iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
Protein-protein Interaction
iRefIndex	Mentha
Post-translational Modifications (PTMs)
dbPPT
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/HECT	HECT	12969426

Classification

Family	E-value	Score	Start	End
E3 activity/HECT	1.80e-109	367.1	689	1029

Active Site

Position(s)	Description	Evidence
997	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvg.....EegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlpl 92
           ++dl+++++v+fv+     E+g+d gG++++f+++++++ ++ ++glf  +e+ +++l+pnp sg+ +++hl++F+flG ll+ka+++g l+d+p+
   Q: 689  EDDLRSSIRVTFVNelgveEAGIDGGGIFKDFMEKITRAAFDVQYGLF--KETADHMLYPNPGSGMIHEQHLQFFHFLGSLLAKAMFEGILVDIPF 782
           689***********9999999***************************..566688999999999999**************************** PP
   S: 93   sksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegike 188
           +++f+++l +k   l+dl+++dpely++l ++k++ + di++  l+l f + ++++ge++eeeL+pgG++++VtneN   +++lv ++rl+ +i++
   Q: 783  ATFFLSKLKQKYNYLNDLPSLDPELYRHLIFLKRY-KGDISD--LELYFVILNNEYGERTEEELLPGGQDMRVTNENVITFIHLVSNHRLNFQIRQ 875
           ***********9999********************.668887..69999999******************************************** PP
   S: 189  qveafreGfneviplellslFteeelellicGe.eeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelk 283
           q  +f +Gf+++ip+e++++F+e+el++li+G+ +++d++dl+++t+y ggy++ + +i++Fwev+++fs e++k+fL+FvTg+sr Pl Gf++l+
   Q: 876  QSSHFLRGFQQLIPKEWIDMFNEHELQVLISGSvDSLDIDDLRNNTNYAGGYHAGHYVIDMFWEVMKSFSTENQKKFLKFVTGCSRGPLLGFKYLE 971
           ************************************************************************************************ PP
   S: 284  prlfvirk......dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           p  f+i++      ++s drlP+s TC+n+LkLP+Y+ske l+ kL+yAi+ ++gF+ls
   Q: 972  PA-FCIQRaagsasNESVDRLPTSATCMNLLKLPPYQSKELLETKLMYAISAEAGFDLS 1029
           88.888888***988888**************************************985 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Probable E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins.

Protein Sequence
(Fasta)

MFFSGDPSTR KRVDLGGRST KERDARKLLE QTRMERNRRL LQKQQNSAAL KIQKFFRGRR 60
SMAIERSKVR HDFCETYGNN CQNVDRHCFE PGSSFLRQFL FFFKAQNSGD FVILVETCRL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATCACCATAA AGATGAGAAA CCATAACACC AGTGATGTTA CAAAAAATAA AATCAACCAA 60
CCAACCAATA GACACAATTT TTTTCCCGTG TAACACGAGA CGACCCAATT ATTCGTCTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR000048--IQ_motif_EF-hand-BS

PROSITE

PS50237--HECT
PS50096--IQ

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

KEGG

ath:AT3G17205

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000469	Aegilops tauschii	55.51	0.00e+00	1008.00
IUUC-Aml-001355	Ailuropoda melanoleuca	46.29	4.00e-104	372.00
IUUC-Atr-002669	Amborella trichopoda	60.67	0.00e+00	1241.00
IUUC-Apl-003731	Anas platyrhynchos	47.28	2.00e-109	390.00
IUUC-Aca-005248	Anolis carolinensis	29.75	2.00e-114	406.00
IUUC-Aly-005768	Arabidopsis lyrata	97.47	0.00e+00	2055.00
IUUC-Ame-010769	Astyanax mexicanus	41.80	3.00e-75	276.00
IUUC-Bta-012841	Bos taurus	47.03	4.00e-107	382.00
IUUC-Bci-013743	Botrytis cinerea	39.28	1.00e-83	304.00
IUUC-Bdi-014123	Brachypodium distachyon	59.82	0.00e+00	1167.00
IUUC-Bol-015467	Brassica oleracea	90.31	0.00e+00	1899.00
IUUC-Bra-017723	Brassica rapa	90.41	0.00e+00	1898.00
IUUC-Cfa-021031	Canis familiaris	46.29	4.00e-105	375.00
IUUC-Cpo-022401	Cavia porcellus	46.29	5.00e-105	375.00
IUUC-Cre-022725	Chlamydomonas reinhardtii	44.50	6.00e-97	347.00
IUUC-Csa-024107	Chlorocebus sabaeus	45.79	3.00e-104	372.00
IUUC-Cho-024750	Choloepus hoffmanni	47.66	6.00e-93	335.00
IUUC-Cin-025750	Ciona intestinalis	34.21	4.00e-99	355.00
IUUC-Csv-026016	Ciona savignyi	35.07	1.00e-102	367.00
IUUC-Cme-027265	Cyanidioschyzon merolae	40.21	3.00e-105	375.00
IUUC-Dre-028196	Danio rerio	47.03	3.00e-107	382.00
IUUC-Dno-029024	Dasypus novemcinctus	46.78	3.00e-106	379.00
IUUC-Ete-033041	Echinops telfairi	44.04	6.00e-68	251.00
IUUC-Eca-033828	Equus caballus	46.53	6.00e-106	378.00
IUUC-Fca-035907	Felis catus	46.29	5.00e-105	375.00
IUUC-Fal-037389	Ficedula albicollis	47.03	7.00e-109	388.00
IUUC-Ggr-039941	Gaeumannomyces graminis	38.83	5.00e-83	302.00
IUUC-Gga-040310	Gallus gallus	47.03	1.00e-108	387.00
IUUC-Gma-042836	Glycine max	69.51	0.00e+00	1467.00
IUUC-Ggo-045031	Gorilla gorilla	46.04	8.00e-105	374.00
IUUC-Hsa-045880	Homo sapiens	46.04	8.00e-105	374.00
IUUC-Hvu-047770	Hordeum vulgare	62.75	0.00e+00	964.00
IUUC-Itr-048372	Ictidomys tridecemlineatus	46.75	7.00e-96	343.00
IUUC-Kpa-049307	Komagataella pastoris	36.58	3.00e-70	259.00
IUUC-Lpe-051428	Leersia perrieri	55.87	0.00e+00	1106.00
IUUC-Loc-052218	Lepisosteus oculatus	46.29	2.00e-105	376.00
IUUC-Mcc-055127	Macaca mulatta	46.04	1.00e-104	374.00
IUUC-Mtr-058154	Medicago truncatula	67.57	0.00e+00	1422.00
IUUC-Mla-059124	Melampsora laricipopulina	44.80	2.00e-93	335.00
IUUC-Mga-059581	Meleagris gallopavo	47.03	7.00e-109	387.00
IUUC-Mvi-060445	Microbotryum violaceum	35.68	9.00e-96	344.00
IUUC-Mmr-061360	Microcebus murinus	46.29	6.00e-105	375.00
IUUC-Mdo-062194	Monodelphis domestica	38.52	3.00e-107	382.00
IUUC-Mmu-064189	Mus musculus	38.34	7.00e-105	374.00
IUUC-Mac-065275	Musa acuminata	59.93	0.00e+00	1046.00
IUUC-Mpu-066439	Mustela putorius furo	46.53	7.00e-106	378.00
IUUC-Mlu-068228	Myotis lucifugus	38.52	4.00e-107	382.00
IUUC-Oan-072800	Ornithorhynchus anatinus	47.28	1.00e-108	387.00
IUUC-Ocu-074587	Oryctolagus cuniculus	46.29	3.00e-105	375.00
IUUC-Oba-075006	Oryza barthii	60.19	0.00e+00	1248.00
IUUC-Obr-076133	Oryza brachyantha	60.33	0.00e+00	1251.00
IUUC-Ogl-077003	Oryza glaberrima	60.19	0.00e+00	1248.00
IUUC-Ogu-078947	Oryza glumaepatula	60.42	0.00e+00	1248.00
IUUC-Oin-079407	Oryza indica	58.26	0.00e+00	1189.00
IUUC-Olo-080475	Oryza longistaminata	60.19	0.00e+00	1249.00
IUUC-Ome-081342	Oryza meridionalis	58.36	0.00e+00	1189.00
IUUC-Oni-082385	Oryza nivara	60.33	0.00e+00	1247.00
IUUC-Opu-083176	Oryza punctata	58.67	0.00e+00	1208.00
IUUC-Oru-084554	Oryza rufipogon	58.41	0.00e+00	1193.00
IUUC-Osa-085355	Oryza sativa	60.39	0.00e+00	1251.00
IUUC-Ola-087209	Oryzias latipes	45.79	4.00e-106	379.00
IUUC-Olu-087699	Ostreococcus lucimarinus	47.47	8.00e-101	359.00
IUUC-Oga-088776	Otolemur garnettii	46.04	4.00e-104	372.00
IUUC-Oar-089441	Ovis aries	47.03	4.00e-107	382.00
IUUC-Ptr-091273	Pan troglodytes	46.04	9.00e-105	374.00
IUUC-Pan-091981	Papio anubis	46.04	9.00e-105	374.00
IUUC-Pma-094738	Petromyzon marinus	34.38	5.00e-108	385.00
IUUC-Pno-095132	Phaeosphaeria nodorum	36.64	9.00e-60	224.00
IUUC-Ppa-095682	Physcomitrella patens	49.86	0.00e+00	945.00
IUUC-Pfo-097511	Poecilia formosa	47.03	2.00e-108	386.00
IUUC-Pop-098928	Populus trichocarpa	71.25	0.00e+00	1494.00
IUUC-Pca-100987	Procavia capensis	48.07	1.00e-99	357.00
IUUC-Ppe-102040	Prunus persica	73.44	0.00e+00	1520.00
IUUC-Pgr-103513	Puccinia graminis	43.81	3.00e-93	336.00
IUUC-Pte-104105	Pyrenophora teres	38.28	1.00e-79	291.00
IUUC-Pyt-104449	Pyrenophora triticirepentis	38.28	3.00e-79	289.00
IUUC-Sja-107889	Schizosaccharomyces japonicus	36.04	1.00e-96	347.00
IUUC-Spo-108097	Schizosaccharomyces pombe	36.20	5.00e-98	352.00
IUUC-Ssl-108520	Sclerotinia sclerotiorum	39.70	5.00e-82	298.00
IUUC-Smo-109007	Selaginella moellendorffii	46.53	0.00e+00	925.00
IUUC-Sit-110457	Setaria italica	60.62	0.00e+00	1237.00
IUUC-Sly-111362	Solanum lycopersicum	68.50	0.00e+00	1418.00
IUUC-Sar-113687	Sorex araneus	42.24	1.00e-60	227.00
IUUC-Sbi-113882	Sorghum bicolor	59.38	0.00e+00	1201.00
IUUC-Tgu-116729	Taeniopygia guttata	46.78	7.00e-108	384.00
IUUC-Tru-118068	Takifugu rubripes	46.78	1.00e-105	377.00
IUUC-Tsy-118942	Tarsius syrichta	49.81	4.00e-71	262.00
IUUC-Tca-121737	Theobroma cacao	74.23	0.00e+00	1586.00
IUUC-Tae-125229	Triticum aestivum	59.56	0.00e+00	1241.00
IUUC-Tme-127102	Tuber melanosporum	38.00	1.00e-82	301.00
IUUC-Tbe-127351	Tupaia belangeri	45.48	1.00e-87	317.00
IUUC-Uma-129343	Ustilago maydis	43.63	2.00e-94	340.00
IUUC-Vvi-131234	Vitis vinifera	71.11	0.00e+00	1490.00
IUUC-Xma-133923	Xiphophorus maculatus	47.03	1.00e-108	387.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence