iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tru-117927

UUCD1 version

UUC-TaR-00608

Ensembl Protein ID

ENSTRUP00000015215.1

UniProt Accession

H2SS28; H2SS28_TAKRU

Protein Name

E3 ubiquitin-protein ligase parkin

Gene Name

park2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000006244.1	ENSTRUT00000015281.1	ENSTRUP00000015212.1
ENSTRUG00000006244.1	ENSTRUT00000015282.1	ENSTRUP00000015213.1
ENSTRUG00000006244.1	ENSTRUT00000015283.1	ENSTRUP00000015214.1
ENSTRUG00000006244.1	ENSTRUT00000015284.1	ENSTRUP00000015215.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UDP/UBQ/UBQ_PIM	1.20e-15	58.4	2	71

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UBQ/UBQ_PIM

   S: 3    ltvktlkgkefelevseddtveelKekiakesgvppeqqkLIyaGkiLkDdttLselgikdgsvvhlvvk 72
           ++v+ + g e+ +e++e+ tv+elKe + +++gv+p+ +++++aG++Lk  +tL+ +++ ++s+vh++v 
   Q: 2    VFVRYNLGPEVVVELQEEATVAELKEVVGQQQGVQPDLLRVLFAGRELKSTSTLQGCDLPEQSTVHIIVP 71
           8999999************************************************************985 PP

Organism

Takifugu rubripes

Functional Description
(View)

Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

Protein Sequence
(Fasta)

SVFVRYNLGP EVVVELQEEA TVAELKEVVG QQQGVQPDLL RVLFAGRELK STSTLQGCDL 60
PEQSTVHIIV PSPASSSYKT LLLPEHLSQG EEENHDSLTR LDLSASRLPT TSSTLGVILE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCCTCAGTGT TTGTGAGGTA TAACCTGGGA CCAGAAGTGG TCGTAGAGCT GCAGGAAGAG 60
GCCACTGTAG CTGAGTTGAA GGAGGTGGTG GGTCAGCAGC AGGGAGTTCA GCCAGATCTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR016150--Casein_kin_II_reg-sub_b-sht
IPR031127--E3_UB_ligase_RBR
IPR002867--IBR_dom
IPR003977--Parkin
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom

PROSITE

PS50053--UBIQUITIN_2

Pfam

PF01485--IBR
PF00240--ubiquitin

PRINTS

PR01475--PARKIN

SMART

SM00647--IBR
SM00213--UBQ

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005739--C:mitochondrion
GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0046872--F:metal ion binding
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0006120--P:mitochondrial electron transport, NADH to ubiquinone
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0042981--P:regulation of apoptotic process
GO:0006979--P:response to oxidative stress
GO:0009266--P:response to temperature stimulus

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001814	Ailuropoda melanoleuca	47.60	5.00e-75	274.00
IUUC-Apl-003304	Anas platyrhynchos	59.81	9.00e-119	419.00
IUUC-Aca-004908	Anolis carolinensis	53.27	6.00e-33	131.00
IUUC-Ame-011856	Astyanax mexicanus	60.16	1.00e-166	579.00
IUUC-Bta-013014	Bos taurus	50.11	5.00e-112	397.00
IUUC-Cel-018687	Caenorhabditis elegans	32.29	7.00e-42	164.00
IUUC-Cja-019274	Callithrix jacchus	49.37	4.00e-76	277.00
IUUC-Cfa-020461	Canis familiaris	48.73	3.00e-77	281.00
IUUC-Cpo-022251	Cavia porcellus	47.50	3.00e-76	278.00
IUUC-Csa-023112	Chlorocebus sabaeus	48.42	1.00e-69	256.00
IUUC-Cho-024504	Choloepus hoffmanni	37.73	8.00e-82	297.00
IUUC-Dre-028202	Danio rerio	60.00	4.00e-154	537.00
IUUC-Dno-028946	Dasypus novemcinctus	57.89	1.00e-24	104.00
IUUC-Dor-030508	Dipodomys ordii	43.23	3.00e-76	278.00
IUUC-Dme-031980	Drosophila melanogaster	42.28	8.00e-111	393.00
IUUC-Ete-032281	Echinops telfairi	42.71	7.00e-51	194.00
IUUC-Eca-033228	Equus caballus	46.86	1.00e-73	269.00
IUUC-Fal-037507	Ficedula albicollis	52.14	1.00e-141	496.00
IUUC-Gmo-038744	Gadus morhua	59.36	6.00e-94	337.00
IUUC-Gga-040353	Gallus gallus	52.16	1.00e-140	493.00
IUUC-Gac-042519	Gasterosteus aculeatus	65.42	0.00e+00	627.00
IUUC-Hsa-046016	Homo sapiens	52.66	1.00e-136	479.00
IUUC-Itr-048744	Ictidomys tridecemlineatus	50.20	4.00e-129	454.00
IUUC-Loc-052389	Lepisosteus oculatus	54.18	3.00e-145	508.00
IUUC-Mcc-054933	Macaca mulatta	52.95	6.00e-137	480.00
IUUC-Meu-055963	Macropus eugenii	41.90	3.00e-84	305.00
IUUC-Mga-059626	Meleagris gallopavo	62.67	6.00e-23	98.20
IUUC-Mmr-061566	Microcebus murinus	59.45	7.00e-63	233.00
IUUC-Mdo-061952	Monodelphis domestica	66.04	3.00e-19	85.90
IUUC-Mmu-063561	Mus musculus	52.87	7.00e-142	497.00
IUUC-Mpu-065799	Mustela putorius furo	47.66	1.00e-76	279.00
IUUC-Mlu-068134	Myotis lucifugus	47.79	2.00e-93	335.00
IUUC-Nle-070078	Nomascus leucogenys	48.47	5.00e-78	284.00
IUUC-Opr-070541	Ochotona princeps	51.53	4.00e-126	444.00
IUUC-Ont-071743	Oreochromis niloticus	64.30	5.00e-172	597.00
IUUC-Ola-086426	Oryzias latipes	70.76	6.00e-72	262.00
IUUC-Oga-088867	Otolemur garnettii	52.05	6.00e-134	470.00
IUUC-Oar-089365	Ovis aries	50.64	5.00e-102	364.00
IUUC-Ptr-091371	Pan troglodytes	52.46	2.00e-135	475.00
IUUC-Pan-092443	Papio anubis	49.53	2.00e-74	272.00
IUUC-Psi-093851	Pelodiscus sinensis	48.09	2.00e-63	234.00
IUUC-Pfo-097194	Poecilia formosa	59.88	1.00e-161	562.00
IUUC-Pab-097999	Pongo abelii	56.90	4.00e-54	204.00
IUUC-Pca-100410	Procavia capensis	50.55	5.00e-110	390.00
IUUC-Pva-102300	Pteropus vampyrus	44.12	3.00e-107	382.00
IUUC-Rno-105556	Rattus norvegicus	49.84	1.00e-76	279.00
IUUC-Sar-113121	Sorex araneus	65.18	5.00e-41	161.00
IUUC-Ssc-116435	Sus scrofa	48.72	2.00e-76	278.00
IUUC-Tgu-117489	Taeniopygia guttata	51.53	4.00e-142	497.00
IUUC-Tsy-119372	Tarsius syrichta	61.99	5.00e-115	407.00
IUUC-Tni-120043	Tetraodon nigroviridis	83.33	0.00e+00	717.00
IUUC-Tbe-127539	Tupaia belangeri	45.03	7.00e-107	380.00
IUUC-Ttr-129149	Tursiops truncatus	49.90	7.00e-136	477.00
IUUC-Vpa-130439	Vicugna pacos	38.65	3.00e-86	312.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence