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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045995
UUCD1 version UUC-HoS-00052
Ensembl Protein ID ENSP00000261609.7
UniProt Accession O95714; Q86SV7; Q86SV8; Q86SV9; Q86YY3; Q86YY4; Q86YY5; Q86YY6; Q86YY7; Q86YY8; Q86YY9; Q86YZ0; Q86YZ1; HERC2_HUMAN
Genbank Protein ID AAD08657.1; AAO27473.1; AAO27473.1; AAO27474.1; AAO27474.1; AAO27475.1; AAO27475.1; AAO27475.1; AAO27475.1; AAO27476.1; AAO27476.1; AAO27479.1; AAO27479.1; AAO27477.1; AAO27478.1; AAO27480.1; AAO27480.1; AAO27481.1; AAO27481.1; AAO27482.1; AAO27482.1; AAO27482.1; AAO27483.1; AAO27483.1; AAO27483.1; AAO27484.1; AAO27484.1
Protein Name E3 ubiquitin-protein ligase HERC2; HECT domain and RCC1-like domain-containing protein 2; HECT-type E3 ubiquitin transferase HERC2
Genbank Nucleotide ID AF071172; AC091304; AF224242; AF224245; AF224244; AF224249; AF224246; AF224247; AF224248; AF224251; AF224250; AF224255; AF224254; AF224252; AF224253; AF224257; AF224256; AF225401; AF225400; AF225404; AF225402; AF225403; AF225407; AF225405; AF225406; AF225409; AF225408
Gene Name HERC2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000128731.15 ENST00000261609.11 ENSP00000261609.7
ENSG00000128731.15 ENST00000569772.1 ENSP00000457745.1
ENSG00000128731.15 ENST00000564734.5 ENSP00000456237.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircRNADbCircNet
miRTarBasemicroRNATRANSFACmiRWalk
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/HECT HECT 21193487; 20304803; 20631078
UBD/ZnF/Other UBD/ZnF/Other 22508508; 24722987
Classification
Family E-value Score Start End
E3 activity/HECT 5.60e-86 290.6 4464 4793
Active Site
Position(s) Description Evidence
4762 Glycyl thioester intermediate {ECO:0000255|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 7    krlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp.....ehlklFeflGrllgkalqdgrlldlp 91
           ++++v+fvgE++ d+gG  +e +a++++elqn  ++l+  ++n++ +   n+d +l +p      h ++F+flG+llg+a+++g +l l+
   Q: 4464 RVWKVKFVGESVDDCGGGYSESIAEICEELQNGLTPLLIVTPNGRDESGANRDCYLLSPaarapVHSSMFRFLGVLLGIAIRTGSPLSLN 4553
           4566****************************************************99999999************************** PP
   S: 92   lsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyr 181
           l+++++k+l g +l++ dl+evd++++  l++i++n+ ++ e +++ l f+     +++++ +++  +++++++t +N+ eYv+l ++yr
   Q: 4554 LAEPVWKQLAGMSLTIADLSEVDKDFIPGLMYIRDNEATSEEFEAMSLPFT-----VPSASGQDIQLSSKHTHITLDNRAEYVRLAINYR 4638
           ************************************9999999999***99.....788999999************************* PP
   S: 182  lkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgs 271
           l+e ++eqv+a+reG+ +v+p  llslFt  ele+++cG+++i ++ lk+ ++ykg ++++ + iqwFwev+e+fs++er+ fL+Fv+g+
   Q: 4639 LHE-FDEQVAAVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVATYKG-IEPSASLIQWFWEVMESFSNTERSLFLRFVWGR 4726
           ***.**************************************************77.********************************* PP
   S: 272  srlPlgGfaelkprlfvirk....dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
            rlP + +a+++ r fvi+     +  d+ lP+s TCf++LkLP+Ys k++l+ekL yAi+ +k++++
   Q: 4727 TRLP-RTIADFRGRDFVIQVldkyNPPDHFLPESYTCFFLLKLPRYSCKQVLEEKLKYAIHFCKSIDT 4793
           ****.8*************999988888***********************************99875 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity.
 E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity.
Protein Sequence
(Fasta)
MPSESFCLAA QARLDSKWLK TDIQLAFTRD GLCGLWNEMV KDGEIVYTGT ESTQNGELPP 60
RKDDSVEPSG TKKEDLNDKE KKDEEETPAP IYRAKSILDS WVWGKQPDVN ELKECLSVLV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045995|E3,HECT;UBD,UBD/ZnF/Other|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCGCCGGCTG AGCCAGCGGC TCTTGGGAGG CTGCGTCCGC GCGCCGGCGA GGCGAGGCGG 60
CCGGGCCCTG CGCGTCAGGT CCTGGCCTGG GGCACCTGGG CGGCCGGTGG CGGGGGCGGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045995|E3,HECT;UBD,UBD/ZnF/Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0225--Disease mutation
KW-0227--DNA damage
KW-0234--DNA repair
KW-0991--Mental retardation
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR004939--APC_su10/DOC_dom
IPR006624--Beta-propeller_rpt_TECPR
IPR021097--CPH_domain
IPR001199--Cyt_B5-like_heme/steroid-bd
IPR008979--Galactose-bd-like
IPR000569--HECT_dom
IPR010606--Mib_Herc2
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR014722--Rib_L2_dom2
IPR000433--Znf_ZZ
PROSITE

PS50255--CYTOCHROME_B5_2
PS51284--DOC
PS50237--HECT
PS51416--MIB_HERC2
PS00626--RCC1_2
PS50012--RCC1_3
PS01357--ZF_ZZ_1
PS50135--ZF_ZZ_2
Pfam

PF03256--ANAPC10
PF11515--Cul7
PF00173--Cyt-b5
PF00632--HECT
PF06701--MIB_HERC2
PF00415--RCC1
PF00569--ZZ
PRINTS

PR00633--RCCNDNSATION
SMART

SM01337--APC10
SM01117--Cyt-b5
SM00119--HECTc
SM00706--TECPR
SM00291--ZnF_ZZ
Gene Ontology

GO:0005814--C:centriole
GO:0005737--C:cytoplasm
GO:0016020--C:membrane
GO:0005743--C:mitochondrial inner membrane
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005085--F:guanyl-nucleotide exchange factor activity
GO:0032183--F:SUMO binding
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0006303--P:double-strand break repair via nonhomologous end joining
GO:0006886--P:intracellular protein transport
GO:0016567--P:protein ubiquitination
GO:0007283--P:spermatogenesis
KEGG hsa:8924
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002112 Ailuropoda melanoleuca 96.79 0.00e+00 7179.00
IUUC-Atr-003065 Amborella trichopoda 35.29 4.00e-51 197.00
IUUC-Apl-003983 Anas platyrhynchos 91.41 0.00e+00 8428.00
IUUC-Aca-004300 Anolis carolinensis 90.25 0.00e+00 8273.00
IUUC-Aly-006441 Arabidopsis lyrata 34.15 1.00e-44 175.00
IUUC-Ame-010621 Astyanax mexicanus 84.95 0.00e+00 6950.00
IUUC-Bta-013067 Bos taurus 95.63 0.00e+00 8651.00
IUUC-Bdi-014093 Brachypodium distachyon 33.25 2.00e-49 191.00
IUUC-Bol-015203 Brassica oleracea 34.55 1.00e-52 202.00
IUUC-Bra-016737 Brassica rapa 34.55 4.00e-48 187.00
IUUC-Cja-019687 Callithrix jacchus 96.49 0.00e+00 8616.00
IUUC-Cfa-020672 Canis familiaris 96.61 0.00e+00 8767.00
IUUC-Cpo-021819 Cavia porcellus 94.07 0.00e+00 8502.00
IUUC-Csa-023817 Chlorocebus sabaeus 98.94 0.00e+00 8928.00
IUUC-Cho-024387 Choloepus hoffmanni 95.76 0.00e+00 1910.00
IUUC-Cin-025709 Ciona intestinalis 54.82 0.00e+00 2233.00
IUUC-Csv-026336 Ciona savignyi 42.21 0.00e+00 3029.00
IUUC-Dre-027717 Danio rerio 82.15 0.00e+00 7294.00
IUUC-Dno-029296 Dasypus novemcinctus 95.56 0.00e+00 8643.00
IUUC-Dor-030979 Dipodomys ordii 91.41 0.00e+00 2931.00
IUUC-Dme-032171 Drosophila melanogaster 60.40 0.00e+00 1531.00
IUUC-Ete-032687 Echinops telfairi 85.70 0.00e+00 2898.00
IUUC-Eca-034046 Equus caballus 95.80 0.00e+00 8695.00
IUUC-Eeu-034859 Erinaceus europaeus 95.10 0.00e+00 1942.00
IUUC-Fca-036262 Felis catus 96.61 0.00e+00 8789.00
IUUC-Fal-037562 Ficedula albicollis 91.22 0.00e+00 8336.00
IUUC-Gmo-039054 Gadus morhua 86.32 0.00e+00 1089.00
IUUC-Gga-040359 Gallus gallus 91.49 0.00e+00 8390.00
IUUC-Gac-041879 Gasterosteus aculeatus 90.57 0.00e+00 1041.00
IUUC-Ggo-044692 Gorilla gorilla 99.47 0.00e+00 4390.00
IUUC-Hvu-047529 Hordeum vulgare 35.65 4.00e-49 190.00
IUUC-Itr-048553 Ictidomys tridecemlineatus 96.38 0.00e+00 2455.00
IUUC-Lch-049808 Latimeria chalumnae 87.26 0.00e+00 3361.00
IUUC-Lpe-051482 Leersia perrieri 33.94 4.00e-46 180.00
IUUC-Loc-052685 Lepisosteus oculatus 84.89 0.00e+00 7600.00
IUUC-Laf-053372 Loxodonta africana 95.10 0.00e+00 8588.00
IUUC-Mcc-054693 Macaca mulatta 99.03 0.00e+00 8963.00
IUUC-Meu-056660 Macropus eugenii 96.30 0.00e+00 1927.00
IUUC-Mga-059371 Meleagris gallopavo 91.59 0.00e+00 7234.00
IUUC-Mmr-060787 Microcebus murinus 97.89 0.00e+00 8907.00
IUUC-Mdo-062518 Monodelphis domestica 89.60 0.00e+00 8082.00
IUUC-Mmu-063690 Mus musculus 95.51 0.00e+00 8647.00
IUUC-Mpu-066478 Mustela putorius furo 96.24 0.00e+00 8702.00
IUUC-Mlu-067596 Myotis lucifugus 89.52 0.00e+00 4348.00
IUUC-Nle-069445 Nomascus leucogenys 98.78 0.00e+00 2251.00
IUUC-Opr-070990 Ochotona princeps 88.31 0.00e+00 2981.00
IUUC-Ont-072285 Oreochromis niloticus 83.08 0.00e+00 7378.00
IUUC-Oan-072721 Ornithorhynchus anatinus 86.66 0.00e+00 3455.00
IUUC-Ocu-074273 Oryctolagus cuniculus 96.56 0.00e+00 8740.00
IUUC-Oba-075573 Oryza barthii 33.68 2.00e-45 178.00
IUUC-Obr-076107 Oryza brachyantha 33.77 3.00e-50 194.00
IUUC-Ogl-077193 Oryza glaberrima 33.68 1.00e-45 178.00
IUUC-Ogu-078817 Oryza glumaepatula 33.68 1.00e-45 178.00
IUUC-Oin-079609 Oryza indica 32.75 2.00e-49 191.00
IUUC-Olo-080629 Oryza longistaminata 33.68 1.00e-45 178.00
IUUC-Ome-081686 Oryza meridionalis 33.68 5.00e-46 180.00
IUUC-Opu-084137 Oryza punctata 33.94 3.00e-46 181.00
IUUC-Oru-085013 Oryza rufipogon 33.68 1.00e-45 178.00
IUUC-Osa-085597 Oryza sativa 33.68 2.00e-45 178.00
IUUC-Ola-087346 Oryzias latipes 92.39 0.00e+00 1193.00
IUUC-Oga-088742 Otolemur garnettii 96.47 0.00e+00 8658.00
IUUC-Oar-090093 Ovis aries 95.93 0.00e+00 8676.00
IUUC-Ptr-091034 Pan troglodytes 94.40 0.00e+00 5896.00
IUUC-Pan-092783 Papio anubis 96.64 0.00e+00 8713.00
IUUC-Psi-094027 Pelodiscus sinensis 91.32 0.00e+00 8017.00
IUUC-Pfo-096208 Poecilia formosa 80.69 0.00e+00 6035.00
IUUC-Pab-097681 Pongo abelii 97.52 0.00e+00 2695.00
IUUC-Pca-100705 Procavia capensis 95.51 0.00e+00 1173.00
IUUC-Pva-103147 Pteropus vampyrus 87.44 0.00e+00 2538.00
IUUC-Rno-105458 Rattus norvegicus 95.62 0.00e+00 8636.00
IUUC-Sha-106959 Sarcophilus harrisii 81.88 0.00e+00 7020.00
IUUC-Sit-109917 Setaria italica 36.47 3.00e-48 187.00
IUUC-Sly-110961 Solanum lycopersicum 34.65 3.00e-53 204.00
IUUC-Sar-113532 Sorex araneus 84.79 0.00e+00 1817.00
IUUC-Sbi-114352 Sorghum bicolor 32.39 1.00e-49 192.00
IUUC-Ssc-115337 Sus scrofa 93.58 0.00e+00 3046.00
IUUC-Tgu-116789 Taeniopygia guttata 91.14 0.00e+00 8367.00
IUUC-Tru-118129 Takifugu rubripes 82.52 0.00e+00 7423.00
IUUC-Tsy-119302 Tarsius syrichta 85.20 0.00e+00 1278.00
IUUC-Tni-120374 Tetraodon nigroviridis 80.83 0.00e+00 7255.00
IUUC-Tca-121094 Theobroma cacao 35.31 8.00e-54 206.00
IUUC-Tae-124157 Triticum aestivum 33.51 1.00e-49 191.00
IUUC-Tur-126300 Triticum urartu 35.29 1.00e-49 192.00
IUUC-Tbe-128137 Tupaia belangeri 88.32 0.00e+00 2351.00
IUUC-Ttr-128273 Tursiops truncatus 91.18 0.00e+00 6362.00
IUUC-Vpa-130471 Vicugna pacos 83.27 0.00e+00 1476.00
IUUC-Xtr-132185 Xenopus tropicalis 86.00 0.00e+00 7772.00
IUUC-Xma-133233 Xiphophorus maculatus 82.76 0.00e+00 7379.00
Created Date 25-Jun-2017

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