iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-054124

UUCD1 version

UUC-LoA-00911

Ensembl Protein ID

ENSLAFP00000027153.1

UniProt Accession

G3UH45; G3UH45_LOXAF

Protein Name

Uncharacterized protein

Gene Name

SOCS5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000015752.2	ENSLAFT00000015752.2	ENSLAFP00000027153.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	4.50e-16	58.8	473	520

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 3    klwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedyq 53
            + l r+ p+SLq++CR +I+rc++++++   d+LPLP++L+d+L++++y+
   Q: 473  TISLNRTFPFSLQYICRAVICRCTTYDGI---DGLPLPSMLQDFLKEYHYK 520
           6778999**********************...****************985 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MDKVGKMWNN FKYRCQNLFS HEGGSRSENM AVNSNRCSSV KEKNTSGEDS APQQQSSPLR 60
ENVALHLAVS PSKNPSRRSQ NCAAEIPQIV EISIEKENDP CVTTPGTRLA RRDSYSRHAP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGATAAAG TGGGGAAAAT GTGGAATAAC TTCAAATACA GGTGCCAGAA TCTCTTCAGT 60
CATGAGGGAG GAAGCCGTAG TGAAAATATG GCCGTGAACT CCAACAGATG TTCGTCTGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR022252--SOCS4/SOCS5_dom
IPR028420--SOCS5
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF12610--SOCS
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005622--C:intracellular
GO:0071404--P:cellular response to low-density lipoprotein particle stimulus
GO:0019221--P:cytokine-mediated signaling pathway
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0007259--P:JAK-STAT cascade
GO:0007175--P:negative regulation of epidermal growth factor-activated receptor activity
GO:0050728--P:negative regulation of inflammatory response
GO:0032715--P:negative regulation of interleukin-6 production
GO:0071638--P:negative regulation of monocyte chemotactic protein-1 production
GO:0045629--P:negative regulation of T-helper 2 cell differentiation
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0045627--P:positive regulation of T-helper 1 cell differentiation
GO:0016567--P:protein ubiquitination
GO:0097699--P:vascular endothelial cell response to fluid shear stress

KEGG

lav:100665538

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000371	Aegilops tauschii	36.73	1.20e-02	32.70
IUUC-Apl-003815	Anas platyrhynchos	89.76	0.00e+00	988.00
IUUC-Aca-004504	Anolis carolinensis	84.92	0.00e+00	865.00
IUUC-Ame-010677	Astyanax mexicanus	63.29	0.00e+00	646.00
IUUC-Bta-012338	Bos taurus	95.16	0.00e+00	1009.00
IUUC-Cja-019828	Callithrix jacchus	94.60	0.00e+00	987.00
IUUC-Cfa-020369	Canis familiaris	93.85	0.00e+00	1004.00
IUUC-Cpo-021397	Cavia porcellus	93.30	0.00e+00	1015.00
IUUC-Csa-023856	Chlorocebus sabaeus	94.97	0.00e+00	1009.00
IUUC-Dre-028262	Danio rerio	64.18	2.00e-173	602.00
IUUC-Dno-029019	Dasypus novemcinctus	94.60	0.00e+00	1033.00
IUUC-Dme-031965	Drosophila melanogaster	68.02	9.00e-70	258.00
IUUC-Eca-033867	Equus caballus	94.41	0.00e+00	1030.00
IUUC-Fca-035806	Felis catus	93.67	0.00e+00	1002.00
IUUC-Fal-037117	Ficedula albicollis	89.94	0.00e+00	976.00
IUUC-Gmo-039066	Gadus morhua	84.43	9.00e-109	387.00
IUUC-Gga-040876	Gallus gallus	89.20	0.00e+00	959.00
IUUC-Gac-042149	Gasterosteus aculeatus	66.85	0.00e+00	645.00
IUUC-Ggo-045169	Gorilla gorilla	93.85	0.00e+00	1003.00
IUUC-Hsa-045805	Homo sapiens	94.97	0.00e+00	1011.00
IUUC-Hvu-047122	Hordeum vulgare	39.02	1.50e-02	33.10
IUUC-Itr-049048	Ictidomys tridecemlineatus	93.85	0.00e+00	1023.00
IUUC-Lch-049686	Latimeria chalumnae	79.41	0.00e+00	840.00
IUUC-Lpe-051639	Leersia perrieri	32.31	1.00e-01	31.60
IUUC-Loc-051745	Lepisosteus oculatus	72.61	0.00e+00	715.00
IUUC-Mcc-055175	Macaca mulatta	94.97	0.00e+00	1009.00
IUUC-Meu-056557	Macropus eugenii	90.54	0.00e+00	1000.00
IUUC-Mga-059214	Meleagris gallopavo	88.45	0.00e+00	975.00
IUUC-Mmr-060613	Microcebus murinus	78.96	0.00e+00	777.00
IUUC-Mdo-062788	Monodelphis domestica	90.72	0.00e+00	966.00
IUUC-Mmu-064333	Mus musculus	92.18	0.00e+00	985.00
IUUC-Mpu-066048	Mustela putorius furo	94.79	0.00e+00	1009.00
IUUC-Mlu-067430	Myotis lucifugus	94.60	0.00e+00	985.00
IUUC-Nle-069086	Nomascus leucogenys	95.16	0.00e+00	1035.00
IUUC-Opr-070312	Ochotona princeps	91.06	0.00e+00	963.00
IUUC-Ont-072299	Oreochromis niloticus	64.41	0.00e+00	630.00
IUUC-Ocu-074123	Oryctolagus cuniculus	89.57	0.00e+00	946.00
IUUC-Ola-086934	Oryzias latipes	67.65	0.00e+00	657.00
IUUC-Oga-088535	Otolemur garnettii	94.79	0.00e+00	1030.00
IUUC-Oar-089875	Ovis aries	94.79	0.00e+00	1009.00
IUUC-Ptr-090541	Pan troglodytes	94.97	0.00e+00	1011.00
IUUC-Pan-092416	Papio anubis	94.97	0.00e+00	1009.00
IUUC-Psi-092960	Pelodiscus sinensis	87.71	0.00e+00	968.00
IUUC-Pma-094222	Petromyzon marinus	51.98	5.00e-136	477.00
IUUC-Pfo-096930	Poecilia formosa	64.53	0.00e+00	655.00
IUUC-Pab-098659	Pongo abelii	95.16	0.00e+00	1012.00
IUUC-Pca-100222	Procavia capensis	92.92	0.00e+00	1019.00
IUUC-Pva-102387	Pteropus vampyrus	94.79	0.00e+00	1009.00
IUUC-Rno-105698	Rattus norvegicus	92.36	0.00e+00	989.00
IUUC-Sha-107234	Sarcophilus harrisii	89.98	0.00e+00	967.00
IUUC-Sar-113698	Sorex araneus	89.01	0.00e+00	902.00
IUUC-Ssc-115985	Sus scrofa	94.60	0.00e+00	1026.00
IUUC-Tgu-116676	Taeniopygia guttata	89.94	0.00e+00	982.00
IUUC-Tru-118441	Takifugu rubripes	57.67	3.00e-150	525.00
IUUC-Tsy-119163	Tarsius syrichta	88.45	0.00e+00	960.00
IUUC-Tni-120436	Tetraodon nigroviridis	66.73	0.00e+00	645.00
IUUC-Tae-124846	Triticum aestivum	36.73	2.80e-02	31.60
IUUC-Tbe-127353	Tupaia belangeri	94.97	0.00e+00	1008.00
IUUC-Ttr-128907	Tursiops truncatus	94.79	0.00e+00	992.00
IUUC-Vpa-130140	Vicugna pacos	94.97	0.00e+00	1013.00
IUUC-Xtr-132817	Xenopus tropicalis	79.00	0.00e+00	861.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence