31	4.00e-167	583.00
IUUC-Cja-019174	Callithrix jacchus	80.01	0.00e+00	3686.00
IUUC-Cfa-021115	Canis familiaris	80.26	0.00e+00	3687.00
IUUC-Cpo-022382	Cavia porcellus	77.05	0.00e+00	3527.00
IUUC-Csa-023230	Chlorocebus sabaeus	80.53	0.00e+00	3736.00
IUUC-Cho-024711	Choloepus hoffmanni	73.70	0.00e+00	1232.00
IUUC-Cin-025342	Ciona intestinalis	52.47	0.00e+00	1331.00
IUUC-Csv-026031	Ciona savignyi	51.66	0.00e+00	1376.00
IUUC-Dre-027435	Danio rerio	94.64	0.00e+00	2464.00
IUUC-Dno-029954	Dasypus novemcinctus	80.45	0.00e+00	3732.00
IUUC-Dor-030734	Dipodomys ordii	89.11	0.00e+00	1320.00
IUUC-Dme-031739	Drosophila melanogaster	59.16	0.00e+00	1592.00
IUUC-Ete-033192	Echinops telfairi	85.21	0.00e+00	1118.00
IUUC-Eca-033434	Equus caballus	80.31	0.00e+00	3724.00
IUUC-Eeu-035031	Erinaceus europaeus	77.36	0.00e+00	983.00
IUUC-Fca-035998	Felis catus	78.57	0.00e+00	3607.00
IUUC-Fal-037468	Ficedula albicollis	85.32	0.00e+00	2499.00
IUUC-Gmo-038495	Gadus morhua	93.07	0.00e+00	1360.00
IUUC-Gga-040736	Gallus gallus	86.55	0.00e+00	2499.00
IUUC-Gac-041777	Gasterosteus aculeatus	95.61	0.00e+00	2448.00
IUUC-Ggo-044677	Gorilla gorilla	76.76	0.00e+00	3492.00
IUUC-Hsa-045879	Homo sapiens	80.53	0.00e+00	3736.00
IUUC-Itr-048664	Ictidomys tridecemlineatus	80.52	0.00e+00	3736.00
IUUC-Lch-050444	Latimeria chalumnae	84.75	0.00e+00	2432.00
IUUC-Loc-051986	Lepisosteus oculatus	82.62	0.00e+00	2694.00
IUUC-Laf-054230	Loxodonta africana	80.38	0.00e+00	3709.00
IUUC-Mcc-054787	Macaca mulatta	80.53	0.00e+00	3736.00
IUUC-Meu-056502	Macropus eugenii	80.10	0.00e+00	979.00
IUUC-Mga-059409	Meleagris gallopavo	92.47	0.00e+00	1838.00
IUUC-Mmr-061667	Microcebus murinus	79.90	0.00e+00	3719.00
IUUC-Mdo-061960	Monodelphis domestica	80.80	0.00e+00	3752.00
IUUC-Mmu-063941	Mus musculus	91.34	0.00e+00	2363.00
IUUC-Mpu-065939	Mustela putorius furo	80.61	0.00e+00	3737.00
IUUC-Mlu-068112	Myotis lucifugus	80.25	0.00e+00	3712.00
IUUC-Nle-069001	Nomascus leucogenys	80.53	0.00e+00	3739.00
IUUC-Opr-071222	Ochotona princeps	88.80	0.00e+00	1974.00
IUUC-Ont-072101	Oreochromis niloticus	90.70	0.00e+00	4160.00
IUUC-Oan-072814	Ornithorhynchus anatinus	80.86	0.00e+00	3744.00
IUUC-Ocu-074011	Oryctolagus cuniculus	80.57	0.00e+00	3742.00
IUUC-Ola-086412	Oryzias latipes	88.80	0.00e+00	3997.00
IUUC-Oar-089668	Ovis aries	80.35	0.00e+00	3732.00
IUUC-Ptr-090517	Pan troglodytes	80.21	0.00e+00	3714.00
IUUC-Pan-091849	Papio anubis	87.98	0.00e+00	2243.00
IUUC-Psi-093390	Pelodiscus sinensis	92.14	0.00e+00	2261.00
IUUC-Pma-094628	Petromyzon marinus	81.48	0.00e+00	1513.00
IUUC-Ppa-095264	Physcomitrella patens	35.71	2.00e-39	158.00
IUUC-Pfo-097075	Poecilia formosa	90.37	0.00e+00	2721.00
IUUC-Pab-098176	Pongo abelii	80.53	0.00e+00	3736.00
IUUC-Pca-101123	Procavia capensis	67.62	0.00e+00	1719.00
IUUC-Pva-103008	Pteropus vampyrus	93.85	0.00e+00	1492.00
IUUC-Rno-105885	Rattus norvegicus	80.46	0.00e+00	3731.00
IUUC-Sha-107048	Sarcophilus harrisii	80.22	0.00e+00	3737.00
IUUC-Sar-113071	Sorex araneus	88.09	0.00e+00	1182.00
IUUC-Ssc-115963	Sus scrofa	91.67	0.00e+00	2373.00
IUUC-Tgu-117167	Taeniopygia guttata	74.43	0.00e+00	2003.00
IUUC-Tru-118626	Takifugu rubripes	94.94	0.00e+00	4365.00
IUUC-Tsy-119504	Tarsius syrichta	82.05	0.00e+00	1974.00
IUUC-Tbe-127602	Tupaia belangeri	85.56	0.00e+00	973.00
IUUC-Ttr-128394	Tursiops truncatus	74.24	0.00e+00	2313.00
IUUC-Vpa-130280	Vicugna pacos	79.49	0.00e+00	3533.00
IUUC-Xtr-131787	Xenopus tropicalis	80.17	0.00e+00	2378.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence