iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Xtr-132194

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

HECT and RLD domain-containing E3 ubiquitin protein ligase 3

Genbank Nucleotide ID

AAMC01083170

Gene Name

herc3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000023652.3	ENSXETT00000051037.3	ENSXETP00000051037.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.30e-94	317.5	716	1039

Active Site

Position(s)	Description	Evidence
1008	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           dlkk l+v f gEe++d gGvt+ef+ ll+kel np +g+f+  ++++  ++ +         + ++F+++G+++g+a+++  ++dl
   Q: 716  DLKKPLKVIFDGEEAVDDGGVTKEFFLLLLKELLNPIYGMFTVYQDSNLLWFSDICFV-----EHNWFHLIGIMCGLAIYNFTVVDL 797
           899****************************************999999999776554.....579********************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklv 177
            ++ ++yk+ll+++ +ledl+e+ p+  +sl+e++++ e+d+++  ++l+f++  e++g ++ + L+ gG++i Vt++N++++v+++
   Q: 798  YFPLALYKKLLNVQPTLEDLKELSPTEGRSLQELLDYPEDDVDDV-FCLNFTICRESYGLAERKPLVAGGDHITVTKDNRQQFVDAY 883
           *************************************99999997.***************************************** PP
   S: 178  veyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkaf 264
           v+y ++++++e +eaf+ Gf +v+  ++l+lF+++el+ ++ G++++++++l++++ ykg+y+  +p++++Fwe++++f  e++k+f
   Q: 884  VNYVFNQSVQEWYEAFSTGFLKVCGGKILELFQPSELRSMVVGSNNYNWQELEENAIYKGDYSTAHPTVRMFWETFHDFPLEKKKKF 970
           *************************************************************************************** PP
   S: 265  LqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           L F+Tgs+r+P+ G+ +l+   ++i+  ++ +d+lP ++TC+n+L+LP+Ysske+l+++L+ Ai++ +gF+l
   Q: 971  LLFLTGSDRIPIYGMSSLR---IIIQSiSSGEDHLPVAHTCYNLLDLPKYSSKETLRRRLTQAIDHYEGFSL 1039
           *******************...8888878899**************************************97 PP

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

MLCWGHSTFG QLGNGHSFQG SVSDPCVCRF SLAACVKEVA CGGKHTLFLL EDGQVYSCGW 60
NGEGQLGHDH EGTDPVQVTT LTEEHITHIA CGQSHNLALS YQGQLYSWGS GNDGQLGHAT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTTATGCT GGGGTCACTC TACTTTTGGC CAGCTTGGTA ATGGTCATAG TTTCCAAGGT 60
TCTGTGTCCG ACCCTTGCGT ATGCAGATTC TCCCTAGCAG CATGTGTCAA GGAAGTTGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001673	Ailuropoda melanoleuca	65.32	0.00e+00	1372.00
IUUC-Apl-003535	Anas platyrhynchos	71.32	0.00e+00	1484.00
IUUC-Aca-005223	Anolis carolinensis	63.05	0.00e+00	1312.00
IUUC-Ame-010816	Astyanax mexicanus	51.98	0.00e+00	871.00
IUUC-Bta-013373	Bos taurus	71.70	0.00e+00	1504.00
IUUC-Cel-018150	Caenorhabditis elegans	31.84	5.00e-133	468.00
IUUC-Cja-019609	Callithrix jacchus	71.27	0.00e+00	1488.00
IUUC-Cfa-021071	Canis familiaris	65.51	0.00e+00	1371.00
IUUC-Cpo-021548	Cavia porcellus	71.17	0.00e+00	1485.00
IUUC-Csa-023987	Chlorocebus sabaeus	71.64	0.00e+00	1494.00
IUUC-Cho-024325	Choloepus hoffmanni	81.77	0.00e+00	1020.00
IUUC-Dre-027472	Danio rerio	54.79	0.00e+00	1131.00
IUUC-Dno-029241	Dasypus novemcinctus	70.38	0.00e+00	1469.00
IUUC-Dor-030672	Dipodomys ordii	51.75	2.00e-174	606.00
IUUC-Ete-032642	Echinops telfairi	68.15	0.00e+00	1367.00
IUUC-Eca-033646	Equus caballus	65.51	0.00e+00	1372.00
IUUC-Eeu-035098	Erinaceus europaeus	68.54	0.00e+00	1116.00
IUUC-Fal-036952	Ficedula albicollis	71.79	0.00e+00	1487.00
IUUC-Gmo-039297	Gadus morhua	58.63	0.00e+00	1151.00
IUUC-Gga-040591	Gallus gallus	70.85	0.00e+00	1473.00
IUUC-Gac-041741	Gasterosteus aculeatus	58.25	0.00e+00	1204.00
IUUC-Ggo-044769	Gorilla gorilla	71.39	0.00e+00	1485.00
IUUC-Hsa-046066	Homo sapiens	71.46	0.00e+00	1490.00
IUUC-Itr-048311	Ictidomys tridecemlineatus	72.11	0.00e+00	1496.00
IUUC-Lch-050301	Latimeria chalumnae	64.67	0.00e+00	1385.00
IUUC-Loc-052803	Lepisosteus oculatus	56.23	0.00e+00	1184.00
IUUC-Laf-053364	Loxodonta africana	71.60	0.00e+00	1488.00
IUUC-Mcc-054930	Macaca mulatta	71.55	0.00e+00	1493.00
IUUC-Meu-056274	Macropus eugenii	53.48	8.00e-152	531.00
IUUC-Mga-059563	Meleagris gallopavo	70.94	0.00e+00	1476.00
IUUC-Mmr-060792	Microcebus murinus	64.78	0.00e+00	1345.00
IUUC-Mdo-062195	Monodelphis domestica	72.99	0.00e+00	1507.00
IUUC-Mmu-063855	Mus musculus	69.47	0.00e+00	1469.00
IUUC-Mpu-066308	Mustela putorius furo	65.60	0.00e+00	1373.00
IUUC-Mlu-066927	Myotis lucifugus	65.05	0.00e+00	1363.00
IUUC-Nle-070090	Nomascus leucogenys	71.64	0.00e+00	1494.00
IUUC-Opr-070891	Ochotona princeps	63.04	0.00e+00	1249.00
IUUC-Ont-072201	Oreochromis niloticus	56.24	0.00e+00	1147.00
IUUC-Ocu-074770	Oryctolagus cuniculus	71.46	0.00e+00	1494.00
IUUC-Ola-086550	Oryzias latipes	53.42	0.00e+00	1110.00
IUUC-Oga-088831	Otolemur garnettii	71.46	0.00e+00	1485.00
IUUC-Oar-090449	Ovis aries	71.51	0.00e+00	1492.00
IUUC-Pan-092135	Papio anubis	71.58	0.00e+00	1489.00
IUUC-Psi-093832	Pelodiscus sinensis	70.47	0.00e+00	1489.00
IUUC-Pfo-097268	Poecilia formosa	53.69	0.00e+00	1111.00
IUUC-Pab-098249	Pongo abelii	71.36	0.00e+00	1488.00
IUUC-Pca-100855	Procavia capensis	63.51	0.00e+00	932.00
IUUC-Pva-102506	Pteropus vampyrus	65.66	0.00e+00	1308.00
IUUC-Rno-105242	Rattus norvegicus	69.75	0.00e+00	1513.00
IUUC-Sar-113612	Sorex araneus	81.68	0.00e+00	640.00
IUUC-Ssc-115473	Sus scrofa	65.60	0.00e+00	1377.00
IUUC-Tgu-116974	Taeniopygia guttata	71.82	0.00e+00	1466.00
IUUC-Tru-118077	Takifugu rubripes	56.89	0.00e+00	1129.00
IUUC-Tsy-119619	Tarsius syrichta	61.53	0.00e+00	1278.00
IUUC-Tni-120807	Tetraodon nigroviridis	56.87	0.00e+00	1136.00
IUUC-Tbe-127640	Tupaia belangeri	68.24	0.00e+00	1379.00
IUUC-Ttr-129172	Tursiops truncatus	71.23	0.00e+00	1483.00
IUUC-Vpa-130442	Vicugna pacos	61.31	0.00e+00	1212.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence