iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046349

UUCD1 version

UUC-HoS-00466

Ensembl Protein ID

ENSP00000433623.1

UniProt Accession

Q9Y4K3; A6NKI7; A8KAB3; D3DR16; Q8NEH5; TRAF6_HUMAN

Genbank Protein ID

AAB38751.1; AAO38054.1; BAF85667.1; EAW68119.1; EAW68120.1; EAW68122.1; AAH31052.1

Protein Name

TNF receptor-associated factor 6; E3 ubiquitin-protein ligase TRAF6; Interleukin-1 signal transducer; RING finger protein 85; RING-type E3 ubiquitin transferase TRAF6

Genbank Nucleotide ID

U78798; AY228337; AK292978; AC009656; CH471064; CH471064; BC031052

Gene Name

TRAF6; RNF85

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000175104.14	ENST00000526995.5	ENSP00000433623.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	TargetScan	miRecords	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Drug and target
TTD	KPID
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	19713527; 19494296; 19201866; 17947236; 17562858; 19898473; 19365808; 19232518; 17346928; 20047764; 17609522; 18824541; 18976280; 23524951; 25545884

Classification

Family	E-value	Score	Start	End
E3 activity/RING/U-box	1.20e-06	30.2	66	127
E3 activity/RING/RING	0.00011	24.3	70	108

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrli 65
           + + CpI l   r+ v +p+G+ + +++I k +++ g++cPv+++ l e++l P ++ +r i
   Q: 66   SKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPDNFAKREI 127
           5689*****************************999999*****************999977 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlC 45
           C+iCl  +++  + +pCgH f++ C+ + +           +CP++
   Q: 70   CPICLMALRE-AVQTPCGHRFCKACIiKSI------RDAGHKCPVD 108
           ********88.888***********97777......8888889997 PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production.

Protein Sequence
(Fasta)

MSLLNCENSC GSSQSESDCC VAMASSCSAV TKDDSVGGTA STGNLSSSFM EEIQGYDVEF 60
DPPLESKYEC PICLMALREA VQTPCGHRFC KACIIKSIRD AGHKCPVDNE ILLENQLFPD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCAGAGAAG GCGGAAGCAG TGGCGTCCGC AGCTGGGGCT TGGCCTGCGG GCGGCCAGCG 60
AAGGTGGCGA AGGCTCCCAC TGGATCCAGA GTTTGCCGTC CAAGCAGCCT CGTCTCGGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0227--DNA damage
KW-0391--Immunity
KW-1017--Isopeptide bond
KW-0551--Lipid droplet
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0892--Osteogenesis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR002083--MATH/TRAF_dom
IPR012227--TNF_rcpt--assoc_TRAF
IPR008974--TRAF-like
IPR027139--TRAF6
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
IPR001293--Znf_TRAF

PROSITE

PS50144--MATH
PS00518--ZF_RING_1
PS50089--ZF_RING_2
PS50145--ZF_TRAF

Pfam

PF02176--zf-TRAF

SMART

SM00061--MATH
SM00184--RING

Gene Ontology

GO:0035631--C:CD40 receptor complex
GO:0005938--C:cell cortex
GO:0005737--C:cytoplasm
GO:0009898--C:cytoplasmic side of plasma membrane
GO:0005829--C:cytosol
GO:0010008--C:endosome membrane
GO:0005811--C:lipid particle
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0043234--C:protein complex
GO:0042826--F:histone deacetylase binding
GO:0042802--F:identical protein binding
GO:0031435--F:mitogen-activated protein kinase kinase kinase binding
GO:0043422--F:protein kinase B binding
GO:0019901--F:protein kinase binding
GO:0047485--F:protein N-terminus binding
GO:0031996--F:thioesterase binding
GO:0005164--F:tumor necrosis factor receptor binding
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0000187--P:activation of MAPK activity
GO:0007250--P:activation of NF-kappaB-inducing kinase activity
GO:0032147--P:activation of protein kinase activity
GO:0019886--P:antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0045453--P:bone resorption
GO:0048468--P:cell development
GO:0006974--P:cellular response to DNA damage stimulus
GO:0071222--P:cellular response to lipopolysaccharide
GO:0038095--P:Fc-epsilon receptor signaling pathway
GO:0007249--P:I-kappaB kinase/NF-kappaB signaling
GO:0070498--P:interleukin-1-mediated signaling pathway
GO:0007254--P:JNK cascade
GO:0031293--P:membrane protein intracellular domain proteolysis
GO:0002755--P:MyD88-dependent toll-like receptor signaling pathway
GO:0002756--P:MyD88-independent toll-like receptor signaling pathway
GO:0043011--P:myeloid dendritic cell differentiation
GO:0043066--P:negative regulation of apoptotic process
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0001843--P:neural tube closure
GO:0070423--P:nucleotide-binding oligomerization domain containing signaling pathway
GO:0042475--P:odontogenesis of dentin-containing tooth
GO:0001503--P:ossification
GO:0030316--P:osteoclast differentiation
GO:0043065--P:positive regulation of apoptotic process
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045084--P:positive regulation of interleukin-12 biosynthetic process
GO:0032743--P:positive regulation of interleukin-2 production
GO:0045410--P:positive regulation of interleukin-6 biosynthetic process
GO:0043507--P:positive regulation of JUN kinase activity
GO:0031666--P:positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0045672--P:positive regulation of osteoclast differentiation
GO:0031398--P:positive regulation of protein ubiquitination
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0048661--P:positive regulation of smooth muscle cell proliferation
GO:0050870--P:positive regulation of T cell activation
GO:0002726--P:positive regulation of T cell cytokine production
GO:0042102--P:positive regulation of T cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:2000679--P:positive regulation of transcription regulatory region DNA binding
GO:0051865--P:protein autoubiquitination
GO:0006461--P:protein complex assembly
GO:0016579--P:protein deubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0000209--P:protein polyubiquitination
GO:0051023--P:regulation of immunoglobulin secretion
GO:0070555--P:response to interleukin-1
GO:0002223--P:stimulatory C-type lectin receptor signaling pathway
GO:0050852--P:T cell receptor signaling pathway
GO:0042088--P:T-helper 1 type immune response
GO:0034162--P:toll-like receptor 9 signaling pathway
GO:0002224--P:toll-like receptor signaling pathway

KEGG

hsa:7189

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001262	Ailuropoda melanoleuca	91.31	0.00e+00	953.00
IUUC-Apl-004062	Anas platyrhynchos	72.60	0.00e+00	830.00
IUUC-Aca-004636	Anolis carolinensis	70.80	0.00e+00	772.00
IUUC-Ame-011682	Astyanax mexicanus	52.05	3.00e-161	561.00
IUUC-Bta-012692	Bos taurus	89.11	0.00e+00	975.00
IUUC-Bci-013998	Botrytis cinerea	24.60	4.00e-14	72.80
IUUC-Cja-019426	Callithrix jacchus	94.84	0.00e+00	1004.00
IUUC-Cfa-020948	Canis familiaris	89.37	0.00e+00	838.00
IUUC-Cpo-021378	Cavia porcellus	88.58	0.00e+00	944.00
IUUC-Csa-024045	Chlorocebus sabaeus	98.47	0.00e+00	1052.00
IUUC-Cho-024973	Choloepus hoffmanni	75.79	2.00e-106	379.00
IUUC-Csv-026300	Ciona savignyi	41.59	1.00e-46	179.00
IUUC-Dre-027557	Danio rerio	56.35	2.00e-175	608.00
IUUC-Dno-030032	Dasypus novemcinctus	84.40	3.00e-143	501.00
IUUC-Dor-030790	Dipodomys ordii	92.21	0.00e+00	979.00
IUUC-Dme-031921	Drosophila melanogaster	26.62	1.00e-38	154.00
IUUC-Ete-032952	Echinops telfairi	88.75	2.00e-170	592.00
IUUC-Eca-033924	Equus caballus	84.71	0.00e+00	867.00
IUUC-Eeu-034734	Erinaceus europaeus	86.42	0.00e+00	887.00
IUUC-Fca-036222	Felis catus	83.21	0.00e+00	838.00
IUUC-Fal-036834	Ficedula albicollis	73.67	0.00e+00	734.00
IUUC-Fox-037935	Fusarium oxysporum	29.44	4.00e-21	96.30
IUUC-Gmo-039061	Gadus morhua	57.30	6.00e-89	321.00
IUUC-Ggr-040084	Gaeumannomyces graminis	28.38	6.00e-13	69.30
IUUC-Gga-040599	Gallus gallus	73.03	0.00e+00	837.00
IUUC-Gac-041977	Gasterosteus aculeatus	55.47	2.00e-166	578.00
IUUC-Ggo-044508	Gorilla gorilla	91.03	0.00e+00	944.00
IUUC-Itr-047966	Ictidomys tridecemlineatus	91.89	0.00e+00	989.00
IUUC-Lch-049821	Latimeria chalumnae	67.08	0.00e+00	754.00
IUUC-Lpe-051025	Leersia perrieri	25.29	3.00e-06	46.20
IUUC-Loc-051995	Lepisosteus oculatus	57.30	0.00e+00	627.00
IUUC-Laf-054115	Loxodonta africana	85.77	0.00e+00	936.00
IUUC-Mcc-055298	Macaca mulatta	98.08	0.00e+00	1046.00
IUUC-Mor-057263	Magnaporthe oryzae	30.09	3.00e-17	83.60
IUUC-Mpo-057517	Magnaporthe poae	28.51	1.00e-14	74.70
IUUC-Mga-059340	Meleagris gallopavo	72.84	0.00e+00	814.00
IUUC-Mvi-060553	Microbotryum violaceum	28.12	6.00e-15	75.90
IUUC-Mmr-061063	Microcebus murinus	91.56	0.00e+00	961.00
IUUC-Mdo-062075	Monodelphis domestica	80.41	0.00e+00	908.00
IUUC-Mmu-063780	Mus musculus	87.92	0.00e+00	906.00
IUUC-Mac-064529	Musa acuminata	25.00	2.00e-09	56.60
IUUC-Mpu-065748	Mustela putorius furo	89.65	0.00e+00	960.00
IUUC-Mlu-067888	Myotis lucifugus	88.66	0.00e+00	947.00
IUUC-Nle-069234	Nomascus leucogenys	99.23	0.00e+00	1059.00
IUUC-Opr-070393	Ochotona princeps	97.18	1.00e-123	436.00
IUUC-Ont-072459	Oreochromis niloticus	53.44	7.00e-174	603.00
IUUC-Oan-073578	Ornithorhynchus anatinus	81.62	0.00e+00	900.00
IUUC-Ocu-074201	Oryctolagus cuniculus	90.94	0.00e+00	967.00
IUUC-Oba-075457	Oryza barthii	27.59	2.00e-08	53.50
IUUC-Ogl-077406	Oryza glaberrima	27.59	2.00e-08	53.90
IUUC-Ogu-078803	Oryza glumaepatula	27.03	9.00e-09	54.70
IUUC-Oin-079307	Oryza indica	27.59	2.00e-08	53.50
IUUC-Olo-080508	Oryza longistaminata	28.16	6.00e-09	55.10
IUUC-Ome-081315	Oryza meridionalis	26.44	8.00e-08	51.60
IUUC-Oni-082966	Oryza nivara	27.03	1.00e-08	54.70
IUUC-Opu-084160	Oryza punctata	25.86	5.00e-08	52.00
IUUC-Oru-085055	Oryza rufipogon	27.03	1.00e-08	54.70
IUUC-Osa-085780	Oryza sativa	27.59	1.00e-08	53.90
IUUC-Ola-087319	Oryzias latipes	58.94	2.00e-90	327.00
IUUC-Olu-087748	Ostreococcus lucimarinus	23.55	3.00e-11	63.20
IUUC-Oga-087936	Otolemur garnettii	89.91	0.00e+00	959.00
IUUC-Oar-089379	Ovis aries	88.56	0.00e+00	975.00
IUUC-Ptr-090758	Pan troglodytes	99.62	0.00e+00	1058.00
IUUC-Pan-092590	Papio anubis	98.28	0.00e+00	1047.00
IUUC-Psi-093948	Pelodiscus sinensis	71.48	0.00e+00	805.00
IUUC-Pma-094434	Petromyzon marinus	50.72	5.00e-76	278.00
IUUC-Pfo-096912	Poecilia formosa	52.38	2.00e-168	585.00
IUUC-Pab-097651	Pongo abelii	99.62	0.00e+00	1061.00
IUUC-Pca-100958	Procavia capensis	90.35	0.00e+00	719.00
IUUC-Pva-103247	Pteropus vampyrus	92.86	2.00e-131	462.00
IUUC-Rno-104994	Rattus norvegicus	86.42	0.00e+00	917.00
IUUC-Sha-106494	Sarcophilus harrisii	83.05	0.00e+00	922.00
IUUC-Sar-113375	Sorex araneus	88.05	0.00e+00	933.00
IUUC-Sre-115218	Sporisorium reilianum	27.63	1.00e-15	78.60
IUUC-Ssc-115417	Sus scrofa	88.91	0.00e+00	967.00
IUUC-Tgu-117232	Taeniopygia guttata	72.48	0.00e+00	790.00
IUUC-Tru-118321	Takifugu rubripes	53.23	4.00e-166	578.00
IUUC-Tni-120475	Tetraodon nigroviridis	56.27	2.00e-164	572.00
IUUC-Tbe-127719	Tupaia belangeri	81.06	0.00e+00	828.00
IUUC-Ttr-129264	Tursiops truncatus	89.33	4.00e-126	445.00
IUUC-Uma-129620	Ustilago maydis	27.67	7.00e-17	82.80
IUUC-Vpa-130244	Vicugna pacos	88.93	2.00e-128	452.00
IUUC-Xtr-131948	Xenopus tropicalis	64.87	0.00e+00	748.00
IUUC-Xma-133132	Xiphophorus maculatus	52.91	1.00e-169	589.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence