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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045980
UUCD1 version UUC-HoS-00409
Ensembl Protein ID ENSP00000306906.4
UniProt Accession Q9P0P0; Q53H81; RN181_HUMAN
Genbank Protein ID AAF36158.1; CAG33446.1; BAD96420.1; AAY24343.1; AAH02803.1
Protein Name E3 ubiquitin-protein ligase RNF181; RING finger protein 181; RING-type E3 ubiquitin transferase RNF181
Genbank Nucleotide ID AF151072; CR457165; AK222700; AC016753; BC002803
Gene Name RNF181; HSPC238
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000168894.9 ENST00000441634.5 ENSP00000412025.1
ENSG00000168894.9 ENST00000306368.8 ENSP00000306906.4
ENSG00000168894.9 ENST00000414390.5 ENSP00000397109.1
ENSG00000168894.9 ENST00000443647.5 ENSP00000391326.1
ENSG00000168894.9 ENST00000456023.1 ENSP00000415246.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBaseCircNetmiRTarBase
microRNATRANSFACTargetScanRepTar
miRNAMapSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdbGWAS CentralOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMHPRD
Phospho.ELMUniProtBioGRID
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 18331836
Classification
Family E-value Score Start End
E3 activity/RING/RING 1.10e-08 37.1 76 117
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdg..plvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C++Cl +f+++   + +pC H+fh +C+  w       sk+ +CPlCr
   Q: 76   CPVCLLEFEEEetAIEMPCHHLFHSSCILPW------LSKTNSCPLCR 117
           ******9*44444667***************......**********8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
 E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
Protein Sequence
(Fasta)
MASYFDEHDC EPSDPEQETR TNMLLELARS LFNRMDFEDL GLVVDWDHHL PPPAAKTVVE 60
NLPRTVIRGS QAELKCPVCL LEFEEEETAI EMPCHHLFHS SCILPWLSKT NSCPLCRYEL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045980|E3,RING|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GAGCAGGGTC CGAGGGCTGT GTCAGAAGGC TGGGCAGCCA TGGCGTCCTA TTTCGATGAA 60
CACGACTGCG AGCCGTCGGA CCCTGAGCAG GAGACGCGAA CCAACATGCT GCTGGAGCTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045980|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF13639--zf-RING_2
SMART

SM00184--RING
Gene Ontology

GO:0005737--C:cytoplasm
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
KEGG hsa:51255
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000512 Aegilops tauschii 47.42 3.00e-19 89.70
IUUC-Aml-002024 Ailuropoda melanoleuca 91.77 3.00e-78 283.00
IUUC-Atr-002553 Amborella trichopoda 49.41 1.00e-18 87.80
IUUC-Aly-005840 Arabidopsis lyrata 47.62 6.00e-18 85.10
IUUC-Ame-011175 Astyanax mexicanus 64.74 4.00e-51 193.00
IUUC-Bta-012728 Bos taurus 93.46 5.00e-79 286.00
IUUC-Bdi-014671 Brachypodium distachyon 47.00 3.00e-19 90.90
IUUC-Bol-015156 Brassica oleracea 51.22 2.00e-19 90.90
IUUC-Bra-017773 Brassica rapa 48.78 3.00e-18 86.70
IUUC-Cja-019559 Callithrix jacchus 98.69 2.00e-83 300.00
IUUC-Cfa-020880 Canis familiaris 92.81 2.00e-78 284.00
IUUC-Cpo-022238 Cavia porcellus 79.76 4.00e-69 253.00
IUUC-Csa-023787 Chlorocebus sabaeus 98.69 1.00e-83 301.00
IUUC-Cin-025410 Ciona intestinalis 41.50 2.00e-20 91.30
IUUC-Dre-028637 Danio rerio 64.10 3.00e-53 200.00
IUUC-Dno-029183 Dasypus novemcinctus 92.81 2.00e-79 287.00
IUUC-Dor-030499 Dipodomys ordii 92.16 2.00e-76 277.00
IUUC-Dme-031824 Drosophila melanogaster 35.29 4.00e-19 87.00
IUUC-Ete-032501 Echinops telfairi 93.55 7.00e-64 235.00
IUUC-Eca-033768 Equus caballus 95.42 2.00e-80 290.00
IUUC-Eeu-035209 Erinaceus europaeus 92.59 2.00e-67 247.00
IUUC-Fca-036074 Felis catus 90.51 1.00e-77 281.00
IUUC-Gmo-038882 Gadus morhua 62.66 6.00e-46 176.00
IUUC-Gac-042217 Gasterosteus aculeatus 64.78 4.00e-53 200.00
IUUC-Gma-044323 Glycine max 51.76 4.00e-21 96.30
IUUC-Ggo-044890 Gorilla gorilla 99.35 3.00e-84 303.00
IUUC-Hvu-047461 Hordeum vulgare 47.00 2.00e-19 90.50
IUUC-Itr-048618 Ictidomys tridecemlineatus 90.85 2.00e-77 280.00
IUUC-Lch-049758 Latimeria chalumnae 66.24 1.00e-53 201.00
IUUC-Lpe-051546 Leersia perrieri 48.81 4.00e-20 94.40
IUUC-Loc-052244 Lepisosteus oculatus 62.73 1.00e-51 195.00
IUUC-Laf-054225 Loxodonta africana 86.14 5.00e-77 279.00
IUUC-Meu-056718 Macropus eugenii 71.43 4.00e-61 226.00
IUUC-Mtr-058205 Medicago truncatula 43.88 3.00e-17 83.60
IUUC-Mmr-061195 Microcebus murinus 92.81 6.00e-78 282.00
IUUC-Mdo-062131 Monodelphis domestica 65.09 5.00e-58 216.00
IUUC-Mmu-063803 Mus musculus 73.77 2.00e-44 171.00
IUUC-Mac-065049 Musa acuminata 47.87 3.00e-19 88.20
IUUC-Mpu-066689 Mustela putorius furo 94.12 6.00e-70 256.00
IUUC-Mlu-067441 Myotis lucifugus 78.44 2.00e-70 257.00
IUUC-Nle-069091 Nomascus leucogenys 94.74 7.00e-80 288.00
IUUC-Opr-070653 Ochotona princeps 93.46 1.00e-79 288.00
IUUC-Ont-071833 Oreochromis niloticus 63.69 4.00e-52 197.00
IUUC-Oan-073246 Ornithorhynchus anatinus 70.70 8.00e-58 215.00
IUUC-Ocu-074317 Oryctolagus cuniculus 93.46 2.00e-79 287.00
IUUC-Obr-076852 Oryza brachyantha 46.24 7.00e-20 93.20
IUUC-Ogl-077246 Oryza glaberrima 49.32 3.00e-16 79.00
IUUC-Ogu-078441 Oryza glumaepatula 51.19 4.00e-21 96.70
IUUC-Oin-079290 Oryza indica 51.19 2.00e-21 95.50
IUUC-Olo-080680 Oryza longistaminata 46.94 6.00e-21 95.90
IUUC-Ome-081782 Oryza meridionalis 45.98 8.00e-17 81.30
IUUC-Oni-082704 Oryza nivara 51.19 9.00e-21 95.10
IUUC-Opu-083695 Oryza punctata 55.00 2.00e-20 95.50
IUUC-Oru-084216 Oryza rufipogon 51.19 3.00e-21 96.70
IUUC-Osa-086033 Oryza sativa 51.19 3.00e-21 96.70
IUUC-Ola-087215 Oryzias latipes 64.97 3.00e-50 190.00
IUUC-Oga-088998 Otolemur garnettii 78.31 7.00e-57 213.00
IUUC-Oar-089622 Ovis aries 92.81 2.00e-79 287.00
IUUC-Ptr-091537 Pan troglodytes 99.35 3.00e-84 303.00
IUUC-Pan-091865 Papio anubis 98.04 4.00e-83 299.00
IUUC-Pfo-097473 Poecilia formosa 66.88 1.00e-54 204.00
IUUC-Pab-097986 Pongo abelii 99.35 3.00e-84 303.00
IUUC-Pop-099046 Populus trichocarpa 46.15 2.00e-18 87.00
IUUC-Pca-100492 Procavia capensis 93.46 9.00e-80 288.00
IUUC-Ppe-101517 Prunus persica 37.24 5.00e-20 92.40
IUUC-Pva-102641 Pteropus vampyrus 96.08 1.00e-81 294.00
IUUC-Rno-105300 Rattus norvegicus 81.33 1.00e-71 262.00
IUUC-Sha-106578 Sarcophilus harrisii 67.68 4.00e-54 203.00
IUUC-Sit-110141 Setaria italica 51.49 3.00e-22 100.00
IUUC-Sly-110977 Solanum lycopersicum 42.16 2.00e-19 90.10
IUUC-Stu-112415 Solanum tuberosum 44.09 7.00e-19 88.20
IUUC-Sar-112952 Sorex araneus 89.09 7.00e-50 188.00
IUUC-Sbi-114270 Sorghum bicolor 50.00 1.00e-17 84.00
IUUC-Ssc-115694 Sus scrofa 95.42 1.00e-80 291.00
IUUC-Tsy-119580 Tarsius syrichta 90.00 5.00e-35 138.00
IUUC-Tni-120075 Tetraodon nigroviridis 65.61 1.00e-53 201.00
IUUC-Tca-121683 Theobroma cacao 44.57 4.00e-19 89.70
IUUC-Tae-124824 Triticum aestivum 51.19 5.00e-19 89.00
IUUC-Tur-126513 Triticum urartu 51.19 5.00e-19 89.00
IUUC-Ttr-129081 Tursiops truncatus 93.46 4.00e-79 286.00
IUUC-Vpa-130305 Vicugna pacos 91.80 1.00e-56 211.00
IUUC-Vvi-131520 Vitis vinifera 47.78 4.00e-19 89.40
IUUC-Xtr-132897 Xenopus tropicalis 61.31 7.00e-43 166.00
IUUC-Xma-133809 Xiphophorus maculatus 66.88 1.00e-54 204.00
Created Date 25-Jun-2017

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