iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mlu-067938

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAPE02036187

Gene Name

USP30

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000010674.2	ENSMLUT00000010687.2	ENSMLUP00000009743.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.30e-71	240.8	69	501

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw...kskkkavsprellkalkkeaeefsgy 87
           Gl NlgNtC+mNS+LQ Ls++p + + l e +++ + ++++  p++ l+ +l +l+++l     +++++ + + ll++l+++  ++s++
   Q: 69   GLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTTQYTGDQKERPPHQYLSLTLLHLLKALScqeVTDDEVLDASCLLDVLRMYRWQISSF 157
           9*****************************77777788888899***************888899999********************* PP
   S: 88   eqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde..........aeekkkkknkslisdlFqgqlksqikclecdnvs.sr 165
           e+qDa+E+++++ ++le+e    ++ +++++++ ++ e++ e          +   ++++n+   ++ F+g+l+s+++c++c+++s +r
   Q: 158  EEQDAHELFHVITSSLEDER--DRQPRVTHLFDVHSLEQQPEvtptqitcrtRGAPHPTSNHWKSQHPFHGRLTSNMVCKHCEHQSpVR 244
           *******************9..678999999999988888889999999999999********************************** PP
   S: 166  eepfldlslpvpgkeetkkeslqdcLesftkeeelegenkyycekck...............kkqeaekklklkklPevLilhLkRfsf 239
           +++f +lsl++p  +  ++++l++cL++f + e++++   + c++c+               ++++ +k+lkl klP++L++hL+R s+
   Q: 245  FDTFDSLSLSIPAATWGHPLTLDHCLHHFISSESVRD---VVCDNCTkieakgtlngekvehQRTTFVKQLKLGKLPQCLCIHLQRLSW 330
           ***********************************97...9******8888888888888777777*********************** PP
   S: 240  seeqksrekinkkvefpleLdlspfcts..................................peekqke.................... 274
           s++ + + k +++v+f++ L ++ +  +                                  +     +                    
   Q: 331  SSH-GTPLKRHEHVQFNEFLMMDIYKYRllghkpgqhspklkekarpaldlqdgpaapksvlN-----Qpggpktqifmngacspsllp 413
           998.8888*********9888887666666778777776666666666666666666555550.....055555555555555555666 PP
   S: 275  ...................kkkYeLiavvvHsGslssGHYvayvkn.........ekgkWllfdDskVtevkeeevleetgstaYvlfY 335
                              ++ ++L+avvvH+G ++sGH+v+y ++         ++++Wl ++D++V++ + +evl+   s+aY+lfY
   Q: 414  tlpapmpfplpvvpdysssTYLFRLMAVVVHHGDMHSGHFVTYRRSppsaknplsTSNQWLWISDDTVRKASLQEVLS---SSAYLLFY 499
           66666666666666666559999***********************9999888888999*******************...******** PP
   S: 336  kr 337
           +r
   Q: 500  ER 501
           98 PP

Organism

Myotis lucifugus

Protein Sequence
(Fasta)

MLSSRAQEAM SAADRALQRF LRTGAAVRYK VMKNWGVIGG LAAALAAGIY VIWGPITERK 60
KRRKGLVPGL VNLGNTCFMN SLLQGLSACP AFIRWLEEFT TQYTGDQKER PPHQYLSLTL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCTGAGCT CCCGGGCCCA GGAGGCGATG AGCGCGGCCG ACAGGGCCCT CCAGCGCTTC 60
CTGCGGACCG GGGCGGCCGT CAGGTGAGCT TTGGGGGGCG GGGCGGCCGG AGCGGCCGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0016021--C:integral component of membrane
GO:0005741--C:mitochondrial outer membrane
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008053--P:mitochondrial fusion
GO:0000422--P:mitophagy
GO:0035871--P:protein K11-linked deubiquitination
GO:0044313--P:protein K6-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000204	Aegilops tauschii	28.38	1.00e-15	77.80
IUUC-Aml-001733	Ailuropoda melanoleuca	94.04	0.00e+00	880.00
IUUC-Atr-002510	Amborella trichopoda	25.05	8.00e-22	98.60
IUUC-Apl-003645	Anas platyrhynchos	72.92	1.00e-106	379.00
IUUC-Aca-004583	Anolis carolinensis	68.42	2.00e-24	103.00
IUUC-Aly-005754	Arabidopsis lyrata	25.83	4.00e-26	112.00
IUUC-Ath-007622	Arabidopsis thaliana	27.95	5.00e-27	115.00
IUUC-Ani-009286	Aspergillus nidulans	21.33	3.00e-12	67.00
IUUC-Ame-010896	Astyanax mexicanus	60.97	7.00e-154	536.00
IUUC-Bta-012321	Bos taurus	92.65	0.00e+00	868.00
IUUC-Bdi-014795	Brachypodium distachyon	27.27	4.00e-18	85.90
IUUC-Bol-015637	Brassica oleracea	27.29	2.00e-24	107.00
IUUC-Bra-016801	Brassica rapa	25.89	3.00e-24	106.00
IUUC-Cel-018308	Caenorhabditis elegans	28.10	2.00e-38	153.00
IUUC-Cja-018826	Callithrix jacchus	92.86	0.00e+00	919.00
IUUC-Cfa-021206	Canis familiaris	92.50	0.00e+00	889.00
IUUC-Cpo-021343	Cavia porcellus	92.02	0.00e+00	852.00
IUUC-Csa-023419	Chlorocebus sabaeus	93.23	0.00e+00	922.00
IUUC-Cho-024475	Choloepus hoffmanni	90.18	4.00e-139	488.00
IUUC-Cgl-026621	Colletotrichum gloeosporioides	21.55	1.00e-12	68.60
IUUC-Cne-027061	Cryptococcus neoformans	24.81	2.00e-09	57.80
IUUC-Dre-027563	Danio rerio	58.50	3.00e-157	548.00
IUUC-Dno-029929	Dasypus novemcinctus	91.88	0.00e+00	892.00
IUUC-Dor-030166	Dipodomys ordii	82.40	0.00e+00	740.00
IUUC-Dse-031517	Dothistroma septosporum	22.33	4.00e-12	66.60
IUUC-Dme-031627	Drosophila melanogaster	34.14	6.00e-36	145.00
IUUC-Ete-032634	Echinops telfairi	79.50	0.00e+00	676.00
IUUC-Eca-033968	Equus caballus	93.47	0.00e+00	838.00
IUUC-Eeu-035279	Erinaceus europaeus	81.71	7.00e-59	221.00
IUUC-Fca-036525	Felis catus	95.55	0.00e+00	917.00
IUUC-Fal-036606	Ficedula albicollis	75.13	2.00e-163	568.00
IUUC-Gmo-038726	Gadus morhua	55.17	9.00e-143	499.00
IUUC-Gga-040718	Gallus gallus	75.19	2.00e-162	565.00
IUUC-Gac-042645	Gasterosteus aculeatus	58.06	8.00e-152	530.00
IUUC-Gma-042890	Glycine max	26.37	4.00e-27	116.00
IUUC-Ggo-045021	Gorilla gorilla	93.23	0.00e+00	919.00
IUUC-Hsa-045832	Homo sapiens	93.23	0.00e+00	919.00
IUUC-Itr-048392	Ictidomys tridecemlineatus	94.29	0.00e+00	852.00
IUUC-Lch-050662	Latimeria chalumnae	70.76	0.00e+00	629.00
IUUC-Lpe-051078	Leersia perrieri	26.36	2.00e-30	127.00
IUUC-Loc-052611	Lepisosteus oculatus	66.14	6.00e-179	620.00
IUUC-Lma-053048	Leptosphaeria maculans	20.47	2.00e-15	77.80
IUUC-Laf-053752	Loxodonta africana	92.24	0.00e+00	832.00
IUUC-Mcc-054892	Macaca mulatta	93.62	0.00e+00	925.00
IUUC-Meu-056673	Macropus eugenii	76.30	8.00e-166	576.00
IUUC-Mor-057143	Magnaporthe oryzae	20.71	2.00e-08	54.70
IUUC-Mtr-057976	Medicago truncatula	26.15	4.00e-33	135.00
IUUC-Mla-058970	Melampsora laricipopulina	22.00	4.00e-19	89.40
IUUC-Mga-059543	Meleagris gallopavo	76.38	0.00e+00	665.00
IUUC-Mmr-061534	Microcebus murinus	92.65	0.00e+00	884.00
IUUC-Mdo-062140	Monodelphis domestica	69.57	8.00e-170	590.00
IUUC-Mmu-063673	Mus musculus	88.97	0.00e+00	831.00
IUUC-Mpu-066328	Mustela putorius furo	93.42	0.00e+00	871.00
IUUC-Nle-069426	Nomascus leucogenys	92.76	0.00e+00	820.00
IUUC-Opr-070796	Ochotona princeps	85.60	7.00e-123	434.00
IUUC-Ont-072248	Oreochromis niloticus	59.29	4.00e-158	551.00
IUUC-Oan-072916	Ornithorhynchus anatinus	80.51	0.00e+00	773.00
IUUC-Ocu-074459	Oryctolagus cuniculus	86.92	0.00e+00	660.00
IUUC-Oba-075765	Oryza barthii	25.56	3.00e-28	120.00
IUUC-Obr-076005	Oryza brachyantha	27.81	6.00e-31	128.00
IUUC-Ogl-077916	Oryza glaberrima	26.31	4.00e-31	129.00
IUUC-Ogu-078263	Oryza glumaepatula	25.93	4.00e-29	122.00
IUUC-Oin-080096	Oryza indica	25.96	1.00e-22	100.00
IUUC-Ome-081928	Oryza meridionalis	25.70	2.00e-29	123.00
IUUC-Oni-082424	Oryza nivara	25.93	5.00e-29	122.00
IUUC-Oru-085117	Oryza rufipogon	25.93	5.00e-29	122.00
IUUC-Ola-087429	Oryzias latipes	56.47	2.00e-148	518.00
IUUC-Oga-087981	Otolemur garnettii	93.02	0.00e+00	891.00
IUUC-Oar-089927	Ovis aries	91.88	0.00e+00	861.00
IUUC-Ptr-090878	Pan troglodytes	93.23	0.00e+00	919.00
IUUC-Pan-092698	Papio anubis	93.62	0.00e+00	925.00
IUUC-Psi-093451	Pelodiscus sinensis	76.52	0.00e+00	715.00
IUUC-Ppa-096015	Physcomitrella patens	25.53	1.00e-09	58.50
IUUC-Pfo-096096	Poecilia formosa	57.97	1.00e-154	539.00
IUUC-Pab-098676	Pongo abelii	92.44	0.00e+00	910.00
IUUC-Pca-100418	Procavia capensis	93.87	9.00e-128	450.00
IUUC-Ppe-101898	Prunus persica	23.95	2.00e-23	103.00
IUUC-Pva-103018	Pteropus vampyrus	93.04	0.00e+00	886.00
IUUC-Pgr-103423	Puccinia graminis	25.77	2.00e-10	61.20
IUUC-Pte-104330	Pyrenophora teres	22.31	1.00e-15	78.20
IUUC-Pyt-104518	Pyrenophora triticirepentis	22.24	3.00e-17	84.00
IUUC-Rno-105708	Rattus norvegicus	88.39	0.00e+00	825.00
IUUC-Sha-106971	Sarcophilus harrisii	82.27	0.00e+00	782.00
IUUC-Sit-110442	Setaria italica	27.59	2.00e-27	117.00
IUUC-Stu-112223	Solanum tuberosum	24.50	2.00e-16	80.50
IUUC-Ssc-116397	Sus scrofa	91.88	0.00e+00	862.00
IUUC-Tgu-117446	Taeniopygia guttata	70.38	0.00e+00	646.00
IUUC-Tru-118268	Takifugu rubripes	57.92	7.00e-143	500.00
IUUC-Tsy-119484	Tarsius syrichta	90.55	5.00e-51	195.00
IUUC-Tni-119735	Tetraodon nigroviridis	55.58	1.00e-121	429.00
IUUC-Tca-121660	Theobroma cacao	24.81	1.00e-27	118.00
IUUC-Tae-125383	Triticum aestivum	27.98	6.00e-29	122.00
IUUC-Tur-126458	Triticum urartu	28.24	9.00e-28	118.00
IUUC-Tbe-127740	Tupaia belangeri	87.23	0.00e+00	799.00
IUUC-Ttr-129273	Tursiops truncatus	90.14	0.00e+00	838.00
IUUC-Vvi-131177	Vitis vinifera	25.53	2.00e-28	120.00
IUUC-Xtr-132374	Xenopus tropicalis	66.20	2.00e-174	605.00
IUUC-Xma-133267	Xiphophorus maculatus	60.20	9.00e-157	546.00
IUUC-Yli-134571	Yarrowia lipolytica	24.65	2.00e-12	67.80
IUUC-Zma-135796	Zea mays	26.93	3.00e-18	86.70

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence