iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Itr-048730

Ensembl Protein ID

ENSSTOP00000009699.2

UniProt Accession

I3MG58; I3MG58_ICTTR

Genbank Protein ID

ENSSTOP00000009699

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGTP01068947

Gene Name

VAV1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSTOG00000010806.2	ENSSTOT00000010810.2	ENSSTOP00000009699.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.90e-20	72.6	786	837

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           ++ yd+ a +  eL+lk+Gd+++++ ++   +gW++g  e  g+ G fP+n+ve+
   Q: 786  KARYDFCARDRSELSLKEGDIIKIL-NKRGQQGWWRG--EIYGRVGWFPSNYVEE 837
           788**********************.89999******..9*************86 PP

Organism

Ictidomys tridecemlineatus

Protein Sequence
(Fasta)

MELWRQCTHW LIQCRVLPPS HRVTWEGAQV CELAQALRDG VLLCQLLNNL LPQAINLREV 60
NLRPQMSQFL CLKNIRTFLS TCGEKFGLKR SELFEPFDLF DVQDFGKVIC TLSALSWTPI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGCTGT GGCGCCAGTG CACCCACTGG CTCATCCAGT GCCGGGTGCT GCCACCCAGC 60
CACCGCGTGA CCTGGGAGGG GGCCCAGGTG TGCGAGCTGG CGCAGGCCCT CCGGGATGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0862--Zinc

Interpro

IPR022613--CAMSAP_CH
IPR001715--CH-domain
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR002219--PE/DAG-bd
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR000980--SH2
IPR001452--SH3_domain
IPR028530--Vav

PROSITE

PS50021--CH
PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50001--SH2
PS50002--SH3
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2

Pfam

PF00130--C1_1
PF11971--CAMSAP_CH
PF00169--PH
PF00621--RhoGEF
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00109--C1
SM00033--CH
SM00233--PH
SM00325--RhoGEF
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005911--C:cell-cell junction
GO:0005622--C:intracellular
GO:0046872--F:metal ion binding
GO:0030676--F:Rac guanyl-nucleotide exchange factor activity
GO:0007186--P:G-protein coupled receptor signaling pathway
GO:0006955--P:immune response
GO:0007229--P:integrin-mediated signaling pathway
GO:0030593--P:neutrophil chemotaxis
GO:0006909--P:phagocytosis
GO:0045785--P:positive regulation of cell adhesion
GO:0045954--P:positive regulation of natural killer cell mediated cytotoxicity
GO:0072593--P:reactive oxygen species metabolic process
GO:0008361--P:regulation of cell size
GO:0035023--P:regulation of Rho protein signal transduction
GO:0007264--P:small GTPase mediated signal transduction
GO:0030217--P:T cell differentiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Bta-013049	Bos taurus	76.01	0.00e+00	1127.00
IUUC-Cja-020009	Callithrix jacchus	89.87	0.00e+00	1508.00
IUUC-Cfa-020768	Canis familiaris	91.17	0.00e+00	1504.00
IUUC-Cin-025115	Ciona intestinalis	36.78	7.00e-133	468.00
IUUC-Csv-025995	Ciona savignyi	36.47	7.00e-139	487.00
IUUC-Cne-026866	Cryptococcus neoformans	52.83	7.00e-11	63.50
IUUC-Dno-029602	Dasypus novemcinctus	90.81	0.00e+00	1512.00
IUUC-Eca-033682	Equus caballus	91.63	0.00e+00	1524.00
IUUC-Fca-035629	Felis catus	90.12	0.00e+00	1532.00
IUUC-Gmo-039693	Gadus morhua	58.66	0.00e+00	936.00
IUUC-Gac-041567	Gasterosteus aculeatus	62.38	0.00e+00	999.00
IUUC-Hsa-045886	Homo sapiens	90.11	0.00e+00	1511.00
IUUC-Loc-051761	Lepisosteus oculatus	66.71	0.00e+00	1143.00
IUUC-Lma-053273	Leptosphaeria maculans	53.06	2.00e-10	61.20
IUUC-Laf-054537	Loxodonta africana	89.52	0.00e+00	1503.00
IUUC-Mcc-054726	Macaca mulatta	90.58	0.00e+00	1518.00
IUUC-Mmr-060980	Microcebus murinus	87.02	0.00e+00	1518.00
IUUC-Mdo-061926	Monodelphis domestica	82.31	0.00e+00	1254.00
IUUC-Mmu-063942	Mus musculus	91.40	0.00e+00	1528.00
IUUC-Mpu-066000	Mustela putorius furo	90.93	0.00e+00	1504.00
IUUC-Mlu-067818	Myotis lucifugus	87.69	0.00e+00	1441.00
IUUC-Ont-072213	Oreochromis niloticus	62.82	0.00e+00	1069.00
IUUC-Ocu-074830	Oryctolagus cuniculus	74.27	0.00e+00	1084.00
IUUC-Ola-087345	Oryzias latipes	60.84	0.00e+00	1013.00
IUUC-Oga-089104	Otolemur garnettii	90.58	0.00e+00	1521.00
IUUC-Oar-089459	Ovis aries	89.74	0.00e+00	1489.00
IUUC-Ptr-090766	Pan troglodytes	89.50	0.00e+00	1395.00
IUUC-Pan-091994	Papio anubis	89.41	0.00e+00	1492.00
IUUC-Psi-093595	Pelodiscus sinensis	74.67	0.00e+00	1222.00
IUUC-Pfo-097210	Poecilia formosa	63.48	0.00e+00	1038.00
IUUC-Pab-098630	Pongo abelii	90.28	0.00e+00	1477.00
IUUC-Pva-102406	Pteropus vampyrus	89.52	0.00e+00	1456.00
IUUC-Pte-104123	Pyrenophora teres	53.06	1.00e-10	62.00
IUUC-Pyt-104567	Pyrenophora triticirepentis	53.06	1.00e-10	62.00
IUUC-Rno-105763	Rattus norvegicus	87.63	0.00e+00	1453.00
IUUC-Sha-106683	Sarcophilus harrisii	82.59	0.00e+00	1412.00
IUUC-Sar-113457	Sorex araneus	78.41	0.00e+00	882.00
IUUC-Ssc-115338	Sus scrofa	90.92	0.00e+00	1415.00
IUUC-Tru-118199	Takifugu rubripes	61.34	0.00e+00	969.00
IUUC-Tni-120548	Tetraodon nigroviridis	60.54	0.00e+00	988.00
IUUC-Tbe-127235	Tupaia belangeri	69.03	1.00e-133	469.00
IUUC-Ttr-128916	Tursiops truncatus	86.59	0.00e+00	908.00
IUUC-Vpa-130066	Vicugna pacos	61.90	2.00e-62	233.00
IUUC-Xtr-132410	Xenopus tropicalis	68.82	0.00e+00	1187.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence