iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Post-translational Modifications (PTMs)
dbPAF	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	5.30e-48	162.3	45	185

Active Site

Position(s)	Description	Evidence
125	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00388}

Domain Profile

E2/UBC

   S: 2    lkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilk...........e 88
           l+ e+k+l+++p+eg+++k+ ++++l+ewev+i+Gp+dt Y+gg+Fk++++fp+dYP++PP+++fltk++hPnvyenG++C+sil+           +
   Q: 45   LAMEYKSLQEEPVEGFRVKLINDDNLFEWEVAIFGPPDTLYQGGYFKAHMKFPHDYPYSPPSIRFLTKVWHPNVYENGDLCISILHppvddpqsgelP 142
           5679*********************************************************************************9999999999999 PP
   S: 89   eekWspalsvesvllsiqsllaepnpesplneeaaellkknre 131
            e+W+p+++v+++lls++sll+epn+ sp+n++a+ +++++r 
   Q: 143  CERWNPTQNVRTILLSVISLLNEPNTFSPANVDASVMYRRWRD 185
           9*************************************99886 PP

Organism

Drosophila melanogaster

Protein Sequence
(Fasta)

MTTAASTSQH ATSSSTMMAG SGSLATSSSA AAPTTTPSSS AVRALAMEYK SLQEEPVEGF 60
RVKLINDDNL FEWEVAIFGP PDTLYQGGYF KAHMKFPHDY PYSPPSIRFL TKVWHPNVYE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCTGGTTCAA GTAATGTCAC CCTGGTTTTT GTTTTGTAAA GTGAAATTGT TGCAAGTCAA 60
ACAACAATAA TAAAAATCAT TAAAAGCGCG TACAAGAAGT CAAAAAGAAT TGCCCACACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005524--F:ATP binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0022008--P:neurogenesis
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001600	Ailuropoda melanoleuca	70.59	7.00e-88	315.00
IUUC-Apl-003563	Anas platyrhynchos	75.51	8.00e-68	248.00
IUUC-Aca-004589	Anolis carolinensis	73.96	3.00e-89	320.00
IUUC-Ate-010563	Aspergillus terreus	43.96	9.00e-39	152.00
IUUC-Ame-011300	Astyanax mexicanus	75.13	6.00e-89	319.00
IUUC-Bta-012968	Bos taurus	74.60	7.00e-88	315.00
IUUC-Cel-018460	Caenorhabditis elegans	69.57	6.00e-77	279.00
IUUC-Cja-018764	Callithrix jacchus	74.09	1.00e-89	321.00
IUUC-Cfa-020955	Canis familiaris	74.09	1.00e-89	321.00
IUUC-Cpo-021451	Cavia porcellus	74.09	1.00e-89	321.00
IUUC-Csa-024239	Chlorocebus sabaeus	74.09	1.00e-89	321.00
IUUC-Cho-024999	Choloepus hoffmanni	61.67	3.00e-20	90.90
IUUC-Cin-025344	Ciona intestinalis	63.59	2.00e-81	294.00
IUUC-Csv-026350	Ciona savignyi	65.00	5.00e-80	289.00
IUUC-Dre-028153	Danio rerio	74.60	8.00e-89	318.00
IUUC-Dno-029368	Dasypus novemcinctus	74.60	7.00e-88	315.00
IUUC-Dor-030686	Dipodomys ordii	74.09	1.00e-89	321.00
IUUC-Ete-033001	Echinops telfairi	74.78	3.00e-49	186.00
IUUC-Eca-034221	Equus caballus	75.34	1.00e-66	244.00
IUUC-Fca-036381	Felis catus	75.00	5.00e-67	245.00
IUUC-Fal-037135	Ficedula albicollis	74.61	5.00e-90	322.00
IUUC-Gmo-039565	Gadus morhua	76.19	1.00e-89	321.00
IUUC-Gga-040477	Gallus gallus	74.36	1.00e-90	324.00
IUUC-Gac-041909	Gasterosteus aculeatus	75.66	2.00e-89	320.00
IUUC-Ggo-045150	Gorilla gorilla	73.58	1.00e-88	318.00
IUUC-Hsa-046611	Homo sapiens	74.09	1.00e-89	321.00
IUUC-Itr-047984	Ictidomys tridecemlineatus	67.19	3.00e-76	277.00
IUUC-Lch-050173	Latimeria chalumnae	74.09	7.00e-90	322.00
IUUC-Loc-052932	Lepisosteus oculatus	74.87	2.00e-89	320.00
IUUC-Lma-052988	Leptosphaeria maculans	47.85	2.00e-36	144.00
IUUC-Laf-053860	Loxodonta africana	74.09	1.00e-89	321.00
IUUC-Mcc-054820	Macaca mulatta	74.09	1.00e-89	321.00
IUUC-Meu-056681	Macropus eugenii	69.27	4.00e-83	300.00
IUUC-Mga-060075	Meleagris gallopavo	71.28	5.00e-86	309.00
IUUC-Mmr-060666	Microcebus murinus	74.09	1.00e-89	321.00
IUUC-Mdo-062804	Monodelphis domestica	74.61	2.00e-90	323.00
IUUC-Mmu-063472	Mus musculus	74.09	1.00e-89	321.00
IUUC-Mpu-066009	Mustela putorius furo	70.59	1.00e-87	314.00
IUUC-Mlu-067397	Myotis lucifugus	74.86	2.00e-85	307.00
IUUC-Nle-070152	Nomascus leucogenys	86.24	2.00e-56	209.00
IUUC-Opr-070826	Ochotona princeps	70.65	2.00e-78	284.00
IUUC-Ont-071627	Oreochromis niloticus	74.87	1.00e-89	321.00
IUUC-Oan-073287	Ornithorhynchus anatinus	72.31	3.00e-86	310.00
IUUC-Ocu-074229	Oryctolagus cuniculus	74.74	3.00e-88	317.00
IUUC-Ola-086587	Oryzias latipes	75.66	2.00e-89	320.00
IUUC-Oga-089161	Otolemur garnettii	74.60	7.00e-88	315.00
IUUC-Oar-089383	Ovis aries	74.09	1.00e-89	321.00
IUUC-Ptr-091096	Pan troglodytes	74.09	1.00e-89	321.00
IUUC-Pan-092560	Papio anubis	74.60	7.00e-88	315.00
IUUC-Psi-093263	Pelodiscus sinensis	76.03	2.00e-67	247.00
IUUC-Pma-094368	Petromyzon marinus	75.34	2.00e-66	243.00
IUUC-Pfo-096974	Poecilia formosa	76.19	1.00e-89	322.00
IUUC-Pab-098344	Pongo abelii	74.09	1.00e-89	321.00
IUUC-Pca-100169	Procavia capensis	70.00	1.00e-51	194.00
IUUC-Pva-102875	Pteropus vampyrus	73.29	5.00e-64	235.00
IUUC-Rno-105821	Rattus norvegicus	74.09	1.00e-89	321.00
IUUC-Sha-107364	Sarcophilus harrisii	74.61	2.00e-90	323.00
IUUC-Sar-112992	Sorex araneus	71.50	3.00e-82	296.00
IUUC-Ssc-115699	Sus scrofa	68.55	2.00e-65	240.00
IUUC-Tgu-117074	Taeniopygia guttata	74.61	5.00e-90	322.00
IUUC-Tru-118641	Takifugu rubripes	75.53	8.00e-89	318.00
IUUC-Tsy-118797	Tarsius syrichta	78.36	9.00e-64	234.00
IUUC-Tni-119817	Tetraodon nigroviridis	75.13	4.00e-89	319.00
IUUC-Tbe-128014	Tupaia belangeri	74.09	1.00e-89	321.00
IUUC-Ttr-129037	Tursiops truncatus	75.00	1.00e-84	304.00
IUUC-Vpa-130680	Vicugna pacos	75.69	1.00e-65	241.00
IUUC-Xtr-131819	Xenopus tropicalis	77.35	7.00e-88	315.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence