iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bta-012621

Ensembl Protein ID

ENSBTAP00000010606.4

UniProt Accession

Q5EA13; Q5EA13_BOVIN

Genbank Protein ID

AAX08773.1

Protein Name

Peroxisome proliferative activated receptor, alpha isoform 1

Genbank Nucleotide ID

DAAA02014949

Gene Name

PPARA

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000008063.4	ENSBTAT00000010606.4	ENSBTAP00000010606.4

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	94.87	0.00e+00	890.00	IUUC-Hsa-046893

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Bos taurus

Protein Sequence
(Fasta)

MEMVDTESPI GPLSPLEADD LESPLSADFL QEMGTIQEIS QSIGEDSSGS FSFTEYQYLG 60
SGPGSDGSVI TDTLSPASSP SSVSYPAVPG SAEESSSIAL NIECRICGDK ASGYHYGVHA 120

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Nucleotide Sequence
(Fasta)

CAAGGTGGTG GAGAGTTTGG CAGAACCAGA GCACAGATCG TTTCCTCCTT TACCTTCTTG 60
CCGCCAAGGC CGGAGGAGGA GGGCCCTGCC TCCTCTGGAA AGTAACAGTC TGTGGCCGGA 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0675--Receptor
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003074--1Cnucl_rcpt
IPR003076--1Cnucl_rcpt_A
IPR000536--Nucl_hrmn_rcpt_lig-bd
IPR001723--Nuclear_hrmn_rcpt
IPR001628--Znf_hrmn_rcpt
IPR013088--Znf_NHR/GATA

PROSITE

PS00031--NUCLEAR_REC_DBD_1
PS51030--NUCLEAR_REC_DBD_2

Pfam

PF00104--Hormone_recep
PF00105--zf-C4

PRINTS

PR01288--PROXISOMEPAR
PR01289--PROXISOMPAAR
PR00398--STRDHORMONER
PR00047--STROIDFINGER

SMART

SM00430--HOLI
SM00399--ZnF_C4

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0003677--F:DNA binding
GO:0008144--F:drug binding
GO:0008289--F:lipid binding
GO:0004872--F:receptor activity
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0004879--F:RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
GO:0043565--F:sequence-specific DNA binding
GO:0003707--F:steroid hormone receptor activity
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001190--F:transcriptional activator activity, RNA polymerase II transcription factor binding
GO:0001078--F:transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0008270--F:zinc ion binding
GO:0032922--P:circadian regulation of gene expression
GO:0070166--P:enamel mineralization
GO:0008544--P:epidermis development
GO:0006631--P:fatty acid metabolic process
GO:0032099--P:negative regulation of appetite
GO:0010887--P:negative regulation of cholesterol storage
GO:0050728--P:negative regulation of inflammatory response
GO:1903038--P:negative regulation of leukocyte cell-cell adhesion
GO:0010745--P:negative regulation of macrophage derived foam cell differentiation
GO:1902894--P:negative regulation of pri-miRNA transcription from RNA polymerase II promoter
GO:0010871--P:negative regulation of receptor biosynthetic process
GO:0010891--P:negative regulation of sequestering of triglyceride
GO:0046321--P:positive regulation of fatty acid oxidation
GO:0045722--P:positive regulation of gluconeogenesis
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0072366--P:regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter
GO:0042752--P:regulation of circadian rhythm
GO:0019217--P:regulation of fatty acid metabolic process
GO:0072363--P:regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter
GO:0072369--P:regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter
GO:0042060--P:wound healing

KEGG

bta:281992

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002222	Ailuropoda melanoleuca	93.43	0.00e+00	897.00
IUUC-Apl-003330	Anas platyrhynchos	88.16	0.00e+00	823.00
IUUC-Aca-004598	Anolis carolinensis	85.32	0.00e+00	822.00
IUUC-Acl-008339	Aspergillus clavatus	45.45	1.10e-01	29.60
IUUC-Ame-011508	Astyanax mexicanus	74.47	0.00e+00	689.00
IUUC-Cja-019688	Callithrix jacchus	94.23	0.00e+00	885.00
IUUC-Cfa-020859	Canis familiaris	95.30	0.00e+00	907.00
IUUC-Cpo-021607	Cavia porcellus	88.03	0.00e+00	825.00
IUUC-Csa-023313	Chlorocebus sabaeus	94.23	0.00e+00	880.00
IUUC-Cho-024741	Choloepus hoffmanni	83.55	0.00e+00	753.00
IUUC-Cgl-026615	Colletotrichum gloeosporioides	34.48	3.30e-01	27.70
IUUC-Dre-027446	Danio rerio	72.34	0.00e+00	667.00
IUUC-Dno-029173	Dasypus novemcinctus	91.06	0.00e+00	832.00
IUUC-Dor-030581	Dipodomys ordii	91.01	0.00e+00	809.00
IUUC-Ete-032330	Echinops telfairi	91.45	0.00e+00	862.00
IUUC-Eca-033712	Equus caballus	95.30	0.00e+00	885.00
IUUC-Fca-036555	Felis catus	95.32	0.00e+00	904.00
IUUC-Fal-036677	Ficedula albicollis	88.25	0.00e+00	822.00
IUUC-Gmo-039240	Gadus morhua	81.55	0.00e+00	641.00
IUUC-Gga-040473	Gallus gallus	88.89	0.00e+00	828.00
IUUC-Gac-041872	Gasterosteus aculeatus	71.88	0.00e+00	682.00
IUUC-Ggo-045226	Gorilla gorilla	94.87	0.00e+00	888.00
IUUC-Hsa-046893	Homo sapiens	94.87	0.00e+00	888.00
IUUC-Itr-048952	Ictidomys tridecemlineatus	92.52	0.00e+00	864.00
IUUC-Lch-050116	Latimeria chalumnae	80.13	0.00e+00	745.00
IUUC-Loc-052131	Lepisosteus oculatus	83.85	0.00e+00	666.00
IUUC-Laf-054323	Loxodonta africana	94.66	0.00e+00	889.00
IUUC-Mcc-054841	Macaca mulatta	94.87	0.00e+00	887.00
IUUC-Meu-056833	Macropus eugenii	82.91	0.00e+00	753.00
IUUC-Mtr-058471	Medicago truncatula	29.82	2.10e-01	30.00
IUUC-Mga-059995	Meleagris gallopavo	79.45	0.00e+00	725.00
IUUC-Mdo-061954	Monodelphis domestica	89.25	0.00e+00	770.00
IUUC-Mmu-064295	Mus musculus	91.24	0.00e+00	826.00
IUUC-Mpu-066216	Mustela putorius furo	94.87	0.00e+00	900.00
IUUC-Nle-069970	Nomascus leucogenys	94.66	0.00e+00	886.00
IUUC-Ont-071594	Oreochromis niloticus	73.78	0.00e+00	676.00
IUUC-Oan-073501	Ornithorhynchus anatinus	92.42	0.00e+00	744.00
IUUC-Ocu-074634	Oryctolagus cuniculus	83.50	0.00e+00	821.00
IUUC-Oni-082926	Oryza nivara	29.41	1.00e-02	30.80
IUUC-Ola-086585	Oryzias latipes	79.63	0.00e+00	636.00
IUUC-Oga-088738	Otolemur garnettii	95.32	0.00e+00	887.00
IUUC-Oar-090453	Ovis aries	98.94	0.00e+00	927.00
IUUC-Ptr-091518	Pan troglodytes	94.66	0.00e+00	882.00
IUUC-Pan-092006	Papio anubis	94.66	0.00e+00	882.00
IUUC-Psi-093352	Pelodiscus sinensis	87.29	0.00e+00	822.00
IUUC-Pfo-096060	Poecilia formosa	72.52	0.00e+00	670.00
IUUC-Pab-098602	Pongo abelii	88.40	0.00e+00	788.00
IUUC-Pva-102175	Pteropus vampyrus	90.17	0.00e+00	841.00
IUUC-Rno-105283	Rattus norvegicus	91.88	0.00e+00	827.00
IUUC-Sce-106436	Saccharomyces cerevisiae	29.03	9.00e-03	32.00
IUUC-Sha-106560	Sarcophilus harrisii	92.54	0.00e+00	848.00
IUUC-Smo-109075	Selaginella moellendorffii	30.00	1.00e-01	29.60
IUUC-Ssc-115266	Sus scrofa	94.87	0.00e+00	904.00
IUUC-Tgu-116778	Taeniopygia guttata	87.45	0.00e+00	820.00
IUUC-Tru-118436	Takifugu rubripes	72.30	0.00e+00	674.00
IUUC-Tsy-119642	Tarsius syrichta	98.27	3.00e-134	471.00
IUUC-Tni-119859	Tetraodon nigroviridis	72.30	0.00e+00	669.00
IUUC-Tvi-122624	Trichoderma virens	33.33	5.30e-02	30.40
IUUC-Tbe-127464	Tupaia belangeri	92.52	0.00e+00	880.00
IUUC-Ttr-129307	Tursiops truncatus	92.96	0.00e+00	856.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence