iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Pma-094279

UUCD1 version

UUC-PeM-00423

Ensembl Protein ID

ENSPMAP00000002835.1

UniProt Accession

S4RCA3; S4RCA3_PETMA

Protein Name

Uncharacterized protein

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPMAG00000002570.1	ENSPMAT00000002849.1	ENSPMAP00000002835.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.70e-126	420.3	622	931

Active Site

Position(s)	Description	Evidence
900	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 25   treflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfyklllgkklsledleev 113
           +re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl +F+f+Gr++++al++g+++d+ +s +fyk++l+kkl+++dle++
   Q: 622  SREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLAYFRFIGRFIAMALYHGKFIDTGFSLPFYKRMLNKKLTIKDLESI 709
           79***********************************9.89************************************************ PP
   S: 114  dpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfnevip 202
           dpe+y+sl ++++n   +iee+gl++ fsv+ e+lg++++++Lkp+G++i Vt+eNkeeY+ l++e+r+ +g++eq++af +Gf+ev+p
   Q: 710  DPEFYNSLIWLRDN---NIEECGLEMFFSVDMELLGKVSSHDLKPDGSDILVTEENKEEYIGLMTEWRFSRGVEEQTKAFLDGFSEVVP 795
           ************99...9*********************************************************************** PP
   S: 203  lellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelk....prlf 287
           l++l +F+e+ele+++cG++eid+ d+++ t y++ y+++s++i wFw+v++e+++e+r ++LqFvTg++rlP+gGfael     p++f
   Q: 796  LQWLLYFDERELEVMLCGMQEIDLADWQRSTIYRH-YNRSSKQISWFWQVVKEMDNEKRLRLLQFVTGTCRLPVGGFAELIgsngPQKF 883
           *********************************99.***************************************************** PP
   S: 288  virkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           +i+k +++++lP+s+TCfn+L+LP+Y+s+e+lkekLlyAieet+gF++
   Q: 884  CIEKVGKETWLPRSHTCFNRLDLPPYKSYEQLKEKLLYAIEETEGFGQ 931
           **********************************************96 PP

Organism

Petromyzon marinus

Protein Sequence
(Fasta)

MADACPPHND SNASPGRTQL QVTVVSARLH GVKRSLIGGN PYVELLVDGQ VDTSKKTEKQ 60
SFSPNPQWSE HFTVMAAPTS RLEFRVWAYY PLKNNSLLGR AVVDIHKELL ENHGRLENVC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCCGATG CGTGTCCTCC CCACAACGAC AGCAACGCCT CGCCCGGTCG CACACAGTTG 60
CAGGTCACCG GTGAGTGAGC GAGCGACGTC ACCGCGGTTT GCGTCATACA CATGCTCAGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0060021--P:palate development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001213	Ailuropoda melanoleuca	56.38	0.00e+00	959.00
IUUC-Apl-003310	Anas platyrhynchos	75.00	0.00e+00	866.00
IUUC-Aca-005388	Anolis carolinensis	72.51	0.00e+00	860.00
IUUC-Ame-010601	Astyanax mexicanus	67.74	0.00e+00	818.00
IUUC-Bta-012857	Bos taurus	73.94	0.00e+00	871.00
IUUC-Cel-018299	Caenorhabditis elegans	58.59	0.00e+00	702.00
IUUC-Cja-019448	Callithrix jacchus	55.42	0.00e+00	969.00
IUUC-Cfa-020728	Canis familiaris	57.11	0.00e+00	980.00
IUUC-Cpo-021635	Cavia porcellus	72.35	0.00e+00	863.00
IUUC-Csa-023805	Chlorocebus sabaeus	75.09	0.00e+00	865.00
IUUC-Cho-024695	Choloepus hoffmanni	65.00	0.00e+00	831.00
IUUC-Cin-025212	Ciona intestinalis	65.07	0.00e+00	759.00
IUUC-Csv-026256	Ciona savignyi	64.95	0.00e+00	759.00
IUUC-Dre-028245	Danio rerio	71.86	0.00e+00	884.00
IUUC-Dno-029618	Dasypus novemcinctus	55.29	0.00e+00	962.00
IUUC-Dor-030176	Dipodomys ordii	71.50	0.00e+00	851.00
IUUC-Dme-032041	Drosophila melanogaster	62.56	0.00e+00	740.00
IUUC-Ete-032779	Echinops telfairi	71.15	0.00e+00	810.00
IUUC-Eca-033313	Equus caballus	72.85	0.00e+00	863.00
IUUC-Eeu-035259	Erinaceus europaeus	51.68	0.00e+00	867.00
IUUC-Fca-035420	Felis catus	75.35	0.00e+00	879.00
IUUC-Fal-037335	Ficedula albicollis	75.00	0.00e+00	869.00
IUUC-Gmo-038842	Gadus morhua	70.66	0.00e+00	820.00
IUUC-Gga-040246	Gallus gallus	75.00	0.00e+00	868.00
IUUC-Gac-042211	Gasterosteus aculeatus	72.22	0.00e+00	881.00
IUUC-Ggo-045001	Gorilla gorilla	57.58	0.00e+00	882.00
IUUC-Hsa-046544	Homo sapiens	56.39	0.00e+00	971.00
IUUC-Itr-048860	Ictidomys tridecemlineatus	51.34	0.00e+00	895.00
IUUC-Lch-050398	Latimeria chalumnae	74.61	0.00e+00	870.00
IUUC-Loc-052116	Lepisosteus oculatus	72.50	0.00e+00	885.00
IUUC-Laf-053551	Loxodonta africana	73.02	0.00e+00	870.00
IUUC-Mcc-055655	Macaca mulatta	71.43	0.00e+00	857.00
IUUC-Meu-055953	Macropus eugenii	65.45	0.00e+00	766.00
IUUC-Mga-059986	Meleagris gallopavo	55.56	0.00e+00	964.00
IUUC-Mmr-060896	Microcebus murinus	71.95	0.00e+00	861.00
IUUC-Mdo-062536	Monodelphis domestica	72.00	0.00e+00	860.00
IUUC-Mmu-063202	Mus musculus	75.35	0.00e+00	873.00
IUUC-Mpu-065773	Mustela putorius furo	57.43	0.00e+00	976.00
IUUC-Mlu-067837	Myotis lucifugus	68.75	0.00e+00	825.00
IUUC-Nle-069188	Nomascus leucogenys	56.60	0.00e+00	975.00
IUUC-Opr-070965	Ochotona princeps	73.95	0.00e+00	848.00
IUUC-Ont-072226	Oreochromis niloticus	71.48	0.00e+00	894.00
IUUC-Oan-073497	Ornithorhynchus anatinus	74.83	0.00e+00	869.00
IUUC-Ocu-074271	Oryctolagus cuniculus	71.25	0.00e+00	852.00
IUUC-Ola-087438	Oryzias latipes	73.09	0.00e+00	890.00
IUUC-Oga-087922	Otolemur garnettii	55.76	0.00e+00	971.00
IUUC-Oar-089317	Ovis aries	73.81	0.00e+00	867.00
IUUC-Ptr-090484	Pan troglodytes	56.28	0.00e+00	970.00
IUUC-Pan-092117	Papio anubis	56.39	0.00e+00	968.00
IUUC-Psi-093338	Pelodiscus sinensis	74.48	0.00e+00	867.00
IUUC-Pfo-096171	Poecilia formosa	73.44	0.00e+00	894.00
IUUC-Pab-098654	Pongo abelii	73.43	0.00e+00	842.00
IUUC-Pca-100596	Procavia capensis	62.02	0.00e+00	721.00
IUUC-Pva-102811	Pteropus vampyrus	75.00	0.00e+00	865.00
IUUC-Rno-106125	Rattus norvegicus	75.35	0.00e+00	872.00
IUUC-Sha-107243	Sarcophilus harrisii	72.95	0.00e+00	861.00
IUUC-Sar-113761	Sorex araneus	68.23	0.00e+00	823.00
IUUC-Ssc-115368	Sus scrofa	75.09	0.00e+00	870.00
IUUC-Tgu-117079	Taeniopygia guttata	75.00	0.00e+00	867.00
IUUC-Tru-118062	Takifugu rubripes	71.09	0.00e+00	892.00
IUUC-Tsy-119507	Tarsius syrichta	53.11	0.00e+00	916.00
IUUC-Tni-120151	Tetraodon nigroviridis	72.44	0.00e+00	877.00
IUUC-Tbe-127793	Tupaia belangeri	62.37	0.00e+00	701.00
IUUC-Ttr-128275	Tursiops truncatus	71.33	0.00e+00	855.00
IUUC-Vpa-130103	Vicugna pacos	74.28	1.00e-142	499.00
IUUC-Xtr-132866	Xenopus tropicalis	64.98	0.00e+00	827.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence