iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-066656

Ensembl Protein ID

ENSMPUP00000005357.1

UniProt Accession

M3Y206; M3Y206_MUSPF

Genbank Protein ID

ENSMPUP00000005357

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEYP01038646

Gene Name

G2E3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000005396.1	ENSMPUT00000005446.1	ENSMPUP00000005357.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.00e-39	136.0	453	761

Active Site

Position(s)	Description	Evidence
731	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 7    krlevefvgEe...gldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlpl 92
           + +ev +v+E+   g +++G+++efl+ll+++l+n+      ++ + +++l+ n+++      +++l++ +G++l+++l++g + + ++
   Q: 453  YTIEVAYVDENdnfGREHPGSKQEFLSLLMQHLENSP----IFEGSLSKNLSLNSQAL-----NENLYYEAGKILAISLVHGGPSPGFF 532
           67899999988888**********************9....45788888889999886.....478*********************** PP
   S: 93   sksfyklllgkklsledleevdpelyks.lkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvvey 180
           sk++y++l+  +   e+++ + +++ ++ + +i  ++  ++ +  +dl++      ++e++++  + g+ +     ++k++  k+++ y
   Q: 533  SKTLYNCLVYGP---ENTQPILDDVSDFdVAQIIIRV--NTATNVADLNSV-----VNECYNYLELIGCLRLITSLSDKYMLAKDILVY 611
           ***********8...*************988888775..555555778776.....7889999999*********************** PP
   S: 181  rlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevl.eefsseerkafLq.. 266
           ++ ++++  +e+f++G++++  le+++ + e   ++++++ e++++e l++   ++  + +d +a+  Fw+ + +++++ + +  ++  
   Q: 612  HVIKRVQAPFESFKQGLKTLGVLEKIQTYPEAFYSIFCHKPENLTAEILSD--LFTVRTLSDVQAL-GFWNSYlQAVEDGKSAVTMEdi 697
           **************************************************9..6666567777777.9999875777777766555555 PP
   S: 267  ..FvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
             F+Tg+s++P++Gf++ + ++ +++      ++P  n+C n+L LP  s++++++e++ +Ai++t +++
   Q: 698  liFATGCSSIPPAGFKPTP-SIECLHM-----DFPVGNKCNNCLALPITSTYQEFQENMDFAIRNTLRLD 761
           55****************9.9999999.....********************************987665 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

MSRVAAGPAP QEAEPSAPSG LQAEVDEFES CGPLDGAARG RLYGSPKEGK SDTTVLELLP 60
SAPCKMNENK PGASQNLACV FCRKNDDCPN KYGEKKTNEK WNLTVHYYCL LMSSGIWQRG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCCTTGAAGG AACTAAACTT CAGTGCGTCT CTGTCCATTT CGTAAACAAG AATATCCTTT 60
CAAGAGTCAC CGGGCAGAAA CGCCGACTCT ACGTCAGGTC TCTTCTGTGA CCTGTGAAGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR034732--EPHD
IPR000569--HECT_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51805--EPHD
PS50237--HECT
PS01359--ZF_PHD_1

Pfam

PF00632--HECT

SMART

SM00119--HECTc
SM00249--PHD

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001501	Ailuropoda melanoleuca	95.47	0.00e+00	1431.00
IUUC-Apl-003763	Anas platyrhynchos	59.60	0.00e+00	857.00
IUUC-Aca-004328	Anolis carolinensis	59.94	0.00e+00	860.00
IUUC-Ame-011288	Astyanax mexicanus	41.36	1.00e-168	587.00
IUUC-Bta-012496	Bos taurus	87.36	0.00e+00	1314.00
IUUC-Cja-019756	Callithrix jacchus	88.64	0.00e+00	1329.00
IUUC-Cfa-020806	Canis familiaris	92.00	0.00e+00	1415.00
IUUC-Cpo-022519	Cavia porcellus	86.54	0.00e+00	1290.00
IUUC-Csa-023957	Chlorocebus sabaeus	90.37	0.00e+00	1360.00
IUUC-Cho-024375	Choloepus hoffmanni	82.97	0.00e+00	1200.00
IUUC-Cin-025325	Ciona intestinalis	41.89	1.00e-67	249.00
IUUC-Csv-026262	Ciona savignyi	42.32	8.00e-68	250.00
IUUC-Dre-027829	Danio rerio	41.26	9.00e-158	550.00
IUUC-Dno-029362	Dasypus novemcinctus	88.14	0.00e+00	1318.00
IUUC-Dor-030710	Dipodomys ordii	82.01	0.00e+00	1253.00
IUUC-Dse-031248	Dothistroma septosporum	36.54	3.00e-03	37.70
IUUC-Dme-031692	Drosophila melanogaster	35.04	8.00e-43	168.00
IUUC-Ete-032282	Echinops telfairi	79.15	0.00e+00	1142.00
IUUC-Eca-033963	Equus caballus	91.22	0.00e+00	1375.00
IUUC-Eeu-035029	Erinaceus europaeus	86.67	0.00e+00	1306.00
IUUC-Fca-036229	Felis catus	95.75	0.00e+00	1435.00
IUUC-Fal-037015	Ficedula albicollis	58.04	0.00e+00	867.00
IUUC-Gmo-039715	Gadus morhua	41.51	2.00e-81	296.00
IUUC-Gga-040298	Gallus gallus	58.78	0.00e+00	897.00
IUUC-Gac-041444	Gasterosteus aculeatus	39.50	7.00e-145	507.00
IUUC-Ggo-045456	Gorilla gorilla	89.66	0.00e+00	1349.00
IUUC-Hsa-046297	Homo sapiens	89.96	0.00e+00	1359.00
IUUC-Itr-047897	Ictidomys tridecemlineatus	87.48	0.00e+00	929.00
IUUC-Lch-050287	Latimeria chalumnae	66.67	3.00e-105	375.00
IUUC-Loc-052839	Lepisosteus oculatus	54.78	1.00e-32	131.00
IUUC-Laf-053581	Loxodonta africana	87.14	0.00e+00	1296.00
IUUC-Mcc-055615	Macaca mulatta	90.10	0.00e+00	1359.00
IUUC-Meu-056753	Macropus eugenii	48.06	4.00e-127	448.00
IUUC-Mga-059902	Meleagris gallopavo	58.78	0.00e+00	901.00
IUUC-Mmr-061522	Microcebus murinus	91.09	0.00e+00	1369.00
IUUC-Mdo-063022	Monodelphis domestica	64.45	0.00e+00	906.00
IUUC-Mmu-063609	Mus musculus	75.79	0.00e+00	1168.00
IUUC-Mlu-067011	Myotis lucifugus	88.83	0.00e+00	1336.00
IUUC-Nle-069949	Nomascus leucogenys	89.66	0.00e+00	1351.00
IUUC-Opr-071224	Ochotona princeps	83.83	8.00e-133	467.00
IUUC-Ont-072174	Oreochromis niloticus	37.69	7.00e-140	491.00
IUUC-Oan-072712	Ornithorhynchus anatinus	66.71	0.00e+00	969.00
IUUC-Ocu-073776	Oryctolagus cuniculus	90.08	0.00e+00	1347.00
IUUC-Ola-087247	Oryzias latipes	38.10	3.00e-132	465.00
IUUC-Oga-088094	Otolemur garnettii	86.52	0.00e+00	1229.00
IUUC-Oar-090248	Ovis aries	87.19	0.00e+00	1341.00
IUUC-Ptr-090634	Pan troglodytes	89.80	0.00e+00	1355.00
IUUC-Pan-092876	Papio anubis	90.23	0.00e+00	1359.00
IUUC-Psi-093580	Pelodiscus sinensis	60.26	0.00e+00	878.00
IUUC-Pma-094295	Petromyzon marinus	52.57	1.00e-72	265.00
IUUC-Pfo-096351	Poecilia formosa	38.04	8.00e-150	524.00
IUUC-Pab-097596	Pongo abelii	90.65	0.00e+00	1363.00
IUUC-Pca-100309	Procavia capensis	80.17	0.00e+00	1201.00
IUUC-Pva-102526	Pteropus vampyrus	92.01	0.00e+00	863.00
IUUC-Rno-105432	Rattus norvegicus	79.83	0.00e+00	1209.00
IUUC-Sha-107089	Sarcophilus harrisii	65.07	0.00e+00	1018.00
IUUC-Sar-113667	Sorex araneus	67.19	0.00e+00	971.00
IUUC-Ssc-116200	Sus scrofa	90.93	0.00e+00	1365.00
IUUC-Tgu-116467	Taeniopygia guttata	57.91	0.00e+00	859.00
IUUC-Tru-117690	Takifugu rubripes	39.48	2.00e-156	546.00
IUUC-Tsy-119481	Tarsius syrichta	86.80	0.00e+00	918.00
IUUC-Tni-119669	Tetraodon nigroviridis	38.70	6.00e-139	488.00
IUUC-Tbe-127241	Tupaia belangeri	81.39	0.00e+00	1167.00
IUUC-Ttr-129057	Tursiops truncatus	82.44	0.00e+00	1185.00
IUUC-Vpa-130685	Vicugna pacos	88.76	0.00e+00	1295.00
IUUC-Xtr-132555	Xenopus tropicalis	52.02	0.00e+00	746.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence