iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
ICGC	COSMIC	CGAP	IntOGen
mRNA Expression
ArrayExpress	TCGA	ICGC	COSMIC
THPA	HPM
DNA & RNA Element
UTRdb	CircNet	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Disease-associated Variation
GWAS Central
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	2.40e-13	51.9	24	90

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklde 67
           +D+ ++v+g+ f+ah+ +L a S +F+al+ +   +s  +++  ++ v  ++f+ +l+FlY+gkld+
   Q: 24   CDCSIIVEGRIFKAHRNILFANSGYFRALLIHYIQDSGRHSTASLDIVTSDAFSIILDFLYSGKLDL 90
           8**********************************998677777777******************96 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MEMQSYYAKL LGELNEQRKR DFFCDCSIIV EGRIFKAHRN ILFANSGYFR ALLIHYIQDS 60
GRHSTASLDI VTSDAFSIIL DFLYSGKLDL CGENVIEVMS AASYLQMNDV VNFCKTYIRS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGTCGGTGC GCGGTGCTCC GTGGCTGCGC TGCTGGAACC CGCTGGAAGG TGAGCGCGAA 60
GAAGCGGGTT GGCGCTGCCG CTTTCGTTGG TTTGGGGAGG ATTCCTAGCA CCCGGGAGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000210--BTB/POZ_dom
IPR004039--Rubredoxin-type_fold
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2

Pfam

PF00651--BTB

SMART

SM00225--BTB
SM00355--ZnF_C2H2

Gene Ontology

GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0046872--F:metal ion binding
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:728116

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ete-032238	Echinops telfairi	79.23	0.00e+00	696.00
IUUC-Eeu-034823	Erinaceus europaeus	88.01	0.00e+00	733.00
IUUC-Gmo-039030	Gadus morhua	47.87	4.00e-103	368.00
IUUC-Gga-040679	Gallus gallus	71.86	2.00e-124	438.00
IUUC-Ggo-045656	Gorilla gorilla	99.02	0.00e+00	847.00
IUUC-Opr-070863	Ochotona princeps	83.16	0.00e+00	703.00
IUUC-Ont-071885	Oreochromis niloticus	48.02	3.00e-111	395.00
IUUC-Pfo-096280	Poecilia formosa	48.74	1.00e-110	394.00
IUUC-Pca-100505	Procavia capensis	77.73	0.00e+00	667.00
IUUC-Ppe-101171	Prunus persica	29.75	3.00e-06	47.00
IUUC-Pva-103229	Pteropus vampyrus	90.81	0.00e+00	780.00
IUUC-Ssc-115944	Sus scrofa	88.50	0.00e+00	746.00
IUUC-Tsy-119437	Tarsius syrichta	92.93	0.00e+00	776.00
IUUC-Tni-120105	Tetraodon nigroviridis	51.68	5.00e-113	401.00
IUUC-Tbe-128037	Tupaia belangeri	73.02	6.00e-88	318.00
IUUC-Ttr-128733	Tursiops truncatus	87.61	0.00e+00	733.00
IUUC-Vpa-130342	Vicugna pacos	87.42	0.00e+00	734.00
IUUC-Xtr-131765	Xenopus tropicalis	65.59	1.00e-168	585.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence