iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ocu-074475

Ensembl Protein ID

ENSOCUP00000011001.2

UniProt Accession

G1T429; G1T429_RABIT

Protein Name

Histone-lysine N-methyltransferase

Gene Name

KMT2B

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000012768.2	ENSOCUT00000012783.2	ENSOCUP00000011001.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	3.80e-27	94.3	1017	1070

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsek..wiCpkCrsk 54
           k+C+vCg++g+++k+l+eCe+Cr+++HpaCl++s ++++ ++++  wiC+ C ++
   Q: 1017 KFCHVCGRKGRGSKHLLECERCRHAYHPACLGPS-YPTRATRKRrhWICSACVRC 1070
           58********************************.88888877777******876 PP

Organism

Oryctolagus cuniculus

Protein Sequence
(Fasta)

IHLTGRHRGL GSLQRLVAGP RVQRVPEEES SDGESDDEEF QGFHSDEDVA PSSLRSALRS 60
QRGRAPRGRG RKHKTTPLPP PRLADVTPTP PKTPARKRGE EGTERMVQAL TELLRRAQAP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTCATTTAA CGGGTAGGCA CCGGGGACTT GGTAGTCTCC AACGTCTAGT GGCCGGCCCG 60
CGCGTTCAGC GAGGCAGGGG CCGGGGCCGG GGCCGGGGCT GGGGCCAGAA CCGGGGCTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001487--Bromodomain
IPR034732--EPHD
IPR003889--FYrich_C
IPR003888--FYrich_N
IPR003616--Post-SET_dom
IPR001214--SET_dom
IPR002857--Znf_CXXC
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51805--EPHD
PS51543--FYRC
PS51542--FYRN
PS50868--POST_SET
PS50280--SET
PS51058--ZF_CXXC
PS50016--ZF_PHD_2

Pfam

PF05965--FYRC
PF05964--FYRN
PF00628--PHD
PF00856--SET
PF02008--zf-CXXC

SMART

SM00542--FYRC
SM00541--FYRN
SM00249--PHD
SM00508--PostSET
SM00317--SET

Gene Ontology

GO:0035097--C:histone methyltransferase complex
GO:0003677--F:DNA binding
GO:0042800--F:histone methyltransferase activity (H3-K4 specific)
GO:0008270--F:zinc ion binding
GO:0016458--P:gene silencing
GO:0080182--P:histone H3-K4 trimethylation
GO:0007613--P:memory
GO:0009994--P:oocyte differentiation
GO:0001541--P:ovarian follicle development
GO:0030728--P:ovulation
GO:0051569--P:regulation of histone H3-K4 methylation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002367	Ailuropoda melanoleuca	89.57	0.00e+00	3190.00
IUUC-Aca-004718	Anolis carolinensis	56.58	0.00e+00	1456.00
IUUC-Ame-010705	Astyanax mexicanus	47.07	0.00e+00	769.00
IUUC-Bta-013578	Bos taurus	92.20	0.00e+00	2892.00
IUUC-Bdi-014882	Brachypodium distachyon	33.99	8.00e-28	118.00
IUUC-Bra-017422	Brassica rapa	33.98	5.00e-28	119.00
IUUC-Cja-019138	Callithrix jacchus	89.65	0.00e+00	3410.00
IUUC-Cfa-020020	Canis familiaris	90.32	0.00e+00	3148.00
IUUC-Cpo-021552	Cavia porcellus	89.03	0.00e+00	3369.00
IUUC-Cre-022891	Chlamydomonas reinhardtii	53.12	1.00e-37	153.00
IUUC-Csa-024216	Chlorocebus sabaeus	90.46	0.00e+00	2492.00
IUUC-Cho-024565	Choloepus hoffmanni	76.72	6.00e-167	582.00
IUUC-Cin-025724	Ciona intestinalis	54.52	2.00e-95	344.00
IUUC-Dre-027440	Danio rerio	44.28	0.00e+00	881.00
IUUC-Dno-029583	Dasypus novemcinctus	89.05	0.00e+00	3201.00
IUUC-Dor-030903	Dipodomys ordii	85.26	0.00e+00	2154.00
IUUC-Dme-032023	Drosophila melanogaster	47.28	1.00e-92	336.00
IUUC-Eca-034026	Equus caballus	92.81	0.00e+00	1922.00
IUUC-Eeu-034687	Erinaceus europaeus	92.47	0.00e+00	1139.00
IUUC-Fca-036311	Felis catus	89.98	0.00e+00	3231.00
IUUC-Gmo-039265	Gadus morhua	45.01	0.00e+00	792.00
IUUC-Gac-042202	Gasterosteus aculeatus	46.67	0.00e+00	724.00
IUUC-Ggo-044791	Gorilla gorilla	92.74	0.00e+00	2122.00
IUUC-Hsa-046988	Homo sapiens	90.05	0.00e+00	2432.00
IUUC-Hvu-047762	Hordeum vulgare	36.57	3.00e-20	93.20
IUUC-Itr-048907	Ictidomys tridecemlineatus	90.74	0.00e+00	3342.00
IUUC-Lpe-051476	Leersia perrieri	31.96	2.00e-24	108.00
IUUC-Loc-052252	Lepisosteus oculatus	53.14	0.00e+00	763.00
IUUC-Laf-053703	Loxodonta africana	91.33	0.00e+00	2143.00
IUUC-Mcc-054782	Macaca mulatta	89.43	0.00e+00	2474.00
IUUC-Meu-056046	Macropus eugenii	80.57	0.00e+00	1868.00
IUUC-Mmr-061316	Microcebus murinus	87.61	0.00e+00	3031.00
IUUC-Mdo-062648	Monodelphis domestica	78.86	0.00e+00	1999.00
IUUC-Mmu-063579	Mus musculus	87.91	0.00e+00	3251.00
IUUC-Mac-064935	Musa acuminata	33.80	4.00e-30	126.00
IUUC-Mpu-066710	Mustela putorius furo	90.42	0.00e+00	3184.00
IUUC-Mlu-067559	Myotis lucifugus	88.76	0.00e+00	2418.00
IUUC-Nle-070085	Nomascus leucogenys	88.70	0.00e+00	2157.00
IUUC-Opr-071148	Ochotona princeps	89.80	0.00e+00	3299.00
IUUC-Ont-071626	Oreochromis niloticus	44.50	0.00e+00	874.00
IUUC-Obr-076458	Oryza brachyantha	34.98	2.00e-28	120.00
IUUC-Ogl-077851	Oryza glaberrima	36.02	2.00e-28	120.00
IUUC-Ogu-078706	Oryza glumaepatula	34.31	1.00e-28	122.00
IUUC-Oin-079802	Oryza indica	31.31	1.00e-23	104.00
IUUC-Osa-085421	Oryza sativa	36.02	2.00e-28	120.00
IUUC-Ola-086609	Oryzias latipes	48.10	0.00e+00	737.00
IUUC-Oga-088140	Otolemur garnettii	90.55	0.00e+00	3215.00
IUUC-Oar-089447	Ovis aries	91.46	0.00e+00	2007.00
IUUC-Ptr-090902	Pan troglodytes	89.99	0.00e+00	2441.00
IUUC-Pan-091930	Papio anubis	90.29	0.00e+00	2489.00
IUUC-Ppa-095221	Physcomitrella patens	37.02	3.00e-31	130.00
IUUC-Pfo-096884	Poecilia formosa	44.65	0.00e+00	866.00
IUUC-Pab-098404	Pongo abelii	76.44	0.00e+00	1789.00
IUUC-Pop-099585	Populus trichocarpa	34.24	7.00e-27	115.00
IUUC-Pca-100949	Procavia capensis	80.94	0.00e+00	1250.00
IUUC-Ppe-101920	Prunus persica	33.50	4.00e-28	120.00
IUUC-Pva-102634	Pteropus vampyrus	90.13	0.00e+00	3254.00
IUUC-Rno-105870	Rattus norvegicus	87.44	0.00e+00	3326.00
IUUC-Sit-110552	Setaria italica	34.83	3.00e-29	123.00
IUUC-Sar-113289	Sorex araneus	88.49	0.00e+00	1731.00
IUUC-Ssc-115509	Sus scrofa	90.18	0.00e+00	3190.00
IUUC-Tru-117736	Takifugu rubripes	44.22	0.00e+00	805.00
IUUC-Tca-121624	Theobroma cacao	33.17	4.00e-28	120.00
IUUC-Tae-124647	Triticum aestivum	36.57	2.00e-20	93.60
IUUC-Tbe-127825	Tupaia belangeri	84.54	0.00e+00	1441.00
IUUC-Ttr-128754	Tursiops truncatus	93.62	0.00e+00	1244.00
IUUC-Xtr-132838	Xenopus tropicalis	45.78	0.00e+00	1047.00
IUUC-Xma-133119	Xiphophorus maculatus	43.40	0.00e+00	964.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence