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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Dme-032171
UUCD1 version UUC-DrM-00390
Ensembl Protein ID FBpp0290558
UniProt Accession Q9VR91; Q8MZ96; Q9N2R1; HERC2_DROME
Genbank Protein ID AAF50913.3; AAM29298.1; AAF61856.1
Protein Name Probable E3 ubiquitin-protein ligase HERC2; HECT domain and RCC1-like domain-containing protein 2; HECT-type E3 ubiquitin transferase HERC2
Genbank Nucleotide ID AE014298; AY113293; AF189221
Gene Name HERC2; CG11734
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
FBgn0031107 FBtr0301344 FBpp0290558
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNARAID2
Protein-protein Interaction
IIDMentha
Post-translational Modifications (PTMs)
dbPAFdbPTMPhospho.ELMUniProt
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 5.40e-76 256.2 4553 4881
Active Site
Position(s) Description Evidence
4850 Glycyl thioester intermediate {ECO:0000255|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 7    krlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp.....ehlklFeflGrllgkalqdgrlldlplsksfy 97
           ++++v+fvgE++ d+gG  +e +a++++elqn +++l+ +++n++ +   n+d +l +p      ++++F+flG+l+g+a+++g +l ++l+++++
   Q: 4553 RVWKVKFVGESVDDCGGGYSESIAEMCDELQNGSVPLLINTPNGRGEAGANRDCFLLDPtlssvLQMNMFRFLGVLMGIAVRTGSPLSINLAEPVW 4648
           4556****************************************************9999**9999****************************** PP
   S: 98   klllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveaf 193
           ++l g+ l   dl evd++++  l  i++++++    ++l+l fs+     ++++ +e   + + +++   N+ eYv+l + +rl+e ++eqv+a+
   Q: 4649 RQLTGEVLRPTDLTEVDRDYVAGLLCIRNMDDDPKLFTALELPFST-----SSARGHEVPLSTRYTHISPRNRAEYVRLALGFRLHE-FDEQVKAV 4738
           ******************************8887888899999994.....55788889999*************************.******** PP
   S: 194  reGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvi 289
           r+G+++vip  llslF++ el+ ++cG+++i +  lk+ ++ykg + ++s  + wFwev+eef+++er+ fL+Fv+g+ rlP + +a+++ r fv+
   Q: 4739 RDGMSKVIPVPLLSLFSAAELQAMVCGSPDIPLGLLKSVATYKG-FDPSSALVTWFWEVMEEFTNQERSLFLRFVWGRTRLP-RTIADFRGRDFVL 4832
           ******************************************77.*************************************.7999999999988 PP
   S: 290  rk...dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           +    +  d+ lP+s TCf++Lk+P+Ys k +l ekL yAi+ +k++++
   Q: 4833 QVlekNPPDHFLPESYTCFFLLKMPRYSCKAVLLEKLKYAIHFCKSIDT 4881
           888768888***********************************99875 PP
   
Organism Drosophila melanogaster
Functional Description
(View)

Functional Description


     Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
 Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
Protein Sequence
(Fasta)
MFNRQASGGA GSSGQGAGSS QTASAAPVSA GVGVGGGGGA SGAAAGAGSA AGSGSGSGSG 60
SAAPPSHSPD LYLRPLPFLD AKWLRADLIA SLRNAADGAV LWNHLIQDCE LVSSPTAPLL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Dme-032171|E3,HECT|Drosophila melanogaster
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGTCAGTTTG CACCTCCCCC TGATATCGAT TGCCATCAAA CAATTTTATT TCATTTTAAA 60
ATAATTCCTT GATTTCAAAT TGCATTGTAC TGGTAACTGG CACTTCCAAT TGTGACCCGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Dme-032171|E3,HECT|Drosophila melanogaster
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR004939--APC_su10/DOC_dom
IPR021097--CPH_domain
IPR001199--Cyt_B5-like_heme/steroid-bd
IPR008979--Galactose-bd-like
IPR000569--HECT_dom
IPR010606--Mib_Herc2
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR014722--Rib_L2_dom2
IPR015940--UBA
IPR009060--UBA-like
PROSITE

PS51284--DOC
PS50237--HECT
PS51416--MIB_HERC2
PS00626--RCC1_2
PS50012--RCC1_3
PS50030--UBA
Pfam

PF11515--Cul7
PF00173--Cyt-b5
PF00632--HECT
PF06701--MIB_HERC2
PF00415--RCC1
PRINTS

PR00633--RCCNDNSATION
SMART

SM01337--APC10
SM00119--HECTc
Gene Ontology

GO:0005814--C:centriole
GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0046872--F:metal ion binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0016567--P:protein ubiquitination
KEGG dme:Dmel_CG11734
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002112 Ailuropoda melanoleuca 59.72 0.00e+00 1561.00
IUUC-Atr-003065 Amborella trichopoda 34.11 7.00e-46 178.00
IUUC-Apl-003983 Anas platyrhynchos 60.45 0.00e+00 1574.00
IUUC-Aca-004300 Anolis carolinensis 60.26 0.00e+00 1575.00
IUUC-Aly-006545 Arabidopsis lyrata 35.22 1.00e-46 181.00
IUUC-Ath-007268 Arabidopsis thaliana 33.46 1.00e-28 121.00
IUUC-Ame-010621 Astyanax mexicanus 60.35 0.00e+00 1560.00
IUUC-Bta-013067 Bos taurus 60.17 0.00e+00 1551.00
IUUC-Bol-015203 Brassica oleracea 34.12 5.00e-49 189.00
IUUC-Bra-016737 Brassica rapa 34.88 8.00e-46 178.00
IUUC-Cja-019687 Callithrix jacchus 36.70 0.00e+00 1557.00
IUUC-Cfa-020672 Canis familiaris 59.72 0.00e+00 1563.00
IUUC-Cpo-021819 Cavia porcellus 70.52 0.00e+00 1272.00
IUUC-Cre-023014 Chlamydomonas reinhardtii 38.65 2.00e-46 178.00
IUUC-Csa-023817 Chlorocebus sabaeus 59.80 0.00e+00 1535.00
IUUC-Cho-024387 Choloepus hoffmanni 43.41 0.00e+00 717.00
IUUC-Cin-025709 Ciona intestinalis 50.11 0.00e+00 1244.00
IUUC-Csv-026336 Ciona savignyi 50.49 0.00e+00 1253.00
IUUC-Dre-027717 Danio rerio 60.16 0.00e+00 1553.00
IUUC-Dno-029296 Dasypus novemcinctus 59.87 0.00e+00 1560.00
IUUC-Dor-030979 Dipodomys ordii 66.91 0.00e+00 757.00
IUUC-Ete-032687 Echinops telfairi 48.50 0.00e+00 648.00
IUUC-Eca-034046 Equus caballus 59.58 0.00e+00 1557.00
IUUC-Eeu-034859 Erinaceus europaeus 56.40 0.00e+00 895.00
IUUC-Fca-036262 Felis catus 59.65 0.00e+00 1560.00
IUUC-Fal-037562 Ficedula albicollis 60.45 0.00e+00 1574.00
IUUC-Gmo-038739 Gadus morhua 65.54 0.00e+00 749.00
IUUC-Gga-040359 Gallus gallus 60.31 0.00e+00 1570.00
IUUC-Gac-041879 Gasterosteus aculeatus 65.54 0.00e+00 766.00
IUUC-Gma-043616 Glycine max 37.73 3.00e-45 175.00
IUUC-Ggo-044692 Gorilla gorilla 59.50 0.00e+00 1524.00
IUUC-Hsa-045995 Homo sapiens 59.80 0.00e+00 1539.00
IUUC-Hvu-047529 Hordeum vulgare 34.27 4.00e-47 182.00
IUUC-Itr-048914 Ictidomys tridecemlineatus 39.50 3.00e-168 585.00
IUUC-Lch-049808 Latimeria chalumnae 71.89 0.00e+00 1286.00
IUUC-Lpe-051165 Leersia perrieri 35.79 3.00e-43 168.00
IUUC-Loc-052685 Lepisosteus oculatus 71.44 0.00e+00 1282.00
IUUC-Laf-053372 Loxodonta africana 59.65 0.00e+00 1556.00
IUUC-Mcc-054693 Macaca mulatta 59.87 0.00e+00 1540.00
IUUC-Meu-056660 Macropus eugenii 64.32 0.00e+00 1335.00
IUUC-Mtr-058277 Medicago truncatula 30.25 5.00e-47 181.00
IUUC-Mga-059371 Meleagris gallopavo 71.86 0.00e+00 1289.00
IUUC-Mmr-060787 Microcebus murinus 59.80 0.00e+00 1549.00
IUUC-Mdo-062518 Monodelphis domestica 62.50 0.00e+00 1103.00
IUUC-Mmu-063690 Mus musculus 59.94 0.00e+00 1562.00
IUUC-Mpu-066478 Mustela putorius furo 59.65 0.00e+00 1550.00
IUUC-Mlu-067596 Myotis lucifugus 38.88 0.00e+00 1054.00
IUUC-Nle-069633 Nomascus leucogenys 39.55 1.00e-162 568.00
IUUC-Opr-070990 Ochotona princeps 61.30 0.00e+00 1523.00
IUUC-Ont-072285 Oreochromis niloticus 60.12 0.00e+00 1562.00
IUUC-Oan-072721 Ornithorhynchus anatinus 60.23 0.00e+00 1562.00
IUUC-Ocu-074273 Oryctolagus cuniculus 59.55 0.00e+00 1552.00
IUUC-Oba-075262 Oryza barthii 36.73 2.00e-43 169.00
IUUC-Obr-076115 Oryza brachyantha 37.86 6.00e-45 174.00
IUUC-Ogl-077586 Oryza glaberrima 36.73 2.00e-43 169.00
IUUC-Ogu-078796 Oryza glumaepatula 36.73 2.00e-43 169.00
IUUC-Oin-079298 Oryza indica 36.73 2.00e-43 169.00
IUUC-Olo-080768 Oryza longistaminata 34.24 1.00e-45 176.00
IUUC-Ome-081908 Oryza meridionalis 31.18 3.00e-43 168.00
IUUC-Oni-082049 Oryza nivara 36.73 2.00e-43 169.00
IUUC-Opu-083608 Oryza punctata 35.59 3.00e-43 168.00
IUUC-Oru-084712 Oryza rufipogon 36.73 2.00e-43 169.00
IUUC-Osa-086078 Oryza sativa 36.73 2.00e-43 169.00
IUUC-Ola-087346 Oryzias latipes 67.82 0.00e+00 890.00
IUUC-Oga-088742 Otolemur garnettii 56.14 0.00e+00 2191.00
IUUC-Oar-090093 Ovis aries 44.29 0.00e+00 2677.00
IUUC-Ptr-091034 Pan troglodytes 52.65 0.00e+00 1289.00
IUUC-Pan-092783 Papio anubis 59.87 0.00e+00 1538.00
IUUC-Psi-094027 Pelodiscus sinensis 72.04 0.00e+00 1291.00
IUUC-Pma-094275 Petromyzon marinus 39.35 2.00e-65 244.00
IUUC-Pfo-097354 Poecilia formosa 67.81 0.00e+00 778.00
IUUC-Pab-097760 Pongo abelii 39.93 1.00e-169 591.00
IUUC-Pop-099121 Populus trichocarpa 34.50 3.00e-46 179.00
IUUC-Pca-100465 Procavia capensis 40.00 5.00e-170 593.00
IUUC-Ppe-101345 Prunus persica 35.47 6.00e-46 179.00
IUUC-Pva-103147 Pteropus vampyrus 47.10 0.00e+00 670.00
IUUC-Rno-105458 Rattus norvegicus 59.87 0.00e+00 1560.00
IUUC-Sha-106959 Sarcophilus harrisii 55.77 0.00e+00 1370.00
IUUC-Smo-108827 Selaginella moellendorffii 34.79 4.00e-48 186.00
IUUC-Sly-111155 Solanum lycopersicum 33.82 1.00e-48 187.00
IUUC-Stu-112166 Solanum tuberosum 35.11 1.00e-44 174.00
IUUC-Sar-113532 Sorex araneus 48.73 2.00e-146 514.00
IUUC-Sbi-114352 Sorghum bicolor 33.42 9.00e-47 181.00
IUUC-Ssc-116304 Sus scrofa 67.30 0.00e+00 671.00
IUUC-Tgu-116789 Taeniopygia guttata 71.83 0.00e+00 1288.00
IUUC-Tru-118129 Takifugu rubripes 60.26 0.00e+00 1564.00
IUUC-Tsy-119302 Tarsius syrichta 46.78 1.00e-143 505.00
IUUC-Tni-120374 Tetraodon nigroviridis 60.03 0.00e+00 1557.00
IUUC-Tca-121094 Theobroma cacao 34.31 2.00e-48 187.00
IUUC-Tae-124157 Triticum aestivum 36.47 1.00e-48 187.00
IUUC-Tur-126300 Triticum urartu 34.27 1.00e-47 184.00
IUUC-Tbe-128137 Tupaia belangeri 64.73 9.00e-161 562.00
IUUC-Ttr-128273 Tursiops truncatus 55.68 0.00e+00 1383.00
IUUC-Vpa-130471 Vicugna pacos 43.29 4.00e-137 483.00
IUUC-Xtr-132185 Xenopus tropicalis 70.95 0.00e+00 1269.00
IUUC-Xma-133233 Xiphophorus maculatus 60.48 0.00e+00 1557.00
Created Date 25-Jun-2017

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