iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
UniProt	PHOSIDA	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	3.40e-16	60.1	430	486

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +v++lydye+q+ deL++k+Gd ++ i ++e ++gW+kg + ++g+ Gl P+n+ve ++
   Q: 430  RVRALYDYEGQEHDELSFKAGDELTKI-EDEDEQGWCKG-RLDSGQVGLYPANYVEAIQ 486
           799************************.9**********.59*************9885 PP

Organism

Mus musculus

Functional Description
(View)

Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. May also play a role in the formation of caveolae at the cell membrane. Recruits DNM2 to caveolae, and thereby plays a role in caveola-mediated endocytosis.

Protein Sequence
(Fasta)

MSVTYDDSVG VEVSSDSFWE VGNYKRTVKR IDDGHRLCGD LMNCLHERAR IEKAYAQQLT 60
EWARRWRQLV EKGPQYGTVE KAWIAVMSEA ERVSELHLEV KASLMNEDFE KIKNWQKEAF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGGCGCGGT CGCGGCTGGC GGCAGAAGCG GCTGCGGCGG GTCTGGGCAG GGCCGGGGAG 60
CTCGGTTGGA GCGGAACGGG AAGGGGTCGG AGTCGCAGCC CGGCCGGGGC GGCGTGCTCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-1003--Cell membrane
KW-0966--Cell projection
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0206--Cytoskeleton
KW-0254--Endocytosis
KW-0967--Endosome
KW-0446--Lipid-binding
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR031160--F_BAR
IPR001060--FCH_dom
IPR028521--PACSIN2
IPR001452--SH3_domain

PROSITE

PS51741--F_BAR
PS50002--SH3

Pfam

PF00611--FCH
PF00018--SH3_1

PRINTS

PR00452--SH3DOMAIN

SMART

SM00055--FCH
SM00326--SH3

Gene Ontology

GO:0005901--C:caveola
GO:0005913--C:cell-cell adherens junction
GO:0005911--C:cell-cell junction
GO:0005737--C:cytoplasm
GO:0030659--C:cytoplasmic vesicle membrane
GO:0005856--C:cytoskeleton
GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0005768--C:endosome
GO:0070062--C:extracellular exosome
GO:0019898--C:extrinsic component of membrane
GO:0005925--C:focal adhesion
GO:0043231--C:intracellular membrane-bounded organelle
GO:0016607--C:nuclear speck
GO:0005886--C:plasma membrane
GO:0055038--C:recycling endosome membrane
GO:0032587--C:ruffle membrane
GO:0098641--F:cadherin binding involved in cell-cell adhesion
GO:0008092--F:cytoskeletal protein binding
GO:0042802--F:identical protein binding
GO:0008289--F:lipid binding
GO:0070300--F:phosphatidic acid binding
GO:0030036--P:actin cytoskeleton organization
GO:0070836--P:caveola assembly
GO:0072584--P:caveolin-mediated endocytosis
GO:0048858--P:cell projection morphogenesis
GO:0045806--P:negative regulation of endocytosis
GO:0097320--P:plasma membrane tubulation
GO:0036010--P:protein localization to endosome
GO:0007165--P:signal transduction

KEGG

mmu:23970

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001887	Ailuropoda melanoleuca	93.42	0.00e+00	870.00
IUUC-Apl-003574	Anas platyrhynchos	86.24	0.00e+00	781.00
IUUC-Aca-004251	Anolis carolinensis	80.62	0.00e+00	753.00
IUUC-Ame-011756	Astyanax mexicanus	66.54	0.00e+00	681.00
IUUC-Bta-013193	Bos taurus	91.15	0.00e+00	828.00
IUUC-Cja-018756	Callithrix jacchus	94.65	0.00e+00	847.00
IUUC-Cfa-020545	Canis familiaris	94.03	0.00e+00	906.00
IUUC-Cpo-022000	Cavia porcellus	90.12	0.00e+00	917.00
IUUC-Csa-024030	Chlorocebus sabaeus	93.26	0.00e+00	756.00
IUUC-Cin-025707	Ciona intestinalis	42.45	9.00e-107	380.00
IUUC-Csv-026244	Ciona savignyi	42.11	3.00e-54	204.00
IUUC-Dre-028104	Danio rerio	63.62	8.00e-167	580.00
IUUC-Dno-029429	Dasypus novemcinctus	93.17	0.00e+00	808.00
IUUC-Dor-030122	Dipodomys ordii	88.48	0.00e+00	793.00
IUUC-Dme-032120	Drosophila melanogaster	44.09	2.00e-107	382.00
IUUC-Eca-033367	Equus caballus	91.56	0.00e+00	848.00
IUUC-Eeu-034821	Erinaceus europaeus	76.75	0.00e+00	690.00
IUUC-Fca-036079	Felis catus	93.16	0.00e+00	863.00
IUUC-Fal-036682	Ficedula albicollis	86.81	0.00e+00	780.00
IUUC-Gmo-039681	Gadus morhua	64.83	4.00e-156	544.00
IUUC-Gga-040717	Gallus gallus	86.38	0.00e+00	781.00
IUUC-Gac-042262	Gasterosteus aculeatus	64.34	2.00e-174	605.00
IUUC-Ggo-044841	Gorilla gorilla	94.03	0.00e+00	814.00
IUUC-Hsa-046411	Homo sapiens	93.83	0.00e+00	812.00
IUUC-Itr-049063	Ictidomys tridecemlineatus	94.44	0.00e+00	841.00
IUUC-Loc-051975	Lepisosteus oculatus	69.81	0.00e+00	691.00
IUUC-Laf-053839	Loxodonta africana	90.40	0.00e+00	839.00
IUUC-Mcc-055783	Macaca mulatta	94.03	0.00e+00	815.00
IUUC-Mga-060087	Meleagris gallopavo	80.64	0.00e+00	711.00
IUUC-Mvi-060548	Microbotryum violaceum	41.51	4.00e-07	50.80
IUUC-Mmr-060827	Microcebus murinus	95.68	0.00e+00	884.00
IUUC-Mpu-066591	Mustela putorius furo	93.83	0.00e+00	875.00
IUUC-Mlu-067826	Myotis lucifugus	93.42	0.00e+00	873.00
IUUC-Nle-069797	Nomascus leucogenys	94.03	0.00e+00	814.00
IUUC-Oan-073076	Ornithorhynchus anatinus	84.35	4.00e-159	553.00
IUUC-Ocu-074425	Oryctolagus cuniculus	93.83	0.00e+00	843.00
IUUC-Ola-087556	Oryzias latipes	65.62	8.00e-166	576.00
IUUC-Oga-089009	Otolemur garnettii	86.06	0.00e+00	798.00
IUUC-Oar-089806	Ovis aries	91.56	0.00e+00	831.00
IUUC-Ptr-091111	Pan troglodytes	93.62	0.00e+00	810.00
IUUC-Pan-091749	Papio anubis	91.29	0.00e+00	800.00
IUUC-Psi-093704	Pelodiscus sinensis	87.23	0.00e+00	803.00
IUUC-Pfo-096680	Poecilia formosa	62.77	6.00e-169	587.00
IUUC-Pab-098584	Pongo abelii	92.43	3.00e-157	547.00
IUUC-Pva-102649	Pteropus vampyrus	92.80	0.00e+00	841.00
IUUC-Rno-105431	Rattus norvegicus	97.54	0.00e+00	935.00
IUUC-Sha-106641	Sarcophilus harrisii	89.48	0.00e+00	824.00
IUUC-Sar-113461	Sorex araneus	80.86	0.00e+00	730.00
IUUC-Ssc-115349	Sus scrofa	92.37	0.00e+00	832.00
IUUC-Tgu-116876	Taeniopygia guttata	86.38	0.00e+00	780.00
IUUC-Tru-118306	Takifugu rubripes	66.93	5.00e-177	613.00
IUUC-Tsy-118901	Tarsius syrichta	83.88	8.00e-156	543.00
IUUC-Tni-120120	Tetraodon nigroviridis	68.16	1.00e-180	626.00
IUUC-Xtr-132925	Xenopus tropicalis	81.11	0.00e+00	756.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence