iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ont-071846

Ensembl Protein ID

ENSONIP00000000476.1

UniProt Accession

I3IV36; I3IV36_ORENI

Genbank Protein ID

ENSONIP00000000476

Protein Name

Presenilin

Genbank Nucleotide ID

AERX01008735

Gene Name

psen1; LOC100697238

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000000378.1	ENSONIT00000000475.1	ENSONIP00000000476.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/CUE	4.10e-08	33.5	292	320

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 2    letaleqLkeiFPnldysviqvvLeantg 30
           +eta+e++++iFP+l+ys+++v+L+++++
   Q: 292  VETAQERNEPIFPALIYSSTMVWLVNMAD 320
           89************************997 PP

Organism

Oreochromis niloticus

Functional Description
(View)

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

Protein Sequence
(Fasta)

MANNAEDIEN NMNQQEANRS PDSTQKPQET GVPRARSRGG SAAGAGAGTG GGGDSGGGGG 60
GNGTGPEQNG QPPAAPAPRV VEREEEEEDE ELTLKYGAKH VIMLFVPVTL CMVVVVATIK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTTGAAAAG TTCCGGTTTG CATGTGAGGA CAAGAGTCCA CCGAGCCAAC AATGGCGAAC 60
AATGCAGAGG ATATCGAAAA CAATATGGTC AGTATTAAAG AAAGTTTCAC AGTGGCTCTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR002031--Pept_A22A_PS1
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN

SMART

SM00730--PSN

Gene Ontology

GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0016021--C:integral component of membrane
GO:0004190--F:aspartic-type endopeptidase activity
GO:0035556--P:intracellular signal transduction
GO:0007219--P:Notch signaling pathway
GO:0016485--P:protein processing

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000686	Aegilops tauschii	34.65	6.00e-24	106.00
IUUC-Aml-001648	Ailuropoda melanoleuca	74.53	1.00e-126	446.00
IUUC-Atr-003039	Amborella trichopoda	31.29	3.00e-38	152.00
IUUC-Apl-003727	Anas platyrhynchos	77.83	2.00e-149	522.00
IUUC-Aca-004582	Anolis carolinensis	77.78	1.00e-152	532.00
IUUC-Aly-005455	Arabidopsis lyrata	30.70	8.00e-18	85.10
IUUC-Ath-006730	Arabidopsis thaliana	32.09	1.00e-18	87.80
IUUC-Ame-011500	Astyanax mexicanus	84.24	3.00e-168	584.00
IUUC-Bta-013026	Bos taurus	75.85	8.00e-150	523.00
IUUC-Bdi-014196	Brachypodium distachyon	33.43	3.00e-30	126.00
IUUC-Bol-015841	Brassica oleracea	32.78	7.00e-32	131.00
IUUC-Cel-018553	Caenorhabditis elegans	52.99	1.00e-100	360.00
IUUC-Cja-019994	Callithrix jacchus	76.79	1.00e-147	516.00
IUUC-Cfa-020074	Canis familiaris	78.00	2.00e-150	525.00
IUUC-Cpo-022237	Cavia porcellus	76.30	5.00e-147	514.00
IUUC-Csa-023537	Chlorocebus sabaeus	76.73	8.00e-148	516.00
IUUC-Cho-024735	Choloepus hoffmanni	69.06	3.00e-137	481.00
IUUC-Cin-025780	Ciona intestinalis	61.76	2.00e-121	429.00
IUUC-Csv-025967	Ciona savignyi	62.04	4.00e-120	424.00
IUUC-Dre-028689	Danio rerio	83.50	8.00e-160	556.00
IUUC-Dno-029758	Dasypus novemcinctus	77.50	2.00e-149	522.00
IUUC-Dor-030609	Dipodomys ordii	56.44	4.00e-105	375.00
IUUC-Dme-031929	Drosophila melanogaster	55.42	3.00e-110	392.00
IUUC-Eeu-035134	Erinaceus europaeus	74.84	8.00e-111	393.00
IUUC-Fca-036243	Felis catus	77.75	7.00e-150	523.00
IUUC-Fal-036600	Ficedula albicollis	79.00	2.00e-153	535.00
IUUC-Gmo-039665	Gadus morhua	80.50	6.00e-132	464.00
IUUC-Gga-040993	Gallus gallus	79.20	8.00e-154	536.00
IUUC-Gac-042342	Gasterosteus aculeatus	74.90	3.00e-157	548.00
IUUC-Hsa-046822	Homo sapiens	76.73	1.00e-147	516.00
IUUC-Hvu-047141	Hordeum vulgare	34.21	4.00e-25	109.00
IUUC-Lch-049946	Latimeria chalumnae	71.43	3.00e-130	458.00
IUUC-Lpe-051132	Leersia perrieri	31.83	4.00e-28	119.00
IUUC-Loc-052469	Lepisosteus oculatus	67.70	4.00e-141	494.00
IUUC-Laf-053979	Loxodonta africana	74.44	2.00e-134	472.00
IUUC-Mcc-055682	Macaca mulatta	76.73	1.00e-147	516.00
IUUC-Meu-056004	Macropus eugenii	62.24	2.00e-117	416.00
IUUC-Mga-059466	Meleagris gallopavo	79.45	3.00e-154	538.00
IUUC-Mdo-062122	Monodelphis domestica	74.59	4.00e-149	521.00
IUUC-Mmu-063176	Mus musculus	76.94	2.00e-141	495.00
IUUC-Mpu-065927	Mustela putorius furo	77.75	2.00e-149	522.00
IUUC-Mlu-067079	Myotis lucifugus	77.14	2.00e-155	541.00
IUUC-Nle-070180	Nomascus leucogenys	76.73	1.00e-147	516.00
IUUC-Opr-070847	Ochotona princeps	74.14	5.00e-141	494.00
IUUC-Oan-072783	Ornithorhynchus anatinus	74.32	3.00e-115	408.00
IUUC-Ocu-074527	Oryctolagus cuniculus	77.69	7.00e-150	524.00
IUUC-Oba-075256	Oryza barthii	32.04	2.00e-26	113.00
IUUC-Ogl-077097	Oryza glaberrima	31.99	9.00e-28	118.00
IUUC-Ogu-078570	Oryza glumaepatula	31.99	1.00e-27	117.00
IUUC-Oin-079244	Oryza indica	31.99	6.00e-28	118.00
IUUC-Olo-080484	Oryza longistaminata	35.94	9.00e-23	100.00
IUUC-Ome-081814	Oryza meridionalis	33.25	1.00e-29	124.00
IUUC-Oni-082057	Oryza nivara	31.99	7.00e-28	118.00
IUUC-Opu-084176	Oryza punctata	31.82	7.00e-27	115.00
IUUC-Oru-084618	Oryza rufipogon	31.99	1.00e-27	117.00
IUUC-Osa-085602	Oryza sativa	32.02	5.00e-28	118.00
IUUC-Oar-090348	Ovis aries	76.75	5.00e-151	527.00
IUUC-Ptr-091060	Pan troglodytes	76.73	1.00e-147	516.00
IUUC-Pan-091855	Papio anubis	72.52	2.00e-131	462.00
IUUC-Psi-093505	Pelodiscus sinensis	77.18	3.00e-152	531.00
IUUC-Pma-094612	Petromyzon marinus	70.96	8.00e-122	430.00
IUUC-Ppa-095431	Physcomitrella patens	29.46	4.00e-38	152.00
IUUC-Pfo-097396	Poecilia formosa	85.13	0.00e+00	692.00
IUUC-Pab-098591	Pongo abelii	76.73	1.00e-147	516.00
IUUC-Pca-101029	Procavia capensis	74.75	1.00e-137	483.00
IUUC-Ppe-101495	Prunus persica	31.53	2.00e-20	94.00
IUUC-Pva-102244	Pteropus vampyrus	74.25	1.00e-142	499.00
IUUC-Rno-105861	Rattus norvegicus	76.69	4.00e-142	498.00
IUUC-Sha-107045	Sarcophilus harrisii	75.06	3.00e-150	525.00
IUUC-Smo-109325	Selaginella moellendorffii	36.19	6.00e-35	141.00
IUUC-Sit-110624	Setaria italica	33.54	4.00e-26	112.00
IUUC-Stu-112433	Solanum tuberosum	31.89	6.00e-30	125.00
IUUC-Sar-113169	Sorex araneus	71.94	1.00e-113	403.00
IUUC-Sbi-114305	Sorghum bicolor	35.24	2.00e-26	114.00
IUUC-Ssc-115766	Sus scrofa	77.23	7.00e-150	523.00
IUUC-Tru-117732	Takifugu rubripes	93.18	0.00e+00	647.00
IUUC-Tsy-119624	Tarsius syrichta	67.99	3.00e-131	462.00
IUUC-Tni-119852	Tetraodon nigroviridis	78.07	4.00e-175	607.00
IUUC-Tae-123984	Triticum aestivum	34.32	3.00e-25	109.00
IUUC-Tur-126237	Triticum urartu	34.32	2.00e-25	110.00
IUUC-Tbe-128148	Tupaia belangeri	65.18	1.00e-104	373.00
IUUC-Ttr-128793	Tursiops truncatus	76.00	3.00e-143	501.00
IUUC-Vpa-130625	Vicugna pacos	64.00	2.00e-114	405.00
IUUC-Vvi-131312	Vitis vinifera	32.51	4.00e-34	139.00
IUUC-Xtr-131790	Xenopus tropicalis	78.95	3.00e-142	498.00
IUUC-Xma-133377	Xiphophorus maculatus	82.88	0.00e+00	653.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence