iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.40e-42	145.4	159	489

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw..kskkkavsprellkalkkeaee.fsgyeqqDaqEf 95
           +Gl+N+ +  Y+N vL +Ls++ +lr+++l+k++ +   + p ++  +l++ + +l++++w   + k++vsp+e+l+a+  ++++ f+ +eq D  +f
   Q: 159  VGLNNIKANDYCNVVLHALSHVGPLRDYFLQKQSYAHVVRPPGDSVFTLVQRFGELMRKMWnpRNFKSHVSPHEMLQAVVLWSSKrFQITEQGDPIDF 256
           6******************************988888889999******************999999********99988776666************ PP
   S: 96   laflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlk................sqikclecdnvssreepfldlslpvp 177
           l+++l++l+++lk                         +k  n+s++ ++F g++k                 q+   e  + ++++++f++l++++p
   Q: 257  LSWFLNTLHRALK------------------------GNKHPNSSILYKIFLGEMKiytrkmppvelddaakAQLLATEEYKDQVEDKNFIYLTCDLP 330
           ************3........................34445555555555555555555555555555555999999999999************** PP
   S: 178  gkeetkke.........slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefple.Ldlsp.f 264
                  e         +l ++L++f  + e e    y++ k     +  k++++++lP+++il +kRf  ++++ + ek+ + v+fp++ +d     
   Q: 331  PPPLFTDEfreniipqvNLYQLLSKFNGTAEKE----YKTYKA----NFMKRFEITRLPQFIILYIKRF--TKNTFFLEKNPTIVNFPIKhVDFGDiL 418
           555443334455566669999999999988887....666555....489*******************..8999**************99****954 PP
   S: 265  ctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkr 337
             ++ +k+ +++kY+L+a +vH G +++G Y a++ ++ ++ W+++ D +Vte+  + +     ++ Y+ +Y+r
   Q: 419  GMRQRDKDVKDTKYNLVANIVHDGDPKKGTYRAHILHKANGqWYEMQDLHVTEILPQMITL---TESYIQIYER 489
           4555666667*************************9964445*****************99...9*******98 PP

Organism

Drosophila melanogaster

Protein Sequence
(Fasta)

MAQTQAPAAK RMKLEKTPAN PVEEDETPSV FNPKYRVCPY LDTINRNLLD FDFEKLCSIS 60
LTRINVYACL VCGKYFQGRG TNTHAYTHSV GEAHHVFLNL HTLRFYCLPD NYEIIDSSLD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGCCAATCGA TAACTGCGGC CAGTCGGACA AACAGTCAAC AAAAGTCTTA ATTTTAGTTT 60
TATATGAATT ACTGACTGAA TCAGCTGGAA AAATGGCGCA AACGCAAGCT CCAGGTAGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR033809--USP39
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0071011--C:precatalytic spliceosome
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0000398--P:mRNA splicing, via spliceosome
GO:0016579--P:protein deubiquitination
GO:0000245--P:spliceosomal complex assembly

KEGG

dme:Dmel_CG7288

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000483	Aegilops tauschii	49.68	5.00e-125	440.00
IUUC-Aml-001846	Ailuropoda melanoleuca	64.71	6.00e-180	622.00
IUUC-Atr-002758	Amborella trichopoda	49.47	9.00e-129	452.00
IUUC-Apl-003336	Anas platyrhynchos	56.79	6.00e-104	370.00
IUUC-Aca-004846	Anolis carolinensis	64.73	1.00e-174	604.00
IUUC-Aly-005683	Arabidopsis lyrata	48.25	5.00e-115	407.00
IUUC-Ath-007661	Arabidopsis thaliana	49.56	1.00e-116	412.00
IUUC-Ago-007802	Ashbya gossypii	32.54	7.00e-65	240.00
IUUC-Acl-008304	Aspergillus clavatus	40.34	3.00e-94	338.00
IUUC-Afl-008735	Aspergillus flavus	57.63	6.00e-39	154.00
IUUC-Afu-009100	Aspergillus fumigatus	47.61	1.00e-90	326.00
IUUC-Ani-009138	Aspergillus nidulans	49.10	1.00e-95	343.00
IUUC-Ang-009661	Aspergillus niger	42.33	6.00e-97	347.00
IUUC-Aor-010235	Aspergillus oryzae	44.15	6.00e-81	294.00
IUUC-Ate-010346	Aspergillus terreus	41.36	2.00e-75	276.00
IUUC-Ame-011688	Astyanax mexicanus	65.57	2.00e-175	607.00
IUUC-Bgr-011998	Blumeria graminis	44.86	5.00e-108	384.00
IUUC-Bta-013407	Bos taurus	64.71	3.00e-179	620.00
IUUC-Bci-013977	Botrytis cinerea	46.35	9.00e-112	396.00
IUUC-Bdi-014361	Brachypodium distachyon	51.74	5.00e-130	457.00
IUUC-Bol-016317	Brassica oleracea	47.69	2.00e-114	405.00
IUUC-Bra-017952	Brassica rapa	47.47	5.00e-114	403.00
IUUC-Cel-018491	Caenorhabditis elegans	58.77	2.00e-157	548.00
IUUC-Cja-019134	Callithrix jacchus	64.71	1.00e-179	622.00
IUUC-Cfa-020098	Canis familiaris	64.71	3.00e-179	620.00
IUUC-Cpo-021595	Cavia porcellus	64.71	3.00e-179	620.00
IUUC-Cre-022886	Chlamydomonas reinhardtii	45.97	1.00e-30	124.00
IUUC-Csa-024121	Chlorocebus sabaeus	64.71	3.00e-179	620.00
IUUC-Cho-025057	Choloepus hoffmanni	56.86	2.00e-61	228.00
IUUC-Cin-025473	Ciona intestinalis	56.34	4.00e-56	210.00
IUUC-Csv-025815	Ciona savignyi	70.90	1.00e-105	376.00
IUUC-Cgl-026416	Colletotrichum gloeosporioides	43.29	3.00e-111	394.00
IUUC-Cne-026802	Cryptococcus neoformans	42.54	3.00e-100	358.00
IUUC-Dre-027870	Danio rerio	65.57	4.00e-175	606.00
IUUC-Dno-029655	Dasypus novemcinctus	64.91	4.00e-179	620.00
IUUC-Dor-030762	Dipodomys ordii	64.71	5.00e-179	620.00
IUUC-Dse-031441	Dothistroma septosporum	44.66	2.00e-109	389.00
IUUC-Ete-032841	Echinops telfairi	61.22	3.00e-167	581.00
IUUC-Eca-033463	Equus caballus	64.71	3.00e-179	620.00
IUUC-Eeu-034438	Erinaceus europaeus	58.65	4.00e-88	318.00
IUUC-Fca-035774	Felis catus	64.71	1.00e-179	622.00
IUUC-Fal-036988	Ficedula albicollis	64.72	0.00e+00	629.00
IUUC-Fox-037895	Fusarium oxysporum	44.71	3.00e-107	381.00
IUUC-Fso-038450	Fusarium solani	45.57	7.00e-108	383.00
IUUC-Gmo-038874	Gadus morhua	65.12	8.00e-175	605.00
IUUC-Ggr-040115	Gaeumannomyces graminis	41.13	5.00e-103	367.00
IUUC-Gac-041650	Gasterosteus aculeatus	64.33	1.00e-176	611.00
IUUC-Gma-043697	Glycine max	49.03	1.00e-126	446.00
IUUC-Ggo-044707	Gorilla gorilla	59.69	2.00e-160	558.00
IUUC-Hsa-046041	Homo sapiens	64.71	2.00e-179	620.00
IUUC-Hvu-047816	Hordeum vulgare	47.63	8.00e-116	409.00
IUUC-Itr-048945	Ictidomys tridecemlineatus	65.96	1.00e-128	451.00
IUUC-Lch-050419	Latimeria chalumnae	65.42	0.00e+00	628.00
IUUC-Lpe-051593	Leersia perrieri	51.31	4.00e-128	450.00
IUUC-Loc-052930	Lepisosteus oculatus	62.35	5.00e-176	609.00
IUUC-Lma-053256	Leptosphaeria maculans	44.59	3.00e-112	398.00
IUUC-Laf-053555	Loxodonta africana	64.84	7.00e-178	615.00
IUUC-Mcc-055630	Macaca mulatta	64.71	3.00e-179	620.00
IUUC-Meu-056579	Macropus eugenii	59.24	2.00e-108	385.00
IUUC-Mor-057078	Magnaporthe oryzae	44.11	3.00e-103	368.00
IUUC-Mpo-057607	Magnaporthe poae	37.79	4.00e-82	298.00
IUUC-Mtr-058644	Medicago truncatula	49.67	9.00e-125	439.00
IUUC-Mla-059120	Melampsora laricipopulina	40.95	3.00e-107	381.00
IUUC-Mvi-060429	Microbotryum violaceum	49.84	3.00e-77	281.00
IUUC-Mmr-061313	Microcebus murinus	64.71	2.00e-179	620.00
IUUC-Mdo-062801	Monodelphis domestica	65.13	3.00e-180	624.00
IUUC-Mmu-064424	Mus musculus	64.71	0.00e+00	628.00
IUUC-Mac-065115	Musa acuminata	50.97	5.00e-127	447.00
IUUC-Mpu-065980	Mustela putorius furo	62.89	2.00e-155	541.00
IUUC-Mlu-067007	Myotis lucifugus	64.91	2.00e-179	621.00
IUUC-Nfi-068274	Neosartorya fischeri	47.86	3.00e-92	332.00
IUUC-Ncr-068829	Neurospora crassa	46.58	2.00e-104	371.00
IUUC-Nle-069171	Nomascus leucogenys	64.71	8.00e-179	619.00
IUUC-Opr-070494	Ochotona princeps	57.73	4.00e-153	533.00
IUUC-Ont-072290	Oreochromis niloticus	64.21	3.00e-180	624.00
IUUC-Oan-073099	Ornithorhynchus anatinus	64.69	4.00e-178	616.00
IUUC-Ocu-074642	Oryctolagus cuniculus	64.71	5.00e-179	620.00
IUUC-Oba-075886	Oryza barthii	50.87	3.00e-128	451.00
IUUC-Obr-076220	Oryza brachyantha	50.66	8.00e-128	449.00
IUUC-Ogl-077682	Oryza glaberrima	50.87	1.00e-128	452.00
IUUC-Ogu-078492	Oryza glumaepatula	50.66	3.00e-128	451.00
IUUC-Oin-079956	Oryza indica	50.87	3.00e-128	451.00
IUUC-Olo-080239	Oryza longistaminata	45.22	3.00e-103	369.00
IUUC-Ome-081573	Oryza meridionalis	50.87	1.00e-128	452.00
IUUC-Oni-082975	Oryza nivara	50.87	3.00e-128	451.00
IUUC-Opu-083724	Oryza punctata	51.09	1.00e-128	452.00
IUUC-Oru-084566	Oryza rufipogon	50.87	2.00e-128	452.00
IUUC-Osa-086008	Oryza sativa	50.87	2.00e-128	451.00
IUUC-Ola-086967	Oryzias latipes	64.82	6.00e-180	622.00
IUUC-Olu-087614	Ostreococcus lucimarinus	41.83	1.00e-95	342.00
IUUC-Oga-088047	Otolemur garnettii	54.71	2.00e-114	405.00
IUUC-Oar-089393	Ovis aries	64.71	2.00e-179	621.00
IUUC-Ptr-090561	Pan troglodytes	64.71	3.00e-179	620.00
IUUC-Pan-091812	Papio anubis	64.71	2.00e-179	620.00
IUUC-Psi-093507	Pelodiscus sinensis	60.49	2.00e-100	358.00
IUUC-Pno-095104	Phaeosphaeria nodorum	42.83	2.00e-109	389.00
IUUC-Ppa-095995	Physcomitrella patens	52.59	2.00e-136	478.00
IUUC-Pfo-096754	Poecilia formosa	64.78	0.00e+00	626.00
IUUC-Pab-098053	Pongo abelii	64.71	3.00e-179	620.00
IUUC-Pop-099230	Populus trichocarpa	50.63	1.00e-130	459.00
IUUC-Pca-100407	Procavia capensis	57.89	4.00e-153	534.00
IUUC-Ppe-101699	Prunus persica	48.60	8.00e-126	443.00
IUUC-Pva-103159	Pteropus vampyrus	62.75	2.00e-168	584.00
IUUC-Pgr-103433	Puccinia graminis	45.55	7.00e-120	423.00
IUUC-Ptt-103701	Puccinia triticina	42.07	3.00e-105	374.00
IUUC-Pte-104281	Pyrenophora teres	42.91	5.00e-114	404.00
IUUC-Pyt-104714	Pyrenophora triticirepentis	43.48	4.00e-113	400.00
IUUC-Rno-105531	Rattus norvegicus	64.92	0.00e+00	629.00
IUUC-Sce-106368	Saccharomyces cerevisiae	30.77	1.00e-50	192.00
IUUC-Sha-107093	Sarcophilus harrisii	65.13	3.00e-179	620.00
IUUC-Sja-108004	Schizosaccharomyces japonicus	45.65	3.00e-120	424.00
IUUC-Spo-108018	Schizosaccharomyces pombe	44.89	6.00e-115	406.00
IUUC-Ssl-108460	Sclerotinia sclerotiorum	43.16	4.00e-100	357.00
IUUC-Smo-108892	Selaginella moellendorffii	51.21	9.00e-131	459.00
IUUC-Sit-110782	Setaria italica	52.48	5.00e-132	463.00
IUUC-Sly-111308	Solanum lycopersicum	51.20	1.00e-136	478.00
IUUC-Stu-112447	Solanum tuberosum	51.42	5.00e-137	480.00
IUUC-Sar-113352	Sorex araneus	62.60	8.00e-139	486.00
IUUC-Sbi-114806	Sorghum bicolor	51.30	2.00e-129	455.00
IUUC-Sre-115059	Sporisorium reilianum	39.22	1.00e-89	322.00
IUUC-Ssc-115677	Sus scrofa	65.65	2.00e-128	451.00
IUUC-Tru-118478	Takifugu rubripes	64.35	1.00e-179	621.00
IUUC-Tsy-119082	Tarsius syrichta	58.36	2.00e-126	444.00
IUUC-Tni-120419	Tetraodon nigroviridis	63.85	2.00e-173	600.00
IUUC-Tca-121294	Theobroma cacao	50.32	1.00e-134	472.00
IUUC-Tre-121962	Trichoderma reesei	45.82	6.00e-106	377.00
IUUC-Tvi-122280	Trichoderma virens	45.92	7.00e-112	396.00
IUUC-Tae-124442	Triticum aestivum	51.30	7.00e-131	459.00
IUUC-Tur-126551	Triticum urartu	51.30	3.00e-130	457.00
IUUC-Tme-126959	Tuber melanosporum	46.85	5.00e-114	404.00
IUUC-Tbe-127737	Tupaia belangeri	64.35	9.00e-173	599.00
IUUC-Ttr-129211	Tursiops truncatus	74.68	5.00e-107	380.00
IUUC-Uma-129591	Ustilago maydis	37.90	6.00e-95	340.00
IUUC-Vda-129674	Verticillium dahliae	41.51	1.00e-97	349.00
IUUC-Vpa-130793	Vicugna pacos	59.87	8.00e-156	542.00
IUUC-Xtr-132430	Xenopus tropicalis	63.77	1.00e-176	611.00
IUUC-Xma-133515	Xiphophorus maculatus	64.91	2.00e-180	624.00
IUUC-Yli-134488	Yarrowia lipolytica	38.68	7.00e-80	290.00
IUUC-Zma-134748	Zea mays	51.08	3.00e-130	457.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence