iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mga-059570

Ensembl Protein ID

ENSMGAP00000006505.2

UniProt Accession

G1N409; G1N409_MELGA

Protein Name

Inhibitor of growth protein

Gene Name

ING2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000006495.2	ENSMGAT00000007258.2	ENSMGAP00000006505.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	6.30e-09	35.6	156	202

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCek..Cr.ewfHpaClklsveeelpnsekwiCpkCr 52
           ++C +C + + +e  ++ C++  C  ewfH+ C++l+    +p+ + w+CpkCr
   Q: 156  TYC-LCNQVSYGE--MIGCDNeqCPiEWFHFSCVGLT---YKPKGK-WYCPKCR 202
           69*.*******99..*****999*99***********...888886.******8 PP

Organism

Meleagris gallopavo

Protein Sequence
(Fasta)

EALKEIDDVY EKYKSENDPV QKKRLQQHLQ RALINSQELG DEKIQIVTQM LELVENRARQ 60
METHSQCFQD LSENDKPLEK AKMESCQPER SSRRPRRQRT SESRDLCHIA NGIDDCDDQP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAAGCTTTAA AAGAAATAGA CGATGTCTAT GAAAAATACA AGTCCGAGAA CGATCCTGTT 60
CAGAAGAAAC GCTTGCAGCA GCATCTCCAG CGTGCTTTAA TCAACAGTCA AGAACTCGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR028639--ING2
IPR028651--ING_fam
IPR024610--ING_N_histone_binding
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF12998--ING

SMART

SM00249--PHD

Gene Ontology

GO:0016602--C:CCAAT-binding factor complex
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0005886--C:plasma membrane
GO:0016580--C:Sin3 complex
GO:0003682--F:chromatin binding
GO:0003677--F:DNA binding
GO:0035091--F:phosphatidylinositol binding
GO:0008270--F:zinc ion binding
GO:0016569--P:covalent chromatin modification
GO:0030317--P:flagellated sperm motility
GO:0048133--P:male germ-line stem cell asymmetric division
GO:0007141--P:male meiosis I
GO:2001234--P:negative regulation of apoptotic signaling pathway
GO:0008285--P:negative regulation of cell proliferation
GO:0031065--P:positive regulation of histone deacetylation
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0030511--P:positive regulation of transforming growth factor beta receptor signaling pathway
GO:2000772--P:regulation of cellular senescence
GO:0072520--P:seminiferous tubule development
GO:0007286--P:spermatid development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002213	Ailuropoda melanoleuca	90.15	6.00e-82	296.00
IUUC-Apl-003705	Anas platyrhynchos	99.10	4.00e-103	366.00
IUUC-Aca-004990	Anolis carolinensis	88.79	6.00e-91	326.00
IUUC-Ame-011426	Astyanax mexicanus	62.96	5.00e-65	240.00
IUUC-Bta-012721	Bos taurus	89.16	2.00e-81	294.00
IUUC-Cja-018960	Callithrix jacchus	88.42	5.00e-73	266.00
IUUC-Cfa-020869	Canis familiaris	89.66	2.00e-81	294.00
IUUC-Cpo-021414	Cavia porcellus	87.68	2.00e-79	288.00
IUUC-Csa-023304	Chlorocebus sabaeus	89.47	3.00e-74	271.00
IUUC-Dre-028562	Danio rerio	67.09	1.00e-69	255.00
IUUC-Dno-029945	Dasypus novemcinctus	90.15	9.00e-83	299.00
IUUC-Dor-030141	Dipodomys ordii	88.18	4.00e-78	283.00
IUUC-Ete-032709	Echinops telfairi	86.55	5.00e-88	317.00
IUUC-Eca-033432	Equus caballus	89.66	1.00e-80	292.00
IUUC-Eeu-035285	Erinaceus europaeus	90.64	5.00e-82	296.00
IUUC-Fca-036467	Felis catus	89.66	5.00e-81	293.00
IUUC-Fal-036700	Ficedula albicollis	98.65	1.00e-102	365.00
IUUC-Gmo-038748	Gadus morhua	61.28	2.00e-69	254.00
IUUC-Gga-040175	Gallus gallus	99.55	3.00e-104	370.00
IUUC-Gac-041403	Gasterosteus aculeatus	63.09	5.00e-71	260.00
IUUC-Hsa-045837	Homo sapiens	89.47	3.00e-74	271.00
IUUC-Itr-049062	Ictidomys tridecemlineatus	89.16	6.00e-81	293.00
IUUC-Lch-049965	Latimeria chalumnae	84.75	4.00e-86	310.00
IUUC-Laf-053353	Loxodonta africana	87.44	1.00e-88	318.00
IUUC-Mcc-055155	Macaca mulatta	88.51	2.00e-64	237.00
IUUC-Meu-056470	Macropus eugenii	89.24	2.00e-89	321.00
IUUC-Mmr-061385	Microcebus murinus	88.95	8.00e-74	269.00
IUUC-Mdo-062144	Monodelphis domestica	89.69	8.00e-90	322.00
IUUC-Mmu-063215	Mus musculus	89.16	6.00e-81	293.00
IUUC-Mpu-065749	Mustela putorius furo	89.66	2.00e-81	294.00
IUUC-Mlu-067245	Myotis lucifugus	68.97	5.00e-73	266.00
IUUC-Nle-069968	Nomascus leucogenys	89.47	1.00e-73	268.00
IUUC-Ont-071524	Oreochromis niloticus	66.95	2.00e-69	255.00
IUUC-Ocu-074870	Oryctolagus cuniculus	90.15	4.00e-82	297.00
IUUC-Oga-088336	Otolemur garnettii	89.47	3.00e-74	271.00
IUUC-Oar-090136	Ovis aries	89.66	9.00e-82	295.00
IUUC-Ptr-091348	Pan troglodytes	89.47	7.00e-74	269.00
IUUC-Pan-092819	Papio anubis	89.47	3.00e-74	271.00
IUUC-Psi-093854	Pelodiscus sinensis	92.53	6.00e-68	249.00
IUUC-Pfo-096633	Poecilia formosa	66.67	6.00e-63	233.00
IUUC-Pab-098346	Pongo abelii	90.00	7.00e-75	273.00
IUUC-Pca-100278	Procavia capensis	86.10	1.00e-87	315.00
IUUC-Pva-103190	Pteropus vampyrus	89.66	4.00e-81	293.00
IUUC-Rno-104940	Rattus norvegicus	87.68	1.00e-79	289.00
IUUC-Sha-107533	Sarcophilus harrisii	89.24	2.00e-89	321.00
IUUC-Sar-113630	Sorex araneus	89.16	1.00e-80	291.00
IUUC-Ssc-115734	Sus scrofa	89.66	4.00e-81	294.00
IUUC-Tgu-117034	Taeniopygia guttata	99.55	2.00e-103	367.00
IUUC-Tru-118168	Takifugu rubripes	58.55	7.00e-63	233.00
IUUC-Tsy-119494	Tarsius syrichta	88.95	2.00e-73	267.00
IUUC-Tni-119663	Tetraodon nigroviridis	60.09	8.00e-63	233.00
IUUC-Ttr-128442	Tursiops truncatus	89.16	1.00e-80	291.00
IUUC-Vpa-130063	Vicugna pacos	90.15	6.00e-82	296.00
IUUC-Xtr-132348	Xenopus tropicalis	75.34	1.00e-50	192.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence