iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	7.10e-06	27.6	12	55

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf..kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC++ +  ++ p++l+C+H+ +  Clq++    + s+k  rCP+Cr
   Q: 12   CQICFNYYspRRRPKLLDCKHTCCSVCLQQM----RTSQKDVRCPWCR 55
           9*****8888555***************999....99**********8 PP

Organism

Mus musculus

Functional Description
(View)

E3 ubiquitin-protein ligase mediating 'Lys-63'-linked polyubiquitination of RRAGA in response to amino acid starvation. Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability (PubMed:25936802). Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation. Induces apoptosis when overexpressed (By similarity).

Protein Sequence
(Fasta)

METLSQDSLL ECQICFNYYS PRRRPKLLDC KHTCCSVCLQ QMRTSQKDVR CPWCRGITKL 60
PPGFSVSQLP DDPEVLAVIA IPHTSEHTPV FIKLPSNGCY MLPLPISKER TLLPGDMGCR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTCCGCGGA GCAGAGCTCA CTCAGCCTCC CGCTCCCTTC AGTGCTTGGG TCTCTGGGGG 60
TGACACCAAA AGCTTCCGCT CAGTGTCCGG TGCCTGGCGG CGGGTGTCCG ATCGTGGAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0458--Lysosome
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR033609--RNF152
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF14634--zf-RING_5

SMART

SM00184--RING

Gene Ontology

GO:0031301--C:integral component of organelle membrane
GO:0005765--C:lysosomal membrane
GO:0005764--C:lysosome
GO:0031267--F:small GTPase binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:0034198--P:cellular response to amino acid starvation
GO:1904262--P:negative regulation of TORC1 signaling
GO:0010508--P:positive regulation of autophagy
GO:0070936--P:protein K48-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination

KEGG

mmu:320311

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001569	Ailuropoda melanoleuca	96.06	1.00e-113	402.00
IUUC-Aca-004700	Anolis carolinensis	94.09	1.00e-110	391.00
IUUC-Ame-011661	Astyanax mexicanus	55.88	6.00e-50	189.00
IUUC-Cja-019799	Callithrix jacchus	96.55	4.00e-106	376.00
IUUC-Cfa-020144	Canis familiaris	94.09	5.00e-99	353.00
IUUC-Cpo-021632	Cavia porcellus	98.52	3.00e-115	406.00
IUUC-Csa-023858	Chlorocebus sabaeus	97.04	2.00e-106	377.00
IUUC-Cho-024669	Choloepus hoffmanni	95.20	1.00e-68	251.00
IUUC-Dre-027881	Danio rerio	58.82	4.00e-57	214.00
IUUC-Dno-029695	Dasypus novemcinctus	91.63	4.00e-98	350.00
IUUC-Dor-030795	Dipodomys ordii	97.54	1.00e-104	372.00
IUUC-Eca-033412	Equus caballus	97.04	4.00e-106	376.00
IUUC-Fca-036256	Felis catus	97.04	8.00e-106	375.00
IUUC-Fal-036943	Ficedula albicollis	93.60	7.00e-103	365.00
IUUC-Gga-040800	Gallus gallus	94.09	2.00e-111	394.00
IUUC-Ggo-045477	Gorilla gorilla	97.54	2.00e-114	404.00
IUUC-Hsa-046568	Homo sapiens	97.54	2.00e-114	404.00
IUUC-Itr-049081	Ictidomys tridecemlineatus	97.04	2.00e-113	400.00
IUUC-Lch-049770	Latimeria chalumnae	85.71	6.00e-97	346.00
IUUC-Loc-052353	Lepisosteus oculatus	86.09	1.00e-59	220.00
IUUC-Laf-054064	Loxodonta africana	97.04	2.00e-113	400.00
IUUC-Mcc-054875	Macaca mulatta	97.04	2.00e-106	377.00
IUUC-Meu-056370	Macropus eugenii	94.61	1.00e-110	391.00
IUUC-Mga-059847	Meleagris gallopavo	94.09	3.00e-111	394.00
IUUC-Mmr-061042	Microcebus murinus	97.54	2.00e-114	404.00
IUUC-Mdo-063047	Monodelphis domestica	94.61	1.00e-110	391.00
IUUC-Mlu-067736	Myotis lucifugus	97.04	6.00e-100	356.00
IUUC-Nle-069697	Nomascus leucogenys	97.04	2.00e-106	377.00
IUUC-Ont-072208	Oreochromis niloticus	74.65	2.00e-85	308.00
IUUC-Oan-073566	Ornithorhynchus anatinus	82.76	4.00e-88	316.00
IUUC-Ocu-074089	Oryctolagus cuniculus	96.55	5.00e-101	360.00
IUUC-Obr-076611	Oryza brachyantha	40.82	2.90e-02	33.10
IUUC-Ola-087210	Oryzias latipes	70.39	6.00e-75	273.00
IUUC-Oga-088395	Otolemur garnettii	97.54	7.00e-104	369.00
IUUC-Oar-090382	Ovis aries	95.83	2.00e-21	93.20
IUUC-Ptr-091480	Pan troglodytes	97.54	2.00e-114	404.00
IUUC-Pan-091715	Papio anubis	97.04	2.00e-106	377.00
IUUC-Psi-093465	Pelodiscus sinensis	93.10	2.00e-109	387.00
IUUC-Pfo-097259	Poecilia formosa	75.94	8.00e-90	322.00
IUUC-Pab-097769	Pongo abelii	97.54	2.00e-114	404.00
IUUC-Pca-100657	Procavia capensis	96.55	3.00e-112	397.00
IUUC-Pva-102521	Pteropus vampyrus	96.55	1.00e-113	401.00
IUUC-Rno-105521	Rattus norvegicus	99.01	7.00e-116	409.00
IUUC-Sha-107197	Sarcophilus harrisii	95.10	9.00e-111	392.00
IUUC-Ssc-116239	Sus scrofa	96.06	4.00e-113	399.00
IUUC-Tru-118315	Takifugu rubripes	74.41	9.00e-82	295.00
IUUC-Tsy-119645	Tarsius syrichta	98.03	1.00e-114	404.00
IUUC-Tni-119835	Tetraodon nigroviridis	73.93	4.00e-86	310.00
IUUC-Tbe-127264	Tupaia belangeri	98.52	2.00e-109	387.00
IUUC-Ttr-128749	Tursiops truncatus	98.03	5.00e-108	382.00
IUUC-Vpa-130808	Vicugna pacos	99.01	6.00e-109	386.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence