iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCJAG00000006474.2	ENSCJAT00000012670.2	ENSCJAP00000012014.2
ENSCJAG00000006474.2	ENSCJAT00000054805.1	ENSCJAP00000050864.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.00e-88	298.9	703	1024

Active Site

Position(s)	Description	Evidence
994	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrll 88
           ++dl+k+l+v+f+gE g dlgGv+ ef+++l++e+ +p++glf+y e+ +++++p + ++    e+ ++F f+G+l+g++l++  + 
   Q: 703  NEDLRKELWVSFSGEIGYDLGGVKTEFFYCLFEEMTQPEYGLFMYPEGASCMWFPVKPKF----EKKRYF-FFGVLCGLSLFNCSVA 784
           689********************************************************9....567888.99************** PP
   S: 89   dlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvk 175
           +lp++ +++k+ll++  sledl+e+ p+l k+l+ i++ + ++ ee  + + f     +  ++++++L+p+G+ni V+++Nk++Yv+
   Q: 785  NLPFPLALFKKLLDQMPSLEDLKELSPDLGKNLQTILDDEGDNFEEV-FYIYFN----VHWDRNDTDLIPNGRNIIVNQTNKRDYVS 866
           *************************************8865555554.666665....667899999******************** PP
   S: 176  lvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerk 262
           ++++y++++++k  +e+fr+Gf++++++++++lF++eel+ +i G++++d+++++k++ yk +y +++p+i +Fwe++++++ ee+k
   Q: 867  KYIDYIFNDSVKVVYEEFRRGFYKMCEEDIIKLFHPEELKDVIVGNTYYDWKTFEKNAHYKPEYDSSHPTIVMFWEAFHKLTLEEKK 953
           *************************************************************************************** PP
   S: 263  afLqFvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           +fL F+Tg++r+ ++ ++++k   f+++++ ++++  ++ TCf++L LP+Ys++e ++e L++Ai++++gF+
   Q: 954  KFLVFLTGTDRIQIKDLKNMK-ITFCCPENWNEREPMRALTCFSVLFLPKYSTMERVEEALQVAINNNRGFG 1024
           *********************.77999999999*************************************96 PP

Organism

Callithrix jacchus

Protein Sequence
(Fasta)

MERRSGRKSR RDRRSVAGQA AASQPAKSPG AQLWLFPSTA GLRRALLRSV EATRQICCSS 60
GRLAFLERGG AGVQVHQLLP GSDGLRTPKC IKLGKNMKIH SMDLGADHML ILSSDGKPFE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGTAGCGGA GGCTGCGGTT CCCCGACGCC ACGCAGCTGC GTGCAACCGG TTCCCGCTCT 60
GTCGCGCGAC GCCCAGAGCA GTGGGCGCGC CCAGTCCCGG GACGTCGAGT TCTGTCCTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0042296--F:ISG15 transferase activity
GO:0016874--F:ligase activity
GO:0003723--F:RNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0032020--P:ISG15-protein conjugation
GO:0050688--P:regulation of defense response to virus

KEGG

cjc:100410536

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001676	Ailuropoda melanoleuca	75.83	0.00e+00	1573.00
IUUC-Bta-012422	Bos taurus	66.47	0.00e+00	1236.00
IUUC-Cfa-020247	Canis familiaris	75.68	0.00e+00	1490.00
IUUC-Csa-023204	Chlorocebus sabaeus	91.70	0.00e+00	1673.00
IUUC-Cho-025101	Choloepus hoffmanni	61.97	1.00e-175	610.00
IUUC-Dno-029795	Dasypus novemcinctus	69.65	0.00e+00	1127.00
IUUC-Dor-030862	Dipodomys ordii	66.67	0.00e+00	1296.00
IUUC-Ete-032585	Echinops telfairi	59.46	0.00e+00	823.00
IUUC-Eca-034358	Equus caballus	74.69	0.00e+00	1462.00
IUUC-Eeu-035282	Erinaceus europaeus	66.61	0.00e+00	744.00
IUUC-Fca-036505	Felis catus	77.90	0.00e+00	1575.00
IUUC-Ggo-045445	Gorilla gorilla	87.91	0.00e+00	1735.00
IUUC-Hsa-046342	Homo sapiens	90.78	0.00e+00	1835.00
IUUC-Itr-049004	Ictidomys tridecemlineatus	70.27	0.00e+00	1415.00
IUUC-Laf-053921	Loxodonta africana	70.78	0.00e+00	1443.00
IUUC-Mcc-054850	Macaca mulatta	91.59	0.00e+00	1675.00
IUUC-Mmr-060783	Microcebus murinus	66.06	0.00e+00	1192.00
IUUC-Mpu-066123	Mustela putorius furo	75.50	0.00e+00	1555.00
IUUC-Mlu-067914	Myotis lucifugus	75.53	0.00e+00	1413.00
IUUC-Nle-069986	Nomascus leucogenys	91.33	0.00e+00	1845.00
IUUC-Opr-070513	Ochotona princeps	69.16	0.00e+00	1041.00
IUUC-Ocu-074305	Oryctolagus cuniculus	72.10	0.00e+00	1374.00
IUUC-Oga-088858	Otolemur garnettii	74.91	0.00e+00	837.00
IUUC-Oar-089456	Ovis aries	75.20	0.00e+00	1494.00
IUUC-Ptr-091216	Pan troglodytes	91.15	0.00e+00	1603.00
IUUC-Pan-091706	Papio anubis	89.81	0.00e+00	1787.00
IUUC-Pab-097883	Pongo abelii	91.87	0.00e+00	763.00
IUUC-Pca-100320	Procavia capensis	65.90	0.00e+00	1335.00
IUUC-Pva-102646	Pteropus vampyrus	77.68	0.00e+00	1575.00
IUUC-Sar-113605	Sorex araneus	75.45	2.00e-150	526.00
IUUC-Tsy-119240	Tarsius syrichta	66.06	0.00e+00	1235.00
IUUC-Tbe-127787	Tupaia belangeri	70.66	0.00e+00	1335.00
IUUC-Ttr-128191	Tursiops truncatus	73.90	0.00e+00	1469.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence