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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046111
UUCD1 version UUC-HoS-00268
Ensembl Protein ID ENSP00000397655.1
UniProt Accession Q8WXK1; Q3ZCP3; Q3ZCP5; Q68D37; ASB15_HUMAN
Genbank Protein ID BAC86146.1; AAI00875.1; AAI00876.1; AAI00877.1; AAI00878.1; CAH18393.1; AAL57352.1
Protein Name Ankyrin repeat and SOCS box protein 15
Genbank Nucleotide ID AK125360; AC006333; BC100875; BC100876; BC100877; CR749595; AF403033
Gene Name ASB15
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000146809.12 ENST00000451558.5 ENSP00000397655.1
ENSG00000146809.12 ENST00000540573.5 ENSP00000438643.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbAREsiteCircNetmicroRNA
TRANSFACTargetScanRepTarmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
InWeb_IM
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRD
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box SOCS 16424087
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box 1.30e-16 61.9 524 578
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box
   S: 1    lsklwllrseprSLqhLCRlaIrrclgsqrl...kaidkLPLPksLkdYLlyedy 52
           + +++++ ++p+SL+hLCRl+Irr++g q+l   ++++kLPLP+++++Y+l ++y
   Q: 524  WPEIRQILENPCSLKHLCRLKIRRLMGLQKLcqpASVEKLPLPPAIQRYILFKEY 578
           568999**********************************************988 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
 May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Protein Sequence
(Fasta)
MDTNDDPDED HLTSYDIQLS IQESIEASKT ALCPERFVPL SAQNRKLVEA IKQGHIPELQ 60
EYVKYKYAMD EADEKGWFPL HEAVVQPIQQ ILEIVLDASY KTLWEFKTCD GETPLTLAVK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046111|E3,SOCS|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AACCCTGGGT TCAGGCTTCT GCTGTATCAT ATTTGCTAAA GACACCAAAA CTAGATAGAG 60
CTATTTGATC CTGACTAAGG TACTGCATAA TTAAGTTTCA TGTAGTGAGA AAATGTGTAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046111|E3,SOCS|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0040--ANK repeat
KW-0181--Complete proteome
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR001496--SOCS_box
PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50225--SOCS
Pfam

PF12796--Ank_2
PF07525--SOCS_box
PRINTS

PR01415--ANKYRIN
SMART

SM00248--ANK
SM00253--SOCS
SM00969--SOCS_box
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0035556--P:intracellular signal transduction
KEGG hsa:142685
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002210 Ailuropoda melanoleuca 92.16 0.00e+00 1128.00
IUUC-Apl-003801 Anas platyrhynchos 78.44 0.00e+00 948.00
IUUC-Aca-005290 Anolis carolinensis 70.13 0.00e+00 931.00
IUUC-Ame-011590 Astyanax mexicanus 54.78 1.00e-169 589.00
IUUC-Bta-013427 Bos taurus 91.99 0.00e+00 1135.00
IUUC-Cel-018167 Caenorhabditis elegans 22.80 1.00e-16 80.90
IUUC-Cja-019662 Callithrix jacchus 97.62 0.00e+00 1196.00
IUUC-Cfa-021155 Canis familiaris 93.07 0.00e+00 1120.00
IUUC-Csa-023294 Chlorocebus sabaeus 97.36 0.00e+00 1075.00
IUUC-Cho-024744 Choloepus hoffmanni 81.62 0.00e+00 910.00
IUUC-Dre-027559 Danio rerio 54.17 2.00e-178 619.00
IUUC-Dno-030076 Dasypus novemcinctus 91.86 0.00e+00 1130.00
IUUC-Dor-030347 Dipodomys ordii 77.59 0.00e+00 820.00
IUUC-Ete-032284 Echinops telfairi 81.36 0.00e+00 885.00
IUUC-Eca-034197 Equus caballus 86.54 0.00e+00 1058.00
IUUC-Eeu-034617 Erinaceus europaeus 85.07 0.00e+00 852.00
IUUC-Fca-035649 Felis catus 93.02 0.00e+00 1148.00
IUUC-Gga-040848 Gallus gallus 75.98 0.00e+00 922.00
IUUC-Gac-041696 Gasterosteus aculeatus 50.85 1.00e-126 447.00
IUUC-Ggo-044907 Gorilla gorilla 99.32 0.00e+00 1211.00
IUUC-Itr-048869 Ictidomys tridecemlineatus 92.98 0.00e+00 1127.00
IUUC-Lch-050248 Latimeria chalumnae 70.60 0.00e+00 865.00
IUUC-Loc-052752 Lepisosteus oculatus 59.87 0.00e+00 693.00
IUUC-Laf-054585 Loxodonta africana 91.31 0.00e+00 1122.00
IUUC-Mcc-054651 Macaca mulatta 97.61 0.00e+00 1192.00
IUUC-Meu-056277 Macropus eugenii 90.91 3.00e-171 595.00
IUUC-Mtr-058049 Medicago truncatula 27.81 5.00e-17 83.20
IUUC-Mga-060130 Meleagris gallopavo 76.36 0.00e+00 930.00
IUUC-Mmr-060879 Microcebus murinus 94.55 0.00e+00 1159.00
IUUC-Mdo-061877 Monodelphis domestica 87.24 0.00e+00 1083.00
IUUC-Mmu-063484 Mus musculus 88.51 0.00e+00 1095.00
IUUC-Mpu-066536 Mustela putorius furo 93.02 0.00e+00 1141.00
IUUC-Mlu-067317 Myotis lucifugus 92.50 0.00e+00 1138.00
IUUC-Nle-069895 Nomascus leucogenys 98.30 0.00e+00 1194.00
IUUC-Opr-070602 Ochotona princeps 77.28 0.00e+00 696.00
IUUC-Ont-071779 Oreochromis niloticus 50.46 2.00e-150 525.00
IUUC-Oan-073430 Ornithorhynchus anatinus 83.05 0.00e+00 1034.00
IUUC-Ocu-073921 Oryctolagus cuniculus 92.33 0.00e+00 1134.00
IUUC-Ola-087235 Oryzias latipes 46.74 1.00e-151 530.00
IUUC-Oga-089182 Otolemur garnettii 92.50 0.00e+00 1142.00
IUUC-Oar-089655 Ovis aries 92.16 0.00e+00 1140.00
IUUC-Ptr-090671 Pan troglodytes 99.32 0.00e+00 1208.00
IUUC-Pan-091931 Papio anubis 97.79 0.00e+00 1192.00
IUUC-Psi-093364 Pelodiscus sinensis 79.15 0.00e+00 977.00
IUUC-Pfo-097338 Poecilia formosa 47.35 9.00e-152 530.00
IUUC-Pab-098552 Pongo abelii 98.81 0.00e+00 1204.00
IUUC-Pca-100415 Procavia capensis 74.76 0.00e+00 810.00
IUUC-Pva-103077 Pteropus vampyrus 94.07 0.00e+00 707.00
IUUC-Rno-104893 Rattus norvegicus 89.37 0.00e+00 1099.00
IUUC-Sha-106824 Sarcophilus harrisii 85.91 0.00e+00 1057.00
IUUC-Sar-113300 Sorex araneus 77.06 0.00e+00 692.00
IUUC-Ssc-115956 Sus scrofa 93.36 0.00e+00 1149.00
IUUC-Tru-117639 Takifugu rubripes 47.76 3.00e-154 538.00
IUUC-Tsy-119263 Tarsius syrichta 96.09 0.00e+00 723.00
IUUC-Tni-120083 Tetraodon nigroviridis 50.19 2.00e-150 526.00
IUUC-Tbe-127228 Tupaia belangeri 88.07 0.00e+00 1046.00
IUUC-Ttr-128657 Tursiops truncatus 83.82 0.00e+00 1011.00
IUUC-Vpa-130435 Vicugna pacos 93.19 0.00e+00 1147.00
IUUC-Xtr-132951 Xenopus tropicalis 68.61 0.00e+00 825.00
Created Date 25-Jun-2017

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