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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063287
UUCD1 version UUC-MuM-00969
Ensembl Protein ID ENSMUSP00000094225.3
UniProt Accession Q9Z0Z3; Q8BSG7; Q8C8Y9; Q8CB22; Q99J53; SKP2_MOUSE
Genbank Protein ID AAD16037.1; BAC28108.1; BAC31819.1; AAH03468.1
Protein Name S-phase kinase-associated protein 2; Cyclin-A/CDK2-associated protein p45; F-box protein Skp2; F-box/WD-40 protein 1
Genbank Nucleotide ID AF083215; AK032979; AK044212; AK037002
Gene Name Skp2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000054115.11 ENSMUST00000096482.9 ENSMUSP00000094225.3
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDMentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 adaptor/Cullin RING/SCF/F-box 26.23 3.00e-27 119.00 IUUC-Cel-018410
E3 adaptor/Cullin RING/SCF/F-box 86.32 0.00e+00 757.00 IUUC-Hsa-046512
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     Substrate recognition component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. The SCF complex provides substrate specificity and interacts with both, the E2 ubiquitin-conjugating enzyme and the substrate. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Promotes ubiquitination and destruction of CDH1 in a CK1-Dependent Manner, thereby regulating cell migration (By similarity).
 Substrate recognition component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. The SCF complex provides substrate specificity and interacts with both, the E2 ubiquitin-conjugating enzyme and the substrate. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Promotes ubiquitination and destruction of CDH1 in a CK1-Dependent Manner, thereby regulating cell migration (By similarity).
Protein Sequence
(Fasta)
MHRKHLQEIP DQSGNVTTSF TWGWDSSKTS ELLSGMGVSA LEKEEVDSEN IPHGLLSNLG 60
HPQSPPRKRV KGKGSDKDFV IIRRPKLSRE NFPGVSWDSL PDELLLGIFS CLCLPELLRV 120
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Protein Fasta Sequence


>IUUC-Mmu-063287|E3,F-box|Mus musculus
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Nucleotide Sequence
(Fasta)
TGGAGTAGGT GTGGTCTTGT TGGAGGAAAT GTGTCACTAG AAGAGGGCTT GGAGGTCTCA 60
AAAGACCCAG CCAGGCTCAC TGGCATAGTC CCTTCCTGCT GCTACAAGGC GTAGAACTCT 120
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Nucleotide Fasta Sequence


>IUUC-Mmu-063287|E3,F-box|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0433--Leucine-rich repeat
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Interpro

IPR001810--F-box_dom
IPR032675--L_dom-like
IPR006553--Leu-rich_rpt_Cys-con_subtyp
PROSITE

PS50181--FBOX
Pfam

PF12937--F-box-like
SMART

SM00256--FBOX
SM00367--LRR_CC
Gene Ontology

GO:0005829--C:cytosol
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0042802--F:identical protein binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0071460--P:cellular response to cell-matrix adhesion
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0000086--P:G2/M transition of mitotic cell cycle
GO:0033148--P:positive regulation of intracellular estrogen receptor signaling pathway
GO:1902916--P:positive regulation of protein polyubiquitination
GO:0048661--P:positive regulation of smooth muscle cell proliferation
GO:0000209--P:protein polyubiquitination
GO:0042981--P:regulation of apoptotic process
GO:0051726--P:regulation of cell cycle
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG mmu:27401
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002197 Ailuropoda melanoleuca 85.14 0.00e+00 722.00
IUUC-Atr-002711 Amborella trichopoda 24.61 2.00e-08 55.10
IUUC-Apl-003453 Anas platyrhynchos 63.66 1.00e-112 399.00
IUUC-Aca-005185 Anolis carolinensis 58.69 4.00e-134 471.00
IUUC-Ame-010665 Astyanax mexicanus 46.15 6.00e-87 314.00
IUUC-Bta-013450 Bos taurus 83.96 0.00e+00 746.00
IUUC-Cel-018410 Caenorhabditis elegans 25.31 1.00e-24 107.00
IUUC-Cja-019834 Callithrix jacchus 86.56 0.00e+00 757.00
IUUC-Cfa-020401 Canis familiaris 85.61 0.00e+00 755.00
IUUC-Cpo-022183 Cavia porcellus 85.85 0.00e+00 751.00
IUUC-Csa-023418 Chlorocebus sabaeus 85.85 0.00e+00 753.00
IUUC-Cho-024412 Choloepus hoffmanni 81.07 5.00e-170 590.00
IUUC-Cin-025248 Ciona intestinalis 31.40 9.00e-41 161.00
IUUC-Csv-026189 Ciona savignyi 30.11 3.00e-38 152.00
IUUC-Dre-028032 Danio rerio 48.53 3.00e-104 371.00
IUUC-Dno-029222 Dasypus novemcinctus 84.43 0.00e+00 744.00
IUUC-Dor-030505 Dipodomys ordii 85.03 1.00e-169 589.00
IUUC-Dme-031972 Drosophila melanogaster 34.02 3.00e-51 196.00
IUUC-Ete-032234 Echinops telfairi 80.00 1.00e-113 402.00
IUUC-Eca-033944 Equus caballus 85.38 0.00e+00 754.00
IUUC-Eeu-035008 Erinaceus europaeus 79.62 2.00e-114 405.00
IUUC-Fca-035412 Felis catus 84.91 0.00e+00 748.00
IUUC-Fal-037337 Ficedula albicollis 60.66 2.00e-132 465.00
IUUC-Gmo-038934 Gadus morhua 42.52 4.00e-39 155.00
IUUC-Gga-041152 Gallus gallus 62.05 1.00e-148 519.00
IUUC-Gac-041819 Gasterosteus aculeatus 45.25 2.00e-75 276.00
IUUC-Ggo-045479 Gorilla gorilla 86.16 0.00e+00 632.00
IUUC-Hsa-046512 Homo sapiens 86.32 0.00e+00 757.00
IUUC-Itr-048515 Ictidomys tridecemlineatus 86.24 0.00e+00 724.00
IUUC-Lch-050115 Latimeria chalumnae 55.13 3.00e-129 454.00
IUUC-Loc-052554 Lepisosteus oculatus 47.89 1.00e-101 363.00
IUUC-Laf-053563 Loxodonta africana 84.83 0.00e+00 717.00
IUUC-Mcc-055143 Macaca mulatta 85.31 0.00e+00 742.00
IUUC-Meu-056593 Macropus eugenii 52.86 2.00e-97 348.00
IUUC-Mga-060084 Meleagris gallopavo 56.67 1.00e-80 292.00
IUUC-Mmr-060660 Microcebus murinus 86.32 0.00e+00 761.00
IUUC-Mdo-062363 Monodelphis domestica 65.57 5.00e-152 530.00
IUUC-Mpu-065791 Mustela putorius furo 85.14 0.00e+00 754.00
IUUC-Mlu-067714 Myotis lucifugus 82.82 0.00e+00 702.00
IUUC-Nle-069823 Nomascus leucogenys 86.32 0.00e+00 756.00
IUUC-Opr-071046 Ochotona princeps 70.70 2.00e-101 362.00
IUUC-Ont-071820 Oreochromis niloticus 44.06 1.00e-64 240.00
IUUC-Ocu-074868 Oryctolagus cuniculus 86.79 0.00e+00 759.00
IUUC-Ola-086608 Oryzias latipes 45.05 4.00e-71 261.00
IUUC-Oga-089044 Otolemur garnettii 84.43 0.00e+00 746.00
IUUC-Oar-089650 Ovis aries 83.73 0.00e+00 740.00
IUUC-Ptr-090743 Pan troglodytes 86.32 0.00e+00 756.00
IUUC-Pan-092501 Papio anubis 85.38 0.00e+00 749.00
IUUC-Psi-094032 Pelodiscus sinensis 63.74 1.00e-152 533.00
IUUC-Pfo-097279 Poecilia formosa 46.13 4.00e-63 235.00
IUUC-Pab-097821 Pongo abelii 86.16 0.00e+00 630.00
IUUC-Pca-100100 Procavia capensis 85.31 5.00e-174 603.00
IUUC-Pva-103181 Pteropus vampyrus 84.46 1.00e-170 592.00
IUUC-Rno-105091 Rattus norvegicus 96.45 0.00e+00 833.00
IUUC-Sha-107226 Sarcophilus harrisii 66.35 2.00e-157 548.00
IUUC-Ssc-115665 Sus scrofa 85.85 0.00e+00 756.00
IUUC-Tgu-116982 Taeniopygia guttata 60.66 2.00e-130 459.00
IUUC-Tru-118276 Takifugu rubripes 44.91 2.00e-70 259.00
IUUC-Tsy-119074 Tarsius syrichta 85.59 0.00e+00 632.00
IUUC-Tni-120702 Tetraodon nigroviridis 47.48 2.00e-48 186.00
IUUC-Tbe-127990 Tupaia belangeri 84.90 8.00e-148 516.00
IUUC-Ttr-128661 Tursiops truncatus 71.54 6.00e-104 370.00
IUUC-Xtr-132166 Xenopus tropicalis 56.22 4.00e-125 441.00
Created Date 25-Jun-2017

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