iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046501

UUCD1 version

UUC-HoS-00179

Ensembl Protein ID

ENSP00000401277.2

UniProt Accession

Q75N03; B7ZM03; Q8TAJ4; Q9H5S6; HAKAI_HUMAN

Genbank Protein ID

BAB15544.1; AAS07390.1; AAH27460.2; AAI30530.1; AAI30532.1; AAI44177.1

Protein Name

E3 ubiquitin-protein ligase Hakai; Casitas B-lineage lymphoma-transforming sequence-like protein 1; RING finger protein 188; RING-type E3 ubiquitin transferase Hakai; c-Cbl-like protein 1

Genbank Nucleotide ID

AK026762; AC002467; BC027460; BC130529; BC130531; BC144176

Gene Name

CBLL1; HAKAI; RNF188

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000105879.11	ENST00000440859.7	ENSP00000401277.2
ENSG00000105879.11	ENST00000432748.5	ENSP00000401374.1
ENSG00000105879.11	ENST00000222597.6	ENSP00000222597.2
ENSG00000105879.11	ENST00000415884.6	ENSP00000401175.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	HPRD
Phospho.ELM	UniProt	BioGRID
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	21283129; 19893985

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	0.012	17.8	121	148

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 13   lvlpCgHvfhadCl.qkwpglknssskefrCPlC 45
           +  pC+Hvf+ dC         +++++  +CP C
   Q: 121  RMIPCKHVFCYDCAiL------HEKKGDKMCPGC 148
           4689*********622......3499******** PP

Organism

Homo sapiens

Functional Description
(View)

Promotes ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1. Targets CDH1 for endocytosis and degradation.

Protein Sequence
(Fasta)

MDHTDNELQG TNSSGSLGGL DVRRRIPIKL ISKQANKAKP APRTQRTINR MPAKAPPGDE 60
EGFDYNEEER YDCKGGELFA NQRRFPGHLF WDFQINILGE KDDTPVHFCD KCGLPIKIYG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTACTCCGC CCGCCGGGGT GGGGCCAGCG CAACGGCCGA GCCTGCGCAG CCAGCCGGCT 60
CCGGGGGCCC CGCGCACTAC AAGTCCCAGA AGGCAGCTCT CCGCGGGGCG GGCAGTCGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

Gene Ontology

GO:0005829--C:cytosol
GO:0016607--C:nuclear speck
GO:0000151--C:ubiquitin ligase complex
GO:0003676--F:nucleic acid binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0035635--P:entry of bacterium into host cell
GO:0007162--P:negative regulation of cell adhesion
GO:0030335--P:positive regulation of cell migration
GO:0045807--P:positive regulation of endocytosis
GO:0016567--P:protein ubiquitination
GO:0030155--P:regulation of cell adhesion
GO:0016337--P:single organismal cell-cell adhesion

KEGG

hsa:79872

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001549	Ailuropoda melanoleuca	95.24	9.00e-180	623.00
IUUC-Apl-003352	Anas platyrhynchos	87.14	3.00e-158	551.00
IUUC-Aca-005084	Anolis carolinensis	80.31	2.00e-145	509.00
IUUC-Bta-013383	Bos taurus	97.76	0.00e+00	630.00
IUUC-Bol-015734	Brassica oleracea	37.23	5.00e-13	69.70
IUUC-Cja-019505	Callithrix jacchus	99.59	0.00e+00	649.00
IUUC-Cfa-020255	Canis familiaris	98.17	0.00e+00	639.00
IUUC-Cpo-022545	Cavia porcellus	92.86	2.00e-144	504.00
IUUC-Csa-023318	Chlorocebus sabaeus	99.80	0.00e+00	647.00
IUUC-Cho-024701	Choloepus hoffmanni	95.89	3.00e-82	298.00
IUUC-Dre-028785	Danio rerio	55.07	6.00e-102	364.00
IUUC-Dor-030317	Dipodomys ordii	98.57	7.00e-178	616.00
IUUC-Eca-033554	Equus caballus	98.17	0.00e+00	635.00
IUUC-Fca-035864	Felis catus	97.74	4.00e-179	621.00
IUUC-Fal-037144	Ficedula albicollis	86.68	2.00e-155	542.00
IUUC-Gmo-039139	Gadus morhua	70.98	6.00e-81	294.00
IUUC-Gga-040912	Gallus gallus	86.61	7.00e-162	563.00
IUUC-Ggo-044818	Gorilla gorilla	99.80	0.00e+00	648.00
IUUC-Itr-048234	Ictidomys tridecemlineatus	98.98	0.00e+00	646.00
IUUC-Lch-049697	Latimeria chalumnae	83.13	5.00e-129	454.00
IUUC-Loc-052013	Lepisosteus oculatus	69.49	4.00e-126	444.00
IUUC-Laf-054485	Loxodonta africana	96.77	6.00e-171	593.00
IUUC-Meu-056453	Macropus eugenii	60.52	4.00e-98	351.00
IUUC-Mga-060082	Meleagris gallopavo	86.50	8.00e-157	546.00
IUUC-Mmr-061363	Microcebus murinus	98.78	0.00e+00	642.00
IUUC-Mdo-062085	Monodelphis domestica	95.11	3.00e-178	617.00
IUUC-Mmu-063370	Mus musculus	97.35	0.00e+00	636.00
IUUC-Mpu-066221	Mustela putorius furo	97.56	0.00e+00	633.00
IUUC-Mlu-067612	Myotis lucifugus	97.36	0.00e+00	631.00
IUUC-Nle-069315	Nomascus leucogenys	99.10	3.00e-164	570.00
IUUC-Opr-070202	Ochotona princeps	95.68	5.00e-154	537.00
IUUC-Ont-071478	Oreochromis niloticus	59.41	6.00e-102	364.00
IUUC-Oan-073158	Ornithorhynchus anatinus	81.50	1.00e-144	506.00
IUUC-Ocu-074385	Oryctolagus cuniculus	97.32	1.00e-162	566.00
IUUC-Oin-079075	Oryza indica	34.04	9.00e-12	65.10
IUUC-Oni-083087	Oryza nivara	34.04	9.00e-12	65.10
IUUC-Opu-083232	Oryza punctata	34.04	4.00e-12	66.20
IUUC-Osa-085908	Oryza sativa	34.04	1.00e-11	65.10
IUUC-Oar-089223	Ovis aries	97.75	2.00e-179	621.00
IUUC-Ptr-091633	Pan troglodytes	100.00	0.00e+00	650.00
IUUC-Pan-092923	Papio anubis	98.98	0.00e+00	633.00
IUUC-Ppa-095417	Physcomitrella patens	36.63	1.00e-13	71.20
IUUC-Pfo-097005	Poecilia formosa	57.62	2.00e-90	326.00
IUUC-Pab-098077	Pongo abelii	99.75	4.00e-174	604.00
IUUC-Pgr-103634	Puccinia graminis	21.76	8.00e-06	43.50
IUUC-Rno-105254	Rattus norvegicus	97.56	0.00e+00	637.00
IUUC-Sha-106599	Sarcophilus harrisii	94.70	6.00e-178	617.00
IUUC-Sit-110573	Setaria italica	23.29	2.00e-03	38.50
IUUC-Sar-113753	Sorex araneus	97.35	2.00e-149	522.00
IUUC-Sbi-114064	Sorghum bicolor	23.29	2.00e-03	38.50
IUUC-Ssc-116446	Sus scrofa	95.51	0.00e+00	662.00
IUUC-Tgu-117363	Taeniopygia guttata	86.31	3.00e-156	545.00
IUUC-Tru-118121	Takifugu rubripes	63.47	2.00e-115	409.00
IUUC-Tsy-119618	Tarsius syrichta	98.58	2.00e-125	442.00
IUUC-Tni-119858	Tetraodon nigroviridis	61.95	2.00e-104	372.00
IUUC-Ttr-129190	Tursiops truncatus	97.76	0.00e+00	634.00
IUUC-Vvi-131653	Vitis vinifera	37.23	1.00e-14	75.10

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence