iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046638

UUCD1 version

UUC-HoS-01066

Ensembl Protein ID

ENSP00000380178.2

UniProt Accession

P62253; B2R7P2; D3DTK0; Q99462; UB2G1_HUMAN

Genbank Protein ID

BAA11410.1; AAP36084.1; BAG35889.1; EAW90445.1; EAW90446.1; AAH02775.1; AAH26288.2

Protein Name

Ubiquitin-conjugating enzyme E2 G1; E2 ubiquitin-conjugating enzyme G1; E217K; UBC7; Ubiquitin carrier protein G1; Ubiquitin-protein ligase G1; Ubiquitin-conjugating enzyme E2 G1, N-terminally processed

Genbank Nucleotide ID

D78514; BT007416; AK313059; CH471108; CH471108; BC002775; BC026288

Gene Name

UBE2G1; UBE2G

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000132388.12	ENST00000396981.6	ENSP00000380178.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	TargetScan	RepTar	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
UniProt	PHOSIDA	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E2/UBC	E2_UBC	19651899; 19103148; 16437165; 16847254

Classification

Family	E-value	Score	Start	End
E2/UBC	3.50e-50	171.0	10	158

Active Site

Position(s)	Description	Evidence
90	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 2    lkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilk...... 87
           l+++l+el+k+p+eg+sa++ d++dl++wevli+Gp+dt YeggvFk++++fp+dYP++PPk+kf+t+i+hPnv++nG+vC+sil+      
   Q: 10   LRRQLAELNKNPVEGFSAGLIDDNDLYRWEVLIIGPPDTLYEGGVFKAHLTFPKDYPLRPPKMKFITEIWHPNVDKNGDVCISILHepgedk 101
           6799*********************************************************************************8888899 PP
   S: 88   .....eeekWspalsvesvllsiqsllaepnpesplneeaaellkknre.eykkkvr 138
                +ee+W p ++ve++++s++s+la+pn +sp+n++aa++++++r+ e+k+kv 
   Q: 102  ygyekPEERWLPIHTVETIMISVISMLADPNGDSPANVDAAKEWREDRNgEFKRKVA 158
           999999******************************************989999985 PP

Organism

Homo sapiens

Functional Description
(View)

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. May be involved in degradation of muscle-specific proteins. Mediates polyubiquitination of CYP3A4.

Protein Sequence
(Fasta)

MTELQSALLL RRQLAELNKN PVEGFSAGLI DDNDLYRWEV LIIGPPDTLY EGGVFKAHLT 60
FPKDYPLRPP KMKFITEIWH PNVDKNGDVC ISILHEPGED KYGYEKPEER WLPIHTVETI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCGGGGGAA GGCACCGGTG GGGCCGACGG GCGGGTTGAA GGAGGGAAGC GGGCGAGCGA 60
AGTCCCAGTG CGCGCCGCGG CAGCCCGGGC ACCCTCCCCT TCCGGGCGTG AGTCGCTGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005524--F:ATP binding
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0044257--P:cellular protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0016567--P:protein ubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:7326

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000411	Aegilops tauschii	46.63	3.00e-41	161.00
IUUC-Aml-001379	Ailuropoda melanoleuca	95.76	4.00e-93	333.00
IUUC-Atr-003150	Amborella trichopoda	63.82	6.00e-47	179.00
IUUC-Apl-003579	Anas platyrhynchos	94.08	3.00e-93	333.00
IUUC-Aca-005146	Anolis carolinensis	99.36	1.00e-90	325.00
IUUC-Aly-005452	Arabidopsis lyrata	64.90	4.00e-52	196.00
IUUC-Ath-007258	Arabidopsis thaliana	63.58	4.00e-51	193.00
IUUC-Afl-008660	Aspergillus flavus	54.22	1.00e-47	182.00
IUUC-Aor-009951	Aspergillus oryzae	54.22	9.00e-48	182.00
IUUC-Ame-010634	Astyanax mexicanus	98.46	5.00e-76	280.00
IUUC-Bta-013324	Bos taurus	100.00	2.00e-89	321.00
IUUC-Bdi-014838	Brachypodium distachyon	61.82	2.00e-55	207.00
IUUC-Bol-016592	Brassica oleracea	63.25	2.00e-53	201.00
IUUC-Bra-017324	Brassica rapa	64.24	2.00e-52	197.00
IUUC-Cel-018162	Caenorhabditis elegans	74.07	2.00e-72	264.00
IUUC-Cja-018734	Callithrix jacchus	94.01	2.00e-91	327.00
IUUC-Cfa-020846	Canis familiaris	96.47	1.00e-95	341.00
IUUC-Cpo-022207	Cavia porcellus	99.36	3.00e-91	326.00
IUUC-Cre-022895	Chlamydomonas reinhardtii	66.87	5.00e-59	219.00
IUUC-Csa-024193	Chlorocebus sabaeus	100.00	2.00e-89	321.00
IUUC-Cho-024621	Choloepus hoffmanni	59.48	2.00e-43	168.00
IUUC-Cin-025131	Ciona intestinalis	68.86	5.00e-68	249.00
IUUC-Csv-026074	Ciona savignyi	74.34	6.00e-68	249.00
IUUC-Cne-026796	Cryptococcus neoformans	57.40	5.00e-49	187.00
IUUC-Cme-027321	Cyanidioschyzon merolae	59.51	1.00e-50	191.00
IUUC-Dre-028653	Danio rerio	98.82	9.00e-98	348.00
IUUC-Dno-029479	Dasypus novemcinctus	100.00	2.00e-89	321.00
IUUC-Dse-031230	Dothistroma septosporum	54.88	2.00e-49	188.00
IUUC-Dme-032132	Drosophila melanogaster	84.25	2.00e-72	264.00
IUUC-Ete-032885	Echinops telfairi	100.00	1.00e-87	315.00
IUUC-Eca-034057	Equus caballus	99.36	1.00e-90	324.00
IUUC-Eeu-035128	Erinaceus europaeus	77.92	9.00e-64	235.00
IUUC-Fca-035835	Felis catus	99.36	1.00e-90	325.00
IUUC-Fal-036778	Ficedula albicollis	100.00	2.00e-89	321.00
IUUC-Gmo-039029	Gadus morhua	94.19	1.00e-91	328.00
IUUC-Gga-040950	Gallus gallus	100.00	2.00e-89	321.00
IUUC-Gac-042438	Gasterosteus aculeatus	93.10	1.00e-85	308.00
IUUC-Gma-044131	Glycine max	65.56	4.00e-46	177.00
IUUC-Ggo-044826	Gorilla gorilla	100.00	2.00e-89	321.00
IUUC-Hvu-047065	Hordeum vulgare	59.60	3.00e-48	185.00
IUUC-Itr-048581	Ictidomys tridecemlineatus	100.00	3.00e-69	253.00
IUUC-Lch-050446	Latimeria chalumnae	99.41	2.00e-98	350.00
IUUC-Lpe-051124	Leersia perrieri	63.27	8.00e-50	189.00
IUUC-Loc-052277	Lepisosteus oculatus	100.00	2.00e-89	321.00
IUUC-Lma-053320	Leptosphaeria maculans	57.50	2.00e-48	185.00
IUUC-Laf-053491	Loxodonta africana	100.00	2.00e-89	321.00
IUUC-Mcc-055624	Macaca mulatta	94.05	1.00e-90	325.00
IUUC-Meu-056870	Macropus eugenii	98.05	5.00e-84	302.00
IUUC-Mtr-058406	Medicago truncatula	63.58	8.00e-52	196.00
IUUC-Mla-059165	Melampsora laricipopulina	58.14	2.00e-59	221.00
IUUC-Mga-060005	Meleagris gallopavo	100.00	2.00e-90	324.00
IUUC-Mvi-060318	Microbotryum violaceum	65.36	8.00e-55	206.00
IUUC-Mmr-061442	Microcebus murinus	100.00	2.00e-89	321.00
IUUC-Mdo-062364	Monodelphis domestica	97.65	2.00e-97	347.00
IUUC-Mmu-064163	Mus musculus	100.00	2.00e-89	321.00
IUUC-Mac-065294	Musa acuminata	62.25	1.00e-50	192.00
IUUC-Mpu-066561	Mustela putorius furo	94.12	2.00e-93	333.00
IUUC-Mlu-067331	Myotis lucifugus	100.00	2.00e-89	321.00
IUUC-Nle-069559	Nomascus leucogenys	100.00	3.00e-56	209.00
IUUC-Opr-070958	Ochotona princeps	100.00	6.00e-90	322.00
IUUC-Ont-071843	Oreochromis niloticus	96.47	7.00e-96	342.00
IUUC-Oan-073302	Ornithorhynchus anatinus	100.00	3.00e-56	209.00
IUUC-Ocu-074321	Oryctolagus cuniculus	94.64	6.00e-92	329.00
IUUC-Oba-075155	Oryza barthii	63.27	1.00e-49	188.00
IUUC-Obr-076863	Oryza brachyantha	61.90	3.00e-49	187.00
IUUC-Ogl-077935	Oryza glaberrima	63.27	1.00e-49	188.00
IUUC-Ogu-078510	Oryza glumaepatula	63.27	1.00e-49	188.00
IUUC-Oin-080104	Oryza indica	63.27	1.00e-49	188.00
IUUC-Olo-080294	Oryza longistaminata	63.27	1.00e-49	188.00
IUUC-Ome-081190	Oryza meridionalis	58.33	2.00e-52	198.00
IUUC-Oni-082689	Oryza nivara	63.27	1.00e-49	188.00
IUUC-Opu-083784	Oryza punctata	63.27	1.00e-49	188.00
IUUC-Oru-084660	Oryza rufipogon	63.27	1.00e-49	188.00
IUUC-Osa-086247	Oryza sativa	63.27	1.00e-49	188.00
IUUC-Ola-087259	Oryzias latipes	94.77	4.00e-87	313.00
IUUC-Olu-087887	Ostreococcus lucimarinus	64.81	4.00e-64	236.00
IUUC-Oga-088473	Otolemur garnettii	94.71	5.00e-94	336.00
IUUC-Oar-090047	Ovis aries	100.00	2.00e-90	324.00
IUUC-Ptr-091331	Pan troglodytes	100.00	6.00e-90	322.00
IUUC-Pan-092230	Papio anubis	100.00	2.00e-89	321.00
IUUC-Psi-093996	Pelodiscus sinensis	100.00	2.00e-90	324.00
IUUC-Ppa-095611	Physcomitrella patens	63.10	3.00e-62	230.00
IUUC-Pfo-096159	Poecilia formosa	97.06	3.00e-96	343.00
IUUC-Pab-098727	Pongo abelii	100.00	2.00e-89	321.00
IUUC-Pop-099881	Populus trichocarpa	64.46	3.00e-59	220.00
IUUC-Pca-100369	Procavia capensis	96.47	4.00e-86	310.00
IUUC-Ppe-101778	Prunus persica	65.56	2.00e-52	198.00
IUUC-Pva-103074	Pteropus vampyrus	100.00	8.00e-90	323.00
IUUC-Pgr-103274	Puccinia graminis	58.46	1.00e-47	182.00
IUUC-Rno-104929	Rattus norvegicus	100.00	2.00e-89	321.00
IUUC-Sha-106753	Sarcophilus harrisii	97.65	2.00e-97	347.00
IUUC-Sja-107917	Schizosaccharomyces japonicus	69.75	3.00e-48	184.00
IUUC-Spo-108104	Schizosaccharomyces pombe	66.27	4.00e-63	233.00
IUUC-Smo-109401	Selaginella moellendorffii	60.48	2.00e-47	181.00
IUUC-Sit-110784	Setaria italica	63.95	3.00e-50	190.00
IUUC-Sly-111843	Solanum lycopersicum	61.11	3.00e-54	204.00
IUUC-Stu-112654	Solanum tuberosum	64.38	1.00e-50	192.00
IUUC-Sar-113227	Sorex araneus	64.12	2.00e-53	201.00
IUUC-Sbi-113787	Sorghum bicolor	61.21	1.00e-54	205.00
IUUC-Sre-114933	Sporisorium reilianum	60.48	3.00e-54	204.00
IUUC-Ssc-115912	Sus scrofa	93.53	1.00e-92	331.00
IUUC-Tgu-116635	Taeniopygia guttata	100.00	2.00e-90	324.00
IUUC-Tru-117873	Takifugu rubripes	93.37	5.00e-91	326.00
IUUC-Tsy-119168	Tarsius syrichta	100.00	5.00e-90	323.00
IUUC-Tni-119853	Tetraodon nigroviridis	93.41	3.00e-90	323.00
IUUC-Tca-121649	Theobroma cacao	63.51	6.00e-51	192.00
IUUC-Tae-123772	Triticum aestivum	61.73	3.00e-54	203.00
IUUC-Tur-126873	Triticum urartu	61.18	8.00e-51	194.00
IUUC-Tbe-127917	Tupaia belangeri	100.00	6.00e-90	322.00
IUUC-Ttr-128609	Tursiops truncatus	100.00	3.00e-89	320.00
IUUC-Uma-129506	Ustilago maydis	61.08	6.00e-55	206.00
IUUC-Vpa-130208	Vicugna pacos	100.00	1.00e-90	325.00
IUUC-Vvi-131730	Vitis vinifera	64.86	4.00e-52	197.00
IUUC-Xtr-131942	Xenopus tropicalis	99.35	4.00e-89	320.00
IUUC-Xma-134050	Xiphophorus maculatus	97.06	3.00e-96	343.00
IUUC-Zma-135532	Zea mays	63.95	7.00e-51	192.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence