iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Xma-134116

Ensembl Protein ID

ENSXMAP00000003105.1

UniProt Accession

M3ZLL3; M3ZLL3_XIPMA

Genbank Protein ID

ENSXMAP00000003105

Protein Name

Estrogen receptor; ER-alpha; Estradiol receptor; Nuclear receptor subfamily 3 group A member 1

Genbank Nucleotide ID

AGAJ01013308

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXMAG00000003084.1	ENSXMAT00000003110.1	ENSXMAP00000003105.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/UMI	55.79	3.00e-129	460.00	IUUC-Hsa-046944

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Xiphophorus maculatus

Functional Description
(View)

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

Protein Sequence
(Fasta)

MLLRQNPVQS KQEFGPALRP RISPASSELE TLSSTRLPPS PRAPLSDMYP EESRGSGGVA 60
AVDFLEGTYD YATPTPAPTP LYSHSTTGYF SAPLDAQGPP SDGSLHSLGS GPTSPLVFVP 120

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Nucleotide Sequence
(Fasta)

TCACAGTTTT GCTCCTGAGG AGTTGATGCA CTTCTCAAAA TGGATGGCAC TATGAGGAAC 60
AAACATTAAG ATGAAATATT GAAGCAACAT TTCAGGACAT CAGCCAGGAA ATGAAAACCT 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0446--Lipid-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0675--Receptor
KW-1185--Reference proteome
KW-0754--Steroid-binding
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000536--Nucl_hrmn_rcpt_lig-bd
IPR001723--Nuclear_hrmn_rcpt
IPR024178--Oest_rcpt/oest-rel_rcp
IPR001292--Oestr_rcpt
IPR001628--Znf_hrmn_rcpt
IPR013088--Znf_NHR/GATA

PROSITE

PS00031--NUCLEAR_REC_DBD_1
PS51030--NUCLEAR_REC_DBD_2

Pfam

PF00104--Hormone_recep
PF02159--Oest_recep
PF00105--zf-C4

PRINTS

PR00398--STRDHORMONER
PR00047--STROIDFINGER

SMART

SM00430--HOLI
SM00399--ZnF_C4

Gene Ontology

GO:0005634--C:nucleus
GO:0030284--F:estrogen receptor activity
GO:0043565--F:sequence-specific DNA binding
GO:0005496--F:steroid binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0008270--F:zinc ion binding
GO:0006351--P:transcription, DNA-templated

KEGG

xma:102235986

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001925	Ailuropoda melanoleuca	63.47	1.00e-128	452.00
IUUC-Apl-003688	Anas platyrhynchos	52.19	6.00e-134	471.00
IUUC-Aca-005222	Anolis carolinensis	50.94	1.00e-138	487.00
IUUC-Ame-010731	Astyanax mexicanus	63.01	8.00e-163	566.00
IUUC-Bta-013112	Bos taurus	62.94	1.00e-129	456.00
IUUC-Cja-019408	Callithrix jacchus	61.54	4.00e-130	458.00
IUUC-Cfa-020694	Canis familiaris	62.76	2.00e-129	456.00
IUUC-Cpo-021426	Cavia porcellus	60.05	1.00e-126	447.00
IUUC-Csa-023736	Chlorocebus sabaeus	61.33	7.00e-130	457.00
IUUC-Dre-027698	Danio rerio	60.28	2.00e-167	582.00
IUUC-Dno-029477	Dasypus novemcinctus	62.24	7.00e-127	447.00
IUUC-Dor-030572	Dipodomys ordii	58.55	3.00e-127	448.00
IUUC-Ete-032849	Echinops telfairi	48.31	7.00e-86	311.00
IUUC-Eca-033605	Equus caballus	50.45	1.00e-129	457.00
IUUC-Eeu-034683	Erinaceus europaeus	56.28	1.00e-53	203.00
IUUC-Fca-035928	Felis catus	62.76	2.00e-127	448.00
IUUC-Fal-036754	Ficedula albicollis	53.12	3.00e-145	508.00
IUUC-Gmo-038872	Gadus morhua	71.93	1.00e-162	565.00
IUUC-Gga-040988	Gallus gallus	53.12	3.00e-142	498.00
IUUC-Gac-042015	Gasterosteus aculeatus	74.61	0.00e+00	750.00
IUUC-Ggo-044749	Gorilla gorilla	61.79	3.00e-130	458.00
IUUC-Hsa-046944	Homo sapiens	64.30	2.00e-131	462.00
IUUC-Itr-048863	Ictidomys tridecemlineatus	48.57	8.00e-129	454.00
IUUC-Loc-052414	Lepisosteus oculatus	63.07	0.00e+00	641.00
IUUC-Mcc-054781	Macaca mulatta	61.79	3.00e-130	458.00
IUUC-Meu-056232	Macropus eugenii	50.50	8.00e-130	457.00
IUUC-Mga-059319	Meleagris gallopavo	52.94	1.00e-141	496.00
IUUC-Mmr-061636	Microcebus murinus	54.50	2.00e-55	209.00
IUUC-Mdo-062661	Monodelphis domestica	50.93	2.00e-132	466.00
IUUC-Mmu-063330	Mus musculus	63.28	4.00e-129	454.00
IUUC-Mpu-065757	Mustela putorius furo	63.02	7.00e-131	461.00
IUUC-Mlu-067712	Myotis lucifugus	64.06	4.00e-129	454.00
IUUC-Nle-069283	Nomascus leucogenys	61.33	2.00e-130	459.00
IUUC-Opr-070391	Ochotona princeps	63.28	4.00e-128	451.00
IUUC-Ont-071369	Oreochromis niloticus	76.73	0.00e+00	780.00
IUUC-Oan-073734	Ornithorhynchus anatinus	43.22	9.00e-59	220.00
IUUC-Ocu-074292	Oryctolagus cuniculus	50.89	3.00e-129	455.00
IUUC-Ola-087052	Oryzias latipes	82.62	0.00e+00	825.00
IUUC-Oga-088586	Otolemur garnettii	62.72	8.00e-127	447.00
IUUC-Oar-090156	Ovis aries	62.63	2.00e-128	452.00
IUUC-Ptr-091321	Pan troglodytes	61.79	3.00e-130	459.00
IUUC-Pan-092851	Papio anubis	61.79	3.00e-130	458.00
IUUC-Psi-093434	Pelodiscus sinensis	52.24	4.00e-140	491.00
IUUC-Pfo-097379	Poecilia formosa	92.66	0.00e+00	975.00
IUUC-Pab-097735	Pongo abelii	61.79	3.00e-130	458.00
IUUC-Pva-102125	Pteropus vampyrus	47.80	3.00e-129	455.00
IUUC-Rno-106121	Rattus norvegicus	63.28	4.00e-129	454.00
IUUC-Sha-107547	Sarcophilus harrisii	51.57	2.00e-130	459.00
IUUC-Sar-113650	Sorex araneus	44.55	2.00e-74	272.00
IUUC-Tgu-117175	Taeniopygia guttata	51.20	7.00e-144	504.00
IUUC-Tru-117545	Takifugu rubripes	76.54	0.00e+00	776.00
IUUC-Tsy-119586	Tarsius syrichta	55.21	3.00e-109	389.00
IUUC-Tni-120121	Tetraodon nigroviridis	69.64	0.00e+00	785.00
IUUC-Tbe-127548	Tupaia belangeri	51.82	1.00e-101	363.00
IUUC-Ttr-128374	Tursiops truncatus	59.28	2.00e-116	413.00
IUUC-Vpa-130464	Vicugna pacos	47.87	1.00e-81	296.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence