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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-064242
UUCD1 version UUC-MuM-00024
Ensembl Protein ID ENSMUSP00000021761.5
UniProt Accession Q62158; Q62157; Q8C2Q5; Q99LK1; TRI27_MOUSE
Genbank Protein ID AAA85354.1; BAC40192.1; AAH03219.1; CAA53092.1
Protein Name Zinc finger protein RFP; RING-type E3 ubiquitin transferase TRIM27; Ret finger protein; Tripartite motif-containing protein 27
Genbank Nucleotide ID L46855; AK088180; BC003219; X75343
Gene Name Trim27; Rfp
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000021326.11 ENSMUST00000021761.11 ENSMUSP00000021761.5
ENSMUSG00000021326.11 ENSMUST00000139287.1 ENSMUSP00000115397.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
miRTarBasemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
CPLMPhosphositePlusmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 18248090
Classification
Family E-value Score Start End
E3 activity/RING/RING 0.00034 22.2 16 57
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C++Cl+ f + p+ l+CgH ++  Cl  +w      + ++ +CP Cr
   Q: 16   CPVCLQYFVE-PMMLDCGHNICCACLaRCW----GAAETNVSCPQCR 57
           *********9.999****************....889*********8 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1, leading to promote endosomal F-actin assembly. Has a transcriptional repressor activity. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA.
 E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Acts as a regulator of retrograde transport: together with MAGEL2, mediates the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1, leading to promote endosomal F-actin assembly. Has a transcriptional repressor activity. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA.
Protein Sequence
(Fasta)
MASGSVAECL QQETTCPVCL QYFVEPMMLD CGHNICCACL ARCWGAAETN VSCPQCRETF 60
PQRHMRPNRH LANVTQLVKQ LRTERPSGPG GEMGVCEKHR EPLKLYCEQD QMPICVVCDR 120
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Protein Fasta Sequence


>IUUC-Mmu-064242|E3,RING|Mus musculus
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Nucleotide Sequence
(Fasta)
CATAGGAACC CACAGCCACG TAGGTTCCTC AGCAGGTGGC AGGGAAGACG AGAGAGAAGT 60
GTGTCGCCAG GCAGCCCTTT GACACGTCGG GTCTGGCTAC TCACTTGAGG AAGTGAGACA 120
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Nucleotide Fasta Sequence


>IUUC-Mmu-064242|E3,RING|Mus musculus
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Sequence Source Ensembl
Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0238--DNA-binding
KW-0967--Endosome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0813--Transport
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR000315--Znf_B-box
IPR020457--Znf_B-box_chordata
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF13765--PRY
PF00622--SPRY
PF00643--zf-B_box
PRINTS

PR01406--BBOXZNFINGER
PR01407--BUTYPHLNCDUF
SMART

SM00336--BBOX
SM00589--PRY
SM00184--RING
SM00449--SPRY
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005768--C:endosome
GO:0001650--C:fibrillar center
GO:0031965--C:nuclear membrane
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0016605--C:PML body
GO:0030904--C:retromer complex
GO:0003677--F:DNA binding
GO:0042802--F:identical protein binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0034314--P:Arp2/3 complex-mediated actin nucleation
GO:0045087--P:innate immune response
GO:0072643--P:interferon-gamma secretion
GO:0002820--P:negative regulation of adaptive immune response
GO:0090281--P:negative regulation of calcium ion import
GO:0045814--P:negative regulation of gene expression, epigenetic
GO:1900041--P:negative regulation of interleukin-2 secretion
GO:0006469--P:negative regulation of protein kinase activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0032720--P:negative regulation of tumor necrosis factor production
GO:1902187--P:negative regulation of viral release from host cell
GO:0032897--P:negative regulation of viral transcription
GO:0051127--P:positive regulation of actin nucleation
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0070534--P:protein K63-linked ubiquitination
GO:0070206--P:protein trimerization
GO:0042147--P:retrograde transport, endosome to Golgi
GO:0006351--P:transcription, DNA-templated
KEGG mmu:19720
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001890 Ailuropoda melanoleuca 98.22 0.00e+00 971.00
IUUC-Apl-003609 Anas platyrhynchos 40.08 4.00e-96 345.00
IUUC-Bta-013520 Bos taurus 99.22 0.00e+00 984.00
IUUC-Cja-019557 Callithrix jacchus 97.66 0.00e+00 969.00
IUUC-Cfa-020583 Canis familiaris 98.36 0.00e+00 918.00
IUUC-Cpo-021738 Cavia porcellus 90.64 0.00e+00 880.00
IUUC-Csa-023502 Chlorocebus sabaeus 98.83 0.00e+00 981.00
IUUC-Cho-024563 Choloepus hoffmanni 95.84 6.00e-180 624.00
IUUC-Dno-029747 Dasypus novemcinctus 95.98 0.00e+00 908.00
IUUC-Dor-030243 Dipodomys ordii 96.10 0.00e+00 931.00
IUUC-Ete-032749 Echinops telfairi 84.34 0.00e+00 796.00
IUUC-Eca-034246 Equus caballus 98.66 0.00e+00 690.00
IUUC-Eeu-034481 Erinaceus europaeus 88.50 0.00e+00 866.00
IUUC-Fca-036152 Felis catus 98.40 0.00e+00 689.00
IUUC-Gac-042288 Gasterosteus aculeatus 36.07 4.00e-75 275.00
IUUC-Ggo-044987 Gorilla gorilla 89.10 0.00e+00 866.00
IUUC-Hsa-046029 Homo sapiens 98.83 0.00e+00 981.00
IUUC-Itr-048438 Ictidomys tridecemlineatus 99.03 0.00e+00 959.00
IUUC-Laf-054488 Loxodonta africana 99.22 0.00e+00 978.00
IUUC-Mcc-055352 Macaca mulatta 98.83 0.00e+00 981.00
IUUC-Mmr-060883 Microcebus murinus 98.83 0.00e+00 980.00
IUUC-Mpu-065958 Mustela putorius furo 98.64 0.00e+00 980.00
IUUC-Mlu-068005 Myotis lucifugus 84.79 0.00e+00 651.00
IUUC-Nle-069710 Nomascus leucogenys 98.02 0.00e+00 636.00
IUUC-Opr-071200 Ochotona princeps 98.25 0.00e+00 970.00
IUUC-Ocu-074081 Oryctolagus cuniculus 97.36 0.00e+00 842.00
IUUC-Ola-087166 Oryzias latipes 33.76 5.00e-70 258.00
IUUC-Oga-088784 Otolemur garnettii 98.83 0.00e+00 982.00
IUUC-Oar-089433 Ovis aries 99.22 0.00e+00 984.00
IUUC-Ptr-090595 Pan troglodytes 98.83 0.00e+00 981.00
IUUC-Pan-092027 Papio anubis 98.83 0.00e+00 981.00
IUUC-Psi-093179 Pelodiscus sinensis 47.36 9.00e-116 410.00
IUUC-Pfo-096858 Poecilia formosa 33.96 3.00e-68 253.00
IUUC-Pab-098331 Pongo abelii 98.83 0.00e+00 981.00
IUUC-Pca-101091 Procavia capensis 99.22 0.00e+00 984.00
IUUC-Pva-103141 Pteropus vampyrus 98.70 0.00e+00 711.00
IUUC-Rno-105507 Rattus norvegicus 99.61 0.00e+00 982.00
IUUC-Sar-113713 Sorex araneus 90.23 0.00e+00 897.00
IUUC-Ssc-115594 Sus scrofa 99.22 0.00e+00 982.00
IUUC-Tru-118630 Takifugu rubripes 34.46 9.00e-72 264.00
IUUC-Tsy-119235 Tarsius syrichta 98.44 0.00e+00 699.00
IUUC-Tni-120295 Tetraodon nigroviridis 37.58 9.00e-75 274.00
IUUC-Tbe-127796 Tupaia belangeri 88.64 7.00e-139 487.00
IUUC-Ttr-128738 Tursiops truncatus 98.93 0.00e+00 690.00
Created Date 25-Jun-2017

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