iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-066069

Ensembl Protein ID

ENSMPUP00000017128.1

UniProt Accession

M3Z0L6; M3Z0L6_MUSPF

Genbank Protein ID

ENSMPUP00000017128

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEYP01026457

Gene Name

HECTD2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000017236.1	ENSMPUT00000017382.1	ENSMPUP00000017128.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.10e-103	345.3	324	662

Active Site

Position(s)	Description	Evidence
630	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkk+l+v+fvgE+gld+gG+t+e++ ll++++++pd+g+f+y+++++++++ + +      ++ + F+++G+l+g+a++++  ld+
   Q: 324  RADLKKKLKVTFVGEAGLDMGGLTKEWFLLLIRQIFHPDYGMFTYHKDSHCHWFSSFKC-----DNYSEFRLVGILMGLAVYNSITLDI 407
           589***************************************************87766.....789********************** PP
   S: 91   plsksfyklllgk..............klsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipV 165
           ++++++yk+ll+               +++ +dl +++pel++ l e++++ e ++ee  +  tf+v +e++g +k+++LkpgG++ipV
   Q: 408  RFPPCCYKKLLSPpiipsdqnipvgicSVTTDDLCQIMPELAHGLSELLSY-EGNVEED-FFSTFQVFQEEFGIIKSYNLKPGGDKIPV 494
           *************666666666665555**********************9.6788885.9**************************** PP
   S: 166  tneNkeeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevle 254
           tn+N++eYv+l++++ l+++i +q++af+ Gf++v+  + l l+++ee+e+l+cG++e+d+++l++ t+y+g y +++ +i++Fw+v+ 
   Q: 495  TNQNRKEYVQLYIDFLLNKSIYKQFAAFYYGFHSVCASNALMLLRPEEVEILVCGSPELDMHALQRSTQYDG-YAKTDLTIRYFWDVVL 582
           **********************************************************************76.**************** PP
   S: 255  efsseerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +f  + +k++L+F+Tgs+r+P+gG+a+l+   f i+k ++s+++lP ++TCfn+L+LP+Y+sk+ lk+kL++ i++++gF+l+
   Q: 583  GFPLDLQKKLLHFTTGSDRVPVGGMADLN---FKISKnETSTNWLPVAHTCFNQLCLPPYKSKKDLKQKLIIGISNSEGFGLE 662
           *****************************...9999967777**************************************985 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

MKAPVLPESV LPNQPKTMKD FQEDIEKVKS SGDWKAVHDF YLATFDSFPE LNAAFKKDAT 60
ASFNTIEDSG INAKFVNAVY DALLNTPQDI QKTVLKGIIN SLLQEWKGPR TKDDLRAYFI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTTTGGACA GAGGATCCAA AGGCCAAATT TCCACTTTTA GCAGTTTTAT TTCAACTGTT 60
AACCAGAAGA AAGAAGCCGC TGAAAACAGA AGTTCACCTA CACATCTTGT TTTCCCTAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001266	Ailuropoda melanoleuca	98.50	0.00e+00	1342.00
IUUC-Apl-003589	Anas platyrhynchos	88.22	0.00e+00	1189.00
IUUC-Aca-004350	Anolis carolinensis	83.84	0.00e+00	1150.00
IUUC-Ago-007908	Ashbya gossypii	35.06	3.00e-80	293.00
IUUC-Acl-008288	Aspergillus clavatus	35.53	6.00e-96	345.00
IUUC-Afl-008402	Aspergillus flavus	34.16	3.00e-89	323.00
IUUC-Afu-008762	Aspergillus fumigatus	34.48	2.00e-92	333.00
IUUC-Ani-009176	Aspergillus nidulans	35.71	1.00e-91	331.00
IUUC-Ang-009791	Aspergillus niger	36.03	1.00e-91	331.00
IUUC-Aor-009921	Aspergillus oryzae	34.00	2.00e-88	320.00
IUUC-Ate-010295	Aspergillus terreus	36.30	2.00e-98	354.00
IUUC-Ame-010660	Astyanax mexicanus	82.94	2.00e-153	535.00
IUUC-Bgr-011981	Blumeria graminis	32.38	8.00e-92	332.00
IUUC-Bta-012945	Bos taurus	96.68	0.00e+00	1298.00
IUUC-Bci-013697	Botrytis cinerea	33.22	3.00e-78	286.00
IUUC-Cja-019263	Callithrix jacchus	96.10	0.00e+00	1291.00
IUUC-Cfa-020486	Canis familiaris	98.45	0.00e+00	1330.00
IUUC-Cpo-021755	Cavia porcellus	96.98	0.00e+00	1326.00
IUUC-Csa-023814	Chlorocebus sabaeus	96.95	0.00e+00	1218.00
IUUC-Cho-024980	Choloepus hoffmanni	78.10	0.00e+00	1001.00
IUUC-Cgl-026526	Colletotrichum gloeosporioides	41.35	2.00e-95	344.00
IUUC-Dre-028551	Danio rerio	79.46	0.00e+00	1082.00
IUUC-Dno-029497	Dasypus novemcinctus	93.98	0.00e+00	1230.00
IUUC-Dor-030867	Dipodomys ordii	82.78	0.00e+00	1092.00
IUUC-Dse-031239	Dothistroma septosporum	29.48	1.00e-87	318.00
IUUC-Ete-032902	Echinops telfairi	82.75	0.00e+00	1099.00
IUUC-Eca-033678	Equus caballus	97.58	0.00e+00	1309.00
IUUC-Eeu-035262	Erinaceus europaeus	78.85	0.00e+00	1014.00
IUUC-Fca-035590	Felis catus	98.49	0.00e+00	1366.00
IUUC-Fal-037123	Ficedula albicollis	84.26	0.00e+00	1120.00
IUUC-Fox-037941	Fusarium oxysporum	40.68	5.00e-99	356.00
IUUC-Fso-038388	Fusarium solani	41.27	1.00e-101	365.00
IUUC-Gmo-039553	Gadus morhua	66.46	0.00e+00	846.00
IUUC-Ggr-040110	Gaeumannomyces graminis	42.86	2.00e-96	347.00
IUUC-Gga-040406	Gallus gallus	88.22	0.00e+00	1219.00
IUUC-Gac-042141	Gasterosteus aculeatus	76.28	0.00e+00	1070.00
IUUC-Ggo-045504	Gorilla gorilla	95.80	0.00e+00	1287.00
IUUC-Hsa-045786	Homo sapiens	96.37	0.00e+00	1293.00
IUUC-Itr-048050	Ictidomys tridecemlineatus	90.36	0.00e+00	1187.00
IUUC-Kpa-049152	Komagataella pastoris	33.98	6.00e-75	275.00
IUUC-Lch-049824	Latimeria chalumnae	83.69	0.00e+00	1029.00
IUUC-Loc-052173	Lepisosteus oculatus	83.62	0.00e+00	1150.00
IUUC-Laf-054017	Loxodonta africana	96.22	0.00e+00	1296.00
IUUC-Mcc-055713	Macaca mulatta	96.55	0.00e+00	1292.00
IUUC-Meu-056212	Macropus eugenii	69.75	2.00e-116	413.00
IUUC-Mor-057045	Magnaporthe oryzae	38.51	4.00e-88	320.00
IUUC-Mla-059187	Melampsora laricipopulina	43.74	4.00e-87	315.00
IUUC-Mga-059884	Meleagris gallopavo	80.72	0.00e+00	1060.00
IUUC-Mmr-061344	Microcebus murinus	96.67	0.00e+00	1321.00
IUUC-Mdo-062653	Monodelphis domestica	91.69	0.00e+00	1235.00
IUUC-Mmu-063775	Mus musculus	93.35	0.00e+00	1209.00
IUUC-Mlu-067925	Myotis lucifugus	96.98	0.00e+00	1302.00
IUUC-Nfi-068439	Neosartorya fischeri	34.65	5.00e-93	336.00
IUUC-Ncr-068903	Neurospora crassa	37.68	7.00e-91	329.00
IUUC-Nle-070046	Nomascus leucogenys	96.10	0.00e+00	1314.00
IUUC-Opr-071085	Ochotona princeps	79.53	1.00e-136	480.00
IUUC-Ont-072126	Oreochromis niloticus	77.19	0.00e+00	1093.00
IUUC-Oan-072933	Ornithorhynchus anatinus	89.80	0.00e+00	1179.00
IUUC-Ocu-073800	Oryctolagus cuniculus	96.98	0.00e+00	1297.00
IUUC-Ola-086988	Oryzias latipes	76.32	0.00e+00	1075.00
IUUC-Oga-088117	Otolemur garnettii	96.90	0.00e+00	1131.00
IUUC-Oar-089371	Ovis aries	96.68	0.00e+00	1276.00
IUUC-Ptr-090551	Pan troglodytes	95.80	0.00e+00	1287.00
IUUC-Pan-092067	Papio anubis	97.13	0.00e+00	1298.00
IUUC-Psi-092963	Pelodiscus sinensis	89.26	0.00e+00	1189.00
IUUC-Pfo-096562	Poecilia formosa	75.23	0.00e+00	1069.00
IUUC-Pab-098680	Pongo abelii	96.53	0.00e+00	1293.00
IUUC-Pca-100986	Procavia capensis	76.50	0.00e+00	897.00
IUUC-Pva-102219	Pteropus vampyrus	86.50	0.00e+00	1036.00
IUUC-Pgr-103315	Puccinia graminis	36.27	4.00e-95	342.00
IUUC-Ptt-103736	Puccinia triticina	41.91	2.00e-94	340.00
IUUC-Rno-105270	Rattus norvegicus	93.81	0.00e+00	1212.00
IUUC-Sce-106306	Saccharomyces cerevisiae	34.65	2.00e-68	253.00
IUUC-Sha-106819	Sarcophilus harrisii	92.46	0.00e+00	1263.00
IUUC-Spo-108271	Schizosaccharomyces pombe	34.53	4.00e-85	309.00
IUUC-Ssl-108657	Sclerotinia sclerotiorum	30.95	1.00e-82	301.00
IUUC-Sar-113134	Sorex araneus	87.48	0.00e+00	1134.00
IUUC-Ssc-115441	Sus scrofa	97.13	0.00e+00	1283.00
IUUC-Tgu-117166	Taeniopygia guttata	87.94	0.00e+00	1161.00
IUUC-Tsy-118898	Tarsius syrichta	83.61	0.00e+00	1054.00
IUUC-Tre-122108	Trichoderma reesei	39.03	5.00e-88	319.00
IUUC-Tvi-122644	Trichoderma virens	39.31	3.00e-93	337.00
IUUC-Tme-127004	Tuber melanosporum	34.56	3.00e-101	363.00
IUUC-Tbe-127292	Tupaia belangeri	78.25	0.00e+00	977.00
IUUC-Ttr-128352	Tursiops truncatus	92.45	0.00e+00	1222.00
IUUC-Vda-129969	Verticillium dahliae	40.66	9.00e-92	332.00
IUUC-Vpa-130218	Vicugna pacos	95.61	0.00e+00	893.00
IUUC-Xtr-132594	Xenopus tropicalis	80.06	0.00e+00	1057.00
IUUC-Xma-134157	Xiphophorus maculatus	75.12	0.00e+00	996.00
IUUC-Yli-134470	Yarrowia lipolytica	34.48	2.00e-75	277.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence