iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ggo-045299

Ensembl Protein ID

ENSGGOP00000018717.1

UniProt Accession

G3RSE2; G3RSE2_GORGO

Protein Name

Tyrosine-protein kinase

Gene Name

ABL1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000010586.2	ENSGGOT00000033137.1	ENSGGOP00000018717.1
ENSGGOG00000010586.2	ENSGGOT00000010630.2	ENSGGOP00000010326.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	3.60e-14	52.9	82	139

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
            +++ +lyd+ a+ d++L+++kG++++v+  ++++++W+++  ++++ +G +P+n+++ ++
   Q: 82   PNLFVALYDFVASGDNTLSITKGEKLRVL-GYNHNGEWCEA--QTKNGQGWVPSNYITPVN 139
           68899************************.***********..79999**********997 PP

Organism

Gorilla gorilla

Protein Sequence
(Fasta)

MGQQPGKVLG DQRRPSLPAL HFIKGAGKKE SSRHGGPHCN VFVEHEALQR PVASDFEPQG 60
LSEAARWNSK ENLLAGPSEN DPNLFVALYD FVASGDNTLS ITKGEKLRVL GYNHNGEWCE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTTGGTGAC TTCCACAGGA AAAGTTCTGG AGGAGTAGCC AAAGACCATC AGCGTTTCCT 60
TTATGTGTGA GAATTGAAAT GACTAGCATT ATTGACCCTT TTCAGCATCC CCTGTGAATA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR033221--ABL1
IPR015015--F-actin_binding
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF08919--F_actin_bind
PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00109--TYRKINASE

SMART

SM00808--FABD
SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0015629--C:actin cytoskeleton
GO:0031252--C:cell leading edge
GO:0005829--C:cytosol
GO:0016604--C:nuclear body
GO:0005730--C:nucleolus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005524--F:ATP binding
GO:0000287--F:magnesium ion binding
GO:0030145--F:manganese ion binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0090135--P:actin filament branching
GO:0050798--P:activated T cell proliferation
GO:1990051--P:activation of protein kinase C activity
GO:0046632--P:alpha-beta T cell differentiation
GO:0002322--P:B cell proliferation involved in immune response
GO:0050853--P:B cell receptor signaling pathway
GO:0001922--P:B-1 B cell homeostasis
GO:0060020--P:Bergmann glial cell differentiation
GO:0072358--P:cardiovascular system development
GO:0070301--P:cellular response to hydrogen peroxide
GO:0071222--P:cellular response to lipopolysaccharide
GO:0021587--P:cerebellum morphogenesis
GO:0048668--P:collateral sprouting
GO:0006975--P:DNA damage induced protein phosphorylation
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0045184--P:establishment of protein localization
GO:0030035--P:microspike assembly
GO:0030514--P:negative regulation of BMP signaling pathway
GO:0022408--P:negative regulation of cell-cell adhesion
GO:2000773--P:negative regulation of cellular senescence
GO:2000352--P:negative regulation of endothelial cell apoptotic process
GO:0070373--P:negative regulation of ERK1 and ERK2 cascade
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045930--P:negative regulation of mitotic cell cycle
GO:1900275--P:negative regulation of phospholipase C activity
GO:0071901--P:negative regulation of protein serine/threonine kinase activity
GO:0051444--P:negative regulation of ubiquitin-protein transferase activity
GO:0001843--P:neural tube closure
GO:0060563--P:neuroepithelial cell differentiation
GO:0050885--P:neuromuscular process controlling balance
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0006909--P:phagocytosis
GO:0035791--P:platelet-derived growth factor receptor-beta signaling pathway
GO:1904531--P:positive regulation of actin filament binding
GO:0043065--P:positive regulation of apoptotic process
GO:0007204--P:positive regulation of cytosolic calcium ion concentration
GO:0070374--P:positive regulation of ERK1 and ERK2 cascade
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:1902715--P:positive regulation of interferon-gamma secretion
GO:1900042--P:positive regulation of interleukin-2 secretion
GO:1904528--P:positive regulation of microtubule binding
GO:0045931--P:positive regulation of mitotic cell cycle
GO:1901216--P:positive regulation of neuron death
GO:0033690--P:positive regulation of osteoblast proliferation
GO:0051353--P:positive regulation of oxidoreductase activity
GO:0050731--P:positive regulation of peptidyl-tyrosine phosphorylation
GO:0051281--P:positive regulation of release of sequestered calcium ion into cytosol
GO:2000096--P:positive regulation of Wnt signaling pathway, planar cell polarity pathway
GO:0009791--P:post-embryonic development
GO:0032956--P:regulation of actin cytoskeleton organization
GO:0030516--P:regulation of axon extension
GO:1903053--P:regulation of extracellular matrix organization
GO:0031113--P:regulation of microtubule polymerization
GO:2001020--P:regulation of response to DNA damage stimulus
GO:0042770--P:signal transduction in response to DNA damage
GO:0048536--P:spleen development
GO:0034446--P:substrate adhesion-dependent cell spreading
GO:0048538--P:thymus development
GO:0002333--P:transitional one stage B cell differentiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001550	Ailuropoda melanoleuca	89.46	0.00e+00	1872.00
IUUC-Atr-002778	Amborella trichopoda	32.99	2.00e-22	101.00
IUUC-Apl-003452	Anas platyrhynchos	81.65	0.00e+00	1647.00
IUUC-Aca-005312	Anolis carolinensis	79.26	0.00e+00	1256.00
IUUC-Ame-011903	Astyanax mexicanus	84.86	0.00e+00	1095.00
IUUC-Bta-012351	Bos taurus	88.62	0.00e+00	1776.00
IUUC-Cja-019491	Callithrix jacchus	96.45	0.00e+00	2062.00
IUUC-Cfa-021256	Canis familiaris	88.86	0.00e+00	1920.00
IUUC-Cpo-022046	Cavia porcellus	90.55	0.00e+00	1615.00
IUUC-Csa-023046	Chlorocebus sabaeus	97.75	0.00e+00	2038.00
IUUC-Dre-028190	Danio rerio	66.27	0.00e+00	1281.00
IUUC-Dno-029853	Dasypus novemcinctus	89.29	0.00e+00	1907.00
IUUC-Dor-030635	Dipodomys ordii	81.40	0.00e+00	1731.00
IUUC-Dme-032098	Drosophila melanogaster	75.32	0.00e+00	779.00
IUUC-Eca-033720	Equus caballus	91.55	0.00e+00	1853.00
IUUC-Eeu-035173	Erinaceus europaeus	88.77	0.00e+00	1522.00
IUUC-Fca-035967	Felis catus	91.54	0.00e+00	1880.00
IUUC-Fal-036723	Ficedula albicollis	82.01	0.00e+00	1651.00
IUUC-Gmo-039550	Gadus morhua	77.26	0.00e+00	1145.00
IUUC-Gga-040481	Gallus gallus	82.01	0.00e+00	1628.00
IUUC-Gac-041643	Gasterosteus aculeatus	67.03	0.00e+00	1305.00
IUUC-Hsa-047033	Homo sapiens	100.00	1.00e-41	160.00
IUUC-Itr-047935	Ictidomys tridecemlineatus	90.14	0.00e+00	1778.00
IUUC-Lch-050530	Latimeria chalumnae	76.88	0.00e+00	1598.00
IUUC-Loc-052430	Lepisosteus oculatus	86.21	0.00e+00	1043.00
IUUC-Laf-053609	Loxodonta africana	90.33	0.00e+00	1869.00
IUUC-Mcc-055654	Macaca mulatta	97.84	0.00e+00	2171.00
IUUC-Meu-056488	Macropus eugenii	78.31	0.00e+00	1627.00
IUUC-Mga-059270	Meleagris gallopavo	81.55	0.00e+00	1668.00
IUUC-Mmr-060593	Microcebus murinus	90.78	0.00e+00	1886.00
IUUC-Mdo-062227	Monodelphis domestica	91.62	0.00e+00	1374.00
IUUC-Mmu-064002	Mus musculus	86.03	0.00e+00	1861.00
IUUC-Mpu-066197	Mustela putorius furo	88.85	0.00e+00	1887.00
IUUC-Mlu-067255	Myotis lucifugus	91.64	0.00e+00	1812.00
IUUC-Nle-069977	Nomascus leucogenys	93.00	0.00e+00	1483.00
IUUC-Opr-070327	Ochotona princeps	83.29	0.00e+00	1590.00
IUUC-Ont-072307	Oreochromis niloticus	65.45	0.00e+00	1288.00
IUUC-Oan-073100	Ornithorhynchus anatinus	84.30	0.00e+00	1723.00
IUUC-Ocu-074892	Oryctolagus cuniculus	83.38	0.00e+00	1608.00
IUUC-Ola-087389	Oryzias latipes	67.30	0.00e+00	1105.00
IUUC-Oga-088145	Otolemur garnettii	92.27	0.00e+00	1870.00
IUUC-Oar-090432	Ovis aries	94.47	0.00e+00	1478.00
IUUC-Ptr-090800	Pan troglodytes	98.79	0.00e+00	2159.00
IUUC-Psi-093078	Pelodiscus sinensis	81.24	0.00e+00	1705.00
IUUC-Pma-094420	Petromyzon marinus	78.34	0.00e+00	900.00
IUUC-Pfo-096979	Poecilia formosa	71.16	0.00e+00	1092.00
IUUC-Pca-100874	Procavia capensis	99.74	0.00e+00	773.00
IUUC-Pva-102415	Pteropus vampyrus	90.15	0.00e+00	1897.00
IUUC-Rno-105682	Rattus norvegicus	85.86	0.00e+00	1854.00
IUUC-Sha-106711	Sarcophilus harrisii	83.51	0.00e+00	1717.00
IUUC-Ssc-115472	Sus scrofa	89.98	0.00e+00	1862.00
IUUC-Tgu-117037	Taeniopygia guttata	82.97	0.00e+00	1771.00
IUUC-Tru-118324	Takifugu rubripes	66.67	0.00e+00	1094.00
IUUC-Tsy-119216	Tarsius syrichta	98.98	0.00e+00	1202.00
IUUC-Tni-119950	Tetraodon nigroviridis	61.07	0.00e+00	1093.00
IUUC-Ttr-128209	Tursiops truncatus	92.23	0.00e+00	1977.00
IUUC-Xtr-132477	Xenopus tropicalis	72.03	0.00e+00	1075.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence