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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046869
UUCD1 version UUC-HoS-00270
Ensembl Protein ID ENSP00000349298.3
UniProt Accession Q8WY64; Q5TIA4; Q9BU73; Q9NRL9; Q9UHE7; MYLIP_HUMAN
Genbank Protein ID AAF18974.1; AAQ13408.1; AAQ13409.1; AAF87323.1; AAG23789.1; AAP35704.1; CAI19548.1; EAW55366.1; AAH02860.1
Protein Name E3 ubiquitin-protein ligase MYLIP; Inducible degrader of the LDL-receptor; Myosin regulatory light chain interacting protein; RING-type E3 ubiquitin transferase MYLIP
Genbank Nucleotide ID AF187016; AF006003; AF006004; AF212221; AF258586; BT007055; AL021407; CH471087; BC002860
Gene Name MYLIP; BZF1; IDOL; BM-023; PP5242
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000007944.14 ENST00000356840.7 ENSP00000349298.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACRepTar
miRNAMapSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusBioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 20427281; 19520913; 21343340; 19783832
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.
 E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.
Protein Sequence
(Fasta)
MLCYVTRPDA VLMEVEVEAK ANGEDCLNQV CRRLGIIEVD YFGLQFTGSK GESLWLNLRN 60
RISQQMDGLA PYRLKLRVKF FVEPHLILQE QTRHIFFLHI KEALLAGHLL CSPEQAVELS 120
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Protein Fasta Sequence


>IUUC-Hsa-046869|E3,RING|Homo sapiens
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Nucleotide Sequence
(Fasta)
GGGCAGCTGG CGGGCAGCGG GTGAGGGGGT GGCGGGGACG CGAGTGGCGG CCGCGGGGCC 60
CCGGACAAGG GTCCGCAGAG CTGCAGCCTT CGAGGGCCAG CCCTCTCCGA GTCCGGGGCT 120
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Nucleotide Fasta Sequence


>IUUC-Hsa-046869|E3,RING|Homo sapiens
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Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0408--Iron
KW-0472--Membrane
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR019749--Band_41_domain
IPR001370--BIR_rpt
IPR000798--Ez/rad/moesin-like
IPR014352--FERM/acyl-CoA-bd_prot_3-hlx
IPR019748--FERM_central
IPR000299--FERM_domain
IPR018979--FERM_N
IPR018980--FERM_PH-like_C
IPR011993--PH_dom-like
IPR029071--Ubiquitin-rel_dom
IPR001841--Znf_RING
PROSITE

PS50057--FERM_3
PS50089--ZF_RING_2
Pfam

PF09380--FERM_C
PF00373--FERM_M
PF09379--FERM_N
PRINTS

PR00935--BAND41
PR00661--ERMFAMILY
SMART

SM00295--B41
SM01196--FERM_C
Gene Ontology

GO:0005829--C:cytosol
GO:0019898--C:extrinsic component of membrane
GO:0005622--C:intracellular
GO:0005886--C:plasma membrane
GO:0008092--F:cytoskeletal protein binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0042632--P:cholesterol homeostasis
GO:0006928--P:movement of cell or subcellular component
GO:0010989--P:negative regulation of low-density lipoprotein particle clearance
GO:0007399--P:nervous system development
GO:0045732--P:positive regulation of protein catabolic process
GO:0031648--P:protein destabilization
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032803--P:regulation of low-density lipoprotein particle receptor catabolic process
KEGG hsa:29116
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001425 Ailuropoda melanoleuca 95.67 0.00e+00 810.00
IUUC-Apl-003704 Anas platyrhynchos 90.93 0.00e+00 772.00
IUUC-Aca-004645 Anolis carolinensis 89.66 0.00e+00 778.00
IUUC-Ame-011401 Astyanax mexicanus 74.77 0.00e+00 655.00
IUUC-Bta-012752 Bos taurus 94.47 0.00e+00 712.00
IUUC-Cja-019734 Callithrix jacchus 98.20 0.00e+00 858.00
IUUC-Cfa-020145 Canis familiaris 95.79 0.00e+00 736.00
IUUC-Cpo-021436 Cavia porcellus 95.79 0.00e+00 723.00
IUUC-Csa-024248 Chlorocebus sabaeus 99.10 0.00e+00 862.00
IUUC-Cho-024528 Choloepus hoffmanni 84.27 0.00e+00 684.00
IUUC-Cin-025748 Ciona intestinalis 36.33 4.00e-47 181.00
IUUC-Csv-025837 Ciona savignyi 38.00 2.00e-91 329.00
IUUC-Dre-027847 Danio rerio 75.11 0.00e+00 666.00
IUUC-Dno-029860 Dasypus novemcinctus 95.26 0.00e+00 695.00
IUUC-Dor-030664 Dipodomys ordii 83.37 0.00e+00 709.00
IUUC-Dse-031509 Dothistroma septosporum 45.10 1.00e-09 59.30
IUUC-Dme-031990 Drosophila melanogaster 31.53 1.00e-38 154.00
IUUC-Ete-032496 Echinops telfairi 75.54 5.00e-149 520.00
IUUC-Eca-033674 Equus caballus 95.99 0.00e+00 873.00
IUUC-Eeu-035048 Erinaceus europaeus 88.31 0.00e+00 780.00
IUUC-Fca-036547 Felis catus 95.43 0.00e+00 813.00
IUUC-Fal-037504 Ficedula albicollis 91.37 0.00e+00 761.00
IUUC-Fox-037905 Fusarium oxysporum 27.27 1.10e-02 32.70
IUUC-Gmo-038660 Gadus morhua 74.41 8.00e-153 533.00
IUUC-Gga-040123 Gallus gallus 91.69 0.00e+00 808.00
IUUC-Gac-042073 Gasterosteus aculeatus 72.54 0.00e+00 632.00
IUUC-Ggo-045387 Gorilla gorilla 99.55 0.00e+00 865.00
IUUC-Itr-047917 Ictidomys tridecemlineatus 94.83 0.00e+00 838.00
IUUC-Lch-049990 Latimeria chalumnae 82.47 0.00e+00 775.00
IUUC-Loc-051908 Lepisosteus oculatus 75.89 0.00e+00 676.00
IUUC-Lma-053223 Leptosphaeria maculans 52.50 2.00e-08 55.80
IUUC-Laf-053915 Loxodonta africana 95.06 0.00e+00 837.00
IUUC-Mcc-054865 Macaca mulatta 98.88 0.00e+00 860.00
IUUC-Meu-056826 Macropus eugenii 86.36 2.00e-74 272.00
IUUC-Mga-059827 Meleagris gallopavo 90.95 0.00e+00 728.00
IUUC-Mmr-060734 Microcebus murinus 97.75 0.00e+00 874.00
IUUC-Mdo-062988 Monodelphis domestica 94.61 0.00e+00 858.00
IUUC-Mmu-064415 Mus musculus 96.18 0.00e+00 810.00
IUUC-Mpu-066118 Mustela putorius furo 95.79 0.00e+00 720.00
IUUC-Mlu-067131 Myotis lucifugus 95.51 0.00e+00 831.00
IUUC-Nle-070112 Nomascus leucogenys 99.33 0.00e+00 861.00
IUUC-Opr-071193 Ochotona princeps 93.17 0.00e+00 795.00
IUUC-Ont-072635 Oreochromis niloticus 74.27 0.00e+00 646.00
IUUC-Oan-073266 Ornithorhynchus anatinus 90.62 0.00e+00 758.00
IUUC-Ocu-074903 Oryctolagus cuniculus 94.38 0.00e+00 840.00
IUUC-Ola-087533 Oryzias latipes 71.59 8.00e-177 613.00
IUUC-Oga-087979 Otolemur garnettii 98.20 0.00e+00 885.00
IUUC-Oar-089747 Ovis aries 94.47 0.00e+00 784.00
IUUC-Ptr-090732 Pan troglodytes 99.78 0.00e+00 867.00
IUUC-Pan-092032 Papio anubis 99.10 0.00e+00 862.00
IUUC-Psi-093296 Pelodiscus sinensis 90.93 0.00e+00 782.00
IUUC-Pma-094351 Petromyzon marinus 50.28 3.00e-32 130.00
IUUC-Pfo-097183 Poecilia formosa 73.52 8.00e-175 606.00
IUUC-Pab-098177 Pongo abelii 99.33 0.00e+00 864.00
IUUC-Pca-100734 Procavia capensis 92.81 0.00e+00 834.00
IUUC-Ppe-101272 Prunus persica 44.83 4.00e-10 59.70
IUUC-Pva-102778 Pteropus vampyrus 96.88 0.00e+00 821.00
IUUC-Rno-106039 Rattus norvegicus 96.40 0.00e+00 844.00
IUUC-Sha-106869 Sarcophilus harrisii 94.23 0.00e+00 799.00
IUUC-Sar-113587 Sorex araneus 65.14 1.00e-147 516.00
IUUC-Ssc-116212 Sus scrofa 95.73 0.00e+00 841.00
IUUC-Tgu-116871 Taeniopygia guttata 91.13 0.00e+00 758.00
IUUC-Tru-117925 Takifugu rubripes 72.77 0.00e+00 671.00
IUUC-Tsy-118815 Tarsius syrichta 95.43 0.00e+00 791.00
IUUC-Tni-120007 Tetraodon nigroviridis 73.42 0.00e+00 640.00
IUUC-Tbe-127381 Tupaia belangeri 93.75 0.00e+00 661.00
IUUC-Ttr-129025 Tursiops truncatus 81.01 0.00e+00 645.00
IUUC-Vpa-130164 Vicugna pacos 91.10 2.00e-148 518.00
IUUC-Xtr-132800 Xenopus tropicalis 82.47 0.00e+00 740.00
Created Date 25-Jun-2017

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