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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Rno-105045
UUCD1 version UUC-RaN-01033
Ensembl Protein ID ENSRNOP00000019612.4
UniProt Accession Q5BJY4; JOS1_RAT
Genbank Protein ID AAH91280.1
Protein Name Josephin-1; Josephin domain-containing protein 1
Genbank Nucleotide ID BC091280
Gene Name Josd1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000014440.6 ENSRNOT00000019612.6 ENSRNOP00000019612.4
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNATRANSFACmiRNAMapRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/Josephin 9.50e-99 328.9 1 201
Active Site
Position(s) Description Evidence
36 Nucleophile ECO:0000255|PROSITE-ProRule:PRU00331}
139 Proton acceptor ECO:0000255|PROSITE-ProRule:PRU00331}
Domain Profile

   DUB/Josephin
   S: 1    msqvpg............aqaapesiyhekqrrelCalhalnnvlqd.elfsreeldeiakrldeeerlqPs.kslldtGnydvnvisa 75
           ms++p+            +qaap++iyhekqrrelCalhalnnv+qd ++f+re+l+ei++rl++++ ++P+ ks+l++Gnydvnvi+a
   Q: 1    MSCMPWkgdkakseslelPQAAPPQIYHEKQRRELCALHALNNVFQDsNAFTRETLQEIFQRLSPNTVVTPHkKSMLGNGNYDVNVIMA 89
           89*********************************************9************************99*************** PP
   S: 76   alkvlGleavwfdkrrelqklaldnvlgfilnlpsslslgllklplkkqhWvtvrkvgkayynldsklkaPeligdetelrkflakllq 164
           al+++G+eavw+dkrr+++++al nv+gfi+nlpssl++g+lklplk+qhW++vr+vg+ayynldsklk+Pe+ig+e+elrkfl+ +l+
   Q: 90   ALQTKGYEAVWWDKRRDVGVIALANVMGFIMNLPSSLCWGPLKLPLKRQHWICVREVGGAYYNLDSKLKMPEWIGGESELRKFLKYHLR 178
           ***************************************************************************************** PP
   S: 165  qkyselllvvkeevedkesdqrld 188
           +k++elllvv+eeve+++s+ r d
   Q: 179  GKNCELLLVVPEEVEAHQSW-RAD 201
           ********************.665 PP
   
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     Deubiquitinates monoubiquitinated probes (in vitro). When ubiquitinated, cleaves 'Lys-63'-linked and 'Lys-48'-linked poly-ubiquitin chains (in vitro), hence may act as a deubiquitinating enzyme. May increase macropinocytosis and suppress clathrin- and caveolae-mediated endocytosis. May enhance membrane dynamics and cell motility independently of its catalytic activity (By similarity).
 Deubiquitinates monoubiquitinated probes (in vitro). When ubiquitinated, cleaves 'Lys-63'-linked and 'Lys-48'-linked poly-ubiquitin chains (in vitro), hence may act as a deubiquitinating enzyme. May increase macropinocytosis and suppress clathrin- and caveolae-mediated endocytosis. May enhance membrane dynamics and cell motility independently of its catalytic activity (By similarity).
Protein Sequence
(Fasta)
MSCMPWKGDK AKSESLELPQ AAPPQIYHEK QRRELCALHA LNNVFQDSNA FTRETLQEIF 60
QRLSPNTVVT PHKKSMLGNG NYDVNVIMAA LQTKGYEAVW WDKRRDVGVI ALANVMGFIM 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-105045|DUB,Josephin|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGAGAAGACA GAAAAGGTAG ACTGGTGGGT TGGGTTTTTT TGTCCCTTTT GGTTCCAACC 60
TTTCCTCCCA GTGACAAAGC ATAAATCATG GACACCAGAG AGTAGGTGAA CCTCAGGAAT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-105045|DUB,Josephin|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Interpro

IPR006155--Josephin
PROSITE

PS50957--JOSEPHIN
Pfam

PF02099--Josephin
SMART

SM01246--Josephin
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005886--C:plasma membrane
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
KEGG rno:315134
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002429 Ailuropoda melanoleuca 96.53 5.00e-109 386.00
IUUC-Apl-003240 Anas platyrhynchos 89.16 1.00e-95 341.00
IUUC-Aca-004262 Anolis carolinensis 89.60 5.00e-102 363.00
IUUC-Ath-007306 Arabidopsis thaliana 40.12 1.00e-29 123.00
IUUC-Afl-008651 Aspergillus flavus 33.82 7.00e-02 29.60
IUUC-Ame-011040 Astyanax mexicanus 70.05 9.00e-81 292.00
IUUC-Bta-012440 Bos taurus 96.53 1.00e-109 388.00
IUUC-Cja-019461 Callithrix jacchus 96.04 7.00e-109 385.00
IUUC-Cfa-021002 Canis familiaris 96.53 4.00e-109 386.00
IUUC-Cpo-021309 Cavia porcellus 97.52 1.00e-110 391.00
IUUC-Csa-023194 Chlorocebus sabaeus 96.53 7.00e-110 389.00
IUUC-Cho-025019 Choloepus hoffmanni 96.53 5.00e-110 389.00
IUUC-Cin-025666 Ciona intestinalis 59.76 2.00e-54 205.00
IUUC-Csv-026011 Ciona savignyi 55.50 3.00e-58 217.00
IUUC-Dre-028692 Danio rerio 69.44 3.00e-80 290.00
IUUC-Dno-029803 Dasypus novemcinctus 96.53 1.00e-109 388.00
IUUC-Dor-030619 Dipodomys ordii 97.86 3.00e-72 264.00
IUUC-Ete-032777 Echinops telfairi 94.12 6.00e-105 372.00
IUUC-Eca-034395 Equus caballus 95.05 2.00e-108 384.00
IUUC-Eeu-035075 Erinaceus europaeus 74.75 8.00e-77 279.00
IUUC-Fca-035819 Felis catus 96.53 1.00e-109 388.00
IUUC-Fal-037330 Ficedula albicollis 91.09 1.00e-98 352.00
IUUC-Gmo-038979 Gadus morhua 74.87 2.00e-76 278.00
IUUC-Gga-040456 Gallus gallus 93.60 7.00e-99 352.00
IUUC-Gac-041797 Gasterosteus aculeatus 74.13 7.00e-81 292.00
IUUC-Ggo-045586 Gorilla gorilla 97.03 3.00e-110 390.00
IUUC-Hsa-047008 Homo sapiens 97.03 3.00e-110 390.00
IUUC-Itr-048432 Ictidomys tridecemlineatus 98.02 7.00e-111 392.00
IUUC-Lch-049682 Latimeria chalumnae 78.71 4.00e-84 303.00
IUUC-Loc-051775 Lepisosteus oculatus 80.23 1.00e-76 279.00
IUUC-Laf-054283 Loxodonta africana 96.08 6.00e-108 382.00
IUUC-Mcc-055073 Macaca mulatta 96.88 3.00e-111 394.00
IUUC-Meu-056650 Macropus eugenii 93.56 2.00e-105 374.00
IUUC-Mga-059703 Meleagris gallopavo 93.56 4.00e-100 357.00
IUUC-Mdo-062114 Monodelphis domestica 94.55 3.00e-107 380.00
IUUC-Mmu-064230 Mus musculus 97.03 3.00e-110 390.00
IUUC-Mpu-065845 Mustela putorius furo 96.04 1.00e-108 385.00
IUUC-Mlu-067564 Myotis lucifugus 92.57 1.00e-97 348.00
IUUC-Nfi-068472 Neosartorya fischeri 30.00 1.90e-01 29.30
IUUC-Nle-069516 Nomascus leucogenys 96.53 1.00e-109 388.00
IUUC-Opr-070945 Ochotona princeps 78.71 4.00e-84 303.00
IUUC-Ont-071439 Oreochromis niloticus 70.05 3.00e-78 284.00
IUUC-Oan-073122 Ornithorhynchus anatinus 90.21 4.00e-68 249.00
IUUC-Ocu-074128 Oryctolagus cuniculus 84.30 7.00e-55 205.00
IUUC-Ola-086972 Oryzias latipes 67.46 3.00e-70 257.00
IUUC-Oga-088786 Otolemur garnettii 96.04 4.00e-116 409.00
IUUC-Oar-089212 Ovis aries 96.06 3.00e-108 384.00
IUUC-Ptr-090936 Pan troglodytes 97.03 3.00e-110 390.00
IUUC-Pan-092234 Papio anubis 97.03 3.00e-110 390.00
IUUC-Psi-093448 Pelodiscus sinensis 93.07 4.00e-104 370.00
IUUC-Pfo-096711 Poecilia formosa 80.68 7.00e-78 283.00
IUUC-Pab-097628 Pongo abelii 96.53 2.00e-108 384.00
IUUC-Pop-099793 Populus trichocarpa 36.14 3.00e-23 101.00
IUUC-Pca-100555 Procavia capensis 95.54 1.00e-85 307.00
IUUC-Pva-102259 Pteropus vampyrus 96.53 1.00e-109 388.00
IUUC-Sha-107606 Sarcophilus harrisii 95.05 8.00e-108 382.00
IUUC-Ssc-115663 Sus scrofa 97.52 1.00e-110 391.00
IUUC-Tgu-117374 Taeniopygia guttata 90.59 4.00e-101 360.00
IUUC-Tru-118030 Takifugu rubripes 80.11 9.00e-77 279.00
IUUC-Tsy-119298 Tarsius syrichta 96.04 2.00e-108 384.00
IUUC-Tni-119797 Tetraodon nigroviridis 78.98 4.00e-76 277.00
IUUC-Tca-121220 Theobroma cacao 39.20 3.00e-29 122.00
IUUC-Tbe-127896 Tupaia belangeri 98.51 1.00e-111 395.00
IUUC-Ttr-128523 Tursiops truncatus 96.04 1.00e-108 384.00
IUUC-Vpa-130184 Vicugna pacos 93.07 5.00e-111 393.00
IUUC-Xtr-131903 Xenopus tropicalis 85.15 9.00e-95 338.00
Created Date 25-Jun-2017

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