iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA
Post-translational Modifications (PTMs)
dbPAF	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.40e-07	32.0	12	53
UBD/SH3	9.90e-38	128.0	142	190

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C++Cle++++  +vlpC+H+f+++Clq +      s+ + rCP Cr
   Q: 12   CSVCLERLDTTSKVLPCQHTFCRKCLQDI----VASQHKLRCPECR 53
           **********9***************999....889999******8 PP

UBD/SH3

   S: 8    vlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFve 60
           +l+d+ + +  +L++kkGd +l+  k+  d++W +g  +++g++G fP n+v+
   Q: 142  ALFDFASGEATDLKFKKGDLILI--KHRIDNNWFVG--QANGQEGTFPINYVK 190
           8********************99..8**********..7*************8 PP

Organism

Drosophila melanogaster

Protein Sequence
(Fasta)

MDEHTLNDLL ECSVCLERLD TTSKVLPCQH TFCRKCLQDI VASQHKLRCP ECRILVSCKI 60
DELPPNVLLM RILEGMKQNA AAGKGEEKGE ETETQPERAK PQPPAESVAP PDNQLLQLQS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CACTGTGTTC AAGTATCAAG CTGGTTTTAT ATCCGTGTGC CTATGTACAT TTGTATCCGC 60
TTGGCCACGA GCTTTGGCTG CACTTGGCAA ACTTAATAAA TTAAACATTG AATCCTGCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome

Interpro

IPR001452--SH3_domain
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50002--SH3
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00018--SH3_1
PF14604--SH3_9

PRINTS

PR00452--SH3DOMAIN

SMART

SM00184--RING
SM00326--SH3

Gene Ontology

GO:0005829--C:cytosol
GO:0019901--F:protein kinase binding
GO:0030159--F:receptor signaling complex scaffold activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0008340--P:determination of adult lifespan
GO:0007391--P:dorsal closure
GO:0007390--P:germ-band shortening
GO:0008258--P:head involution
GO:0045087--P:innate immune response
GO:0060548--P:negative regulation of cell death
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0022407--P:regulation of cell-cell adhesion
GO:0032494--P:response to peptidoglycan

KEGG

dme:Dmel_CG4909

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001528	Ailuropoda melanoleuca	45.52	1.00e-60	227.00
IUUC-Apl-003961	Anas platyrhynchos	46.62	2.00e-62	233.00
IUUC-Aca-004386	Anolis carolinensis	45.49	5.00e-62	231.00
IUUC-Ago-007765	Ashbya gossypii	42.19	2.00e-10	59.30
IUUC-Ame-010659	Astyanax mexicanus	46.92	2.00e-34	140.00
IUUC-Bta-013400	Bos taurus	43.94	4.00e-30	125.00
IUUC-Cja-019730	Callithrix jacchus	41.90	3.00e-60	226.00
IUUC-Cfa-020992	Canis familiaris	45.52	2.00e-60	226.00
IUUC-Cpo-021304	Cavia porcellus	45.90	4.00e-61	228.00
IUUC-Csa-023925	Chlorocebus sabaeus	41.90	2.00e-60	226.00
IUUC-Cin-025274	Ciona intestinalis	42.45	3.00e-59	221.00
IUUC-Csv-026136	Ciona savignyi	39.50	2.00e-57	215.00
IUUC-Dre-028290	Danio rerio	46.62	6.00e-66	244.00
IUUC-Dno-029083	Dasypus novemcinctus	41.90	6.00e-60	225.00
IUUC-Dor-030388	Dipodomys ordii	42.05	1.00e-59	224.00
IUUC-Ete-032513	Echinops telfairi	41.54	1.00e-51	197.00
IUUC-Eca-034241	Equus caballus	42.22	2.00e-51	196.00
IUUC-Eeu-034636	Erinaceus europaeus	44.70	9.00e-31	127.00
IUUC-Fca-036439	Felis catus	45.52	1.00e-60	227.00
IUUC-Fal-037074	Ficedula albicollis	47.69	4.00e-32	132.00
IUUC-Gmo-038856	Gadus morhua	68.85	8.00e-25	104.00
IUUC-Gga-040469	Gallus gallus	44.58	8.00e-59	220.00
IUUC-Gac-041420	Gasterosteus aculeatus	44.40	3.00e-65	242.00
IUUC-Ggo-045079	Gorilla gorilla	42.69	3.00e-58	219.00
IUUC-Hsa-046507	Homo sapiens	45.04	2.00e-33	137.00
IUUC-Lch-049453	Latimeria chalumnae	48.84	1.00e-32	134.00
IUUC-Loc-052248	Lepisosteus oculatus	45.31	2.00e-30	126.00
IUUC-Laf-053651	Loxodonta africana	45.86	1.00e-61	230.00
IUUC-Mcc-054688	Macaca mulatta	41.90	1.00e-60	227.00
IUUC-Meu-056291	Macropus eugenii	67.95	9.00e-31	128.00
IUUC-Mga-059944	Meleagris gallopavo	47.69	4.00e-32	132.00
IUUC-Mmr-061553	Microcebus murinus	45.52	2.00e-60	226.00
IUUC-Mdo-062313	Monodelphis domestica	44.49	5.00e-59	222.00
IUUC-Mmu-063516	Mus musculus	43.31	3.00e-60	226.00
IUUC-Mpu-066064	Mustela putorius furo	45.15	4.00e-60	225.00
IUUC-Mlu-067312	Myotis lucifugus	45.52	5.00e-61	228.00
IUUC-Nle-069035	Nomascus leucogenys	41.90	1.00e-60	227.00
IUUC-Opr-070739	Ochotona princeps	40.30	2.00e-53	202.00
IUUC-Ont-071484	Oreochromis niloticus	44.85	1.00e-66	247.00
IUUC-Oan-073305	Ornithorhynchus anatinus	47.39	4.00e-64	238.00
IUUC-Ocu-074936	Oryctolagus cuniculus	45.52	1.00e-60	227.00
IUUC-Ola-086675	Oryzias latipes	39.49	1.00e-53	204.00
IUUC-Oga-088276	Otolemur garnettii	42.42	5.00e-30	125.00
IUUC-Oar-090315	Ovis aries	43.94	4.00e-30	125.00
IUUC-Ptr-090865	Pan troglodytes	41.90	1.00e-60	227.00
IUUC-Pan-092362	Papio anubis	41.90	2.00e-60	226.00
IUUC-Psi-093876	Pelodiscus sinensis	46.62	3.00e-63	236.00
IUUC-Ppa-095766	Physcomitrella patens	36.11	4.00e-07	47.40
IUUC-Pfo-097116	Poecilia formosa	46.99	3.00e-66	245.00
IUUC-Pab-098127	Pongo abelii	41.90	2.00e-60	226.00
IUUC-Pca-100485	Procavia capensis	45.90	6.00e-61	228.00
IUUC-Pva-102661	Pteropus vampyrus	45.11	9.00e-62	231.00
IUUC-Rno-105728	Rattus norvegicus	43.66	2.00e-60	227.00
IUUC-Sce-106404	Saccharomyces cerevisiae	52.63	7.00e-12	64.30
IUUC-Sha-106515	Sarcophilus harrisii	45.11	4.00e-60	224.00
IUUC-Spo-108340	Schizosaccharomyces pombe	42.00	2.00e-10	58.90
IUUC-Smo-109517	Selaginella moellendorffii	40.30	2.00e-08	49.30
IUUC-Stu-112783	Solanum tuberosum	37.68	1.00e-07	50.10
IUUC-Sar-113161	Sorex araneus	45.15	7.00e-61	228.00
IUUC-Ssc-115314	Sus scrofa	44.78	1.00e-60	227.00
IUUC-Tgu-117012	Taeniopygia guttata	43.84	5.00e-62	231.00
IUUC-Tru-118467	Takifugu rubripes	46.92	8.00e-35	142.00
IUUC-Tsy-118968	Tarsius syrichta	42.31	4.00e-48	185.00
IUUC-Tni-120900	Tetraodon nigroviridis	37.55	2.00e-48	186.00
IUUC-Tbe-128070	Tupaia belangeri	41.90	6.00e-60	224.00
IUUC-Ttr-128161	Tursiops truncatus	45.74	1.00e-57	217.00
IUUC-Vpa-130075	Vicugna pacos	44.26	2.00e-28	120.00
IUUC-Xtr-132628	Xenopus tropicalis	45.11	1.00e-62	233.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence