iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Nfi-068405

Ensembl Protein ID

CADNFIAP00002683

UniProt Accession

A1D9Z6; DCL2_NEOFI

Genbank Protein ID

EAW20627.1

Protein Name

Dicer-like protein 2; Endoribonuclease dcl2; ATP-dependent helicase dcl2

Genbank Nucleotide ID

DS027693

Gene Name

NFIA_030600; dcl2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
CADNFIAG00002760	CADNFIAT00002760	CADNFIAP00002683

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/CARD	25.00	2.00e-25	116.00	IUUC-Hsa-046671

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Neosartorya fischeri

Functional Description
(View)

Dicer-like endonuclease involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. Produces 21 to 25 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs leading to sequence-specific suppression of gene expression, called post-transcriptional gene silencing (PTGS). Part of a broad host defense response against viral infection and transposons (By similarity).

Protein Sequence
(Fasta)

MASSVTACQG ASPYQPRNYQ LEMLEASMKE NIIVAMDTGS GKTHIAVLRI KAELDICPPD 60
KLVWFLAPTV ALCIQQHEVI ASNLPAVRTR TLTGLDKVEL WTEQSIWDAV LNGYRVIVST 120

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Nucleotide Sequence
(Fasta)

ATGGCCTCCT CCGTTACTGC ATGCCAAGGT GCCTCTCCTT ACCAGCCACG GAATTATCAG 60
CTTGAGATGC TGGAGGCTAG CATGAAAGAG AATATTATTG TGGCAGTATG TTCCCTTATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0051--Antiviral defense
KW-0930--Antiviral protein
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0347--Helicase
KW-0378--Hydrolase
KW-0460--Magnesium
KW-0464--Manganese
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0694--RNA-binding

Interpro

IPR011545--DEAD/DEAH_box_helicase_dom
IPR005034--Dicer_dimerisation_dom
IPR014001--Helicase_ATP-bd
IPR001650--Helicase_C
IPR027417--P-loop_NTPase
IPR000999--RNase_III_dom

PROSITE

PS51327--DICER_DSRBF
PS51192--HELICASE_ATP_BIND_1
PS51194--HELICASE_CTER
PS00517--RNASE_3_1
PS50142--RNASE_3_2

Pfam

PF00270--DEAD
PF03368--Dicer_dimer
PF00271--Helicase_C
PF00636--Ribonuclease_3

SMART

SM00487--DEXDc
SM00490--HELICc
SM00535--RIBOc

Gene Ontology

GO:0005524--F:ATP binding
GO:0004386--F:helicase activity
GO:0046872--F:metal ion binding
GO:0004525--F:ribonuclease III activity
GO:0003723--F:RNA binding
GO:0051607--P:defense response to virus
GO:0050688--P:regulation of defense response to virus
GO:0006396--P:RNA processing

KEGG

nfi:NFIA_030600

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001898	Ailuropoda melanoleuca	24.07	6.00e-20	91.30
IUUC-Apl-003900	Anas platyrhynchos	27.03	3.00e-27	115.00
IUUC-Aca-005329	Anolis carolinensis	35.54	1.00e-13	70.90
IUUC-Ani-009130	Aspergillus nidulans	34.88	4.20e-01	28.10
IUUC-Ame-011950	Astyanax mexicanus	27.57	6.00e-13	68.20
IUUC-Bta-012361	Bos taurus	24.49	2.00e-21	96.70
IUUC-Cel-018230	Caenorhabditis elegans	26.52	5.00e-10	58.50
IUUC-Cja-018716	Callithrix jacchus	24.91	3.00e-26	112.00
IUUC-Cfa-020269	Canis familiaris	28.19	6.00e-16	78.20
IUUC-Cpo-022507	Cavia porcellus	24.53	3.00e-26	112.00
IUUC-Cre-022916	Chlamydomonas reinhardtii	24.29	3.00e-04	39.30
IUUC-Csa-024209	Chlorocebus sabaeus	24.40	3.00e-28	119.00
IUUC-Cho-025104	Choloepus hoffmanni	25.19	7.00e-24	104.00
IUUC-Cin-025792	Ciona intestinalis	25.86	1.00e-29	122.00
IUUC-Cgl-026385	Colletotrichum gloeosporioides	36.08	0.00e+00	753.00
IUUC-Dre-028305	Danio rerio	29.70	2.00e-12	66.60
IUUC-Dno-028954	Dasypus novemcinctus	24.08	2.00e-25	109.00
IUUC-Dor-030410	Dipodomys ordii	28.26	1.00e-12	67.00
IUUC-Ete-032950	Echinops telfairi	33.63	6.00e-10	58.50
IUUC-Eca-034039	Equus caballus	25.94	3.00e-27	115.00
IUUC-Eeu-035009	Erinaceus europaeus	25.65	6.00e-20	91.30
IUUC-Fca-036169	Felis catus	24.09	4.00e-22	98.60
IUUC-Fal-037579	Ficedula albicollis	24.96	5.00e-29	121.00
IUUC-Fso-038398	Fusarium solani	33.76	0.00e+00	728.00
IUUC-Gmo-038598	Gadus morhua	27.77	3.00e-25	108.00
IUUC-Gga-040467	Gallus gallus	27.65	5.00e-29	121.00
IUUC-Gac-042316	Gasterosteus aculeatus	24.48	1.00e-21	97.40
IUUC-Gma-044318	Glycine max	27.47	5.00e-04	38.10
IUUC-Ggo-045318	Gorilla gorilla	24.82	2.00e-27	116.00
IUUC-Hsa-046671	Homo sapiens	25.00	1.00e-27	117.00
IUUC-Itr-047996	Ictidomys tridecemlineatus	25.44	9.00e-27	114.00
IUUC-Lch-049913	Latimeria chalumnae	25.81	9.00e-23	100.00
IUUC-Loc-052768	Lepisosteus oculatus	25.81	1.00e-26	114.00
IUUC-Laf-053933	Loxodonta africana	24.91	2.00e-24	106.00
IUUC-Mcc-055390	Macaca mulatta	24.53	7.00e-27	114.00
IUUC-Meu-056365	Macropus eugenii	27.93	2.00e-15	76.60
IUUC-Mga-059205	Meleagris gallopavo	26.86	5.00e-26	111.00
IUUC-Mvi-060497	Microbotryum violaceum	37.76	4.00e-29	122.00
IUUC-Mmr-061407	Microcebus murinus	25.72	9.00e-27	114.00
IUUC-Mdo-063079	Monodelphis domestica	24.53	5.00e-26	111.00
IUUC-Mmu-064066	Mus musculus	24.70	1.00e-24	107.00
IUUC-Mpu-066226	Mustela putorius furo	26.79	1.00e-14	73.60
IUUC-Mlu-068196	Myotis lucifugus	28.67	1.00e-12	67.00
IUUC-Nle-069479	Nomascus leucogenys	28.67	1.00e-12	67.40
IUUC-Opr-070717	Ochotona princeps	29.37	4.00e-13	68.60
IUUC-Ont-071702	Oreochromis niloticus	25.14	5.00e-21	95.10
IUUC-Oan-073639	Ornithorhynchus anatinus	27.13	2.00e-28	119.00
IUUC-Ocu-073959	Oryctolagus cuniculus	25.00	8.00e-25	107.00
IUUC-Ola-086351	Oryzias latipes	23.37	4.00e-21	95.10
IUUC-Oga-089173	Otolemur garnettii	23.75	4.00e-24	105.00
IUUC-Oar-089369	Ovis aries	24.87	4.00e-24	105.00
IUUC-Ptr-091032	Pan troglodytes	25.00	1.00e-27	117.00
IUUC-Pan-092383	Papio anubis	24.02	9.00e-27	114.00
IUUC-Psi-093432	Pelodiscus sinensis	26.46	1.00e-27	116.00
IUUC-Pma-094367	Petromyzon marinus	31.29	3.00e-10	58.50
IUUC-Pfo-096401	Poecilia formosa	30.19	6.00e-14	71.20
IUUC-Pab-098416	Pongo abelii	24.66	8.00e-27	114.00
IUUC-Pca-100993	Procavia capensis	29.58	7.00e-13	67.80
IUUC-Pva-102966	Pteropus vampyrus	25.56	1.00e-25	110.00
IUUC-Pgr-103529	Puccinia graminis	29.22	3.00e-60	226.00
IUUC-Rno-105198	Rattus norvegicus	24.79	3.00e-23	102.00
IUUC-Sha-107622	Sarcophilus harrisii	25.42	5.00e-22	98.60
IUUC-Sar-113202	Sorex araneus	31.55	6.00e-14	71.20
IUUC-Ssc-116120	Sus scrofa	24.90	6.00e-26	111.00
IUUC-Tgu-117314	Taeniopygia guttata	24.44	7.00e-28	117.00
IUUC-Tru-118445	Takifugu rubripes	26.01	9.00e-25	107.00
IUUC-Tsy-119512	Tarsius syrichta	31.97	5.00e-11	62.00
IUUC-Tni-120711	Tetraodon nigroviridis	24.65	7.00e-22	97.80
IUUC-Tre-122194	Trichoderma reesei	35.54	0.00e+00	707.00
IUUC-Tbe-127644	Tupaia belangeri	38.10	5.00e-13	68.60
IUUC-Ttr-128421	Tursiops truncatus	25.23	1.00e-20	93.60
IUUC-Vpa-130602	Vicugna pacos	30.73	4.00e-16	78.60
IUUC-Xtr-131927	Xenopus tropicalis	26.20	2.00e-27	116.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence