iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oga-088643

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAQR03070700

Gene Name

FBXW8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000012368.2	ENSOGAT00000012373.2	ENSOGAP00000011071.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.00e-12	46.8	472	502
UBD/Beta-Prp	1.50e-43	149.1	206	505

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    HtdsvtclafsdtllvsGsdDgtikvWDlrt 32
           H+ +v++++ +d+ +vsG+  g + vWD+r 
   Q: 472  HQLGVSAIQMDDWKIVSGGEEGLVSVWDYRM 502
           777899999966****************875 PP

UBD/Beta-Prp

   S: 8    hhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheae.........vtavkfspdgkilvtgseDrtikvwdlstgkcv 87
            +++v+++v+   ++ ++++g+++g ++vwd++t+++++ + + e e         v+ v+++++  + v + eD+++++wdl+tgk+ 
   Q: 206  VPDAVLCDVHS--HDGVVIAGYTSGDVRVWDTRTWDYVAPFLESEYEedepgmqpyVSFVRINSS--LAVAAYEDGILNIWDLRTGKYP 290
           57889997777..9***********************5555444444455569999*********..9********************* PP
   S: 88   htlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdg.nllvsGslDrtvrlWdlktgkllrtl 175
           ++  +h++++ +l++s+++  ++++s+ ++++++  e+g++  + + + +++v ++++ pd+ ++ v+ ++ + + ++ lk ++  rtl
   Q: 291  IHRFEHDARIQALALSQEDAAVATASAFDVVMLYPNEEGYWQISAEFEVQKLVDYLEIVPDTgRYPVAVATAGDL-VYLLKAEDSARTL 378
           *9999*********************************************************************9.5************ PP
   S: 176  tgghtdsvyslsfdsng.....kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfs.pnderlvsgssDgsiriWdlrsgdllk 258
                ++v++l+++ n+     k+l ++ + +++ +++l++++c+ +l +    +++v++  +  +++vsg++D+ +ri+dlr++++  
   Q: 379  HYVYGQPVTCLDVSANQvafgvKSLGWVYEGNKILVYSLEAERCLSKLGNALGDFTCVNLRnSPPNLMVSGNMDRRVRIHDLRTDKIAL 467
           999*********************************************************978899*********************** PP
   S: 259  tlqlhnssvisvavlsfgdnvlvlgsedskvniwklkknep 299
           +l+ h+  v+++++   +d+++v+g+e++ v +w++++n++
   Q: 468  SLSAHQLGVSAIQM---DDWKIVSGGEEGLVSVWDYRMNQK 505
           ******99999999...********************9875 PP

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

MDDHSLEEFR RRWQEELSQA QAQRKRRRPE AAERRRPEVA PGRGEQASGY LALAQGLLEG 60
AGRPPAARAT RAEREDAASR SRSPPAREDA GGGEQLVDQL IRDLNEMDDV PFFDIQLPYE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGACGACC ACAGCTTAGA GGAGTTCCGT CGGCGCTGGC AGGAGGAGCT CTCGCAGGCC 60
CAGGCGCAGA GGAAGAGGCG ACGACCCGAG GCTGCAGAGC GGCGGAGGCC GGAGGTGGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR001810--F-box_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12937--F-box-like

SMART

SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:1990393--C:3M complex
GO:0031467--C:Cul7-RING ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008283--P:cell proliferation
GO:0007030--P:Golgi organization
GO:0060716--P:labyrinthine layer blood vessel development
GO:0050775--P:positive regulation of dendrite morphogenesis
GO:0060712--P:spongiotrophoblast layer development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001274	Ailuropoda melanoleuca	94.02	0.00e+00	1026.00
IUUC-Apl-003239	Anas platyrhynchos	61.52	0.00e+00	719.00
IUUC-Aca-004756	Anolis carolinensis	62.87	8.00e-143	499.00
IUUC-Ame-011198	Astyanax mexicanus	46.50	6.00e-60	224.00
IUUC-Bta-012430	Bos taurus	61.01	6.00e-158	550.00
IUUC-Cja-019131	Callithrix jacchus	82.11	0.00e+00	925.00
IUUC-Cfa-021022	Canis familiaris	84.53	0.00e+00	999.00
IUUC-Cpo-021898	Cavia porcellus	83.14	0.00e+00	993.00
IUUC-Csa-023452	Chlorocebus sabaeus	86.12	0.00e+00	1005.00
IUUC-Cho-024759	Choloepus hoffmanni	80.87	0.00e+00	902.00
IUUC-Dre-028123	Danio rerio	45.37	6.00e-157	547.00
IUUC-Dno-029045	Dasypus novemcinctus	94.53	0.00e+00	910.00
IUUC-Dor-030433	Dipodomys ordii	82.91	0.00e+00	846.00
IUUC-Ete-032465	Echinops telfairi	86.67	0.00e+00	820.00
IUUC-Eca-034134	Equus caballus	93.90	0.00e+00	974.00
IUUC-Eeu-035047	Erinaceus europaeus	82.45	0.00e+00	838.00
IUUC-Fca-036574	Felis catus	93.47	0.00e+00	955.00
IUUC-Fal-037665	Ficedula albicollis	62.08	0.00e+00	638.00
IUUC-Gmo-039137	Gadus morhua	40.10	1.00e-69	256.00
IUUC-Gga-040711	Gallus gallus	60.75	0.00e+00	707.00
IUUC-Gac-041675	Gasterosteus aculeatus	54.21	7.00e-59	219.00
IUUC-Ggo-045331	Gorilla gorilla	87.60	0.00e+00	893.00
IUUC-Hsa-046240	Homo sapiens	86.96	0.00e+00	996.00
IUUC-Itr-048412	Ictidomys tridecemlineatus	93.50	0.00e+00	947.00
IUUC-Loc-052631	Lepisosteus oculatus	51.85	7.00e-176	610.00
IUUC-Laf-054127	Loxodonta africana	81.82	1.00e-65	241.00
IUUC-Mcc-055083	Macaca mulatta	86.96	0.00e+00	995.00
IUUC-Mga-060113	Meleagris gallopavo	64.04	0.00e+00	684.00
IUUC-Mmr-061780	Microcebus murinus	91.99	0.00e+00	1007.00
IUUC-Mdo-063066	Monodelphis domestica	64.34	0.00e+00	768.00
IUUC-Mmu-063524	Mus musculus	83.11	0.00e+00	917.00
IUUC-Mpu-066913	Mustela putorius furo	93.47	0.00e+00	988.00
IUUC-Mlu-067924	Myotis lucifugus	90.10	0.00e+00	1009.00
IUUC-Nle-069558	Nomascus leucogenys	86.04	0.00e+00	931.00
IUUC-Opr-070506	Ochotona princeps	89.26	0.00e+00	988.00
IUUC-Ont-071514	Oreochromis niloticus	46.91	8.00e-153	533.00
IUUC-Ocu-074477	Oryctolagus cuniculus	91.34	0.00e+00	939.00
IUUC-Ola-087416	Oryzias latipes	45.63	2.00e-155	542.00
IUUC-Oar-090172	Ovis aries	91.46	0.00e+00	947.00
IUUC-Ptr-090870	Pan troglodytes	87.12	0.00e+00	993.00
IUUC-Pan-092017	Papio anubis	85.79	0.00e+00	1005.00
IUUC-Psi-093794	Pelodiscus sinensis	66.87	0.00e+00	702.00
IUUC-Pfo-096192	Poecilia formosa	51.87	2.00e-155	542.00
IUUC-Pab-097882	Pongo abelii	85.45	0.00e+00	968.00
IUUC-Pca-100902	Procavia capensis	81.34	2.00e-160	559.00
IUUC-Pva-103139	Pteropus vampyrus	90.65	0.00e+00	1032.00
IUUC-Rno-105798	Rattus norvegicus	78.69	0.00e+00	938.00
IUUC-Sha-106576	Sarcophilus harrisii	65.65	0.00e+00	721.00
IUUC-Ssc-115923	Sus scrofa	79.56	0.00e+00	966.00
IUUC-Tgu-116667	Taeniopygia guttata	58.13	1.00e-124	439.00
IUUC-Tru-118323	Takifugu rubripes	46.28	7.00e-149	520.00
IUUC-Tsy-118818	Tarsius syrichta	78.74	3.00e-113	401.00
IUUC-Tni-120438	Tetraodon nigroviridis	44.10	2.00e-145	509.00
IUUC-Tbe-127784	Tupaia belangeri	95.15	8.00e-116	410.00
IUUC-Ttr-128288	Tursiops truncatus	83.28	0.00e+00	874.00
IUUC-Vpa-130307	Vicugna pacos	87.48	0.00e+00	850.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence