iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-033793

UUCD1 version

UUC-EqC-00474

Ensembl Protein ID

ENSECAP00000014414.1

UniProt Accession

F6XN76; F6XN76_HORSE

Protein Name

E3 ubiquitin-protein ligase

Gene Name

ITCH

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000016216.1	ENSECAT00000017728.1	ENSECAP00000014414.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.90e-136	454.5	540	872

Active Site

Position(s)	Description	Evidence
841	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl+v f gEegld+gGv+re+++lls+e+ np+++lf+y  +d+++lq+np+s++ np+hlk+F+f+Gr++++al++g+++d+
   Q: 540  PQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYI-NPDHLKYFRFIGRFIAMALFHGKFIDT 627
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+k++ l+dle++dpe+y+sl ++ken   +iee+gl++ fsv++eilge+k+++Lkp+G ni Vt+eNkeeY++ v+e
   Q: 628  GFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKEN---NIEECGLEMYFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAE 713
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +rl +g++eq++af eGfne++p++ l++F+++ele+l+cG++eid++d+++++ y++ yt++s++i wFw++++e+++e+r ++LqFv
   Q: 714  WRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRH-YTRTSKQIMWFWQFVKEIDNEKRMRLLQFV 801
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGfa+l+    p++f+i+k +++++lP+s+TCfn+L+LP+Y+s+e+lkekLl+Aieet+gF++
   Q: 802  TGTCRLPVGGFADLMgingPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQ 872
           *********************************************************************96 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

CCVQVCRPIG GMSDSGSQLG SMGSLTMKSQ LQITVISAKL KENKKNWFGP SPYVEVTVDG 60
QSKKTEKCNN TSSPKWKQPL TVIVTPVSKL HFRVWSHQTL KSDVLLGTAA LDIYETLKSN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGCTGTGTTC AGGTTTGCCG TCCTATTGGT GGTATGTCTG ACAGTGGATC ACAGCTTGGT 60
TCAATGGGTA GCCTGACCAT GAAATCACAA CTTCAGATCA CTGGTAAGTC TTAAAAAGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005938--C:cell cortex
GO:0031410--C:cytoplasmic vesicle
GO:0070062--C:extracellular exosome
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0016874--F:ligase activity
GO:0043021--F:ribonucleoprotein complex binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0046642--P:negative regulation of alpha-beta T cell proliferation
GO:0043066--P:negative regulation of apoptotic process
GO:0050687--P:negative regulation of defense response to virus
GO:0046329--P:negative regulation of JNK cascade
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0045732--P:positive regulation of protein catabolic process
GO:0002669--P:positive regulation of T cell anergy
GO:0035519--P:protein K29-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0090085--P:regulation of protein deubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002302	Ailuropoda melanoleuca	97.36	0.00e+00	1629.00
IUUC-Apl-003752	Anas platyrhynchos	83.85	0.00e+00	1454.00
IUUC-Aca-005338	Anolis carolinensis	81.31	0.00e+00	1439.00
IUUC-Ago-007742	Ashbya gossypii	48.71	8.00e-162	564.00
IUUC-Ame-010601	Astyanax mexicanus	88.07	0.00e+00	1120.00
IUUC-Bta-012782	Bos taurus	97.56	0.00e+00	1595.00
IUUC-Cja-018899	Callithrix jacchus	93.47	0.00e+00	1578.00
IUUC-Cfa-020648	Canis familiaris	96.34	0.00e+00	1592.00
IUUC-Cpo-022073	Cavia porcellus	97.33	0.00e+00	1642.00
IUUC-Csa-023252	Chlorocebus sabaeus	96.98	0.00e+00	1639.00
IUUC-Cho-024695	Choloepus hoffmanni	90.14	0.00e+00	1618.00
IUUC-Dre-028451	Danio rerio	73.71	0.00e+00	1308.00
IUUC-Dno-029884	Dasypus novemcinctus	97.10	0.00e+00	1674.00
IUUC-Eeu-034716	Erinaceus europaeus	93.01	0.00e+00	891.00
IUUC-Fca-035605	Felis catus	97.52	0.00e+00	1651.00
IUUC-Fal-037126	Ficedula albicollis	84.01	0.00e+00	1449.00
IUUC-Gmo-038596	Gadus morhua	80.72	0.00e+00	1011.00
IUUC-Gga-040832	Gallus gallus	84.00	0.00e+00	1467.00
IUUC-Gac-041520	Gasterosteus aculeatus	88.74	0.00e+00	1118.00
IUUC-Ggo-044535	Gorilla gorilla	93.59	0.00e+00	1621.00
IUUC-Hsa-046564	Homo sapiens	93.24	0.00e+00	1630.00
IUUC-Itr-048918	Ictidomys tridecemlineatus	96.06	0.00e+00	1575.00
IUUC-Kpa-049273	Komagataella pastoris	49.05	9.00e-163	566.00
IUUC-Lch-050454	Latimeria chalumnae	77.53	0.00e+00	1397.00
IUUC-Loc-052647	Lepisosteus oculatus	74.92	0.00e+00	1357.00
IUUC-Laf-054383	Loxodonta africana	97.69	0.00e+00	1656.00
IUUC-Mcc-055532	Macaca mulatta	96.98	0.00e+00	1640.00
IUUC-Mga-059661	Meleagris gallopavo	83.48	0.00e+00	1457.00
IUUC-Mmr-061135	Microcebus murinus	97.22	0.00e+00	1664.00
IUUC-Mdo-062505	Monodelphis domestica	86.96	0.00e+00	1504.00
IUUC-Mmu-063375	Mus musculus	95.49	0.00e+00	1593.00
IUUC-Mpu-066203	Mustela putorius furo	97.37	0.00e+00	1630.00
IUUC-Mlu-067837	Myotis lucifugus	97.37	0.00e+00	1660.00
IUUC-Nle-069244	Nomascus leucogenys	96.06	0.00e+00	1621.00
IUUC-Opr-070585	Ochotona princeps	90.70	0.00e+00	1579.00
IUUC-Ont-071798	Oreochromis niloticus	87.93	0.00e+00	1142.00
IUUC-Oan-073679	Ornithorhynchus anatinus	66.67	0.00e+00	972.00
IUUC-Ocu-074298	Oryctolagus cuniculus	97.57	0.00e+00	1637.00
IUUC-Ola-086526	Oryzias latipes	85.41	0.00e+00	1120.00
IUUC-Oga-088167	Otolemur garnettii	90.06	0.00e+00	1511.00
IUUC-Oar-090316	Ovis aries	80.94	0.00e+00	1208.00
IUUC-Ptr-090819	Pan troglodytes	92.46	0.00e+00	1591.00
IUUC-Pan-092454	Papio anubis	96.78	0.00e+00	1650.00
IUUC-Psi-093319	Pelodiscus sinensis	82.37	0.00e+00	1425.00
IUUC-Pfo-097346	Poecilia formosa	84.84	0.00e+00	1106.00
IUUC-Pab-097580	Pongo abelii	86.49	0.00e+00	1471.00
IUUC-Pca-100923	Procavia capensis	79.58	0.00e+00	1369.00
IUUC-Pva-103209	Pteropus vampyrus	96.52	0.00e+00	1590.00
IUUC-Rno-104924	Rattus norvegicus	94.74	0.00e+00	1612.00
IUUC-Sha-107175	Sarcophilus harrisii	89.08	0.00e+00	1504.00
IUUC-Sja-107941	Schizosaccharomyces japonicus	46.70	2.00e-159	556.00
IUUC-Sar-113761	Sorex araneus	87.03	0.00e+00	1494.00
IUUC-Tgu-116632	Taeniopygia guttata	80.92	0.00e+00	1332.00
IUUC-Tru-118442	Takifugu rubripes	88.75	0.00e+00	1120.00
IUUC-Tsy-119198	Tarsius syrichta	90.26	0.00e+00	1521.00
IUUC-Tni-120168	Tetraodon nigroviridis	86.88	0.00e+00	1060.00
IUUC-Tbe-127756	Tupaia belangeri	77.96	0.00e+00	1308.00
IUUC-Ttr-128504	Tursiops truncatus	92.11	0.00e+00	1199.00
IUUC-Vpa-130103	Vicugna pacos	83.08	0.00e+00	1404.00
IUUC-Xtr-132885	Xenopus tropicalis	76.13	0.00e+00	1379.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence